白藜芦醇软膏治疗病理性瘢痕的临床疗效研究
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摘要
[目的]探讨白藜芦醇软膏治疗病理性瘢痕的临床疗效。[方法]将68例病理性瘢痕患者随机分为治疗组和对照组,每组各34例。治疗组外用白藜芦醇软膏,对照组外用美宝疤痕软膏,分别于皮肤瘢痕部位外涂,每日早晚各涂一次,使用周期为90d。两组治疗前后均进行温哥华瘢痕量表(Vancouver scar scale,VSS)评分,治疗结束后进行临床疗效判定。[结果]治疗后两组患者VSS评分均低于治疗前,差异有统计学意义(P<0.05);治疗后组间比较,治疗组VSS评分低于对照组,差异有统计学意义(P<0.05);治疗组VSS评分降低程度高于对照组(P<0.05);治疗组总显效率为87.75%,高于对照组总显效率68.08%,差异有统计学意义(P<0.05)。[结论]白藜芦醇软膏有较好的祛除瘢痕作用,未发现任何不良反应,不失为一种安全有效的祛瘢产品。
[Objective] To investigate the clinical efficacy of resveratrol ointment in the treatment of pathological scars. [Methods] Sixty-eight patients with pathological scars were randomly divided into treatment group and control group, 34 cases in each group. On the skin scar area, patients in two groups separately coated with resveratrol ointment and MEBO scar ointment twice a day morning and evening, for the period of 90 days. Both groups were scored by the Vancouver scar scale(VSS) before and after treatment, and clinical efficacy evaluation was performed after treatment.[Results] After treatment, the VSS scores of the scars in both groups decreased, there was significance difference, compared with pretreatment( P<0.05), but the VSS scores of the scars in treatment group were significantly lower than those in control group, the difference was statistically significant( P <0.05). The total effective rate of treatment group was significantly better than that of control group, and there was statistical significance( P<0.05).[Conclusion] Resveratrol ointment has a good effect of removing scars and no adverse reactions have been found. It is a safe and effective remove scar product.
[Objective] To investigate the clinical efficacy of resveratrol ointment in the treatment of pathological scars. [Methods] Sixty-eight patients with pathological scars were randomly divided into treatment group and control group, 34 cases in each group. On the skin scar area, patients in two groups separately coated with resveratrol ointment and MEBO scar ointment twice a day morning and evening, for the period of 90 days. Both groups were scored by the Vancouver scar scale(VSS) before and after treatment, and clinical efficacy evaluation was performed after treatment.[Results] After treatment, the VSS scores of the scars in both groups decreased, there was significance difference, compared with pretreatment( P<0.05), but the VSS scores of the scars in treatment group were significantly lower than those in control group, the difference was statistically significant( P <0.05). The total effective rate of treatment group was significantly better than that of control group, and there was statistical significance( P<0.05).[Conclusion] Resveratrol ointment has a good effect of removing scars and no adverse reactions have been found. It is a safe and effective remove scar product.
引文
[1] Van Der Veer W M, Bloemen M C, Ulrich M M, et al.Potential cellular and molecular causes of hypertrophic scar formation[J].Burns,2009,35(1):15-29.
[2] Bloemen M C, van der Veer W M, Ulrich M M, et al.Prevention and curative management of hypertrophic scar formation[J].Burns,2009,35(4):463-475.
[3]焦慧琴,王蕤,孙海梅,等.白藜芦醇对人皮肤癌细胞株A431生长抑制机制实验研究[J].首都医科大学学报,2009,30(2):212-217.
[4]丁继存,翟晓翔,唐志铭.白藜芦醇对病理性瘢痕成纤维细胞及TGF-β1/Smads信号通路的影响[J].河北医科大学学报,2014,35(1):37-41.
[5]王闰,孟慧,许勇.复方甘草软膏的制备及含量测定法的建立[J].东南国防医药,2015,17(4):389-392.
[6]李荟元,鲁开化,郭树忠.新编瘢痕学[M].西安:第四军医大学出版社,2003:15.
[7]黄丽萍,王兴林,张冷,等.射频消融治疗增生性瘢痕的疗效观察[J].大连医科大学学报,2014,36(1):35-38.
