胞二磷胆碱干预基底后循环缺血致眩晕患者疗效及血流动力学变化
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摘要
目的探究胞二磷胆碱干预治疗基底后循环缺血导致的眩晕患者疗效及其对血流动力学变化的影响。方法选取该院2015年1月—2017年1月间收治的基底后循环缺血所致眩晕患者116例,按照随机数表法平均分为观察组(58例)行静脉注射胞二磷胆碱干预,对照组(58例)静脉注射倍他司汀,两侧椎动脉(VA)及基底动脉(BA)平均血流速度、临床疗效;对比两种方法干预后患者上述指标变化。结果两组患者治疗后左VA(35.74±5.89)mL/min,右VA(37.13±6.22)mL/min(t=6.685,P=0.000,t=6.273,P=0.000)。平均血流速度均显著提高(P<0.05);且观察组流速显著高于对照组(P<0.05);观察组患者(96.55%)总有效率显著高于对照组(86.21%)(χ~2=6.787,P=0.009)。结论胞二磷胆碱干预基底后循环所致眩晕患者,能有效改善脑血管扩张能力,提高颅内供血,降低血液中胆固醇、甘油三酯等脂质含量,降低血浆粘滞度,改善动脉粥样硬化情况,效果理想。
Objective To investigate the effect of citicoline on the treatment of vertigo caused by circulatory ischemia and its effect on hemodynamic changes. Methods A total of 116 patients with vertigo caused by basal ganglia ischemia were enrolled in our hospital from January 2015 to January 2017. The patients were randomly divided into observation group(58 cases) and intravenous phosphatidylcholine alkaline intervention, the control group(58 cases) intravenous betahistine, bilateral vertebral artery(VA) and basilar artery(BA) mean blood flow velocity, clinical efficacy; the changes of the above indicators were compared between the two methods. Results Left VA(35.74 ±5.89)mL/min and right(37.13±6.22)mL/min before and after treatment.(t =6.685,P =0.000,t =6.273, P = 0.000). The mean blood flow velocity was significantly increased(P<0.05); the flow rate of the observation group was significantly higher than that of the control group(P<0.05); the total effective rate of the observation group(96.55%) was significantly higher than that of the control group(86.21%)(χ~2=6.787, P=0.009). Conclusion Citicoline is effective in improving cerebral vasodilation, improving intracranial blood supply, lowering blood lipids and triglycerides, and reducing blood lipids plasma viscosity,improve atherosclerosis, the effect is ideal.
Objective To investigate the effect of citicoline on the treatment of vertigo caused by circulatory ischemia and its effect on hemodynamic changes. Methods A total of 116 patients with vertigo caused by basal ganglia ischemia were enrolled in our hospital from January 2015 to January 2017. The patients were randomly divided into observation group(58 cases) and intravenous phosphatidylcholine alkaline intervention, the control group(58 cases) intravenous betahistine, bilateral vertebral artery(VA) and basilar artery(BA) mean blood flow velocity, clinical efficacy; the changes of the above indicators were compared between the two methods. Results Left VA(35.74 ±5.89)mL/min and right(37.13±6.22)mL/min before and after treatment.(t =6.685,P =0.000,t =6.273, P = 0.000). The mean blood flow velocity was significantly increased(P<0.05); the flow rate of the observation group was significantly higher than that of the control group(P<0.05); the total effective rate of the observation group(96.55%) was significantly higher than that of the control group(86.21%)(χ~2=6.787, P=0.009). Conclusion Citicoline is effective in improving cerebral vasodilation, improving intracranial blood supply, lowering blood lipids and triglycerides, and reducing blood lipids plasma viscosity,improve atherosclerosis, the effect is ideal.
引文
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[2]Wang Fujiang,Nong Zining,Xu Chunshen,et al.Clinical observation on the treatment of Cervical Vertigo with Acupoint of Acupuncture and release of muscle combined with stellate ganglion Block[J].Asian-Pacific traditional Medicine,2018,14(1):155-157.
[3]阮明军,郑峰,黄德莲.三参通络汤配合臭氧自体血回输对后循环缺血性眩晕(气虚血瘀型)患者TCD的影响[J]世界中西医结合杂志,2018,13(1):59-62.
[4]刘兰,刘筠,许亮,等.后循环缺血性眩晕患者椎-基底动脉形态学改变[J].中国脑血管病杂志,2016(2):62-66,99.
[5]胡小东,王鹏琴.眼体针结合治疗后循环缺血性眩晕40例[J].针灸临床杂志,2016,32(1):24-26.
[6]梁炳松,李育英,宋柳全,等.法舒地尔联合长春西汀治疗后循环缺血性眩晕的临床效果[J].中国当代医药,201623(4):58-60.
[7]杨潮萍,芮汉臣,范桂梅,等.多模式CT在后循环缺血性孤立性眩晕中的应用价值[J].中国卒中杂志,2018,13(6)567-572.
[8]黄志平,张俊锋,洪枫,等.醒神通腑方联合胞二磷胆碱注射液治疗急性脑梗死昏迷疗效及对VCAM-1、IL-10、TNF-α的影响[J].中国中医急症,2017,26(6):1055-1057.