CEA、CA19-9、CA125、HE4与绝经期ROMA值测定对子宫内膜癌临床分期的价值研究
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摘要
目的探讨癌胚抗原(CEA)、糖类抗原199(CA19-9)、糖类抗原125(CA125)、人附睾蛋白4(HE4)和卵巢癌风险预测模型(ROMA)的联合检测在子宫内膜癌中的诊断作用和意义。方法选取2014年5月至2017年5月该院收治的80例子宫内膜癌患者,根据其临床病理分期分为观察一组和观察二组,收集患者血清并检测血清中CEA、CA19-9、CA125和HE4水平变化进行统计分析,并结合绝经状态计算ROMA值。结果与对照组相比,观察一组和观察二组子宫内膜癌患者血清内CA19-9、CA125和HE4水平有明显增高,绝经状态计算ROMA值显著增高,差异有统计学意义(P<0.05);且随着子宫内膜癌分期的进展,与观察一组相比,观察二组患者血清内CEA、CA19-9、CA125和HE4水平明显增高,绝经状态计算ROMA值显著上升,差异有统计学意义(P<0.05)。子宫内膜癌患者血清中CEA、CA19-9、CA125、HE4和ROMA的联合检出率显著高于各指标的单独检出率,差异有统计学意义(P<0.05)。结论患者血清中异常升高的CEA、CA19-9、CA125、HE4和ROMA值,对于临床辅助诊断子宫内膜癌及判断其临床分期具有重要的意义和作用。
Objective To investigate the effects of carcinoembryonic antigen(CEA),carbohy-drate antigen(CA19-9),carbohy-drate antigen(CA125),human epididymis protein 4(HE4)And the combined detection of ovarian cancer risk prediction model(ROMA)in the diagnosis and significance of endometrial cancer.Methods From May 2014 to May 2010,80 patients with endometrial cancer were treated.According to its clinical pathology is divided into observation 1 group and observation 2 group.Serum samples were collected and serum CEA,CA19-9,CA125 and HE4 levels were analyzed statistically and the ROMA values were calculated according to menopausal status.Results Compared with the control group,the levels of CEA,CA19-9,CA125 and HE4 in the serum of observation group patients with endometrial carcinoma were significantly higher than those in the control group,the ROMA value of the menopausal state was significantly higher,the difference was statistically significant(P<0.05).And with the progression of endometrial cancer staging,compared with the observation 1 group,the levels of CA19-9,CA125 and HE4 in the serum of the observation 2 group were significantly higher,the ROMA values of the menopausal states were significantly increased,the difference was statistically significant(P<0.05).The combined detection rate of CEA,CA19-9,CA125,HE4 and ROMA in serum of patients with endometrial carcinoma was significantly higher than that of each index(P<0.05).Conclusion The abnormally elevated levels of CEA,CA19-9,CA125,HE4,and ROMA in the serum of patients have important significance and role in the clinical diagnosis of endometrial cancer and its clinical staging.
Objective To investigate the effects of carcinoembryonic antigen(CEA),carbohy-drate antigen(CA19-9),carbohy-drate antigen(CA125),human epididymis protein 4(HE4)And the combined detection of ovarian cancer risk prediction model(ROMA)in the diagnosis and significance of endometrial cancer.Methods From May 2014 to May 2010,80 patients with endometrial cancer were treated.According to its clinical pathology is divided into observation 1 group and observation 2 group.Serum samples were collected and serum CEA,CA19-9,CA125 and HE4 levels were analyzed statistically and the ROMA values were calculated according to menopausal status.Results Compared with the control group,the levels of CEA,CA19-9,CA125 and HE4 in the serum of observation group patients with endometrial carcinoma were significantly higher than those in the control group,the ROMA value of the menopausal state was significantly higher,the difference was statistically significant(P<0.05).And with the progression of endometrial cancer staging,compared with the observation 1 group,the levels of CA19-9,CA125 and HE4 in the serum of the observation 2 group were significantly higher,the ROMA values of the menopausal states were significantly increased,the difference was statistically significant(P<0.05).The combined detection rate of CEA,CA19-9,CA125,HE4 and ROMA in serum of patients with endometrial carcinoma was significantly higher than that of each index(P<0.05).Conclusion The abnormally elevated levels of CEA,CA19-9,CA125,HE4,and ROMA in the serum of patients have important significance and role in the clinical diagnosis of endometrial cancer and its clinical staging.
