老年女性血清25-羟基维生素D的独立相关因素
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摘要
目的通过筛选老年女性血清25-羟基维生素D[25(OH)D]的独立相关因素,寻找提高老年女性血清25(OH)D的方法。方法对280例老年女性进行伴随疾病和生活方式的调查,并进行骨代谢、血液生化、性激素和贫血等指标的检测,运用多元回归分析方法筛选老年女性血清25(OH)D的独立相关因素。结果老年女性血清25(OH)D的独立相关因素包括血PTH(β=-0.097,P<0.01)、血磷(β=-18.144,P<0.01)、血钙(β=19.912,P<0.01)、服用复方钙剂(β=5.362,P<0.01)和晒太阳(β=0.974,P<0.05)。结论坚持晒太阳、服用复方钙剂和补充维生素D,可能是提高老年女性血清25(OH)D水平的重要方法。
Objective To probe into the ways to improve serum 25-hydroxyvitamin D(25 OHD) by means of screening independent factors associated with serum 25 OHD in elder women. Methods A cross-sectional survey was conducted in a cohort comprising 280 women. All subjects underwent a survey on underlying chronic diseases and lifestyle factors. The serum levels of bone metabolism markers, biomedical index, anemia-related index as well as sex steroids were detected. Univariate analysis and multivariate regression analysis were performed to discover independent factors associated with 25 OHD. Results It was showed that serum parathyroid hormone(β=-0.097, P<0.01), potassium(β=-18.144, P<0.01), calcium(β=19.912, P<0.01), calcium compound supplement(β=5.362, P<0.01), and sun exposure(β=0.974, P<0.05) were independent 25 OHD-associated factors. Conclusion Sun exposure and vitamin D and calcium supplement may help increase serum 25 OHD in elder women.
Objective To probe into the ways to improve serum 25-hydroxyvitamin D(25 OHD) by means of screening independent factors associated with serum 25 OHD in elder women. Methods A cross-sectional survey was conducted in a cohort comprising 280 women. All subjects underwent a survey on underlying chronic diseases and lifestyle factors. The serum levels of bone metabolism markers, biomedical index, anemia-related index as well as sex steroids were detected. Univariate analysis and multivariate regression analysis were performed to discover independent factors associated with 25 OHD. Results It was showed that serum parathyroid hormone(β=-0.097, P<0.01), potassium(β=-18.144, P<0.01), calcium(β=19.912, P<0.01), calcium compound supplement(β=5.362, P<0.01), and sun exposure(β=0.974, P<0.05) were independent 25 OHD-associated factors. Conclusion Sun exposure and vitamin D and calcium supplement may help increase serum 25 OHD in elder women.
引文
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[9] 夏清,李成江,边平达,等.80岁以上高龄女性血清甲状旁腺素的独立相关因素[J].中国老年学杂志,2017,37(4):894-896.
[10] 夏清,边平达,寿张轩,等.老年女性服用钙复方制剂与BMD、BTMs及25(OH)D水平的相关性研究[J].浙江医学,2017,39(1):34-37.
[2] 边平达,寿张轩,张庆芳,等.360例老年女性维生素D补充情况的调查分析[J].浙江医学,2016,38(19):1614-1615,1624.
[3] 廖祥鹏,张增利,张红红,等.维生素D与成年人骨骼健康应用指南(2014年标准版)[J].中国骨质疏松杂志,2014,20(9):1011-1025.
[4] 江巍,高凤荣.维生素D缺乏相关性疾病研究进展[J].中国骨质疏松杂志,2014,20(3):331-337.
[5] Durazo-Arvizu RA,Dawson-Hughes B,Kramer H,et al.The reverse J-shaped association between serum total 25-hydroxyvitamin D concentration and all-cause mortality:the impact of assay standardization[J].Am J Epidemiol,2017,185(8):720-726.
[6] 中华医学会骨质疏松和骨矿盐疾病分会.原发性骨质疏松症诊疗指南(2017)[J].中华骨质疏松和骨矿盐疾病杂志,2017,10(5):413-443.
[7] Pentek M,Gulacsi L,Toth E,et al.Ten-year fracture risk by FRAX of women with osteoporosis attending osteoporosis care in Hungary[J].Orv Hetil,2016,157(4):146-153.
[8] 边平达,寿张轩,王珏,等.老年女性晒太阳与其血清25-羟基维生素D关系的调查[J].中国骨质疏松杂志,2017,23(3):307-309.
[9] 夏清,李成江,边平达,等.80岁以上高龄女性血清甲状旁腺素的独立相关因素[J].中国老年学杂志,2017,37(4):894-896.
[10] 夏清,边平达,寿张轩,等.老年女性服用钙复方制剂与BMD、BTMs及25(OH)D水平的相关性研究[J].浙江医学,2017,39(1):34-37.