白细胞介素33在妊娠相关疾病中的研究进展
|
摘要
白细胞介素(interleukin,IL)-33在多种组织和细胞均可表达,其在稳态维持和环境应激应答中起重要作用,能通过IL-33/ST2信号通路参与众多疾病的发生与发展。研究表明IL-33参与母胎界面免疫耐受和促进胎盘形成等正常妊娠过程,而IL-33表达异常与流产、早产、子痫前期等妊娠相关疾病的发生发展有关,深入研究IL-33在妊娠中的作用,可能为正常妊娠维持及妊娠特发疾病的诊治提供新思路。
Interleukin(interleukin,IL)-33 can be expressed in various tissues and cells. It plays an important role in the maintenance of homeostasis and the response to environmental stress. It can participate in the formation and development of many diseases through IL-33/ST2 signaling pathway. Studies have shown that IL-33 is involved in maternal and fetal interface immune tolerance and placenta formation,while abnormal expression of IL-33 is related to the formation and development of pregnancy-related diseases such as abortion,preterm delivery and preeclampsia. The roles of IL-33 in pregnancy are deeply studied,and it may provide new ideas for the diagnosis and treatment of normal pregnancy maintenance and pregnancy specific diseases.
Interleukin(interleukin,IL)-33 can be expressed in various tissues and cells. It plays an important role in the maintenance of homeostasis and the response to environmental stress. It can participate in the formation and development of many diseases through IL-33/ST2 signaling pathway. Studies have shown that IL-33 is involved in maternal and fetal interface immune tolerance and placenta formation,while abnormal expression of IL-33 is related to the formation and development of pregnancy-related diseases such as abortion,preterm delivery and preeclampsia. The roles of IL-33 in pregnancy are deeply studied,and it may provide new ideas for the diagnosis and treatment of normal pregnancy maintenance and pregnancy specific diseases.
引文
[1]PrabhuDas M,Bonney E,Caron K,et al.Immune mechanisms at the maternal-fetal interface:perspectives and challenges[J].Nat Immunol,2015,16(4):328-334
[2]Scott LM,Bryant AH,Rees A,et al.Production and regulation of interleukin-1 family cytokines at the materno-fetal interface[J].Cytokine,2017,99:194-202
[3]Schmitz J,Owyang A,Oldham E,et al.IL-33,an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines[J].Immunity,2005,23(5):479-490
[4]Martin NT,Martin MU.Interleukin 33 is a guardian of barriers and a local alarmin[J].Nat Immunol,2016,17(2):122-131
[5]Bertheloot D,Latz E.HMGB1,IL-1α,IL-33 and S100 proteins:dual-function alarmins[J].Cell Mol Immunol,2017,14(1):43-64
[6]Moussion C,Ortega N,Girard JP.The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo:a novel'alarmin'?[J].PLoS One,2008,3(10):e3331
[7]Byers DE,Alexander-Brett J,Patel AC,et al.Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease[J].J Clin Invest,2013,123(9):3967-3982
[8]Reichenbach DK,Schwarze V,Matta BM,et al.The IL-33/ST2 axis augments effector T-cell responses during acute GVHD[J].Blood,2015,125(20):3183-3192
[9]Savinko T,Matikainen S,Saarialho-Kere U,et al.IL-33and ST2 in atopic dermatitis:expression profiles and modulation by triggering factors[J].J Invest Dermatol,2012,132(5):1392-1400
[10]Liew FY,Girard JP,Turnquist HR.Interleukin-33 in health and disease[J].Nat Rev Immunol,2016,16(11):676-689
[11]Liu X,Hammel M,He Y,et al.Structural insights into the interaction of IL-33 with its receptors[J].Proc Natl Acad Sci USA,2013,110(37):14918-14923
