兔VX2肿瘤放射治疗后早期DWI及~1H-MRS的评价作用
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摘要
肿瘤放射治疗是局部恶性肿瘤综合治疗的重要组成部分,它对肿瘤局部控制或手术前缩小瘤灶发挥着重要的作用。但临床上肿瘤外放射治疗后不会进行肿瘤病理检测,无法获得病理与影像的对照资料。因此,利用兔VX2肿瘤放射治疗模型来评价肿瘤放射治疗早期DWI和~1H-MRS的表现,可为肿瘤放射治疗前后病理和影像学的变化提供动物实验模型依据。本文对VX2肿瘤放射治疗后功能磁共振的影像学评估现状和前景进行综述。
External radiotherapy is one of the important method of the comprehensive treatment on malignant tumors. It plays a great important role in local tumor control or reducing the tumor size before surgery. Clinically,it is not a conventional examination to get tumor specimen for pathological examination after radiotherapy. So it is impossible to get image-pathology comparisons.The method using DWI and~1H-MRS to evaluate the early radiotherapeutic effects on VX2 tumor model may establish the evidence on experimental animal model for image-pathology comparisons between before and after tumor radiotherapy. The recent radiological evaluation methods and prospects of functional magnetic resonance imaging related to VX2 tumor after radiotherapy were reviewed in this article.
External radiotherapy is one of the important method of the comprehensive treatment on malignant tumors. It plays a great important role in local tumor control or reducing the tumor size before surgery. Clinically,it is not a conventional examination to get tumor specimen for pathological examination after radiotherapy. So it is impossible to get image-pathology comparisons.The method using DWI and~1H-MRS to evaluate the early radiotherapeutic effects on VX2 tumor model may establish the evidence on experimental animal model for image-pathology comparisons between before and after tumor radiotherapy. The recent radiological evaluation methods and prospects of functional magnetic resonance imaging related to VX2 tumor after radiotherapy were reviewed in this article.
引文
[1]Rous P,Beard JW.The progression to carcinoma of virus-induced rabbit papillomas(Shope)[J].J Exp Med,1935,62:523-548.
[2]万仁均,林征宇,李跃明,等.磁共振引导下兔肝脏血管旁VX2肿瘤模型制作[J].医学影像学杂志,2014,24(5):865-867.
[3]Zhao S,Yu H,Du N.Experimental study of doxorubicin interventional chemotheray in the treatment of rabbit VX2 renal transplantation carcinoma[J].Int J Clin Exp Med,2015,8(7):10739-10745.
[4]Wang CW,Zhou Y,Bai JP,et al.Application of volumetric modulated arc therapy and simultaneous integrated boost techniques to prepare“safe magin”in the rabbit VX2 limb tumor model[J].Med Sci Monit,2015,21:2397-2405.
[5]黄昊,何仕诚,冯国栋,等.骨水泥对兔脊柱VX2肿瘤转移模型的作用研究[J].介入放射学杂志,2015,24(6):520-523.
[6]Shuo L,Hua DX,Xin H,et al.MR diffusion-weighted imaging for evaluation of radiotherapeatic effects on rabbit VX2 tumor model[J].Chin Med Sci J,2008,23(3):172-177.
[7]兰为顺,胡道予,李震,等.磁共振氢质子波谱评价无水乙醇消融治疗兔软组织VX2肿瘤疗效[J].放射学实践,2014,29(6):635-639.
[8]Koh DM,Blackledge M,Collins DJ,et al.Reproducibility and changes in the apparent diffusion coefficients of solid tumours treated with combretastatin a4 phosphate and bevacizumab in a two-centre phase I clinical trial[J].Eur Radiol,2009,19(11):2728-2738.
[9]Afaq A,Andreou A,Koh DM.Diffusion-weighted magnetic resonance imaging for tumour response assessment:why,when and how?[J].Cancer Imaging,2010,10(spec no AN):179-188.
[10]Liu YB,Lu LG,Jin HS,et al.Radiofrequency ablation of liver VX2 tumor:experimental results with MR diffusion-weighted imaging at 3.0T[J].PLo S One,2014,9(8):e104239.
[11]Lencioni R,Cioni D,Crocetti L,et al.Early-stage hepatocellular carcinoma in patients with cirrhosis:longterm results of percutaneous image-guided radiofrequency ablation[J].Radiology,2005,234(3):961-967.
