Current global trends in the incidence of pediatric-onset inflammatory bowel disease
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摘要
AIM To perform a comprehensive review and provide an up-to-date synopsis of the incidence and trends of inflammatory bowel disease(IBD). METHODS We systematically searched the MEDLINE(source Pub Med), EMBASE and Cochrane Library databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines(period: 1985-2018) to identify studies reporting population-based data on the incidence of pediatriconset(< 19 years at diagnosis) IBD in full manuscripts. Two authors carried out screening and data extraction. Choropleth interactive maps and temporal trends were used to illustrate the international differences and incidences of and changes in IBD and subtypes.RESULTS In total, one hundred forty studies reporting data from 38 countries were considered in this review. The highest annual pediatric incidences of IBD were 23/100000 person-years in Europe, 15.2/100000 in North America, and 11.4/100000 in Asia/the Middle East and Oceania. The highest annual incidences of Crohn's disease(CD) were 13.9/100000 in North America and 12.3/100000 in Europe. The highest annual incidences of ulcerative colitis(UC) were 15.0/100000 in Europe and 10.6/100000 in North America. The highest annual incidences of IBD-unclassified(IBD-U) were 3.6/100000 in Europe and 2.1/100000 in North America. In the time-trend analyses, 67% of CD, 46% of UC and 11% of IBD-U studies reported an increasing incidence(P < 0.05). The risk of IBD is increasing among firstgeneration of migrant populations.CONCLUSION Globally, the incidence of IBD varies greatly by geographical areas. The steadily increasing incidence of pediatric IBD over time indicates its emergence as a global disease, suggesting that studies should investigate the environmental risk factors among pediatric cohorts.
AIM To perform a comprehensive review and provide an up-to-date synopsis of the incidence and trends of inflammatory bowel disease(IBD). METHODS We systematically searched the MEDLINE(source Pub Med), EMBASE and Cochrane Library databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines(period: 1985-2018) to identify studies reporting population-based data on the incidence of pediatriconset(< 19 years at diagnosis) IBD in full manuscripts. Two authors carried out screening and data extraction. Choropleth interactive maps and temporal trends were used to illustrate the international differences and incidences of and changes in IBD and subtypes.RESULTS In total, one hundred forty studies reporting data from 38 countries were considered in this review. The highest annual pediatric incidences of IBD were 23/100000 person-years in Europe, 15.2/100000 in North America, and 11.4/100000 in Asia/the Middle East and Oceania. The highest annual incidences of Crohn's disease(CD) were 13.9/100000 in North America and 12.3/100000 in Europe. The highest annual incidences of ulcerative colitis(UC) were 15.0/100000 in Europe and 10.6/100000 in North America. The highest annual incidences of IBD-unclassified(IBD-U) were 3.6/100000 in Europe and 2.1/100000 in North America. In the time-trend analyses, 67% of CD, 46% of UC and 11% of IBD-U studies reported an increasing incidence(P < 0.05). The risk of IBD is increasing among firstgeneration of migrant populations.CONCLUSION Globally, the incidence of IBD varies greatly by geographical areas. The steadily increasing incidence of pediatric IBD over time indicates its emergence as a global disease, suggesting that studies should investigate the environmental risk factors among pediatric cohorts.
AIM To perform a comprehensive review and provide an up-to-date synopsis of the incidence and trends of inflammatory bowel disease(IBD). METHODS We systematically searched the MEDLINE(source Pub Med), EMBASE and Cochrane Library databases in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines(period: 1985-2018) to identify studies reporting population-based data on the incidence of pediatriconset(< 19 years at diagnosis) IBD in full manuscripts. Two authors carried out screening and data extraction. Choropleth interactive maps and temporal trends were used to illustrate the international differences and incidences of and changes in IBD and subtypes.RESULTS In total, one hundred forty studies reporting data from 38 countries were considered in this review. The highest annual pediatric incidences of IBD were 23/100000 person-years in Europe, 15.2/100000 in North America, and 11.4/100000 in Asia/the Middle East and Oceania. The highest annual incidences of Crohn's disease(CD) were 13.9/100000 in North America and 12.3/100000 in Europe. The highest annual incidences of ulcerative colitis(UC) were 15.0/100000 in Europe and 10.6/100000 in North America. The highest annual incidences of IBD-unclassified(IBD-U) were 3.6/100000 in Europe and 2.1/100000 in North America. In the time-trend analyses, 67% of CD, 46% of UC and 11% of IBD-U studies reported an increasing incidence(P < 0.05). The risk of IBD is increasing among firstgeneration of migrant populations.CONCLUSION Globally, the incidence of IBD varies greatly by geographical areas. The steadily increasing incidence of pediatric IBD over time indicates its emergence as a global disease, suggesting that studies should investigate the environmental risk factors among pediatric cohorts.
引文
1 Abraham BP,Mehta S,El-Serag HB.Natural history of pediatriconset inflammatory bowel disease:a systematic review.J Clin Gastroenterol 2012;46:581-589[PMID:22772738 DOI:10.1097/MCG.0b013e318247c32f]
2 Henderson P,Rogers P,Gillett P,Wilson D.The epidemiology and natural history of paediatric inflammatory bowel disease in a UK region:a prospective 14-year study.Arch Dis Child 2012;97:A53.2-A54[DOI:10.1136/archdischild-2012-301885.130]
3 Ng SC,Shi HY,Hamidi N,Underwood FE,Tang W,Benchimol EI,Panaccione R,Ghosh S,Wu JCY,Chan FKL,Sung JJY,Kaplan GG.Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century:a systematic review of population-based studies.Lancet 2018;390:2769-2778[PMID:29050646 DOI:10.1016/S0140-6736(17)32448-0]
4 Benchimol EI,Fortinsky KJ,Gozdyra P,Van den Heuvel M,Van Limbergen J,Griffiths AM.Epidemiology of pediatric inflammatory bowel disease:a systematic review of international trends.Inflamm Bowel Dis 2011;17:423-439[PMID:20564651 DOI:10.1002/ibd.21349]
5 da Silva BC,Lyra AC,Rocha R,Santana GO.Epidemiology,demographic characteristics and prognostic predictors of ulcerative colitis.World J Gastroenterol 2014;20:9458-9467[PMID:25071340 DOI:10.3748/wjg.v20.i28.9458]
6 Van Limbergen J,Russell RK,Drummond HE,Aldhous MC,Round NK,Nimmo ER,Smith L,Gillett PM,Mc Grogan P,Weaver LT,Bisset WM,Mahdi G,Arnott ID,Satsangi J,Wilson DC.Definition of phenotypic characteristics of childhoodonset inflammatory bowel disease.Gastroenterology 2008;135:1114-1122[PMID:18725221 DOI:10.1053/j.gastro.2008.06.081]
7 Misra R,Faiz O,Munkholm P,Burisch J,Arebi N.Epidemiology of inflammatory bowel disease in racial and ethnic migrant groups.World J Gastroenterol 2018;24:424-437[PMID:29391765 DOI:10.3748/wjg.v24.i3.424]
8 Girardelli M,Basaldella F,Paolera SD,Vuch J,Tommasini A,Martelossi S,Crovella S,Bianco AM.Genetic profile of patients with early onset inflammatory bowel disease.Gene 2018;645:18-29[PMID:29248579 DOI:10.1016/j.gene.2017.12.029]
9 Jakobsen C,Cleynen I,Andersen PS,Vermeire S,Munkholm P,Paerregaard A,Wewer V.Genetic susceptibility and genotypephenotype association in 588 Danish children with inflammatory bowel disease.J Crohns Colitis 2014;8:678-685[PMID:24394805DOI:10.1016/j.crohns.2013.12.010]
10 Fang YH,Luo YY,Yu JD,Lou JG,Chen J.Phenotypic and genotypic characterization of inflammatory bowel disease in children under six years of age in China.World J Gastroenterol2018;24:1035-1045[PMID:29531467 DOI:10.3748/wjg.v24.i9.1035]
11 von Allmen D.Pediatric Crohn‘s Disease.Clin Colon Rectal Surg2018;31:80-88[PMID:29487490 DOI:10.1055/s-0037-1609022]
12 Liberati A,Altman DG,Tetzlaff J,Mulrow C,G?tzsche PC,Ioannidis JP,Clarke M,Devereaux PJ,Kleijnen J,Moher D.The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions:explanation and elaboration.PLo S Med 2009;6:e1000100[PMID:19621070 DOI:10.1371/journal.pmed.1000100]
13 United Nations.Composition of macro Geographical(Continental)Regions,Geographical Sub-Regions,and Selected Economic and Other Groupings.Available from:URL:http://unstats.un.org/unsd/methods/m49/m49regin.htm
14 Lennard-Jones JE.Classification of inflammatory bowel disease.Scand J Gastroenterol Suppl 1989;170:2-6;discussion 16-19[PMID:2617184 DOI:10.3109/00365528909091339]
15 Sanderson S,Tatt ID,Higgins JP.Tools for assessing quality and susceptibility to bias in observational studies in epidemiology:a systematic review and annotated bibliography.Int J Epidemiol2007;36:666-676[PMID:17470488 DOI:10.1093/ije/dym018]
16 Sawczenko A,Sandhu BK,Logan RF,Jenkins H,Taylor CJ,Mian S,Lynn R.Prospective survey of childhood inflammatory bowel disease in the British Isles.Lancet 2001;357:1093-1094[PMID:11297962 DOI:10.1016/S0140-6736(00)04309-9]
17 Tsironi E,Feakins RM,Probert CS,Rampton DS,Phil D.Incidence of inflammatory bowel disease is rising and abdominal tuberculosis is falling in Bangladeshis in East London,United Kingdom.Am J Gastroenterol 2004;99:1749-1755[PMID:15330914 DOI:10.1111/j.1572-0241.2004.30445.x]
18 Pinsk V,Lemberg DA,Grewal K,Barker CC,Schreiber RA,Jacobson K.Inflammatory bowel disease in the South Asian pediatric population of British Columbia.Am J Gastroenterol2007;102:1077-1083[PMID:17378907 DOI:10.1111/j.1572-0241.2007.01124.x]
19 Hammer T,Nielsen KR,Munkholm P,Burisch J,Lynge E.The Faroese IBD Study:Incidence of Inflammatory Bowel Diseases Across 54 Years of Population-based Data.J Crohns Colitis 2016;10:934-942[PMID:26933031 DOI:10.1093/ecco-jcc/jjw050]
20 Abramson O,Durant M,Mow W,Finley A,Kodali P,Wong A,Tavares V,Mc Croskey E,Liu L,Lewis JD,Allison JE,Flowers N,Hutfless S,Velayos FS,Perry GS,Cannon R,Herrinton LJ.Incidence,prevalence,and time trends of pediatric inflammatory bowel disease in Northern California,1996 to 2006.J Pediatr2010;157:233-239.e1[PMID:20400099 DOI:10.1016/j.jpeds.2010.02.024]
21 Kugathasan S,Judd RH,Hoffmann RG,Heikenen J,Telega G,Khan F,Weisdorf-Schindele S,San Pablo W Jr,Perrault J,Park R,Yaffe M,Brown C,Rivera-Bennett MT,Halabi I,Martinez A,Blank E,Werlin SL,Rudolph CD,Binion DG;Wisconsin Pediatric Inflammatory Bowel Disease Alliance.Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin:a statewide population-based study.J Pediatr 2003;143:525-531[PMID:14571234 DOI:10.1067/S0022-3476(03)00444-X]
22 Adamiak T,Walkiewicz-Jedrzejczak D,Fish D,Brown C,Tung J,Khan K,Faubion W Jr,Park R,Heikenen J,Yaffee M,RiveraBennett MT,Wiedkamp M,Stephens M,Noel R,Nugent M,Nebel J,Simpson P,Kappelman MD,Kugathasan S.Incidence,clinical characteristics,and natural history of pediatric IBD in Wisconsin:a population-based epidemiological study.Inflamm Bowel Dis 2013;19:1218-1223[PMID:23528339 DOI:10.1097/MIB.0b013e318280b13e]
23 Ogunbi SO,Ransom JA,Sullivan K,Schoen BT,Gold BD.Inflammatory bowel disease in African-American children living in Georgia.J Pediatr 1998;133:103-107[PMID:9672520 DOI:10.1016/S0022-3476(98)70187-8]
24 Naidoo CM,Leach ST,Day AS,Lemberg DA.Inflammatory bowel disease in children of middle eastern descent.Int J Pediatr 2014;2014:906128[PMID:24987422 DOI:10.1155/2014/906128]
25 Benchimol EI,Mack DR,Guttmann A,Nguyen GC,To T,Mojaverian N,Quach P,Manuel DG.Inflammatory bowel disease in immigrants to Canada and their children:a population-based cohort study.Am J Gastroenterol 2015;110:553-563[PMID:25756238 DOI:10.1038/ajg.2015.52]
26 Yap J,Wesley A,Mouat S,Chin S.Paediatric inflammatory bowel disease in New Zealand.N Z Med J 2008;121:19-34[PMID:18841182]