[12]Stampalija T,Chaiworapongsa T,Romero R,et al.Soluble ST2,a modulator of the inflammatory response,in preterm and term labor[J].J Matern Fetal Neonatal Med,2014,27(2):111-121
[13]Günther S,Deredge D,Bowers AL,et al.IL-1 family cytokines use distinct molecular mechanisms to signal through their shared co-receptor[J].Immunity,2017,47(3):510-523.e4
[14]Kakkar R,Lee RT.The IL-33/ST2 pathway:therapeutic target and novel biomarker[J].Nat Rev Drug Discov,2008,7(10):827-840
[15]Endo Y,Hirahara K,Iinuma T,et al.The interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway[J].Immunity,2015,42(2):294-308
[16]Bessa J,Meyer CA,de Vera Mudry MC,et al.Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation[J].J Autoimmun,2014,55:33-41
[17]Mildner M,Storka A,Lichtenauer M,et al.Primary sources and immunological prerequisites for sST2 secretion in humans[J].Cardiovasc Res,2010,87(4):769-777
[18]Bulek K,Swaidani S,Qin J,et al.The essential role of single Ig IL-1 receptor-related molecule/Toll IL-1R8 in regulation of Th2 immune response[J].J Immunol,2009,182(5):2601-2609
[19]Cohen ES,Scott IC,Majithiya JB,et al.Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation[J].Nat Commun,2015,6:8327
[20]Lu J,Kang J,Zhang C,et al.The role of IL-33/ST2L signals in the immune cells[J].Immunol Lett,2015,164(1):11-17
[21]Kim DK,Jin HR,Eun KM,et al.The role of interleukin-33 in chronic rhinosinusitis[J].Thorax,2017,72(7):635-645
[22]Wang JX,Kaieda S,Ameri S,et al.IL-33/ST2 axis promotes mast cell survival via BCLXL[J].Proc Natl Acad Sci USA,2014,111(28):10281-10286
[23]DMW Z,Gause WC,Osborne LC,et al.Emerging functions of amphiregulin in orchestrating immunity,inflammation,and tissue repair[J].Immunity,2015,42(2):216-226
[24]Lott JM,Sumpter TL,Turnquist HR.New dog and new tricks:evolving roles for IL-33 in type 2 immunity[J].JLeukoc Biol,2015,97(6):1037-1048
[25]Bonilla WV,Fr?hlich A,Senn K,et al.The alarmin interleukin-33 drives protective antiviral CD8+T cell responses[J].Science,2012,335(6071):984-989
[26]Gao K,Li X,Zhang L,et al.Transgenic expression of IL-33 activates CD8+T cells and NK cells and inhibits tumor growth and metastasis in mice[J].Cancer Lett,2013,335(2):463-471
[27]章建飞,曹文达,汪璟,等.人白细胞介素-33在胶质瘤中高表达并能促进胶质瘤细胞U251的侵袭作用[J].南京医科大学学报(自然科学版),2016,36(6):682-686
[28]杨丽,卢凯华,查天麒,等.人白细胞介素-33在肾细胞癌中高表达并通过EMT促进肾癌细胞的侵袭能力[J].南京医科大学学报(自然科学版),2017,37(4):409-412
[29]Salker MS,Nautiyal J,Steel JH,et al.Disordered IL-33/ST2 activation in decidualizing stromal cells prolongs uterine receptivity in women with recurrent pregnancy loss[J].PLoS One,2012,7(12):e52252
[30]Nussbaum JC,Van Dyken SJ,von MJ,et al.Type 2 innate lymphoid cells control eosinophil homeostasis[J].Nature,2013,502(7470):245-248
[31]Topping V,Romero R,Than NG,et al.Interleukin-33 in the human placenta[J].J Matern Fetal Neonatal Med,2013,26(4):327-338
[32]Granne I,Southcombe JH,Snider JV,et al.ST2 and IL-33in pregnancy and pre-eclampsia[J].PLoS One,2011,6(9):e24463
[33]Hu WT,Huang LL,Li MQ,et al.Decidual stromal cell-derived IL-33 contributes to Th2 bias and inhibits decidual NK cell cytotoxicity through NF-κB signaling in human early pregnancy[J].J Reprod Immunol,2015,109:52-65
[34]Sheng YR,Hu WT,Wei CY,et al.IL-33/ST2 axis affects the polarization and efferocytosis of decidual macrophages in early pregnancy[J].Am J Reprod Immunol,2018,79(6):e12836