[8]刘斌,李静,胡惠清.A型肉毒素治疗瘢痕增生的疗效和安全性分析[J].中国中西医结合皮肤性病学杂志,2017,16(1):25-27.
[9]王琨,刘刚.瘢痕疙瘩的治疗进展[J].中国中西医结合皮肤性病学杂志, 2012,11(3):202-204.
[10]李佳军,韩金良,田玉顺.白藜芦醇及其衍生物药理作用的研究现状[J].药学研究, 2017,36(3):161-163.
[11] Vieira de Almeida L M, Pineiro C C, Leite M C, et al.Protective effects of resveratrol on hydrogen peroxide induced toxicity in primary cortical astrocyte culture[J].Neurochem Res, 2008, 33(1):8-15.
[12] Zhai X X, Ding J C, Tang Z M. Resveratrol inhibits proliferation and induces apoptosis of pathological scar fibroblasts through the mechanism involving TGF-β1/Smads signaling pathway[J].Cell Biochem Biophys,2015,71(3):1267-1272.
[13] Tang Z M, Zhai X X, Ding J C. Expression of mTOR/70S6K signaling pathway in pathological scar fibroblasts and the effects of resveratrol intervention[J].Mol Med Rep,2017,15(5):2546-2550.
[14]唐志铭,丁继存,翟晓翔,等.白藜芦醇对病理性瘢痕成纤维细胞mTOR信号通路相关分子表达的影响[J].中国中西医结合皮肤性病学杂志,2017,16(2):103-107.
[2] Bloemen M C, van der Veer W M, Ulrich M M, et al.Prevention and curative management of hypertrophic scar formation[J].Burns,2009,35(4):463-475.
[3]焦慧琴,王蕤,孙海梅,等.白藜芦醇对人皮肤癌细胞株A431生长抑制机制实验研究[J].首都医科大学学报,2009,30(2):212-217.
[4]丁继存,翟晓翔,唐志铭.白藜芦醇对病理性瘢痕成纤维细胞及TGF-β1/Smads信号通路的影响[J].河北医科大学学报,2014,35(1):37-41.
[5]王闰,孟慧,许勇.复方甘草软膏的制备及含量测定法的建立[J].东南国防医药,2015,17(4):389-392.
[6]李荟元,鲁开化,郭树忠.新编瘢痕学[M].西安:第四军医大学出版社,2003:15.
[7]黄丽萍,王兴林,张冷,等.射频消融治疗增生性瘢痕的疗效观察[J].大连医科大学学报,2014,36(1):35-38.
[8]刘斌,李静,胡惠清.A型肉毒素治疗瘢痕增生的疗效和安全性分析[J].中国中西医结合皮肤性病学杂志,2017,16(1):25-27.
[9]王琨,刘刚.瘢痕疙瘩的治疗进展[J].中国中西医结合皮肤性病学杂志, 2012,11(3):202-204.
[10]李佳军,韩金良,田玉顺.白藜芦醇及其衍生物药理作用的研究现状[J].药学研究, 2017,36(3):161-163.
[11] Vieira de Almeida L M, Pineiro C C, Leite M C, et al.Protective effects of resveratrol on hydrogen peroxide induced toxicity in primary cortical astrocyte culture[J].Neurochem Res, 2008, 33(1):8-15.
[12] Zhai X X, Ding J C, Tang Z M. Resveratrol inhibits proliferation and induces apoptosis of pathological scar fibroblasts through the mechanism involving TGF-β1/Smads signaling pathway[J].Cell Biochem Biophys,2015,71(3):1267-1272.
[13] Tang Z M, Zhai X X, Ding J C. Expression of mTOR/70S6K signaling pathway in pathological scar fibroblasts and the effects of resveratrol intervention[J].Mol Med Rep,2017,15(5):2546-2550.
[14]唐志铭,丁继存,翟晓翔,等.白藜芦醇对病理性瘢痕成纤维细胞mTOR信号通路相关分子表达的影响[J].中国中西医结合皮肤性病学杂志,2017,16(2):103-107.