27 Probert CS,Jayanthi V,Pinder D,Wicks AC,Mayberry JF.Epidemiological study of ulcerative proctocolitis in Indian migrants and the indigenous population of Leicestershire.Gut 1992;33:687-693[PMID:1307684 DOI:10.1136/gut.33.5.687]
28 Malaty HM,Mehta S,Abraham B,Garnett EA,Ferry GD.The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood:within a 25 year period.Clin Exp Gastroenterol 2013;6:115-121[PMID:23901288 DOI:10.2147/CEG.S44700]
29 Agnarsson U,Bj?rnsson S,Jóhansson JH,Sigurdsson L.Inflammatory bowel disease in Icelandic children 1951-2010.Population-based study involving one nation over six decades.Scand J Gastroenterol 2013;48:1399-1404[PMID:24164345DOI:10.3109/00365521.2013.845799]
30 Ahmed M,Davies IH,Hood K,Jenkins HR.Incidence of paediatric inflammatory bowel disease in South Wales.Arch Dis Child 2006;91:344-345[PMID:16551790 DOI:10.1136/adc.2004.067413]
31 Benchimol EI,Bernstein CN,Bitton A,Carroll MW,Singh H,Otley AR,Vutcovici M,El-Matary W,Nguyen GC,Griffiths AM,Mack DR,Jacobson K,Mojaverian N,Tanyingoh D,Cui Y,Nugent ZJ,Coulombe J,Targownik LE,Jones JL,Leddin D,Murthy SK,Kaplan GG.Trends in Epidemiology of Pediatric Inflammatory Bowel Disease in Canada:Distributed Network Analysis of Multiple Population-Based Provincial Health Administrative Databases.Am J Gastroenterol 2017;112:1120-1134[PMID:28417994 DOI:10.1038/ajg.2017.97]
32 Chouraki V,Savoye G,Dauchet L,Vernier-Massouille G,Dupas JL,Merle V,Laberenne JE,Salomez JL,Lerebours E,Turck D,Cortot A,Gower-Rousseau C,Colombel JF.The changing pattern of Crohn‘s disease incidence in northern France:a continuing increase in the 10-to 19-year-old age bracket(1988-2007).Aliment Pharmacol Ther 2011;33:1133-1142[PMID:21488915 DOI:10.1111/j.1365-2036.2011.04628.x]
33 Jakobsen C,Wewer V,Urne F,Andersen J,Faerk J,Kramer I,Stagegaard B,Pilgaard B,Weile B,Paerregaard A.Incidence of ulcerative colitis and Crohn‘s disease in Danish children:Still rising or levelling out?J Crohns Colitis 2008;2:152-157[PMID:21172205 DOI:10.1016/j.crohns.2008.01.006]
34 Jakobsen C,Paerregaard A,Munkholm P,Wewer V.Paediatric inflammatory bowel disease during a 44-year period in Copenhagen County:occurrence,course and prognosis--a population-based study from the Danish Crohn Colitis Database.Eur J Gastroenterol Hepatol 2009;21:1291-1301[PMID:19581873 DOI:10.1097/MEG.0b013e32832a4ed6]
35 Lapidus A,Bernell O,Hellers G,Persson PG,L?fberg R.Incidence of Crohn‘s disease in Stockholm County 1955-1989.Gut 1997;41:480-486[PMID:9391246 DOI:10.1136/gut.41.4.480]
36 Loftus EV Jr,Silverstein MD,Sandborn WJ,Tremaine WJ,Harmsen WS,Zinsmeister AR.Crohn‘s disease in Olmsted County,Minnesota,1940-1993:incidence,prevalence,and survival.Gastroenterology 1998;114:1161-1168[PMID:9609752 DOI:10.1016/S0016-5085(98)70421-4]
37 Ponsonby AL,Catto-Smith AG,Pezic A,Dupuis S,Halliday J,Cameron D,Morley R,Carlin J,Dwyer T.Association between early-life factors and risk of child-onset Crohn‘s disease among Victorian children born 1983-1998:a birth cohort study.Inflamm Bowel Dis 2009;15:858-866[PMID:19107784 DOI:10.1002/ibd.20842]
38 Malmborg P,Grahnquist L,Lindholm J,Montgomery S,Hildebrand H.Increasing incidence of paediatric inflammatory bowel disease in northern Stockholm County,2002-2007.J Pediatr Gastroenterol Nutr 2013;57:29-34[PMID:23459320 DOI:10.1097/MPG.0b013e31828f21b4]
39 Bernstein CN,Wajda A,Svenson LW,Mac Kenzie A,Koehoorn M,Jackson M,Fedorak R,Israel D,Blanchard JF.The epidemiology of inflammatory bowel disease in Canada:a population-based study.Am J Gastroenterol 2006;101:1559-1568[PMID:16863561 DOI:10.1111/j.1572-0241.2006.00603.x]
40 Shivananda S,Lennard-Jones J,Logan R,Fear N,Price A,Carpenter L,van Blankenstein M.Incidence of inflammatory bowel disease across Europe:is there a difference between north and south?Results of the European Collaborative Study on Inflammatory Bowel Disease(EC-IBD).Gut 1996;39:690-697[PMID:9014768 DOI:10.1136/gut.39.5.690]
41 Burisch J.Crohn‘s disease and ulcerative colitis.Occurrence,course and prognosis during the first year of disease in a European population-based inception cohort.Dan Med J 2014;61:B4778[PMID:24393595]
42 Martín-de-Carpi J,Rodríguez A,Ramos E,Jiménez S,MartínezGómez MJ,Medina E;SPIRIT-IBD Working Group of Sociedad Espa?ola de Gastroenterología,Hepatología y Nutricion Pediátrica.Increasing incidence of pediatric inflammatory bowel disease in Spain(1996-2009):the SPIRIT Registry.Inflamm Bowel Dis 2013;19:73-80[PMID:22535573 DOI:10.1002/ibd.22980]
43 Auvin S,MoliniéF,Gower-Rousseau C,Brazier F,Merle V,Grandbastien B,Marti R,Lerebours E,Dupas JL,Colombel JF,Salomez JL,Cortot A,Turck D.Incidence,clinical presentation and location at diagnosis of pediatric inflammatory bowel disease:a prospective population-based study in northern France(1988-1999).J Pediatr Gastroenterol Nutr 2005;41:49-55[PMID:15990630DOI:10.1097/01.MPG.0000162479.74277.86]
44 Rodrigo L,Riestra S,Ni?o P,Cadahía V,Tojo R,Fuentes D,Moreno M,González Ballina E,Fernández E.A population-based study on the incidence of inflammatory bowel disease in Oviedo(Northern Spain).Rev Esp Enferm Dig 2004;96:296-305[PMID:15180441 DOI:10.4321/S1130-01082004000500002]
45 Schwarz J,Sykora J,CvalínováD,Pomaha?ováR,Kle?kováJ,Kryl M,V?elák P.Inflammatory bowel disease incidence in Czech children:A regional prospective study,2000-2015.World J Gastroenterol 2017;23:4090-4101[PMID:28652662 DOI:10.3748/wjg.v23.i22.4090]
46 Lovasz BD,Lakatos L,Horvath A,Pandur T,Erdelyi Z,Balogh M,Szipocs I,Vegh Z,Veres G,Müller KE,Golovics PA,Kiss LS,Mandel MD,Lakatos PL.Incidence rates and disease course of paediatric inflammatory bowel diseases in Western Hungary between 1977 and 2011.Dig Liver Dis 2014;46:405-411[PMID:24495511 DOI:10.1016/j.dld.2013.12.013]
47 Sinci?BM,Vuceli?B,Persi?M,Brnci?N,Erzen DJ,Radakovi?B,Mi?ovi?V,Stimac D.Incidence of inflammatory bowel disease in Primorsko-goranska County,Croatia,2000-2004:A prospective population-based study.Scand J Gastroenterol 2006;41:437-444[PMID:16635912 DOI:10.1080/00365520500320094]
48 Urlep D,Blagus R,Orel R.Incidence Trends and Geographical Variability of Pediatric Inflammatory Bowel Disease in Slovenia:A Nationwide Study.Biomed Res Int 2015;2015:921730[PMID:26688822 DOI:10.1155/2015/921730]
49 Urlep D,Trop TK,Blagus R,Orel R.Incidence and phenotypic characteristics of pediatric IBD in northeastern Slovenia,2002-2010.J Pediatr Gastroenterol Nutr 2014;58:325-332[PMID:24135984 DOI:10.1097/MPG.0000000000000207]
50 Fernández A,Hernández V,Martínez-Ares D,Sanromán L,de Castro ML,Pineda JR,Carmona A,González-Portela C,Salgado C,Martínez-Cadilla J,Pereira S,García-Burriel JI,Vázquez S,Rodríguez-Prada I;Epi Com Group.Incidence and phenotype at diagnosis of inflammatory bowel disease.Results in Spain of the Epi Com study.Gastroenterol Hepatol 2015;38:534-540[PMID:25890448 DOI:10.1016/j.gastrohep.2015.03.001]
51 Martín-de-Carpi J,Rodríguez A,Ramos E,Jiménez S,MartínezGómez MJ,Medina E,Navas-López VM;SPIRIT-IBD Working Group of SEGHNP(Sociedad Espa?ola de Gastroenterología Hepatología Nutrición Pediátrica).The complete picture of changing pediatric inflammatory bowel disease incidence in Spain in 25 years(1985-2009):the EXPERIENCE registry.J Crohns Colitis 2014;8:763-769[PMID:24462789 DOI:10.1016/j.crohns.2014.01.005]
52 Malaty HM,Fan X,Opekun AR,Thibodeaux C,Ferry GD.Rising incidence of inflammatory bowel disease among children:a 12-year study.J Pediatr Gastroenterol Nutr 2010;50:27-31[PMID:19934770 DOI:10.1097/MPG.0b013e3181b99baa]
53 Armitage E,Drummond HE,Wilson DC,Ghosh S.Increasing incidence of both juvenile-onset Crohn‘s disease and ulcerative colitis in Scotland.Eur J Gastroenterol Hepatol 2001;13:1439-1447[PMID:11742192 DOI:10.1097/00042737-200112000-00007]
54 Benchimol EI,Guttmann A,Griffiths AM,Rabeneck L,Mack DR,Brill H,Howard J,Guan J,To T.Increasing incidence of paediatric inflammatory bowel disease in Ontario,Canada:evidence from health administrative data.Gut 2009;58:1490-1497[PMID:19651626 DOI:10.1136/gut.2009.188383]
55 Molodecky NA,Soon IS,Rabi DM,Ghali WA,Ferris M,Chernoff G,Benchimol EI,Panaccione R,Ghosh S,Barkema HW,Kaplan GG.Increasing incidence and prevalence of the inflammatory bowel diseases with time,based on systematic review.Gastroenterology2012;142:46-54.e42;quiz e30[PMID:22001864 DOI:10.1053/j.gastro.2011.10.001]
56 Ekbom A,Helmick C,Zack M,Adami HO.The epidemiology of inflammatory bowel disease:a large,population-based study in Sweden.Gastroenterology 1991;100:350-358[PMID:1985033DOI:10.1016/0016-5085(91)90202-V]
57 Cosgrove M,Al-Atia RF,Jenkins HR.The epidemiology of paediatric inflammatory bowel disease.Arch Dis Child 1996;74:460-461[PMID:8669968 DOI:10.1136/adc.74.5.460]
58 Loftus CG,Loftus EV Jr,Harmsen WS,Zinsmeister AR,Tremaine WJ,Melton LJ 3rd,Sandborn WJ.Update on the incidence and prevalence of Crohn‘s disease and ulcerative colitis in Olmsted County,Minnesota,1940-2000.Inflamm Bowel Dis 2007;13:254-261[PMID:17206702 DOI:10.1002/ibd.20029]
59 Hildebrand H,Finkel Y,Grahnquist L,Lindholm J,Ekbom A,Askling J.Changing pattern of paediatric inflammatory bowel disease in northern Stockholm 1990-2001.Gut 2003;52:1432-1434[PMID:12970135 DOI:10.1136/gut.52.10.1432]
60 Perminow G,Frigessi A,Rydning A,Nakstad B,Vatn MH.Incidence and clinical presentation of IBD in children:comparison between prospective and retrospective data in a selected Norwegian population.Scand J Gastroenterol 2006;41:1433-1439[PMID:17101574 DOI:10.1080/00365520600789891]
61 Barton JR,Gillon S,Ferguson A.Incidence of inflammatory bowel disease in Scottish children between 1968 and 1983;marginal fall in ulcerative colitis,three-fold rise in Crohn‘s disease.Gut 1989;30:618-622[PMID:2786488 DOI:10.1136/gut.30.5.618]
62 Munkholm P,Langholz E,Nielsen OH,Kreiner S,Binder V.Incidence and prevalence of Crohn‘s disease in the county of Copenhagen,1962-87:a sixfold increase in incidence.Scand JGastroenterol 1992;27:609-614[PMID:1641589 DOI:10.3109/00365529209000127]
63 Castro M,Papadatou B,Baldassare M,Balli F,Barabino A,Barbera C,Barca S,Barera G,Bascietto F,Berni Canani R,Calacoci M,Campanozzi A,Castellucci G,Catassi C,Colombo M,Covoni MR,Cucchiara S,D‘Altilia MR,De Angelis GL,De Virgilis S,Di Ciommo V,Fontana M,Guariso G,Knafelz D,Lambertini A,Licciardi S,Lionetti P,Liotta L,Lombardi G,Maestri L,Martelossi S,Mastella G,Oderda G,Perini R,Pesce F,Ravelli A,Roggero P,Romano C,Rotolo N,Rutigliano V,Scotta S,Sferlazzas C,Staiano A,Ventura A,Zaniboni MG.Inflammatory bowel disease in children and adolescents in Italy:data from the pediatric national IBD register(1996-2003).Inflamm Bowel Dis 2008;14:1246-1252[PMID:18521916 DOI:10.1002/ibd.20470]
64 Turunen P,Kolho KL,Auvinen A,Iltanen S,Huhtala H,Ashorn M.Incidence of inflammatory bowel disease in Finnish children,1987-2003.Inflamm Bowel Dis 2006;12:677-683[PMID:16917221 DOI:10.1097/00054725-200608000-00002]
65 Lehtinen P,Ashorn M,Iltanen S,Jauhola R,Jauhonen P,Kolho KL,Auvinen A.Incidence trends of pediatric inflammatory bowel disease in Finland,1987-2003,a nationwide study.Inflamm Bowel Dis 2011;17:1778-1783[PMID:21744433 DOI:10.1002/ibd.21550]
66 Virta LJ,Saarinen MM,Kolho KL.Inflammatory Bowel Disease Incidence is on the Continuous Rise Among All Paediatric Patients Except for the Very Young:A Nationwide Registry-based Study on 28-Year Follow-up.J Crohns Colitis 2017;11:150-156[PMID:27555642 DOI:10.1093/ecco-jcc/jjw148]
67 Karolewska-Bochenek K,Lazowska-Przeorek I,Albrecht P,Grzybowska K,Ryzko J,Szamotulska K,Radzikowski A,Landowski P,Krzesiek E,Ignys I,Fyderek K,CzerwionkaSzaflarska M,Jarocka-Cyrta E.Epidemiology of inflammatory bowel disease among children in Poland.A prospective,populationbased,2-year study,2002-2004.Digestion 2009;79:121-129[PMID:19321943 DOI:10.1159/000209382]
68 Lindberg E,Lindquist B,Holmquist L,Hildebrand H.Inflammatory bowel disease in children and adolescents in Sweden,1984-1995.J Pediatr Gastroenterol Nutr 2000;30:259-264[PMID:10749408 DOI:10.1097/00005176-200003000-00009]