[12]Lu DS,Yu NC,Raman SS,et al.Radiofrequency ablation of hepatocellular carcinoma:treatment success as defined by histologic examination of the explanted liver[J].Radiology,2005,234(3):954-960.
[13]Morimoto M,Sugimori K,Shirato K,et al.Treatment of hepatocellular carcinoma with radiofrequency ablation:radiologic-histologic correlation during follow-up periods[J].Hepatology,2002,35(6):1467-1475.
[14]Kuszyk BS,Boitnott JK,Choti MA,et al.Local tumor recurrence following hepatic cryoablation:radiologic-histopathologic correlation in a rabbit model[J].Radiology,2000,217(2):477-486.
[15]Qian T,Chen M,Gao F,et al.Diffusion-weighted magnetic resonance imaging to evaluate microvascular density after transarterial embolization ablation in a rabbit VX2 liver tumor model[J].Magn Reson Imaging,2014,32(8):1052-1057.
[16]Wu H,Liu H,Liang C,et al.Diffusion-weighted multiparametric MRI for monitoring longitudinal changes of parameters in rabbit VX2 liver tumors[J].J Magn Reson Imaging,2016,44(3):707-714.
[17]Shao H,Ni Y,Zhang J,et al.Dynamic contrast-enhanced and diffusion-weighted magnetic resonance imaging noninvasive evaluation of vascular disrupting treatment on rabbit liver tumors[J].PLo S One,2013,8(12):e82649.
[18]Galbán S,Lemasson B,Williams TM,et al.DW-MRI as a biomarker to compare therapeutic outcomes in radiotherapy regimens incorporating temozolomide or gemcitabine in glioblastoma[J].PLo S One,2012,7(4):e35857.
[19]Mardor Y,Roth Y,Ochershvilli A,et al.Pretreatment prediction of brain tumors'response to radiation therapy using high b-value diffusion-weighted MRI[J].Neoplasia,2004,6(2):136-142.
[20]Liu L,Wu N,Ouyang H,et al.Diffusion-weighted MRI in early assessment of tumor response to radiotherapy in high-risk prostate cancer[J].Br J Radiol,2014,87(1043):20140359.
[21]Baur A,Huber A,Arbogast S,et al.Diffusion-weighted imaging of tumor recurrencies and posttherapeutical soft tissue changes in humans[J].Eur Radiol,2001,11(5):828-833.
[22]张森,康钰,杜湘珂.扩散加权成像评估结直肠癌区域淋巴结转移预后相关因素分析[J].中国医学影像学杂志,2015,23(7):513-516,522.
[23]Xu Jifei,Wu Xingwang,Wang Wanqin,et al.Value of diffusion-weighted magnetic resonance imaging on the follow-up of nasopharyngeal carcinoma after radiotherapy[J].Journal of X-Ray Science and Technology,2014,22(5):605-612.
[24]Li Hong,Li Na,Xiang Qin,et al.Value of hepatic diffusionweighted magnetic resonance imaging in evaluating liver fibrosis following transarterial chemoembolization with low doses of chemotherapy[J].Experimental And Theraputic Medicine,2014,8(2):642-646.
[25]Kuehl H,Antoch G,Stergar H,et al.Comparison of FDG-PET,PET/CT and MRI for follow-up of colorectal liver metastases treated with radiofrequency ablation:initial results[J].Eur J Radiol,2008,67(2):362-371.
[26]Zhao XJ,Wei JP,Wen TL,et al.Effect of b value on monitoring therapeutic response by diffusion-weighted imaging[J].World J Gastroenterol,2008,14(38):5893-5899.
[27]李跃明,邢振,林娜,等.3.0T MRI在小肝细胞癌与肝脏局灶性结节增生中的鉴别诊断价值[J].中国医学影像学杂志,2014,22(7):501-504.
[28]Buijs M,Vossen JA,Geschwind JF,et al.Quantitative proton MR spectroscopy as a biomarker of tumor necrosis in the rabbit VX2 liver tumor[J].J Vasc Interv Radiol,2011,22(8):1175-1180.
[29]Tang ZY,Zhao JN,Zhong WJ,et al.The value of proton magnetic resonance spectroscopy in high-intensity focused ultrasound treatment of experimental liver cancer[J].Transl Oncol,2015,8(3):163-168.
[30]李勇刚,王仁法,张景峰,等.兔VX2软组织肿瘤的1H-MRS研究[J].中国临床医学影像杂志,2005,16(12):707-709.