[35]Huang B,Faucette AN,Pawlitz MD,et al.Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor[J].Nat Med,2017,23(1):128-135
[36]Cekmez Y,Cekmez F,Ozkaya E,et al.u PAR,IL-33,and ST2 values as a predictor of subclinical chorioamnionitis in preterm premature rupture of membranes[J].J Interferon Cytokine Res,2013,33(12):778-782
[37]Eda G,?zdegˇirmenci?,Elmas B,et al.Evaluation of AD-AMTS12,ADAMTS16,ADAMTS18 and IL-33 serum levels in pre-eclampsia[J].J Matern Fetal Neonatal Med,2016,29(15):2451-2456
[38]Hu WT,Li MQ,Liu W,et al.IL-33 enhances proliferation and invasiveness of decidual stromal cells by up-regulation of CCL2/CCR2 via NF-κB and ERK1/2 signaling[J].Mol Hum Reprod,2014,20(4):358-372
[39]Fock V,Mairhofer M,Otti GR,et al.Macrophage-derived IL-33 is a critical factor for placental growth[J].J Immunol,2013,191(7):3734-3743
[40]Wang XH,Liu W,Fan DX,et al.IL-33 restricts invasion and adhesion of trophoblast cell line JEG3 by downregulation of integrinα4β1 and CD62L[J].Mol Med Rep,2017,16(4):3887-3893
[41]Kaitu’u-Lino TJ,Tuohey L,Tong S.Maternal serum interleukin-33 and soluble ST2 across early pregnancy,and their association with miscarriage[J].J Reprod Immunol,2012,95(1-2):46-49
[42]Yue J,Tong Y,Xie L,et al.Genetic variant in IL-33 is associated with idiopathic recurrent miscarriage in Chinese Han population[J].Sci Rep,2016,6:23806
[43]罗金,刘雪丽,王雅琴,等.肥大细胞及IL-33/ST2在复发性自然流产小鼠模型中的作用初探[J].生殖医学杂志,2016,25(2):154-159
[44]Romero R,Dey SK,Fisher SJ.Preterm labor:one syndrome,many causes[J].Science,2014,345(6198):760-765
[45]Ferrarelli LK.B cells prevent preterm labor[J].Sci Signal,2017,10(462):eaam7592
[46]Stampalija T,Chaiworapongsa T,Romero R,et al.Maternal plasma concentrations of sST2 and angiogenic/anti-angiogenic factors in preeclampsia[J].J Matern Fetal Neonatal Med,2013,26(14):1359-1370
[47]Chen H,Zhou X,Han TL,et al.Decreased IL-33 production contributes to trophoblast cell dysfunction in pregnancies with preeclampsia[J].Mediators Inflamm,2018,2018:9787239
[48]石书明,徐昉,张华.自噬调节白介素-33的表达与子痫前期发病机制的关系[J].重庆医科大学学报,2016,41(7):663-668
[49]Yu J,Qian L,Wu F,et al.Decreased frequency of peripheral blood CD8+CD25+FoxP3+regulatory T cells correlates with IL-33 levels in pre-eclampsia[J].Hypertens Pregnancy,2017,36(2):217-225
[50]Alijotas-Reig J,Melnychuk T,Gris JM.Regulatory T cells,maternal-foetal immune tolerance and recurrent miscarriage:new therapeutic challenging opportunities[J].Med Clin(Barc),2015,144(6):265-2682018-11-25
[2]Scott LM,Bryant AH,Rees A,et al.Production and regulation of interleukin-1 family cytokines at the materno-fetal interface[J].Cytokine,2017,99:194-202
[3]Schmitz J,Owyang A,Oldham E,et al.IL-33,an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines[J].Immunity,2005,23(5):479-490
[4]Martin NT,Martin MU.Interleukin 33 is a guardian of barriers and a local alarmin[J].Nat Immunol,2016,17(2):122-131
[5]Bertheloot D,Latz E.HMGB1,IL-1α,IL-33 and S100 proteins:dual-function alarmins[J].Cell Mol Immunol,2017,14(1):43-64
[6]Moussion C,Ortega N,Girard JP.The IL-1-like cytokine IL-33 is constitutively expressed in the nucleus of endothelial cells and epithelial cells in vivo:a novel'alarmin'?[J].PLoS One,2008,3(10):e3331