69 Mahdi B,Mahdi BM.A Review Of Inflammatory Bowel Disease Unclassified--Indeterminate Colitis.J Gastroenterol Hepatol Res2012;1:241-246
70 Prenzel F,Uhlig HH.Frequency of indeterminate colitis in children and adults with IBD-a metaanalysis.J Crohns Colitis 2009;3:277-281[PMID:21172287 DOI:10.1016/j.crohns.2009.07.001]
71 Legaki E,Gazouli M.Influence of environmental factors in the development of inflammatory bowel diseases.World J Gastrointest Pharmacol Ther 2016;7:112-125[PMID:26855817 DOI:10.4292/wjgpt.v7.i1.112]
72 Kamm MA.Rapid changes in epidemiology of inflammatory bowel disease.Lancet 2018;390:2741-2742[PMID:29050647DOI:10.1016/S0140-6736(17)32669-7]
73 M‘Koma AE.Inflammatory bowel disease:an expanding global health problem.Clin Med Insights Gastroenterol 2013;6:33-47[PMID:24833941 DOI:10.4137/CGast.S12731]
74 Leach ST,Day AS,Moore D,Lemberg DA.Low rate of inflammatory bowel disease in the Australian indigenous paediatric population.J Paediatr Child Health 2014;50:328-329[PMID:24698068 DOI:10.1111/jpc.12535]
75 Gismera CS,Aladrén BS.Inflammatory bowel diseases:a disease(s)of modern times?Is incidence still increasing?World J Gastroenterol 2008;14:5491-5498[PMID:18810764 DOI:10.3748/WJG.14.5491]
76 Herrinton LJ,Liu L,Lewis JD,Griffin PM,Allison J.Incidence and prevalence of inflammatory bowel disease in a Northern California managed care organization,1996-2002.Am JGastroenterol 2008;103:1998-2006[PMID:18796097 DOI:10.1111/j.1572-0241.2008.01960.x]
77 Shapiro JM,Zoega H,Shah SA,Bright RM,Mallette M,Moniz H,Grabert SA,Bancroft B,Merrick M,Flowers NT,Samad Z,Lidofsky S,Le Leiko NS,Sands BE.Incidence of Crohn‘s Disease and Ulcerative Colitis in Rhode Island:Report from the Ocean State Crohn‘s and Colitis Area Registry.Inflamm Bowel Dis 2016;22:1456-1461[PMID:26926039 DOI:10.1097/MIB.0000000000000745]
78 Bitton A,Vutcovici M,Patenaude V,Sewitch M,Suissa S,Brassard P.Epidemiology of inflammatory bowel disease in Québec:recent trends.Inflamm Bowel Dis 2014;20:1770-1776[PMID:25159452DOI:10.1097/MIB.0000000000000162]
79 El-Matary W,Moroz SP,Bernstein CN.Inflammatory bowel disease in children of Manitoba:30 years‘experience of a tertiary center.J Pediatr Gastroenterol Nutr 2014;59:763-766[PMID:25111222 DOI:10.1097/MPG.0000000000000525]
80 Lowe AM,Roy PO,B-Poulin M,Michel P,Bitton A,St-Onge L,Brassard P.Epidemiology of Crohn‘s disease in Québec,Canada.Inflamm Bowel Dis 2009;15:429-435[PMID:18942744 DOI:10.1002/ibd.20756]
81 Grieci T,Bütter A.The incidence of inflammatory bowel disease in the pediatric population of Southwestern Ontario.J Pediatr Surg 2009;44:977-980[PMID:19433182 DOI:10.1016/j.jpedsurg.2009.01.038]
82 Griffiths AM.Specificities of inflammatory bowel disease in childhood.Best Pract Res Clin Gastroenterol 2004;18:509-523[PMID:15157824 DOI:10.1016/j.bpg.2004.01.002]
83 Leddin D,Tamim H,Levy AR.Decreasing incidence of inflammatory bowel disease in eastern Canada:a population database study.BMC Gastroenterol 2014;14:140[PMID:25108544 DOI:10.1186/1471-230X-14-140]
84 Benchimol EI,Manuel DG,Guttmann A,Nguyen GC,Mojaverian N,Quach P,Mack DR.Changing age demographics of inflammatory bowel disease in Ontario,Canada:a population-based cohort study of epidemiology trends.Inflamm Bowel Dis 2014;20:1761-1769[PMID:25159453 DOI:10.1097/MIB.0000000000000103]
85 Bentsen BS,Moum B,Ekbom A.Incidence of inflammatory bowel disease in children in southeastern Norway:a prospective population-based study 1990-94.Scand J Gastroenterol 2002;37:540-545[PMID:12059055 DOI:10.1080/00365520252903080]
86 Benchimol EI,Mack DR,Nguyen GC,Snapper SB,Li W,Mojaverian N,Quach P,Muise AM.Incidence,outcomes,and health services burden of very early onset inflammatory bowel disease.Gastroenterology 2014;147:803-813.e7;quiz e14-e15[PMID:24951840 DOI:10.1053/j.gastro.2014.06.023]
87 Vicentín R,Wagener M,Pais AB,Contreras M,Orsi M.One-year prospective registry of inflammatory bowel disease in the Argentine pediatric population.Arch Argent Pediatr 2017;115:533-540[PMID:29087106 DOI:10.5546/aap.2017.eng.533]
88 Pebody RG,Paunio M,Ruutu P.Measles,measles vaccination,and Crohn‘s disease.Crohn‘s disease has not increased in Finland.BMJ 1998;316:1745-1746[PMID:9652932 DOI:10.1136/bmj.316.7146.1745]
89 Lehtinen P,Pasanen K,Kolho KL,Auvinen A.Incidence of Pediatric Inflammatory Bowel Disease in Finland:An Environmental Study.J Pediatr Gastroenterol Nutr 2016;63:65-70[PMID:26636498 DOI:10.1097/MPG.0000000000001050]
90 Jussila A,Virta LJ,Kautiainen H,Rekiaro M,Nieminen U,F?rkkil?MA.Increasing incidence of inflammatory bowel diseases between 2000 and 2007:a nationwide register study in Finland.Inflamm Bowel Dis 2012;18:555-561[PMID:21425214 DOI:10.1002/ibd.21695]
91 Solberg IC,Vatn MH,H?ie O,Stray N,Sauar J,Jahnsen J,Moum B,Lygren I;IBSEN Study Group.Clinical course in Crohn‘s disease:results of a Norwegian population-based ten-year follow-up study.Clin Gastroenterol Hepatol 2007;5:1430-1438[PMID:18054751DOI:10.1016/j.cgh.2007.09.002]
92 Perminow G,Brackmann S,Lyckander LG,Franke A,Borthne A,Rydning A,Aamodt G,Schreiber S,Vatn MH;IBSEN-II Group.Acharacterization in childhood inflammatory bowel disease,a new population-based inception cohort from South-Eastern Norway,2005-07,showing increased incidence in Crohn‘s disease.Scand JGastroenterol 2009;44:446-456[PMID:19117240 DOI:10.1080/00365520802647434]
93 St?rdal K,Jahnsen J,Bentsen B S,Moum B.Pediatric inflammatory bowel disease in southeastern Norway:a five-year follow-up study.Digestion 2004;70:226-230[PMID:15627770DOI:10.1159/000082893]
94 Moum B,Vatn MH,Ekbom A,Fausa O,Aadland E,Lygren I,Sauar J,Schulz T.Incidence of inflammatory bowel disease in southeastern Norway:evaluation of methods after 1 year of registration.Southeastern Norway IBD Study Group of Gastroenterologists.Digestion 1995;56:377-381[PMID:8549880DOI:10.1159/000201262]
95 Moum B,Vatn MH,Ekbom A,Aadland E,Fausa O,Lygren I,Sauar J,Schulz T,Stray N.Incidence of ulcerative colitis and indeterminate colitis in four counties of southeastern Norway,1990-93.A prospective population-based study.The Inflammatory Bowel South-Eastern Norway(IBSEN)Study Group of Gastroenterologists.Scand J Gastroenterol 1996;31:362-366[PMID:8726304 DOI:10.3109/00365529609006411]
96 Moum B,Vatn MH,Ekbom A,Aadland E,Fausa O,Lygren I,Stray N,Sauar J,Schulz T.Incidence of Crohn‘s disease in four counties in southeastern Norway,1990-93.A prospective population-based study.The Inflammatory Bowel South-Eastern Norway(IBSEN)Study Group of Gastroenterologists.Scand J Gastroenterol 1996;31:355-361[PMID:8726303 DOI:10.3109/00365529609006410]
97 Olafsdottir EJ,Fluge G,Haug K.Chronic inflammatory bowel disease in children in western Norway.J Pediatr Gastroenterol Nutr1989;8:454-458[PMID:2723937 DOI:10.1097/00005176-198905000-00006]
98 Lindberg E,J?rnerot G.The incidence of Crohn‘s disease is not decreasing in Sweden.Scand J Gastroenterol 1991;26:495-500[PMID:1871542 DOI:10.3109/00365529108998572]
99 Askling J,Grahnquist L,Ekbom A,Finkel Y.Incidence of paediatric Crohn‘s disease in Stockholm,Sweden.Lancet 1999;354:1179[PMID:10513717 DOI:10.1016/S0140-6736(99)02625-2]
100 Sj?berg D,Holmstr?m T,Larsson M,Nielsen AL,Holmquist L,Ekbom A,R?nnblom A.Incidence and natural history of ulcerative colitis in the Uppsala Region of Sweden 2005-2009-results from the IBD cohort of the Uppsala Region(ICURE).J Crohns Colitis 2013;7:e351-e357[PMID:23491313 DOI:10.1016/j.crohns.2013.02.006]
101 Sj?berg D,Holmstr?m T,Larsson M,Nielsen AL,Holmquist L,Ekbom A,R?nnblom A.Incidence and clinical course of Crohn‘s disease during the first year-results from the IBD Cohort of the Uppsala Region(ICURE)of Sweden 2005-2009.J Crohns Colitis 2014;8:215-222[PMID:24035547 DOI:10.1016/j.crohns.2013.08.009]
102 Vind I,Riis L,Jess T,Knudsen E,Pedersen N,Elkjaer M,Bak Andersen I,Wewer V,N?rregaard P,Moesgaard F,Bendtsen F,Munkholm P;DCCD study group.Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County,2003-2005:a population-based study from the Danish Crohn colitis database.Am J Gastroenterol2006;101:1274-1282[PMID:16771949 DOI:10.1111/j.1572-0241.2006.00552.x]
103 Lophaven SN,Lynge E,Burisch J.The incidence of inflammatory bowel disease in Denmark 1980-2013:a nationwide cohort study.Aliment Pharmacol Ther 2017;45:961-972[PMID:28229470DOI:10.1111/apt.13971]
104 Jacobsen BA,Fallingborg J,Rasmussen HH,Nielsen KR,Drewes AM,Puho E,Nielsen GL,S?rensen HT.Increase in incidence and prevalence of inflammatory bowel disease in northern Denmark:a population-based study,1978-2002.Eur J Gastroenterol Hepatol2006;18:601-606[PMID:16702848 DOI:10.1097/00042737-200606000-00005]
105 Langholz E,Munkholm P,Krasilnikoff PA,Binder V.Inflammatory bowel diseases with onset in childhood.Clinical features,morbidity,and mortality in a regional cohort.Scand J Gastroenterol 1997;32:139-147[PMID:9051874 DOI:10.3109/00365529709000184]
106 Langholz E,Munkholm P,Nielsen OH,Kreiner S,Binder V.Incidence and prevalence of ulcerative colitis in Copenhagen county from 1962 to 1987.Scand J Gastroenterol 1991;26:1247-1256[PMID:1763295 DOI:10.3109/00365529108998621]
107 Fonager K,S?rensen HT,Olsen J.Change in incidence of Crohn‘s disease and ulcerative colitis in Denmark.A study based on the National Registry of Patients,1981-1992.Int J Epidemiol 1997;26:1003-1008[PMID:9363521 DOI:10.1093/ije/26.5.1003]
108 Urne FU,Paerregaard A.[Chronic inflammatory bowel disease in children.An epidemiological study from eastern Denmark1998-2000].Ugeskr Laeger 2002;164:5810-5814[PMID:12523226]
109 Larsen L,Jensen MD,Larsen MD,Nielsen RG,Thorsgaard N,Vind I,Wildt S,Kjeldsen J.The Danish National Registry for Biological Therapy in Inflammatory Bowel Disease.Clin Epidemiol2016;8:607-612[PMID:27822107 DOI:10.2147/CLEP.S99478]
110 Jakobsen C,Paerregaard A,Munkholm P,Faerk J,Lange A,Andersen J,Jakobsen M,Kramer I,Czernia-Mazurkiewicz J,Wewer V.Pediatric inflammatory bowel disease:increasing incidence,decreasing surgery rate,and compromised nutritional status:A prospective population-based cohort study 2007-2009.Inflamm Bowel Dis 2011;17:2541-2550[PMID:21381152 DOI:10.1002/ibd.21654]
111 N?rg?rd BM,Nielsen J,Fonager K,Kjeldsen J,Jacobsen BA,Qvist N.The incidence of ulcerative colitis(1995-2011)and Crohn‘s disease(1995-2012)-based on nationwide Danish registry data.J Crohns Colitis 2014;8:1274-1280[PMID:24675473 DOI:10.1016/j.crohns.2014.03.006]
112 Bj?rnsson S,Jóhannsson JH.Inflammatory bowel disease in Iceland,1990-1994:a prospective,nationwide,epidemiological study.Eur J Gastroenterol Hepatol 2000;12:31-38[PMID:10656207 DOI:10.1097/00042737-200012010-00007]
113 Armitage E,Drummond H,Ghosh S,Ferguson A.Incidence of juvenile-onset Crohn‘s disease in Scotland.Lancet1999;353:1496-1497[PMID:10232323 DOI:10.1016/S0140-6736(99)00333-5]
114 Armitage EL,Aldhous MC,Anderson N,Drummond HE,Riemersma RA,Ghosh S,Satsangi J.Incidence of juvenile-onset Crohn‘s disease in Scotland:association with northern latitude and affluence.Gastroenterology 2004;127:1051-1057[PMID:15480983 DOI:10.1053/j.gastro.2004.06.024]
115 Watson AJ,Johnston AT,Barker PM,Youngson GG,Bisset WM,Mahomed AA.The presentation and management of juvenile-onset chronic inflammatory bowel disease in Northeastern Scotland.JPediatr Surg 2002;37:83-86[PMID:11781993 DOI:10.1053/jpsu.2002.29434]
116 Ashton JJ,Wiskin AE,Ennis S,Batra A,Afzal NA,Beattie RM.Rising incidence of paediatric inflammatory bowel disease(PIBD)in Wessex,Southern England.Arch Dis Child 2014;99:659-664[PMID:24728445 DOI:10.1136/archdischild-2013-305419]
117 Ashton JJ,Cullen M,Afzal NA,Coelho T,Batra A,Beattie RM.Is the incidence of paediatric inflammatory bowel disease still increasing?Arch Dis Child 2018;Epub ahead of print[PMID:29519945 DOI:10.1136/archdischild-2018-315038]
118 Hassan K,Cowan FJ,Jenkins HR.The incidence of childhood inflammatory bowel disease in Wales.Eur J Pediatr 2000;159:261-263[PMID:10789930 DOI:10.1007/s004310050066]
