摘要
采用循环伏安法和差分脉冲伏安法考察了临床药物盐酸非那吡啶在功能化复合介孔膜修饰的水/1,6-二氯己烷(W/DCH)界面上的转移行为.研究结果表明,盐酸非那吡啶中的非那吡啶(PAP)可在酸性条件下发生质子化形成非那吡啶阳离子(HPAP+)并在该界面上发生转移.根据循环伏安曲线峰电流与扫描速率的关系以及Randles-Sevˇcik方程,计算得到HPAP+在复合介孔膜内水相中的扩散系数为5. 14×10-8cm2/s.研究发现,相对于空白膜修饰的W/DCH界面,该复合介孔膜修饰的W/DCH界面可增强非那吡啶阳离子转移时的电流响应,并提升非那吡啶阳离子的检测性能.另外,利用液/液界面电化学方法绘制了非那吡啶在功能化复合介孔膜修饰的W/DCH界面上的离子分布图,从而得到非那吡啶在该界面上不同条件下的分布情况及其分配系数和吉布斯转移自由能.
The transfer behavior of a clinical drug, phenazopyridine hydrochloride, at the water/1,6-dichlorhexane(W/DCH) interface modified by functionalized mesoporous silica membrane was studied by cyclic voltammetry and differential pulse voltammetry. It was found that the phenazopyridine(PAP) can be protonated to form phenazopyridine cation(HPAP+) under acidic condition,which can transfer at such a membrane-modified W/DCH interface. According to the relationship between the transfer peak current and the scan rate,as well as the equation of Randles-Sevˇcik,the diffusion coefficient of HPAP+in the functionalized hybrid mesoporous silica membrane was calculated to be 5. 14 × 10-8 cm2/s. In addition,the electrochemical response of ion-transfer of HPAP+at the W/DCH interface modified by functionalized hybrid mesoporous silica membrane is much higher than bare PET membrane,which can improve the electrochemical detection performance of phenazopyridine cation. Moreover,the ionic partition diagram of HPAP+at the W/DCH interface modified by functionalized hybrid mesoporous silica membrane was obtained by differential pulse voltammetry,which can not only understand the distribution of HPAP+under different conditions(pH value and interfacial potential),but also obtain the distribution coefficient and ion-transfer Gibbs free energy of HPAP+,which helps to understand the transmembrane process of HPAP+across biological membrane and provide a new electrochemical method to detect phenazopyridine hydrochloride.
引文
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