[7]Byers DE,Alexander-Brett J,Patel AC,et al.Long-term IL-33-producing epithelial progenitor cells in chronic obstructive lung disease[J].J Clin Invest,2013,123(9):3967-3982
[8]Reichenbach DK,Schwarze V,Matta BM,et al.The IL-33/ST2 axis augments effector T-cell responses during acute GVHD[J].Blood,2015,125(20):3183-3192
[9]Savinko T,Matikainen S,Saarialho-Kere U,et al.IL-33and ST2 in atopic dermatitis:expression profiles and modulation by triggering factors[J].J Invest Dermatol,2012,132(5):1392-1400
[10]Liew FY,Girard JP,Turnquist HR.Interleukin-33 in health and disease[J].Nat Rev Immunol,2016,16(11):676-689
[11]Liu X,Hammel M,He Y,et al.Structural insights into the interaction of IL-33 with its receptors[J].Proc Natl Acad Sci USA,2013,110(37):14918-14923
[12]Stampalija T,Chaiworapongsa T,Romero R,et al.Soluble ST2,a modulator of the inflammatory response,in preterm and term labor[J].J Matern Fetal Neonatal Med,2014,27(2):111-121
[13]Günther S,Deredge D,Bowers AL,et al.IL-1 family cytokines use distinct molecular mechanisms to signal through their shared co-receptor[J].Immunity,2017,47(3):510-523.e4
[14]Kakkar R,Lee RT.The IL-33/ST2 pathway:therapeutic target and novel biomarker[J].Nat Rev Drug Discov,2008,7(10):827-840
[15]Endo Y,Hirahara K,Iinuma T,et al.The interleukin-33-p38 kinase axis confers memory T helper 2 cell pathogenicity in the airway[J].Immunity,2015,42(2):294-308
[16]Bessa J,Meyer CA,de Vera Mudry MC,et al.Altered subcellular localization of IL-33 leads to non-resolving lethal inflammation[J].J Autoimmun,2014,55:33-41
[17]Mildner M,Storka A,Lichtenauer M,et al.Primary sources and immunological prerequisites for sST2 secretion in humans[J].Cardiovasc Res,2010,87(4):769-777
[18]Bulek K,Swaidani S,Qin J,et al.The essential role of single Ig IL-1 receptor-related molecule/Toll IL-1R8 in regulation of Th2 immune response[J].J Immunol,2009,182(5):2601-2609
[19]Cohen ES,Scott IC,Majithiya JB,et al.Oxidation of the alarmin IL-33 regulates ST2-dependent inflammation[J].Nat Commun,2015,6:8327
[20]Lu J,Kang J,Zhang C,et al.The role of IL-33/ST2L signals in the immune cells[J].Immunol Lett,2015,164(1):11-17
[21]Kim DK,Jin HR,Eun KM,et al.The role of interleukin-33 in chronic rhinosinusitis[J].Thorax,2017,72(7):635-645
[22]Wang JX,Kaieda S,Ameri S,et al.IL-33/ST2 axis promotes mast cell survival via BCLXL[J].Proc Natl Acad Sci USA,2014,111(28):10281-10286
[23]DMW Z,Gause WC,Osborne LC,et al.Emerging functions of amphiregulin in orchestrating immunity,inflammation,and tissue repair[J].Immunity,2015,42(2):216-226
[24]Lott JM,Sumpter TL,Turnquist HR.New dog and new tricks:evolving roles for IL-33 in type 2 immunity[J].JLeukoc Biol,2015,97(6):1037-1048
[25]Bonilla WV,Fr?hlich A,Senn K,et al.The alarmin interleukin-33 drives protective antiviral CD8+T cell responses[J].Science,2012,335(6071):984-989
[26]Gao K,Li X,Zhang L,et al.Transgenic expression of IL-33 activates CD8+T cells and NK cells and inhibits tumor growth and metastasis in mice[J].Cancer Lett,2013,335(2):463-471
[27]章建飞,曹文达,汪璟,等.人白细胞介素-33在胶质瘤中高表达并能促进胶质瘤细胞U251的侵袭作用[J].南京医科大学学报(自然科学版),2016,36(6):682-686
[28]杨丽,卢凯华,查天麒,等.人白细胞介素-33在肾细胞癌中高表达并通过EMT促进肾癌细胞的侵袭能力[J].南京医科大学学报(自然科学版),2017,37(4):409-412
[29]Salker MS,Nautiyal J,Steel JH,et al.Disordered IL-33/ST2 activation in decidualizing stromal cells prolongs uterine receptivity in women with recurrent pregnancy loss[J].PLoS One,2012,7(12):e52252