119 Gunesh S,Thomas GA,Williams GT,Roberts A,Hawthorne AB.The incidence of Crohn‘s disease in Cardiff over the last 75 years:an update for 1996-2005.Aliment Pharmacol Ther 2008;27:211-219[PMID:18005244 DOI:10.1111/j.1365-2036.2007.03576.x]
120 Hope B,Shahdadpuri R,Dunne C,Broderick AM,Grant T,Hamzawi M,O‘Driscoll K,Quinn S,Hussey S,Bourke B.Rapid rise in incidence of Irish paediatric inflammatory bowel disease.Arch Dis Child 2012;97:590-594[PMID:22550323 DOI:10.1136/archdischild-2011-300651]
121 Coughlan A,Wylde R,Lafferty L,Quinn S,Broderick A,Bourke B,Hussey S;DOCHAS Study.A rising incidence and poorer male outcomes characterise early onset paediatric inflammatory bowel disease.Aliment Pharmacol Ther 2017;45:1534-1541[PMID:28449214 DOI:10.1111/apt.14070]
122 Petritsch W,Fuchs S,Berghold A,Bachmaier G,H?genauer C,Hauer AC,Weiglhofer U,Wenzl HH.Incidence of inflammatory bowel disease in the province of Styria,Austria,from 1997 to 2007:a population-based study.J Crohns Colitis 2013;7:58-69[PMID:22542057 DOI:10.1016/j.crohns.2012.03.012]
123 Ott C,Obermeier F,Thieler S,Kemptner D,Bauer A,Sch?lmerich J,Rogler G,Timmer A.The incidence of inflammatory bowel disease in a rural region of Southern Germany:a prospective populationbased study.Eur J Gastroenterol Hepatol 2008;20:917-923[PMID:18794607 DOI:10.1097/MEG.0b013e3282f97b33]
124 van der Zaag-Loonen HJ,Casparie M,Taminiau JA,Escher JC,Pereira RR,Derkx HH.The incidence of pediatric inflammatory bowel disease in the Netherlands:1999-2001.J Pediatr Gastroenterol Nutr 2004;38:302-307[PMID:15076631 DOI:10.1097/00005176-200403000-00014]
125 Gower-Rousseau C,Vasseur F,Fumery M,Savoye G,Salleron J,Dauchet L,Turck D,Cortot A,Peyrin-Biroulet L,Colombel JF.Epidemiology of inflammatory bowel diseases:new insights from a French population-based registry(EPIMAD).Dig Liver Dis 2013;45:89-94[PMID:23107487 DOI:10.1016/j.dld.2012.09.005]
126 Bequet E,Sarter H,Fumery M,Vasseur F,Armengol-Debeir L,Pariente B,Ley D,Spyckerelle C,Coevoet H,Laberenne JE,Peyrin-Biroulet L,Savoye G,Turck D,Gower-Rousseau C;EPIMAD Group.Incidence and Phenotype at Diagnosis of Veryearly-onset Compared with Later-onset Paediatric Inflammatory Bowel Disease:A Population-based Study[1988-2011].J Crohns Colitis 2017;11:519-526[PMID:28453757 DOI:10.1093/eccojcc/jjw194]
127 Vernier-Massouille G,Balde M,Salleron J,Turck D,Dupas JL,Mouterde O,Merle V,Salomez JL,Branche J,Marti R,Lerebours E,Cortot A,Gower-Rousseau C,Colombel JF.Natural history of pediatric Crohn‘s disease:a population-based cohort study.Gastroenterology 2008;135:1106-1113[PMID:18692056 DOI:10.1053/j.gastro.2008.06.079]
128 Abakar-Mahamat A,Filippi J,Pradier C,Dozol A,Hébuterne X.Incidence of inflammatory bowel disease in Corsica from 2002to 2003.Gastroenterol Clin Biol 2007;31:1098-1103[PMID:18176365 DOI:10.1016/S0399-8320(07)78343-4]
129 Tourtelier Y,Dabadie A,Tron I,Alexandre JL,Robaskiewicz M,Cruchant E,Seyrig JA,Heresbach D,Bretagne JF.Incidence of inflammatory bowel disease in children in Brittany(1994-1997).Arch Pediatr 2000;7:377-384[DOI:10.1016/s0929-693x(00)88832-6]
130 Gottrand F,Colombel JF,Moreno L,Salomez JL,Farriaux JP,Cortot A.[Incidence of inflammatory bowel diseases in children in the Nord-Pas-de-Calais region].Arch Fr Pediatr 1991;48:25-28[PMID:2018416]
131 Ghione S,Sarter H,Fumery M,Armengol-Debeir L,Savoye G,Ley D,Spyckerelle C,Pariente B,Peyrin-Biroulet L,Turck D,GowerRousseau C;Epimad Group.Dramatic Increase in Incidence of Ulcerative Colitis and Crohn‘s Disease(1988-2011):A PopulationBased Study of French Adolescents.Am J Gastroenterol 2018;113:265-272[PMID:28809388 DOI:10.1038/ajg.2017.228]
132 Pittet V,Juillerat P,Mottet C,Felley C,Ballabeni P,Burnand B,Michetti P,Vader JP;Swiss IBD Cohort Study Group.Cohort profile:the Swiss Inflammatory Bowel Disease Cohort Study(SIBDCS).Int J Epidemiol 2009;38:922-931[PMID:18782896DOI:10.1093/ije/dyn180]
133 De Greef E,Mahachie John JM,Hoffman I,Smets F,Van Biervliet S,Scaillon M,Hauser B,Paquot I,Alliet P,Arts W,Dewit O,Peeters H,Baert F,D‘Haens G,Rahier JF,Etienne I,Bauraind O,Van Gossum A,Vermeire S,Fontaine F,Muls V,Louis E,Van de Mierop F,Coche JC,Van Steen K,Veereman G;IBD working group of the Belgian Society of Pediatric Gastroenterology,Hepatology and Nutrition(Be SPGHAN);Belgian IBD Research and Development.Profile of pediatric Crohn‘s disease in Belgium.J Crohns Colitis 2013;7:e588-e598[PMID:23664896 DOI:10.1016/j.crohns.2013.04.016]
134 Ranzi T,Bodini P,Zambelli A,Politi P,Lupinacci G,Campanini MC,Dal Lago AL,Lisciandrano D,Bianchi PA.Epidemiological aspects of inflammatory bowel disease in a north Italian population:a 4-year prospective study.Eur J Gastroenterol Hepatol 1996;8:657-661[PMID:8853254]
135 Di Domenicantonio R,Cappai G,ArcàM,Agabiti N,Kohn A,Vernia P,Biancone L,Armuzzi A,Papi C,Davoli M.Occurrence of inflammatory bowel disease in central Italy:a study based on health information systems.Dig Liver Dis 2014;46:777-782[PMID:24890621 DOI:10.1016/j.dld.2014.04.014]
136 Trallori G,Palli D,Saieva C,Bardazzi G,Bonanomi AG,d‘Albasio G,Galli M,Vannozzi G,Milla M,Tarantino O,Renai F,Messori A,Amorosi A,Pacini F,Morettini A.A population-based study of inflammatory bowel disease in Florence over 15 years(1978-92).Scand J Gastroenterol 1996;31:892-899[PMID:8888437 DOI:10.3109/00365529609051998]
137 Arin Letamendia A,Borda Celaya F,Burusco Paternain MJ,Prieto Martínez C,Martínez Echeverría A,Elizalde Apestegui I,Laiglesia Izquierdo M,Macias Mendizábal E,Tamburri Moso P,Sánchez Valverde F.[High incidence rates of inflammatory bowel disease in Navarra(Spain).Results of a prospective,population-based study].Gastroenterol Hepatol 2008;31:111-116[PMID:18341841 DOI:10.1157/13116497]
138 Cachia E,Calleja N,Aakeroy R,Degaetano J,Vassallo M.Incidence of inflammatory bowel disease in Malta between 1993and 2005:a retrospective study.Inflamm Bowel Dis 2008;14:550-553[PMID:18183599 DOI:10.1002/ibd.20321]
139 Pozler O,Maly J,Bonova O,Dedek P,Frühauf P,Havlickova A,Janatova T,Jimramovsky F,Klimova L,Klusacek D,Kocourkova D,Kolek A,Kotalova R,Marx D,Nevoral J,Petro R,Petru O,Plasilova I,Seidl Z,Sekyrova I,Semendak N,Schreierova I,Stanek J,Sykora J,Sulakova A,Toukalkova L,Travnickova R,Volf V,Zahradnicek L,ZeniskováI.Incidence of Crohn disease in the Czech Republic in the years 1990 to 2001 and assessment of pediatric population with inflammatory bowel disease.J Pediatr Gastroenterol Nutr 2006;42:186-189[PMID:16456413 DOI:10.1097/01.mpg.0000189328.47150.bc]
140 Kolek A,Janout V,TichyM,Grepl M.The incidence of inflammatory bowel disease is increasing among children 15 years old and younger in the Czech Republic.J Pediatr Gastroenterol Nutr 2004;38:362-363[PMID:15076645 DOI:10.1097/00005176-200403000-00028]
141 Müller KE,Lakatos PL,AratóA,Kovács JB,Várkonyiá,Sz?cs D,Szakos E,Sólyom E,Kovács M,Polgár M,Nemesé,Guthy I,Tokodi I,Tóth G,Horváthá,Tárnok A,Csoszánszki N,Balogh M,Vass N,Bódi P,Dezs?fi A,Gárdos L,Micskey E,Papp M,Csehá,SzabóD,V?r?s P,Veres G;Hungarian IBD Registry Group(HUPIR).Incidence,Paris classification,and follow-up in a nationwide incident cohort of pediatric patients with inflammatory bowel disease.J Pediatr Gastroenterol Nutr 2013;57:576-582[PMID:23820399 DOI:10.1097/MPG.0b013e31829f7d8c]
142 Lakatos L,Kiss LS,David G,Pandur T,Erdelyi Z,Mester G,Balogh M,Szipocs I,Molnar C,Komaromi E,Lakatos PL.Incidence,disease phenotype at diagnosis,and early disease course in inflammatory bowel diseases in Western Hungary,2002-2006.Inflamm Bowel Dis 2011;17:2558-2565[PMID:22072315 DOI:10.1002/ibd.21607]
143 Orel R,Kamhi T,Vidmar G,Mamula P.Epidemiology of pediatric chronic inflammatory bowel disease in central and western Slovenia,1994-2005.J Pediatr Gastroenterol Nutr 2009;48:579-586[PMID:19367184 DOI:10.1097/MPG.0b013e318164d903]
144 Vuceli?B,Kora?B,Senti?M,Milici?D,Hadzi?N,Juresa V,Bozikov J,Rotkvi?I,Buljevac M,Kovacevi?I.Ulcerative colitis in Zagreb,Yugoslavia:incidence and prevalence 1980-1989.Int JEpidemiol 1991;20:1043-1047[PMID:1800402 DOI:10.1093/ije/20.4.1043]
145 Vuceli?B,Kora?B,Senti?M,Milici?D,Hadzi?N,Juresa V,Bozikov J,Rotkvi?I,Buljevac M,Kovacevi?I.Epidemiology of Crohn‘s disease in Zagreb,Yugoslavia:a ten-year prospective study.Int J Epidemiol 1991;20:216-220[PMID:2066223 DOI:10.1093/ije/20.1.216]
146 Ahmaida A,Al-Shaikhi S.Childhood Inflammatory Bowel Disease in Libya:Epidemiological and Clinical features.Libyan J Med2009;4:70-74[PMID:21483512 DOI:10.4176/081210]
147 Odes HS,Locker C,Neumann L,Zirkin HJ,Weizman Z,Sperber AD,Fraser GM,Krugliak P,Gaspar N,Eidelman L.Epidemiology of Crohn‘s disease in southern Israel.Am J Gastroenterol 1994;89:1859-1862[PMID:7942683]
148 Grossman A,Fireman Z,Lilos P,Novis B,Rozen P,Gilat T.Epidemiology of ulcerative colitis in the Jewish population of central Israel 1970-1980.Hepatogastroenterology 1989;36:193-197[PMID:2807136]
149 El Mouzan MI,Saadah O,Al-Saleem K,Al Edreesi M,Hasosah M,Alanazi A,Al Mofarreh M,Asery A,Al Qourain A,Nouli K,Al Hussaini A,Telmesani A,Al Reheili K,Alghamdi S,Alrobiaa N,Alzaben A,Mehmadi A,Al Hebbi H,Al Sarkhy A,Al Mehaidib A,Al Saleem B,Assiri A,Wali S.Incidence of pediatric inflammatory bowel disease in Saudi Arabia:a multicenter national study.Inflamm Bowel Dis 2014;20:1085-1090[PMID:24788219 DOI:10.1097/MIB.0000000000000048]
150 El Mouzan MI,Abdullah AM,Al Habbal MT.Epidemiology of juvenile-onset inflammatory bowel disease in central Saudi Arabia.J Trop Pediatr 2006;52:69-71[PMID:15947013 DOI:10.1093/tropej/fmi039]
151 Al-Qabandi WA,Buhamrah EK,Hamadi KA,Al-Osaimi SA,AlRuwayeh AA,Madda J.Inflammatory bowel disease in children,an evolving problem in Kuwait.Saudi J Gastroenterol 2011;17:323-327[PMID:21912059 DOI:10.4103/1319-3767.84487]
152 Zayyani NR,Malaty HM,Graham DY.Increasing Incidence of Crohn‘s Disease with Familial Clustering in the Kingdom of Bahrain:A 25-Year Population-based Study.Inflamm Bowel Dis 2017;23:304-309[PMID:28092308 DOI:10.1097/MIB.0000000000001016]
153 Wang XQ,Zhang Y,Xu CD,Jiang LR,Huang Y,Du HM,Wang XJ.Inflammatory bowel disease in Chinese children:a multicenter analysis over a decade from Shanghai.Inflamm Bowel Dis 2013;19:423-428[PMID:23340680 DOI:10.1097/MIB.0b013e318286f9f2]
154 Tsai CH,Chen HL,Ni YH,Hsu HY,Jeng YM,Chang CJ,Chang MH.Characteristics and trends in incidence of inflammatory bowel disease in Taiwanese children.J Formos Med Assoc 2004;103:685-691[PMID:15361941]
155 Chu HP,Logarajah V,Tan N,Phua KB.Paediatric inflammatory bowel disease in a multiracial Asian country.Singapore Med J 2013;54:201-205[PMID:23624446 DOI:10.11622/smedj.2013073]
156 Yang SK,Hong WS,Min YI,Kim HY,Yoo JY,Rhee PL,Rhee JC,Chang DK,Song IS,Jung SA,Park EB,Yoo HM,Lee DK,Kim YK.Incidence and prevalence of ulcerative colitis in the SongpaKangdong District,Seoul,Korea,1986-1997.J Gastroenterol Hepatol 2000;15:1037-1042[PMID:11059934 DOI:10.1046/j.1440-1746.2000.02252.x]
157 Jung YS,Han M,Kim WH,Park S,Cheon JH.Incidence and Clinical Outcomes of Inflammatory Bowel Disease in South Korea,2011-2014:A Nationwide Population-Based Study.Dig Dis Sci 2017;62:2102-2112[PMID:28593437 DOI:10.1007/s10620-017-4640-9]
158 Phavichitr N,Cameron DJ,Catto-Smith AG.Increasing incidence of Crohn‘s disease in Victorian children.J Gastroenterol Hepatol 2003;18:329-332[PMID:12603535 DOI:10.1046/j.1440-1746.2003.02975.x]
159 Schildkraut V,Alex G,Cameron DJ,Hardikar W,Lipschitz B,Oliver MR,Simpson DM,Catto-Smith AG.Sixty-year study of incidence of childhood ulcerative colitis finds eleven-fold increase beginning in 1990s.Inflamm Bowel Dis 2013;19:1-6[PMID:22532319 DOI:10.1002/ibd.22997]
160 Lopez RN,Evans HM,Appleton L,Bishop J,Chin S,Mouat S,Gearry RB,Day AS.Prospective Incidence of Paediatric Inflammatory Bowel Disease in New Zealand in 2015:Results From the Paediatric Inflammatory Bowel Disease in New Zealand(PINZ)Study.J Pediatr Gastroenterol Nutr 2018;66:e122-e126[PMID:29077643 DOI:10.1097/MPG.0000000000001806]