引文
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[11]屈明利,邓晓红,赵侃侃,等.血清CA125、CEA、AFP联合检测在卵巢恶性肿瘤诊断中的临床价值[J].实用癌症杂志,2017,32(7):1065-1068.
[12]戴仕芬,郭苑莉.联合检测子宫内膜样腺癌组织Ki-67、ER与CEA表达的临床诊断价值[J].解剖学研究,2017,39(1):5-8.
[13]王淑贞,王秋红.HIF-1α和VEGF在子宫内膜癌中的临床表达及相关性[J].实用癌症杂志,2017,32(4):536-538.
[14]灵琴,陈曦,陈鲁,等.人附睾分泌蛋白-4和CA-125联合检测在子宫内膜恶性肿瘤与子宫良性肿瘤鉴别诊断中的价值[J].中国癌症杂志,2012,22(11):820-824.
[15]CHEN W T,GAO X,HAN X D,et al.HE4as a serum biomarker for ROMA prediction and prognosis of epithelial ovarian cancer[J]Asian Pac J Cancer Prev,2014,15(1):101-105.
[16]曾磊.恶性肿瘤风险指数与肿瘤标志物用于盆腔包块良恶性诊断的临床价值[J].东南大学学报(医学版),2016,35(6):965-969.
[2]陈瑞芳,鹿欣.子宫内膜癌血清肿瘤标志物研究进展[J].国际肿瘤学杂志,2014,41(5):364-367.
[3]高慧娟,李小毛.子宫内膜癌肿瘤标志物研究进展[J].广东医学,2014,25(6):940-943.
[4]张智,陈红霞,徐晓霞.血清人附睾蛋白-4、CA125、CA199联合诊断子宫内膜癌的价值[J].实用医学杂志,2016,32(7):1108-1112.
[5]白韬,杜潇,卜君,等.乳腺超声光散射成像联合血清CA15-3、CEA检测在乳腺肿瘤中的诊断价值[J].标记免疫分析与临床,2017,24(7):762-765.
[6]徐定华,蔡春仙,黄光学.乳腺钼靶X射线摄片联合四种血清肿瘤标志物对乳腺癌的诊断价值[J].海南医学院学报,2015,21(9):1294-1296
[7] WULF H U.At last-A new and precise International Set of menopause-related definitions[J].Menopause M anagement,2000,9(1):47.
[8]彭鸿灵,赵霞.2015年NCCN子宫内膜癌临床实践指南解读[J].中国医师杂志,2015,17(8):1144-1146
[9]余祝英,曾维红.CA125在子宫内膜癌组织中的表达及与ER和PR的相关性研究[J].解剖学研究,2016,38(6):465-467.
[10]徐仁根,王君.7种血清肿瘤标志物对原发性卵巢癌患者的临床诊断研究[J].检验医学与临床,2016,13(4):480-481.
[11]屈明利,邓晓红,赵侃侃,等.血清CA125、CEA、AFP联合检测在卵巢恶性肿瘤诊断中的临床价值[J].实用癌症杂志,2017,32(7):1065-1068.
[12]戴仕芬,郭苑莉.联合检测子宫内膜样腺癌组织Ki-67、ER与CEA表达的临床诊断价值[J].解剖学研究,2017,39(1):5-8.
[13]王淑贞,王秋红.HIF-1α和VEGF在子宫内膜癌中的临床表达及相关性[J].实用癌症杂志,2017,32(4):536-538.
[14]灵琴,陈曦,陈鲁,等.人附睾分泌蛋白-4和CA-125联合检测在子宫内膜恶性肿瘤与子宫良性肿瘤鉴别诊断中的价值[J].中国癌症杂志,2012,22(11):820-824.
[15]CHEN W T,GAO X,HAN X D,et al.HE4as a serum biomarker for ROMA prediction and prognosis of epithelial ovarian cancer[J]Asian Pac J Cancer Prev,2014,15(1):101-105.
[16]曾磊.恶性肿瘤风险指数与肿瘤标志物用于盆腔包块良恶性诊断的临床价值[J].东南大学学报(医学版),2016,35(6):965-969.