[30]Nussbaum JC,Van Dyken SJ,von MJ,et al.Type 2 innate lymphoid cells control eosinophil homeostasis[J].Nature,2013,502(7470):245-248
[31]Topping V,Romero R,Than NG,et al.Interleukin-33 in the human placenta[J].J Matern Fetal Neonatal Med,2013,26(4):327-338
[32]Granne I,Southcombe JH,Snider JV,et al.ST2 and IL-33in pregnancy and pre-eclampsia[J].PLoS One,2011,6(9):e24463
[33]Hu WT,Huang LL,Li MQ,et al.Decidual stromal cell-derived IL-33 contributes to Th2 bias and inhibits decidual NK cell cytotoxicity through NF-κB signaling in human early pregnancy[J].J Reprod Immunol,2015,109:52-65
[34]Sheng YR,Hu WT,Wei CY,et al.IL-33/ST2 axis affects the polarization and efferocytosis of decidual macrophages in early pregnancy[J].Am J Reprod Immunol,2018,79(6):e12836
[35]Huang B,Faucette AN,Pawlitz MD,et al.Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor[J].Nat Med,2017,23(1):128-135
[36]Cekmez Y,Cekmez F,Ozkaya E,et al.u PAR,IL-33,and ST2 values as a predictor of subclinical chorioamnionitis in preterm premature rupture of membranes[J].J Interferon Cytokine Res,2013,33(12):778-782
[37]Eda G,?zdegˇirmenci?,Elmas B,et al.Evaluation of AD-AMTS12,ADAMTS16,ADAMTS18 and IL-33 serum levels in pre-eclampsia[J].J Matern Fetal Neonatal Med,2016,29(15):2451-2456
[38]Hu WT,Li MQ,Liu W,et al.IL-33 enhances proliferation and invasiveness of decidual stromal cells by up-regulation of CCL2/CCR2 via NF-κB and ERK1/2 signaling[J].Mol Hum Reprod,2014,20(4):358-372
[39]Fock V,Mairhofer M,Otti GR,et al.Macrophage-derived IL-33 is a critical factor for placental growth[J].J Immunol,2013,191(7):3734-3743
[40]Wang XH,Liu W,Fan DX,et al.IL-33 restricts invasion and adhesion of trophoblast cell line JEG3 by downregulation of integrinα4β1 and CD62L[J].Mol Med Rep,2017,16(4):3887-3893
[41]Kaitu’u-Lino TJ,Tuohey L,Tong S.Maternal serum interleukin-33 and soluble ST2 across early pregnancy,and their association with miscarriage[J].J Reprod Immunol,2012,95(1-2):46-49
[42]Yue J,Tong Y,Xie L,et al.Genetic variant in IL-33 is associated with idiopathic recurrent miscarriage in Chinese Han population[J].Sci Rep,2016,6:23806
[43]罗金,刘雪丽,王雅琴,等.肥大细胞及IL-33/ST2在复发性自然流产小鼠模型中的作用初探[J].生殖医学杂志,2016,25(2):154-159
[44]Romero R,Dey SK,Fisher SJ.Preterm labor:one syndrome,many causes[J].Science,2014,345(6198):760-765
[45]Ferrarelli LK.B cells prevent preterm labor[J].Sci Signal,2017,10(462):eaam7592
[46]Stampalija T,Chaiworapongsa T,Romero R,et al.Maternal plasma concentrations of sST2 and angiogenic/anti-angiogenic factors in preeclampsia[J].J Matern Fetal Neonatal Med,2013,26(14):1359-1370
[47]Chen H,Zhou X,Han TL,et al.Decreased IL-33 production contributes to trophoblast cell dysfunction in pregnancies with preeclampsia[J].Mediators Inflamm,2018,2018:9787239
[48]石书明,徐昉,张华.自噬调节白介素-33的表达与子痫前期发病机制的关系[J].重庆医科大学学报,2016,41(7):663-668
[49]Yu J,Qian L,Wu F,et al.Decreased frequency of peripheral blood CD8+CD25+FoxP3+regulatory T cells correlates with IL-33 levels in pre-eclampsia[J].Hypertens Pregnancy,2017,36(2):217-225
[50]Alijotas-Reig J,Melnychuk T,Gris JM.Regulatory T cells,maternal-foetal immune tolerance and recurrent miscarriage:new therapeutic challenging opportunities[J].Med Clin(Barc),2015,144(6):265-2682018-11-25