161 Lopez RN,Appleton L,Gearry RB,Day AS.Rising Incidence of Paediatric Inflammatory Bowel Disease in Canterbury,New Zealand,1996-2015.J Pediatr Gastroenterol Nutr 2018;66:e45-e50[PMID:28727653 DOI:10.1097/MPG.0000000000001688]
162 Levine A,Koletzko S,Turner D,Escher JC,Cucchiara S,de Ridder L,Kolho KL,Veres G,Russell RK,Paerregaard A,Buderus S,Greer ML,Dias JA,Veereman-Wauters G,Lionetti P,Sladek M,Martin de Carpi J,Staiano A,Ruemmele FM,Wilson DC;European Society of Pediatric Gastroenterology,Hepatology,and Nutrition.ESPGHAN revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents.J Pediatr Gastroenterol Nutr 2014;58:795-806[PMID:24231644 DOI:10.1097/MPG.0000000000000239]
163 Haug K,Schrumpf E,Barstad S,Fluge G,Halvorsen JF.Epidemiology of ulcerative colitis in western Norway.Scand JGastroenterol 1988;23:517-522[PMID:3399823 DOI:10.3109/00365528809093904]
164 Hildebrand H,Brydolf M,Holmquist L,Krantz I,Kristiansson B.Incidence and prevalence of inflammatory bowel disease in children in south-western Sweden.Acta Paediatr 1994;83:640-645[PMID:7919763 DOI:10.1111/j.1651-2227.1994.tb13098.x]
165 Tysk C,J?rnerot G.Ulcerative proctocolitis in Orebro,Sweden.A retrospective epidemiologic study,1963-1987.Scand JGastroenterol 1992;27:945-950[PMID:1455192 DOI:10.3109/00365529209000168]
166 Hildebrand H,Fredrikzon B,Holmquist L,Kristiansson B,Lindquist B.Chronic inflammatory bowel disease in children and adolescents in Sweden.J Pediatr Gastroenterol Nutr 1991;13:293-297[PMID:1791507 DOI:10.1097/00005176-199110000-00010]
167 Gollop JH,Phillips SF,Melton LJ 3rd,Zinsmeister AR.Epidemiologic aspects of Crohn‘s disease:a population based study in Olmsted County,Minnesota,1943-1982.Gut 1988;29:49-56[PMID:3343012 DOI:10.1136/gut.29.1.49]
168 Loftus EV Jr,Silverstein MD,Sandborn WJ,Tremaine WJ,Harmsen WS,Zinsmeister AR.Ulcerative colitis in Olmsted County,Minnesota,1940-1993:incidence,prevalence,and survival.Gut 2000;46:336-343[PMID:10673294 DOI:10.1136/gut.46.3.336]
169 Kuo CJ,Yu KH,See LC,Chiu CT,Su MY,Hsu CM,Kuo CF,Chiou MJ,Liu JR,Wang HW.The Trend of Inflammatory Bowel Diseases in Taiwan:A Population-Based Study.Dig Dis Sci 2015;60:2454-2462[PMID:25837597 DOI:10.1007/s10620-015-3630-z]
170 González FN,García BC,Polo RE,Hernández CM.Inflammatory bowel disease in pediatric patients in Asturias,Spain(1993-2000):epidemiology and clinical features.Acta Pediatr Esp 2004;62:466-472
171 Lopez Miguel C,Sicilia B,Sierra E,Lopez Zaborras J,Arribas F,Gomollon F.[Incidence of inflammatory bowel disease in Aragon:outcome of a prospective population-based study].Gastroenterol Hepatol 1999;22:323-328[PMID:10535203]
2 Henderson P,Rogers P,Gillett P,Wilson D.The epidemiology and natural history of paediatric inflammatory bowel disease in a UK region:a prospective 14-year study.Arch Dis Child 2012;97:A53.2-A54[DOI:10.1136/archdischild-2012-301885.130]
3 Ng SC,Shi HY,Hamidi N,Underwood FE,Tang W,Benchimol EI,Panaccione R,Ghosh S,Wu JCY,Chan FKL,Sung JJY,Kaplan GG.Worldwide incidence and prevalence of inflammatory bowel disease in the 21st century:a systematic review of population-based studies.Lancet 2018;390:2769-2778[PMID:29050646 DOI:10.1016/S0140-6736(17)32448-0]
4 Benchimol EI,Fortinsky KJ,Gozdyra P,Van den Heuvel M,Van Limbergen J,Griffiths AM.Epidemiology of pediatric inflammatory bowel disease:a systematic review of international trends.Inflamm Bowel Dis 2011;17:423-439[PMID:20564651 DOI:10.1002/ibd.21349]
5 da Silva BC,Lyra AC,Rocha R,Santana GO.Epidemiology,demographic characteristics and prognostic predictors of ulcerative colitis.World J Gastroenterol 2014;20:9458-9467[PMID:25071340 DOI:10.3748/wjg.v20.i28.9458]
6 Van Limbergen J,Russell RK,Drummond HE,Aldhous MC,Round NK,Nimmo ER,Smith L,Gillett PM,Mc Grogan P,Weaver LT,Bisset WM,Mahdi G,Arnott ID,Satsangi J,Wilson DC.Definition of phenotypic characteristics of childhoodonset inflammatory bowel disease.Gastroenterology 2008;135:1114-1122[PMID:18725221 DOI:10.1053/j.gastro.2008.06.081]
7 Misra R,Faiz O,Munkholm P,Burisch J,Arebi N.Epidemiology of inflammatory bowel disease in racial and ethnic migrant groups.World J Gastroenterol 2018;24:424-437[PMID:29391765 DOI:10.3748/wjg.v24.i3.424]
8 Girardelli M,Basaldella F,Paolera SD,Vuch J,Tommasini A,Martelossi S,Crovella S,Bianco AM.Genetic profile of patients with early onset inflammatory bowel disease.Gene 2018;645:18-29[PMID:29248579 DOI:10.1016/j.gene.2017.12.029]
9 Jakobsen C,Cleynen I,Andersen PS,Vermeire S,Munkholm P,Paerregaard A,Wewer V.Genetic susceptibility and genotypephenotype association in 588 Danish children with inflammatory bowel disease.J Crohns Colitis 2014;8:678-685[PMID:24394805DOI:10.1016/j.crohns.2013.12.010]
10 Fang YH,Luo YY,Yu JD,Lou JG,Chen J.Phenotypic and genotypic characterization of inflammatory bowel disease in children under six years of age in China.World J Gastroenterol2018;24:1035-1045[PMID:29531467 DOI:10.3748/wjg.v24.i9.1035]
11 von Allmen D.Pediatric Crohn‘s Disease.Clin Colon Rectal Surg2018;31:80-88[PMID:29487490 DOI:10.1055/s-0037-1609022]
12 Liberati A,Altman DG,Tetzlaff J,Mulrow C,G?tzsche PC,Ioannidis JP,Clarke M,Devereaux PJ,Kleijnen J,Moher D.The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions:explanation and elaboration.PLo S Med 2009;6:e1000100[PMID:19621070 DOI:10.1371/journal.pmed.1000100]
13 United Nations.Composition of macro Geographical(Continental)Regions,Geographical Sub-Regions,and Selected Economic and Other Groupings.Available from:URL:http://unstats.un.org/unsd/methods/m49/m49regin.htm
14 Lennard-Jones JE.Classification of inflammatory bowel disease.Scand J Gastroenterol Suppl 1989;170:2-6;discussion 16-19[PMID:2617184 DOI:10.3109/00365528909091339]
15 Sanderson S,Tatt ID,Higgins JP.Tools for assessing quality and susceptibility to bias in observational studies in epidemiology:a systematic review and annotated bibliography.Int J Epidemiol2007;36:666-676[PMID:17470488 DOI:10.1093/ije/dym018]
16 Sawczenko A,Sandhu BK,Logan RF,Jenkins H,Taylor CJ,Mian S,Lynn R.Prospective survey of childhood inflammatory bowel disease in the British Isles.Lancet 2001;357:1093-1094[PMID:11297962 DOI:10.1016/S0140-6736(00)04309-9]
17 Tsironi E,Feakins RM,Probert CS,Rampton DS,Phil D.Incidence of inflammatory bowel disease is rising and abdominal tuberculosis is falling in Bangladeshis in East London,United Kingdom.Am J Gastroenterol 2004;99:1749-1755[PMID:15330914 DOI:10.1111/j.1572-0241.2004.30445.x]
18 Pinsk V,Lemberg DA,Grewal K,Barker CC,Schreiber RA,Jacobson K.Inflammatory bowel disease in the South Asian pediatric population of British Columbia.Am J Gastroenterol2007;102:1077-1083[PMID:17378907 DOI:10.1111/j.1572-0241.2007.01124.x]
19 Hammer T,Nielsen KR,Munkholm P,Burisch J,Lynge E.The Faroese IBD Study:Incidence of Inflammatory Bowel Diseases Across 54 Years of Population-based Data.J Crohns Colitis 2016;10:934-942[PMID:26933031 DOI:10.1093/ecco-jcc/jjw050]
20 Abramson O,Durant M,Mow W,Finley A,Kodali P,Wong A,Tavares V,Mc Croskey E,Liu L,Lewis JD,Allison JE,Flowers N,Hutfless S,Velayos FS,Perry GS,Cannon R,Herrinton LJ.Incidence,prevalence,and time trends of pediatric inflammatory bowel disease in Northern California,1996 to 2006.J Pediatr2010;157:233-239.e1[PMID:20400099 DOI:10.1016/j.jpeds.2010.02.024]
21 Kugathasan S,Judd RH,Hoffmann RG,Heikenen J,Telega G,Khan F,Weisdorf-Schindele S,San Pablo W Jr,Perrault J,Park R,Yaffe M,Brown C,Rivera-Bennett MT,Halabi I,Martinez A,Blank E,Werlin SL,Rudolph CD,Binion DG;Wisconsin Pediatric Inflammatory Bowel Disease Alliance.Epidemiologic and clinical characteristics of children with newly diagnosed inflammatory bowel disease in Wisconsin:a statewide population-based study.J Pediatr 2003;143:525-531[PMID:14571234 DOI:10.1067/S0022-3476(03)00444-X]
22 Adamiak T,Walkiewicz-Jedrzejczak D,Fish D,Brown C,Tung J,Khan K,Faubion W Jr,Park R,Heikenen J,Yaffee M,RiveraBennett MT,Wiedkamp M,Stephens M,Noel R,Nugent M,Nebel J,Simpson P,Kappelman MD,Kugathasan S.Incidence,clinical characteristics,and natural history of pediatric IBD in Wisconsin:a population-based epidemiological study.Inflamm Bowel Dis 2013;19:1218-1223[PMID:23528339 DOI:10.1097/MIB.0b013e318280b13e]
23 Ogunbi SO,Ransom JA,Sullivan K,Schoen BT,Gold BD.Inflammatory bowel disease in African-American children living in Georgia.J Pediatr 1998;133:103-107[PMID:9672520 DOI:10.1016/S0022-3476(98)70187-8]
24 Naidoo CM,Leach ST,Day AS,Lemberg DA.Inflammatory bowel disease in children of middle eastern descent.Int J Pediatr 2014;2014:906128[PMID:24987422 DOI:10.1155/2014/906128]
25 Benchimol EI,Mack DR,Guttmann A,Nguyen GC,To T,Mojaverian N,Quach P,Manuel DG.Inflammatory bowel disease in immigrants to Canada and their children:a population-based cohort study.Am J Gastroenterol 2015;110:553-563[PMID:25756238 DOI:10.1038/ajg.2015.52]
26 Yap J,Wesley A,Mouat S,Chin S.Paediatric inflammatory bowel disease in New Zealand.N Z Med J 2008;121:19-34[PMID:18841182]
27 Probert CS,Jayanthi V,Pinder D,Wicks AC,Mayberry JF.Epidemiological study of ulcerative proctocolitis in Indian migrants and the indigenous population of Leicestershire.Gut 1992;33:687-693[PMID:1307684 DOI:10.1136/gut.33.5.687]
28 Malaty HM,Mehta S,Abraham B,Garnett EA,Ferry GD.The natural course of inflammatory bowel disease-indeterminate from childhood to adulthood:within a 25 year period.Clin Exp Gastroenterol 2013;6:115-121[PMID:23901288 DOI:10.2147/CEG.S44700]
29 Agnarsson U,Bj?rnsson S,Jóhansson JH,Sigurdsson L.Inflammatory bowel disease in Icelandic children 1951-2010.Population-based study involving one nation over six decades.Scand J Gastroenterol 2013;48:1399-1404[PMID:24164345DOI:10.3109/00365521.2013.845799]
30 Ahmed M,Davies IH,Hood K,Jenkins HR.Incidence of paediatric inflammatory bowel disease in South Wales.Arch Dis Child 2006;91:344-345[PMID:16551790 DOI:10.1136/adc.2004.067413]
31 Benchimol EI,Bernstein CN,Bitton A,Carroll MW,Singh H,Otley AR,Vutcovici M,El-Matary W,Nguyen GC,Griffiths AM,Mack DR,Jacobson K,Mojaverian N,Tanyingoh D,Cui Y,Nugent ZJ,Coulombe J,Targownik LE,Jones JL,Leddin D,Murthy SK,Kaplan GG.Trends in Epidemiology of Pediatric Inflammatory Bowel Disease in Canada:Distributed Network Analysis of Multiple Population-Based Provincial Health Administrative Databases.Am J Gastroenterol 2017;112:1120-1134[PMID:28417994 DOI:10.1038/ajg.2017.97]
32 Chouraki V,Savoye G,Dauchet L,Vernier-Massouille G,Dupas JL,Merle V,Laberenne JE,Salomez JL,Lerebours E,Turck D,Cortot A,Gower-Rousseau C,Colombel JF.The changing pattern of Crohn‘s disease incidence in northern France:a continuing increase in the 10-to 19-year-old age bracket(1988-2007).Aliment Pharmacol Ther 2011;33:1133-1142[PMID:21488915 DOI:10.1111/j.1365-2036.2011.04628.x]
33 Jakobsen C,Wewer V,Urne F,Andersen J,Faerk J,Kramer I,Stagegaard B,Pilgaard B,Weile B,Paerregaard A.Incidence of ulcerative colitis and Crohn‘s disease in Danish children:Still rising or levelling out?J Crohns Colitis 2008;2:152-157[PMID:21172205 DOI:10.1016/j.crohns.2008.01.006]
34 Jakobsen C,Paerregaard A,Munkholm P,Wewer V.Paediatric inflammatory bowel disease during a 44-year period in Copenhagen County:occurrence,course and prognosis--a population-based study from the Danish Crohn Colitis Database.Eur J Gastroenterol Hepatol 2009;21:1291-1301[PMID:19581873 DOI:10.1097/MEG.0b013e32832a4ed6]
35 Lapidus A,Bernell O,Hellers G,Persson PG,L?fberg R.Incidence of Crohn‘s disease in Stockholm County 1955-1989.Gut 1997;41:480-486[PMID:9391246 DOI:10.1136/gut.41.4.480]
36 Loftus EV Jr,Silverstein MD,Sandborn WJ,Tremaine WJ,Harmsen WS,Zinsmeister AR.Crohn‘s disease in Olmsted County,Minnesota,1940-1993:incidence,prevalence,and survival.Gastroenterology 1998;114:1161-1168[PMID:9609752 DOI:10.1016/S0016-5085(98)70421-4]
37 Ponsonby AL,Catto-Smith AG,Pezic A,Dupuis S,Halliday J,Cameron D,Morley R,Carlin J,Dwyer T.Association between early-life factors and risk of child-onset Crohn‘s disease among Victorian children born 1983-1998:a birth cohort study.Inflamm Bowel Dis 2009;15:858-866[PMID:19107784 DOI:10.1002/ibd.20842]
38 Malmborg P,Grahnquist L,Lindholm J,Montgomery S,Hildebrand H.Increasing incidence of paediatric inflammatory bowel disease in northern Stockholm County,2002-2007.J Pediatr Gastroenterol Nutr 2013;57:29-34[PMID:23459320 DOI:10.1097/MPG.0b013e31828f21b4]
39 Bernstein CN,Wajda A,Svenson LW,Mac Kenzie A,Koehoorn M,Jackson M,Fedorak R,Israel D,Blanchard JF.The epidemiology of inflammatory bowel disease in Canada:a population-based study.Am J Gastroenterol 2006;101:1559-1568[PMID:16863561 DOI:10.1111/j.1572-0241.2006.00603.x]
40 Shivananda S,Lennard-Jones J,Logan R,Fear N,Price A,Carpenter L,van Blankenstein M.Incidence of inflammatory bowel disease across Europe:is there a difference between north and south?Results of the European Collaborative Study on Inflammatory Bowel Disease(EC-IBD).Gut 1996;39:690-697[PMID:9014768 DOI:10.1136/gut.39.5.690]
41 Burisch J.Crohn‘s disease and ulcerative colitis.Occurrence,course and prognosis during the first year of disease in a European population-based inception cohort.Dan Med J 2014;61:B4778[PMID:24393595]
42 Martín-de-Carpi J,Rodríguez A,Ramos E,Jiménez S,MartínezGómez MJ,Medina E;SPIRIT-IBD Working Group of Sociedad Espa?ola de Gastroenterología,Hepatología y Nutricion Pediátrica.Increasing incidence of pediatric inflammatory bowel disease in Spain(1996-2009):the SPIRIT Registry.Inflamm Bowel Dis 2013;19:73-80[PMID:22535573 DOI:10.1002/ibd.22980]
43 Auvin S,MoliniéF,Gower-Rousseau C,Brazier F,Merle V,Grandbastien B,Marti R,Lerebours E,Dupas JL,Colombel JF,Salomez JL,Cortot A,Turck D.Incidence,clinical presentation and location at diagnosis of pediatric inflammatory bowel disease:a prospective population-based study in northern France(1988-1999).J Pediatr Gastroenterol Nutr 2005;41:49-55[PMID:15990630DOI:10.1097/01.MPG.0000162479.74277.86]
44 Rodrigo L,Riestra S,Ni?o P,Cadahía V,Tojo R,Fuentes D,Moreno M,González Ballina E,Fernández E.A population-based study on the incidence of inflammatory bowel disease in Oviedo(Northern Spain).Rev Esp Enferm Dig 2004;96:296-305[PMID:15180441 DOI:10.4321/S1130-01082004000500002]
45 Schwarz J,Sykora J,CvalínováD,Pomaha?ováR,Kle?kováJ,Kryl M,V?elák P.Inflammatory bowel disease incidence in Czech children:A regional prospective study,2000-2015.World J Gastroenterol 2017;23:4090-4101[PMID:28652662 DOI:10.3748/wjg.v23.i22.4090]
46 Lovasz BD,Lakatos L,Horvath A,Pandur T,Erdelyi Z,Balogh M,Szipocs I,Vegh Z,Veres G,Müller KE,Golovics PA,Kiss LS,Mandel MD,Lakatos PL.Incidence rates and disease course of paediatric inflammatory bowel diseases in Western Hungary between 1977 and 2011.Dig Liver Dis 2014;46:405-411[PMID:24495511 DOI:10.1016/j.dld.2013.12.013]
47 Sinci?BM,Vuceli?B,Persi?M,Brnci?N,Erzen DJ,Radakovi?B,Mi?ovi?V,Stimac D.Incidence of inflammatory bowel disease in Primorsko-goranska County,Croatia,2000-2004:A prospective population-based study.Scand J Gastroenterol 2006;41:437-444[PMID:16635912 DOI:10.1080/00365520500320094]
48 Urlep D,Blagus R,Orel R.Incidence Trends and Geographical Variability of Pediatric Inflammatory Bowel Disease in Slovenia:A Nationwide Study.Biomed Res Int 2015;2015:921730[PMID:26688822 DOI:10.1155/2015/921730]
49 Urlep D,Trop TK,Blagus R,Orel R.Incidence and phenotypic characteristics of pediatric IBD in northeastern Slovenia,2002-2010.J Pediatr Gastroenterol Nutr 2014;58:325-332[PMID:24135984 DOI:10.1097/MPG.0000000000000207]
50 Fernández A,Hernández V,Martínez-Ares D,Sanromán L,de Castro ML,Pineda JR,Carmona A,González-Portela C,Salgado C,Martínez-Cadilla J,Pereira S,García-Burriel JI,Vázquez S,Rodríguez-Prada I;Epi Com Group.Incidence and phenotype at diagnosis of inflammatory bowel disease.Results in Spain of the Epi Com study.Gastroenterol Hepatol 2015;38:534-540[PMID:25890448 DOI:10.1016/j.gastrohep.2015.03.001]
51 Martín-de-Carpi J,Rodríguez A,Ramos E,Jiménez S,MartínezGómez MJ,Medina E,Navas-López VM;SPIRIT-IBD Working Group of SEGHNP(Sociedad Espa?ola de Gastroenterología Hepatología Nutrición Pediátrica).The complete picture of changing pediatric inflammatory bowel disease incidence in Spain in 25 years(1985-2009):the EXPERIENCE registry.J Crohns Colitis 2014;8:763-769[PMID:24462789 DOI:10.1016/j.crohns.2014.01.005]
52 Malaty HM,Fan X,Opekun AR,Thibodeaux C,Ferry GD.Rising incidence of inflammatory bowel disease among children:a 12-year study.J Pediatr Gastroenterol Nutr 2010;50:27-31[PMID:19934770 DOI:10.1097/MPG.0b013e3181b99baa]
53 Armitage E,Drummond HE,Wilson DC,Ghosh S.Increasing incidence of both juvenile-onset Crohn‘s disease and ulcerative colitis in Scotland.Eur J Gastroenterol Hepatol 2001;13:1439-1447[PMID:11742192 DOI:10.1097/00042737-200112000-00007]
54 Benchimol EI,Guttmann A,Griffiths AM,Rabeneck L,Mack DR,Brill H,Howard J,Guan J,To T.Increasing incidence of paediatric inflammatory bowel disease in Ontario,Canada:evidence from health administrative data.Gut 2009;58:1490-1497[PMID:19651626 DOI:10.1136/gut.2009.188383]
55 Molodecky NA,Soon IS,Rabi DM,Ghali WA,Ferris M,Chernoff G,Benchimol EI,Panaccione R,Ghosh S,Barkema HW,Kaplan GG.Increasing incidence and prevalence of the inflammatory bowel diseases with time,based on systematic review.Gastroenterology2012;142:46-54.e42;quiz e30[PMID:22001864 DOI:10.1053/j.gastro.2011.10.001]
56 Ekbom A,Helmick C,Zack M,Adami HO.The epidemiology of inflammatory bowel disease:a large,population-based study in Sweden.Gastroenterology 1991;100:350-358[PMID:1985033DOI:10.1016/0016-5085(91)90202-V]
57 Cosgrove M,Al-Atia RF,Jenkins HR.The epidemiology of paediatric inflammatory bowel disease.Arch Dis Child 1996;74:460-461[PMID:8669968 DOI:10.1136/adc.74.5.460]
58 Loftus CG,Loftus EV Jr,Harmsen WS,Zinsmeister AR,Tremaine WJ,Melton LJ 3rd,Sandborn WJ.Update on the incidence and prevalence of Crohn‘s disease and ulcerative colitis in Olmsted County,Minnesota,1940-2000.Inflamm Bowel Dis 2007;13:254-261[PMID:17206702 DOI:10.1002/ibd.20029]
59 Hildebrand H,Finkel Y,Grahnquist L,Lindholm J,Ekbom A,Askling J.Changing pattern of paediatric inflammatory bowel disease in northern Stockholm 1990-2001.Gut 2003;52:1432-1434[PMID:12970135 DOI:10.1136/gut.52.10.1432]
60 Perminow G,Frigessi A,Rydning A,Nakstad B,Vatn MH.Incidence and clinical presentation of IBD in children:comparison between prospective and retrospective data in a selected Norwegian population.Scand J Gastroenterol 2006;41:1433-1439[PMID:17101574 DOI:10.1080/00365520600789891]
61 Barton JR,Gillon S,Ferguson A.Incidence of inflammatory bowel disease in Scottish children between 1968 and 1983;marginal fall in ulcerative colitis,three-fold rise in Crohn‘s disease.Gut 1989;30:618-622[PMID:2786488 DOI:10.1136/gut.30.5.618]
62 Munkholm P,Langholz E,Nielsen OH,Kreiner S,Binder V.Incidence and prevalence of Crohn‘s disease in the county of Copenhagen,1962-87:a sixfold increase in incidence.Scand JGastroenterol 1992;27:609-614[PMID:1641589 DOI:10.3109/00365529209000127]
63 Castro M,Papadatou B,Baldassare M,Balli F,Barabino A,Barbera C,Barca S,Barera G,Bascietto F,Berni Canani R,Calacoci M,Campanozzi A,Castellucci G,Catassi C,Colombo M,Covoni MR,Cucchiara S,D‘Altilia MR,De Angelis GL,De Virgilis S,Di Ciommo V,Fontana M,Guariso G,Knafelz D,Lambertini A,Licciardi S,Lionetti P,Liotta L,Lombardi G,Maestri L,Martelossi S,Mastella G,Oderda G,Perini R,Pesce F,Ravelli A,Roggero P,Romano C,Rotolo N,Rutigliano V,Scotta S,Sferlazzas C,Staiano A,Ventura A,Zaniboni MG.Inflammatory bowel disease in children and adolescents in Italy:data from the pediatric national IBD register(1996-2003).Inflamm Bowel Dis 2008;14:1246-1252[PMID:18521916 DOI:10.1002/ibd.20470]
64 Turunen P,Kolho KL,Auvinen A,Iltanen S,Huhtala H,Ashorn M.Incidence of inflammatory bowel disease in Finnish children,1987-2003.Inflamm Bowel Dis 2006;12:677-683[PMID:16917221 DOI:10.1097/00054725-200608000-00002]
65 Lehtinen P,Ashorn M,Iltanen S,Jauhola R,Jauhonen P,Kolho KL,Auvinen A.Incidence trends of pediatric inflammatory bowel disease in Finland,1987-2003,a nationwide study.Inflamm Bowel Dis 2011;17:1778-1783[PMID:21744433 DOI:10.1002/ibd.21550]
66 Virta LJ,Saarinen MM,Kolho KL.Inflammatory Bowel Disease Incidence is on the Continuous Rise Among All Paediatric Patients Except for the Very Young:A Nationwide Registry-based Study on 28-Year Follow-up.J Crohns Colitis 2017;11:150-156[PMID:27555642 DOI:10.1093/ecco-jcc/jjw148]
67 Karolewska-Bochenek K,Lazowska-Przeorek I,Albrecht P,Grzybowska K,Ryzko J,Szamotulska K,Radzikowski A,Landowski P,Krzesiek E,Ignys I,Fyderek K,CzerwionkaSzaflarska M,Jarocka-Cyrta E.Epidemiology of inflammatory bowel disease among children in Poland.A prospective,populationbased,2-year study,2002-2004.Digestion 2009;79:121-129[PMID:19321943 DOI:10.1159/000209382]
68 Lindberg E,Lindquist B,Holmquist L,Hildebrand H.Inflammatory bowel disease in children and adolescents in Sweden,1984-1995.J Pediatr Gastroenterol Nutr 2000;30:259-264[PMID:10749408 DOI:10.1097/00005176-200003000-00009]
69 Mahdi B,Mahdi BM.A Review Of Inflammatory Bowel Disease Unclassified--Indeterminate Colitis.J Gastroenterol Hepatol Res2012;1:241-246
70 Prenzel F,Uhlig HH.Frequency of indeterminate colitis in children and adults with IBD-a metaanalysis.J Crohns Colitis 2009;3:277-281[PMID:21172287 DOI:10.1016/j.crohns.2009.07.001]
71 Legaki E,Gazouli M.Influence of environmental factors in the development of inflammatory bowel diseases.World J Gastrointest Pharmacol Ther 2016;7:112-125[PMID:26855817 DOI:10.4292/wjgpt.v7.i1.112]
72 Kamm MA.Rapid changes in epidemiology of inflammatory bowel disease.Lancet 2018;390:2741-2742[PMID:29050647DOI:10.1016/S0140-6736(17)32669-7]
73 M‘Koma AE.Inflammatory bowel disease:an expanding global health problem.Clin Med Insights Gastroenterol 2013;6:33-47[PMID:24833941 DOI:10.4137/CGast.S12731]
74 Leach ST,Day AS,Moore D,Lemberg DA.Low rate of inflammatory bowel disease in the Australian indigenous paediatric population.J Paediatr Child Health 2014;50:328-329[PMID:24698068 DOI:10.1111/jpc.12535]
75 Gismera CS,Aladrén BS.Inflammatory bowel diseases:a disease(s)of modern times?Is incidence still increasing?World J Gastroenterol 2008;14:5491-5498[PMID:18810764 DOI:10.3748/WJG.14.5491]
76 Herrinton LJ,Liu L,Lewis JD,Griffin PM,Allison J.Incidence and prevalence of inflammatory bowel disease in a Northern California managed care organization,1996-2002.Am JGastroenterol 2008;103:1998-2006[PMID:18796097 DOI:10.1111/j.1572-0241.2008.01960.x]
77 Shapiro JM,Zoega H,Shah SA,Bright RM,Mallette M,Moniz H,Grabert SA,Bancroft B,Merrick M,Flowers NT,Samad Z,Lidofsky S,Le Leiko NS,Sands BE.Incidence of Crohn‘s Disease and Ulcerative Colitis in Rhode Island:Report from the Ocean State Crohn‘s and Colitis Area Registry.Inflamm Bowel Dis 2016;22:1456-1461[PMID:26926039 DOI:10.1097/MIB.0000000000000745]
78 Bitton A,Vutcovici M,Patenaude V,Sewitch M,Suissa S,Brassard P.Epidemiology of inflammatory bowel disease in Québec:recent trends.Inflamm Bowel Dis 2014;20:1770-1776[PMID:25159452DOI:10.1097/MIB.0000000000000162]
79 El-Matary W,Moroz SP,Bernstein CN.Inflammatory bowel disease in children of Manitoba:30 years‘experience of a tertiary center.J Pediatr Gastroenterol Nutr 2014;59:763-766[PMID:25111222 DOI:10.1097/MPG.0000000000000525]
80 Lowe AM,Roy PO,B-Poulin M,Michel P,Bitton A,St-Onge L,Brassard P.Epidemiology of Crohn‘s disease in Québec,Canada.Inflamm Bowel Dis 2009;15:429-435[PMID:18942744 DOI:10.1002/ibd.20756]
81 Grieci T,Bütter A.The incidence of inflammatory bowel disease in the pediatric population of Southwestern Ontario.J Pediatr Surg 2009;44:977-980[PMID:19433182 DOI:10.1016/j.jpedsurg.2009.01.038]
82 Griffiths AM.Specificities of inflammatory bowel disease in childhood.Best Pract Res Clin Gastroenterol 2004;18:509-523[PMID:15157824 DOI:10.1016/j.bpg.2004.01.002]
83 Leddin D,Tamim H,Levy AR.Decreasing incidence of inflammatory bowel disease in eastern Canada:a population database study.BMC Gastroenterol 2014;14:140[PMID:25108544 DOI:10.1186/1471-230X-14-140]
84 Benchimol EI,Manuel DG,Guttmann A,Nguyen GC,Mojaverian N,Quach P,Mack DR.Changing age demographics of inflammatory bowel disease in Ontario,Canada:a population-based cohort study of epidemiology trends.Inflamm Bowel Dis 2014;20:1761-1769[PMID:25159453 DOI:10.1097/MIB.0000000000000103]
85 Bentsen BS,Moum B,Ekbom A.Incidence of inflammatory bowel disease in children in southeastern Norway:a prospective population-based study 1990-94.Scand J Gastroenterol 2002;37:540-545[PMID:12059055 DOI:10.1080/00365520252903080]
86 Benchimol EI,Mack DR,Nguyen GC,Snapper SB,Li W,Mojaverian N,Quach P,Muise AM.Incidence,outcomes,and health services burden of very early onset inflammatory bowel disease.Gastroenterology 2014;147:803-813.e7;quiz e14-e15[PMID:24951840 DOI:10.1053/j.gastro.2014.06.023]
87 Vicentín R,Wagener M,Pais AB,Contreras M,Orsi M.One-year prospective registry of inflammatory bowel disease in the Argentine pediatric population.Arch Argent Pediatr 2017;115:533-540[PMID:29087106 DOI:10.5546/aap.2017.eng.533]
88 Pebody RG,Paunio M,Ruutu P.Measles,measles vaccination,and Crohn‘s disease.Crohn‘s disease has not increased in Finland.BMJ 1998;316:1745-1746[PMID:9652932 DOI:10.1136/bmj.316.7146.1745]
89 Lehtinen P,Pasanen K,Kolho KL,Auvinen A.Incidence of Pediatric Inflammatory Bowel Disease in Finland:An Environmental Study.J Pediatr Gastroenterol Nutr 2016;63:65-70[PMID:26636498 DOI:10.1097/MPG.0000000000001050]
90 Jussila A,Virta LJ,Kautiainen H,Rekiaro M,Nieminen U,F?rkkil?MA.Increasing incidence of inflammatory bowel diseases between 2000 and 2007:a nationwide register study in Finland.Inflamm Bowel Dis 2012;18:555-561[PMID:21425214 DOI:10.1002/ibd.21695]
91 Solberg IC,Vatn MH,H?ie O,Stray N,Sauar J,Jahnsen J,Moum B,Lygren I;IBSEN Study Group.Clinical course in Crohn‘s disease:results of a Norwegian population-based ten-year follow-up study.Clin Gastroenterol Hepatol 2007;5:1430-1438[PMID:18054751DOI:10.1016/j.cgh.2007.09.002]
92 Perminow G,Brackmann S,Lyckander LG,Franke A,Borthne A,Rydning A,Aamodt G,Schreiber S,Vatn MH;IBSEN-II Group.Acharacterization in childhood inflammatory bowel disease,a new population-based inception cohort from South-Eastern Norway,2005-07,showing increased incidence in Crohn‘s disease.Scand JGastroenterol 2009;44:446-456[PMID:19117240 DOI:10.1080/00365520802647434]
93 St?rdal K,Jahnsen J,Bentsen B S,Moum B.Pediatric inflammatory bowel disease in southeastern Norway:a five-year follow-up study.Digestion 2004;70:226-230[PMID:15627770DOI:10.1159/000082893]
94 Moum B,Vatn MH,Ekbom A,Fausa O,Aadland E,Lygren I,Sauar J,Schulz T.Incidence of inflammatory bowel disease in southeastern Norway:evaluation of methods after 1 year of registration.Southeastern Norway IBD Study Group of Gastroenterologists.Digestion 1995;56:377-381[PMID:8549880DOI:10.1159/000201262]
95 Moum B,Vatn MH,Ekbom A,Aadland E,Fausa O,Lygren I,Sauar J,Schulz T,Stray N.Incidence of ulcerative colitis and indeterminate colitis in four counties of southeastern Norway,1990-93.A prospective population-based study.The Inflammatory Bowel South-Eastern Norway(IBSEN)Study Group of Gastroenterologists.Scand J Gastroenterol 1996;31:362-366[PMID:8726304 DOI:10.3109/00365529609006411]
96 Moum B,Vatn MH,Ekbom A,Aadland E,Fausa O,Lygren I,Stray N,Sauar J,Schulz T.Incidence of Crohn‘s disease in four counties in southeastern Norway,1990-93.A prospective population-based study.The Inflammatory Bowel South-Eastern Norway(IBSEN)Study Group of Gastroenterologists.Scand J Gastroenterol 1996;31:355-361[PMID:8726303 DOI:10.3109/00365529609006410]
97 Olafsdottir EJ,Fluge G,Haug K.Chronic inflammatory bowel disease in children in western Norway.J Pediatr Gastroenterol Nutr1989;8:454-458[PMID:2723937 DOI:10.1097/00005176-198905000-00006]
98 Lindberg E,J?rnerot G.The incidence of Crohn‘s disease is not decreasing in Sweden.Scand J Gastroenterol 1991;26:495-500[PMID:1871542 DOI:10.3109/00365529108998572]
99 Askling J,Grahnquist L,Ekbom A,Finkel Y.Incidence of paediatric Crohn‘s disease in Stockholm,Sweden.Lancet 1999;354:1179[PMID:10513717 DOI:10.1016/S0140-6736(99)02625-2]
100 Sj?berg D,Holmstr?m T,Larsson M,Nielsen AL,Holmquist L,Ekbom A,R?nnblom A.Incidence and natural history of ulcerative colitis in the Uppsala Region of Sweden 2005-2009-results from the IBD cohort of the Uppsala Region(ICURE).J Crohns Colitis 2013;7:e351-e357[PMID:23491313 DOI:10.1016/j.crohns.2013.02.006]
101 Sj?berg D,Holmstr?m T,Larsson M,Nielsen AL,Holmquist L,Ekbom A,R?nnblom A.Incidence and clinical course of Crohn‘s disease during the first year-results from the IBD Cohort of the Uppsala Region(ICURE)of Sweden 2005-2009.J Crohns Colitis 2014;8:215-222[PMID:24035547 DOI:10.1016/j.crohns.2013.08.009]
102 Vind I,Riis L,Jess T,Knudsen E,Pedersen N,Elkjaer M,Bak Andersen I,Wewer V,N?rregaard P,Moesgaard F,Bendtsen F,Munkholm P;DCCD study group.Increasing incidences of inflammatory bowel disease and decreasing surgery rates in Copenhagen City and County,2003-2005:a population-based study from the Danish Crohn colitis database.Am J Gastroenterol2006;101:1274-1282[PMID:16771949 DOI:10.1111/j.1572-0241.2006.00552.x]
103 Lophaven SN,Lynge E,Burisch J.The incidence of inflammatory bowel disease in Denmark 1980-2013:a nationwide cohort study.Aliment Pharmacol Ther 2017;45:961-972[PMID:28229470DOI:10.1111/apt.13971]
104 Jacobsen BA,Fallingborg J,Rasmussen HH,Nielsen KR,Drewes AM,Puho E,Nielsen GL,S?rensen HT.Increase in incidence and prevalence of inflammatory bowel disease in northern Denmark:a population-based study,1978-2002.Eur J Gastroenterol Hepatol2006;18:601-606[PMID:16702848 DOI:10.1097/00042737-200606000-00005]
105 Langholz E,Munkholm P,Krasilnikoff PA,Binder V.Inflammatory bowel diseases with onset in childhood.Clinical features,morbidity,and mortality in a regional cohort.Scand J Gastroenterol 1997;32:139-147[PMID:9051874 DOI:10.3109/00365529709000184]
106 Langholz E,Munkholm P,Nielsen OH,Kreiner S,Binder V.Incidence and prevalence of ulcerative colitis in Copenhagen county from 1962 to 1987.Scand J Gastroenterol 1991;26:1247-1256[PMID:1763295 DOI:10.3109/00365529108998621]
107 Fonager K,S?rensen HT,Olsen J.Change in incidence of Crohn‘s disease and ulcerative colitis in Denmark.A study based on the National Registry of Patients,1981-1992.Int J Epidemiol 1997;26:1003-1008[PMID:9363521 DOI:10.1093/ije/26.5.1003]
108 Urne FU,Paerregaard A.[Chronic inflammatory bowel disease in children.An epidemiological study from eastern Denmark1998-2000].Ugeskr Laeger 2002;164:5810-5814[PMID:12523226]
109 Larsen L,Jensen MD,Larsen MD,Nielsen RG,Thorsgaard N,Vind I,Wildt S,Kjeldsen J.The Danish National Registry for Biological Therapy in Inflammatory Bowel Disease.Clin Epidemiol2016;8:607-612[PMID:27822107 DOI:10.2147/CLEP.S99478]
110 Jakobsen C,Paerregaard A,Munkholm P,Faerk J,Lange A,Andersen J,Jakobsen M,Kramer I,Czernia-Mazurkiewicz J,Wewer V.Pediatric inflammatory bowel disease:increasing incidence,decreasing surgery rate,and compromised nutritional status:A prospective population-based cohort study 2007-2009.Inflamm Bowel Dis 2011;17:2541-2550[PMID:21381152 DOI:10.1002/ibd.21654]
111 N?rg?rd BM,Nielsen J,Fonager K,Kjeldsen J,Jacobsen BA,Qvist N.The incidence of ulcerative colitis(1995-2011)and Crohn‘s disease(1995-2012)-based on nationwide Danish registry data.J Crohns Colitis 2014;8:1274-1280[PMID:24675473 DOI:10.1016/j.crohns.2014.03.006]
112 Bj?rnsson S,Jóhannsson JH.Inflammatory bowel disease in Iceland,1990-1994:a prospective,nationwide,epidemiological study.Eur J Gastroenterol Hepatol 2000;12:31-38[PMID:10656207 DOI:10.1097/00042737-200012010-00007]
113 Armitage E,Drummond H,Ghosh S,Ferguson A.Incidence of juvenile-onset Crohn‘s disease in Scotland.Lancet1999;353:1496-1497[PMID:10232323 DOI:10.1016/S0140-6736(99)00333-5]
114 Armitage EL,Aldhous MC,Anderson N,Drummond HE,Riemersma RA,Ghosh S,Satsangi J.Incidence of juvenile-onset Crohn‘s disease in Scotland:association with northern latitude and affluence.Gastroenterology 2004;127:1051-1057[PMID:15480983 DOI:10.1053/j.gastro.2004.06.024]
115 Watson AJ,Johnston AT,Barker PM,Youngson GG,Bisset WM,Mahomed AA.The presentation and management of juvenile-onset chronic inflammatory bowel disease in Northeastern Scotland.JPediatr Surg 2002;37:83-86[PMID:11781993 DOI:10.1053/jpsu.2002.29434]
116 Ashton JJ,Wiskin AE,Ennis S,Batra A,Afzal NA,Beattie RM.Rising incidence of paediatric inflammatory bowel disease(PIBD)in Wessex,Southern England.Arch Dis Child 2014;99:659-664[PMID:24728445 DOI:10.1136/archdischild-2013-305419]
117 Ashton JJ,Cullen M,Afzal NA,Coelho T,Batra A,Beattie RM.Is the incidence of paediatric inflammatory bowel disease still increasing?Arch Dis Child 2018;Epub ahead of print[PMID:29519945 DOI:10.1136/archdischild-2018-315038]
118 Hassan K,Cowan FJ,Jenkins HR.The incidence of childhood inflammatory bowel disease in Wales.Eur J Pediatr 2000;159:261-263[PMID:10789930 DOI:10.1007/s004310050066]
119 Gunesh S,Thomas GA,Williams GT,Roberts A,Hawthorne AB.The incidence of Crohn‘s disease in Cardiff over the last 75 years:an update for 1996-2005.Aliment Pharmacol Ther 2008;27:211-219[PMID:18005244 DOI:10.1111/j.1365-2036.2007.03576.x]
120 Hope B,Shahdadpuri R,Dunne C,Broderick AM,Grant T,Hamzawi M,O‘Driscoll K,Quinn S,Hussey S,Bourke B.Rapid rise in incidence of Irish paediatric inflammatory bowel disease.Arch Dis Child 2012;97:590-594[PMID:22550323 DOI:10.1136/archdischild-2011-300651]
121 Coughlan A,Wylde R,Lafferty L,Quinn S,Broderick A,Bourke B,Hussey S;DOCHAS Study.A rising incidence and poorer male outcomes characterise early onset paediatric inflammatory bowel disease.Aliment Pharmacol Ther 2017;45:1534-1541[PMID:28449214 DOI:10.1111/apt.14070]
122 Petritsch W,Fuchs S,Berghold A,Bachmaier G,H?genauer C,Hauer AC,Weiglhofer U,Wenzl HH.Incidence of inflammatory bowel disease in the province of Styria,Austria,from 1997 to 2007:a population-based study.J Crohns Colitis 2013;7:58-69[PMID:22542057 DOI:10.1016/j.crohns.2012.03.012]
123 Ott C,Obermeier F,Thieler S,Kemptner D,Bauer A,Sch?lmerich J,Rogler G,Timmer A.The incidence of inflammatory bowel disease in a rural region of Southern Germany:a prospective populationbased study.Eur J Gastroenterol Hepatol 2008;20:917-923[PMID:18794607 DOI:10.1097/MEG.0b013e3282f97b33]
124 van der Zaag-Loonen HJ,Casparie M,Taminiau JA,Escher JC,Pereira RR,Derkx HH.The incidence of pediatric inflammatory bowel disease in the Netherlands:1999-2001.J Pediatr Gastroenterol Nutr 2004;38:302-307[PMID:15076631 DOI:10.1097/00005176-200403000-00014]
125 Gower-Rousseau C,Vasseur F,Fumery M,Savoye G,Salleron J,Dauchet L,Turck D,Cortot A,Peyrin-Biroulet L,Colombel JF.Epidemiology of inflammatory bowel diseases:new insights from a French population-based registry(EPIMAD).Dig Liver Dis 2013;45:89-94[PMID:23107487 DOI:10.1016/j.dld.2012.09.005]
126 Bequet E,Sarter H,Fumery M,Vasseur F,Armengol-Debeir L,Pariente B,Ley D,Spyckerelle C,Coevoet H,Laberenne JE,Peyrin-Biroulet L,Savoye G,Turck D,Gower-Rousseau C;EPIMAD Group.Incidence and Phenotype at Diagnosis of Veryearly-onset Compared with Later-onset Paediatric Inflammatory Bowel Disease:A Population-based Study[1988-2011].J Crohns Colitis 2017;11:519-526[PMID:28453757 DOI:10.1093/eccojcc/jjw194]
127 Vernier-Massouille G,Balde M,Salleron J,Turck D,Dupas JL,Mouterde O,Merle V,Salomez JL,Branche J,Marti R,Lerebours E,Cortot A,Gower-Rousseau C,Colombel JF.Natural history of pediatric Crohn‘s disease:a population-based cohort study.Gastroenterology 2008;135:1106-1113[PMID:18692056 DOI:10.1053/j.gastro.2008.06.079]
128 Abakar-Mahamat A,Filippi J,Pradier C,Dozol A,Hébuterne X.Incidence of inflammatory bowel disease in Corsica from 2002to 2003.Gastroenterol Clin Biol 2007;31:1098-1103[PMID:18176365 DOI:10.1016/S0399-8320(07)78343-4]
129 Tourtelier Y,Dabadie A,Tron I,Alexandre JL,Robaskiewicz M,Cruchant E,Seyrig JA,Heresbach D,Bretagne JF.Incidence of inflammatory bowel disease in children in Brittany(1994-1997).Arch Pediatr 2000;7:377-384[DOI:10.1016/s0929-693x(00)88832-6]
130 Gottrand F,Colombel JF,Moreno L,Salomez JL,Farriaux JP,Cortot A.[Incidence of inflammatory bowel diseases in children in the Nord-Pas-de-Calais region].Arch Fr Pediatr 1991;48:25-28[PMID:2018416]
131 Ghione S,Sarter H,Fumery M,Armengol-Debeir L,Savoye G,Ley D,Spyckerelle C,Pariente B,Peyrin-Biroulet L,Turck D,GowerRousseau C;Epimad Group.Dramatic Increase in Incidence of Ulcerative Colitis and Crohn‘s Disease(1988-2011):A PopulationBased Study of French Adolescents.Am J Gastroenterol 2018;113:265-272[PMID:28809388 DOI:10.1038/ajg.2017.228]
132 Pittet V,Juillerat P,Mottet C,Felley C,Ballabeni P,Burnand B,Michetti P,Vader JP;Swiss IBD Cohort Study Group.Cohort profile:the Swiss Inflammatory Bowel Disease Cohort Study(SIBDCS).Int J Epidemiol 2009;38:922-931[PMID:18782896DOI:10.1093/ije/dyn180]
133 De Greef E,Mahachie John JM,Hoffman I,Smets F,Van Biervliet S,Scaillon M,Hauser B,Paquot I,Alliet P,Arts W,Dewit O,Peeters H,Baert F,D‘Haens G,Rahier JF,Etienne I,Bauraind O,Van Gossum A,Vermeire S,Fontaine F,Muls V,Louis E,Van de Mierop F,Coche JC,Van Steen K,Veereman G;IBD working group of the Belgian Society of Pediatric Gastroenterology,Hepatology and Nutrition(Be SPGHAN);Belgian IBD Research and Development.Profile of pediatric Crohn‘s disease in Belgium.J Crohns Colitis 2013;7:e588-e598[PMID:23664896 DOI:10.1016/j.crohns.2013.04.016]
134 Ranzi T,Bodini P,Zambelli A,Politi P,Lupinacci G,Campanini MC,Dal Lago AL,Lisciandrano D,Bianchi PA.Epidemiological aspects of inflammatory bowel disease in a north Italian population:a 4-year prospective study.Eur J Gastroenterol Hepatol 1996;8:657-661[PMID:8853254]
135 Di Domenicantonio R,Cappai G,ArcàM,Agabiti N,Kohn A,Vernia P,Biancone L,Armuzzi A,Papi C,Davoli M.Occurrence of inflammatory bowel disease in central Italy:a study based on health information systems.Dig Liver Dis 2014;46:777-782[PMID:24890621 DOI:10.1016/j.dld.2014.04.014]
136 Trallori G,Palli D,Saieva C,Bardazzi G,Bonanomi AG,d‘Albasio G,Galli M,Vannozzi G,Milla M,Tarantino O,Renai F,Messori A,Amorosi A,Pacini F,Morettini A.A population-based study of inflammatory bowel disease in Florence over 15 years(1978-92).Scand J Gastroenterol 1996;31:892-899[PMID:8888437 DOI:10.3109/00365529609051998]
137 Arin Letamendia A,Borda Celaya F,Burusco Paternain MJ,Prieto Martínez C,Martínez Echeverría A,Elizalde Apestegui I,Laiglesia Izquierdo M,Macias Mendizábal E,Tamburri Moso P,Sánchez Valverde F.[High incidence rates of inflammatory bowel disease in Navarra(Spain).Results of a prospective,population-based study].Gastroenterol Hepatol 2008;31:111-116[PMID:18341841 DOI:10.1157/13116497]
138 Cachia E,Calleja N,Aakeroy R,Degaetano J,Vassallo M.Incidence of inflammatory bowel disease in Malta between 1993and 2005:a retrospective study.Inflamm Bowel Dis 2008;14:550-553[PMID:18183599 DOI:10.1002/ibd.20321]
139 Pozler O,Maly J,Bonova O,Dedek P,Frühauf P,Havlickova A,Janatova T,Jimramovsky F,Klimova L,Klusacek D,Kocourkova D,Kolek A,Kotalova R,Marx D,Nevoral J,Petro R,Petru O,Plasilova I,Seidl Z,Sekyrova I,Semendak N,Schreierova I,Stanek J,Sykora J,Sulakova A,Toukalkova L,Travnickova R,Volf V,Zahradnicek L,ZeniskováI.Incidence of Crohn disease in the Czech Republic in the years 1990 to 2001 and assessment of pediatric population with inflammatory bowel disease.J Pediatr Gastroenterol Nutr 2006;42:186-189[PMID:16456413 DOI:10.1097/01.mpg.0000189328.47150.bc]
140 Kolek A,Janout V,TichyM,Grepl M.The incidence of inflammatory bowel disease is increasing among children 15 years old and younger in the Czech Republic.J Pediatr Gastroenterol Nutr 2004;38:362-363[PMID:15076645 DOI:10.1097/00005176-200403000-00028]
141 Müller KE,Lakatos PL,AratóA,Kovács JB,Várkonyiá,Sz?cs D,Szakos E,Sólyom E,Kovács M,Polgár M,Nemesé,Guthy I,Tokodi I,Tóth G,Horváthá,Tárnok A,Csoszánszki N,Balogh M,Vass N,Bódi P,Dezs?fi A,Gárdos L,Micskey E,Papp M,Csehá,SzabóD,V?r?s P,Veres G;Hungarian IBD Registry Group(HUPIR).Incidence,Paris classification,and follow-up in a nationwide incident cohort of pediatric patients with inflammatory bowel disease.J Pediatr Gastroenterol Nutr 2013;57:576-582[PMID:23820399 DOI:10.1097/MPG.0b013e31829f7d8c]
142 Lakatos L,Kiss LS,David G,Pandur T,Erdelyi Z,Mester G,Balogh M,Szipocs I,Molnar C,Komaromi E,Lakatos PL.Incidence,disease phenotype at diagnosis,and early disease course in inflammatory bowel diseases in Western Hungary,2002-2006.Inflamm Bowel Dis 2011;17:2558-2565[PMID:22072315 DOI:10.1002/ibd.21607]
143 Orel R,Kamhi T,Vidmar G,Mamula P.Epidemiology of pediatric chronic inflammatory bowel disease in central and western Slovenia,1994-2005.J Pediatr Gastroenterol Nutr 2009;48:579-586[PMID:19367184 DOI:10.1097/MPG.0b013e318164d903]
144 Vuceli?B,Kora?B,Senti?M,Milici?D,Hadzi?N,Juresa V,Bozikov J,Rotkvi?I,Buljevac M,Kovacevi?I.Ulcerative colitis in Zagreb,Yugoslavia:incidence and prevalence 1980-1989.Int JEpidemiol 1991;20:1043-1047[PMID:1800402 DOI:10.1093/ije/20.4.1043]
145 Vuceli?B,Kora?B,Senti?M,Milici?D,Hadzi?N,Juresa V,Bozikov J,Rotkvi?I,Buljevac M,Kovacevi?I.Epidemiology of Crohn‘s disease in Zagreb,Yugoslavia:a ten-year prospective study.Int J Epidemiol 1991;20:216-220[PMID:2066223 DOI:10.1093/ije/20.1.216]
146 Ahmaida A,Al-Shaikhi S.Childhood Inflammatory Bowel Disease in Libya:Epidemiological and Clinical features.Libyan J Med2009;4:70-74[PMID:21483512 DOI:10.4176/081210]
147 Odes HS,Locker C,Neumann L,Zirkin HJ,Weizman Z,Sperber AD,Fraser GM,Krugliak P,Gaspar N,Eidelman L.Epidemiology of Crohn‘s disease in southern Israel.Am J Gastroenterol 1994;89:1859-1862[PMID:7942683]
148 Grossman A,Fireman Z,Lilos P,Novis B,Rozen P,Gilat T.Epidemiology of ulcerative colitis in the Jewish population of central Israel 1970-1980.Hepatogastroenterology 1989;36:193-197[PMID:2807136]
149 El Mouzan MI,Saadah O,Al-Saleem K,Al Edreesi M,Hasosah M,Alanazi A,Al Mofarreh M,Asery A,Al Qourain A,Nouli K,Al Hussaini A,Telmesani A,Al Reheili K,Alghamdi S,Alrobiaa N,Alzaben A,Mehmadi A,Al Hebbi H,Al Sarkhy A,Al Mehaidib A,Al Saleem B,Assiri A,Wali S.Incidence of pediatric inflammatory bowel disease in Saudi Arabia:a multicenter national study.Inflamm Bowel Dis 2014;20:1085-1090[PMID:24788219 DOI:10.1097/MIB.0000000000000048]
150 El Mouzan MI,Abdullah AM,Al Habbal MT.Epidemiology of juvenile-onset inflammatory bowel disease in central Saudi Arabia.J Trop Pediatr 2006;52:69-71[PMID:15947013 DOI:10.1093/tropej/fmi039]
151 Al-Qabandi WA,Buhamrah EK,Hamadi KA,Al-Osaimi SA,AlRuwayeh AA,Madda J.Inflammatory bowel disease in children,an evolving problem in Kuwait.Saudi J Gastroenterol 2011;17:323-327[PMID:21912059 DOI:10.4103/1319-3767.84487]
152 Zayyani NR,Malaty HM,Graham DY.Increasing Incidence of Crohn‘s Disease with Familial Clustering in the Kingdom of Bahrain:A 25-Year Population-based Study.Inflamm Bowel Dis 2017;23:304-309[PMID:28092308 DOI:10.1097/MIB.0000000000001016]
153 Wang XQ,Zhang Y,Xu CD,Jiang LR,Huang Y,Du HM,Wang XJ.Inflammatory bowel disease in Chinese children:a multicenter analysis over a decade from Shanghai.Inflamm Bowel Dis 2013;19:423-428[PMID:23340680 DOI:10.1097/MIB.0b013e318286f9f2]
154 Tsai CH,Chen HL,Ni YH,Hsu HY,Jeng YM,Chang CJ,Chang MH.Characteristics and trends in incidence of inflammatory bowel disease in Taiwanese children.J Formos Med Assoc 2004;103:685-691[PMID:15361941]
155 Chu HP,Logarajah V,Tan N,Phua KB.Paediatric inflammatory bowel disease in a multiracial Asian country.Singapore Med J 2013;54:201-205[PMID:23624446 DOI:10.11622/smedj.2013073]
156 Yang SK,Hong WS,Min YI,Kim HY,Yoo JY,Rhee PL,Rhee JC,Chang DK,Song IS,Jung SA,Park EB,Yoo HM,Lee DK,Kim YK.Incidence and prevalence of ulcerative colitis in the SongpaKangdong District,Seoul,Korea,1986-1997.J Gastroenterol Hepatol 2000;15:1037-1042[PMID:11059934 DOI:10.1046/j.1440-1746.2000.02252.x]
157 Jung YS,Han M,Kim WH,Park S,Cheon JH.Incidence and Clinical Outcomes of Inflammatory Bowel Disease in South Korea,2011-2014:A Nationwide Population-Based Study.Dig Dis Sci 2017;62:2102-2112[PMID:28593437 DOI:10.1007/s10620-017-4640-9]
158 Phavichitr N,Cameron DJ,Catto-Smith AG.Increasing incidence of Crohn‘s disease in Victorian children.J Gastroenterol Hepatol 2003;18:329-332[PMID:12603535 DOI:10.1046/j.1440-1746.2003.02975.x]
159 Schildkraut V,Alex G,Cameron DJ,Hardikar W,Lipschitz B,Oliver MR,Simpson DM,Catto-Smith AG.Sixty-year study of incidence of childhood ulcerative colitis finds eleven-fold increase beginning in 1990s.Inflamm Bowel Dis 2013;19:1-6[PMID:22532319 DOI:10.1002/ibd.22997]
160 Lopez RN,Evans HM,Appleton L,Bishop J,Chin S,Mouat S,Gearry RB,Day AS.Prospective Incidence of Paediatric Inflammatory Bowel Disease in New Zealand in 2015:Results From the Paediatric Inflammatory Bowel Disease in New Zealand(PINZ)Study.J Pediatr Gastroenterol Nutr 2018;66:e122-e126[PMID:29077643 DOI:10.1097/MPG.0000000000001806]
161 Lopez RN,Appleton L,Gearry RB,Day AS.Rising Incidence of Paediatric Inflammatory Bowel Disease in Canterbury,New Zealand,1996-2015.J Pediatr Gastroenterol Nutr 2018;66:e45-e50[PMID:28727653 DOI:10.1097/MPG.0000000000001688]
162 Levine A,Koletzko S,Turner D,Escher JC,Cucchiara S,de Ridder L,Kolho KL,Veres G,Russell RK,Paerregaard A,Buderus S,Greer ML,Dias JA,Veereman-Wauters G,Lionetti P,Sladek M,Martin de Carpi J,Staiano A,Ruemmele FM,Wilson DC;European Society of Pediatric Gastroenterology,Hepatology,and Nutrition.ESPGHAN revised porto criteria for the diagnosis of inflammatory bowel disease in children and adolescents.J Pediatr Gastroenterol Nutr 2014;58:795-806[PMID:24231644 DOI:10.1097/MPG.0000000000000239]
163 Haug K,Schrumpf E,Barstad S,Fluge G,Halvorsen JF.Epidemiology of ulcerative colitis in western Norway.Scand JGastroenterol 1988;23:517-522[PMID:3399823 DOI:10.3109/00365528809093904]
164 Hildebrand H,Brydolf M,Holmquist L,Krantz I,Kristiansson B.Incidence and prevalence of inflammatory bowel disease in children in south-western Sweden.Acta Paediatr 1994;83:640-645[PMID:7919763 DOI:10.1111/j.1651-2227.1994.tb13098.x]
165 Tysk C,J?rnerot G.Ulcerative proctocolitis in Orebro,Sweden.A retrospective epidemiologic study,1963-1987.Scand JGastroenterol 1992;27:945-950[PMID:1455192 DOI:10.3109/00365529209000168]
166 Hildebrand H,Fredrikzon B,Holmquist L,Kristiansson B,Lindquist B.Chronic inflammatory bowel disease in children and adolescents in Sweden.J Pediatr Gastroenterol Nutr 1991;13:293-297[PMID:1791507 DOI:10.1097/00005176-199110000-00010]
167 Gollop JH,Phillips SF,Melton LJ 3rd,Zinsmeister AR.Epidemiologic aspects of Crohn‘s disease:a population based study in Olmsted County,Minnesota,1943-1982.Gut 1988;29:49-56[PMID:3343012 DOI:10.1136/gut.29.1.49]
168 Loftus EV Jr,Silverstein MD,Sandborn WJ,Tremaine WJ,Harmsen WS,Zinsmeister AR.Ulcerative colitis in Olmsted County,Minnesota,1940-1993:incidence,prevalence,and survival.Gut 2000;46:336-343[PMID:10673294 DOI:10.1136/gut.46.3.336]
169 Kuo CJ,Yu KH,See LC,Chiu CT,Su MY,Hsu CM,Kuo CF,Chiou MJ,Liu JR,Wang HW.The Trend of Inflammatory Bowel Diseases in Taiwan:A Population-Based Study.Dig Dis Sci 2015;60:2454-2462[PMID:25837597 DOI:10.1007/s10620-015-3630-z]
170 González FN,García BC,Polo RE,Hernández CM.Inflammatory bowel disease in pediatric patients in Asturias,Spain(1993-2000):epidemiology and clinical features.Acta Pediatr Esp 2004;62:466-472
171 Lopez Miguel C,Sicilia B,Sierra E,Lopez Zaborras J,Arribas F,Gomollon F.[Incidence of inflammatory bowel disease in Aragon:outcome of a prospective population-based study].Gastroenterol Hepatol 1999;22:323-328[PMID:10535203]