[31]Zhang Z,Zeng Q,Liu Y,et al.Assessment of the intrinsic radiosensitivity of glioma cells and monitoring of metabolite ratio changes after irradiation by 14.7-T high-resolution1H MRS[J].NMR Biomed,2014,27(5):547-552.
[32]Lee SC,Poptani H,Pickup S,et al.Early detection of radiation therapy response in non-Hodgkin’s lymphoma xenografts by in vivo1H magnetic resonance spectroscopy and imaging[J].NMR Biomed,2010,23(6):624-632.
[2]万仁均,林征宇,李跃明,等.磁共振引导下兔肝脏血管旁VX2肿瘤模型制作[J].医学影像学杂志,2014,24(5):865-867.
[3]Zhao S,Yu H,Du N.Experimental study of doxorubicin interventional chemotheray in the treatment of rabbit VX2 renal transplantation carcinoma[J].Int J Clin Exp Med,2015,8(7):10739-10745.
[4]Wang CW,Zhou Y,Bai JP,et al.Application of volumetric modulated arc therapy and simultaneous integrated boost techniques to prepare“safe magin”in the rabbit VX2 limb tumor model[J].Med Sci Monit,2015,21:2397-2405.
[5]黄昊,何仕诚,冯国栋,等.骨水泥对兔脊柱VX2肿瘤转移模型的作用研究[J].介入放射学杂志,2015,24(6):520-523.
[6]Shuo L,Hua DX,Xin H,et al.MR diffusion-weighted imaging for evaluation of radiotherapeatic effects on rabbit VX2 tumor model[J].Chin Med Sci J,2008,23(3):172-177.
[7]兰为顺,胡道予,李震,等.磁共振氢质子波谱评价无水乙醇消融治疗兔软组织VX2肿瘤疗效[J].放射学实践,2014,29(6):635-639.
[8]Koh DM,Blackledge M,Collins DJ,et al.Reproducibility and changes in the apparent diffusion coefficients of solid tumours treated with combretastatin a4 phosphate and bevacizumab in a two-centre phase I clinical trial[J].Eur Radiol,2009,19(11):2728-2738.
[9]Afaq A,Andreou A,Koh DM.Diffusion-weighted magnetic resonance imaging for tumour response assessment:why,when and how?[J].Cancer Imaging,2010,10(spec no AN):179-188.
[10]Liu YB,Lu LG,Jin HS,et al.Radiofrequency ablation of liver VX2 tumor:experimental results with MR diffusion-weighted imaging at 3.0T[J].PLo S One,2014,9(8):e104239.
[11]Lencioni R,Cioni D,Crocetti L,et al.Early-stage hepatocellular carcinoma in patients with cirrhosis:longterm results of percutaneous image-guided radiofrequency ablation[J].Radiology,2005,234(3):961-967.
[12]Lu DS,Yu NC,Raman SS,et al.Radiofrequency ablation of hepatocellular carcinoma:treatment success as defined by histologic examination of the explanted liver[J].Radiology,2005,234(3):954-960.
[13]Morimoto M,Sugimori K,Shirato K,et al.Treatment of hepatocellular carcinoma with radiofrequency ablation:radiologic-histologic correlation during follow-up periods[J].Hepatology,2002,35(6):1467-1475.
[14]Kuszyk BS,Boitnott JK,Choti MA,et al.Local tumor recurrence following hepatic cryoablation:radiologic-histopathologic correlation in a rabbit model[J].Radiology,2000,217(2):477-486.
[15]Qian T,Chen M,Gao F,et al.Diffusion-weighted magnetic resonance imaging to evaluate microvascular density after transarterial embolization ablation in a rabbit VX2 liver tumor model[J].Magn Reson Imaging,2014,32(8):1052-1057.
[16]Wu H,Liu H,Liang C,et al.Diffusion-weighted multiparametric MRI for monitoring longitudinal changes of parameters in rabbit VX2 liver tumors[J].J Magn Reson Imaging,2016,44(3):707-714.
[17]Shao H,Ni Y,Zhang J,et al.Dynamic contrast-enhanced and diffusion-weighted magnetic resonance imaging noninvasive evaluation of vascular disrupting treatment on rabbit liver tumors[J].PLo S One,2013,8(12):e82649.
[18]Galbán S,Lemasson B,Williams TM,et al.DW-MRI as a biomarker to compare therapeutic outcomes in radiotherapy regimens incorporating temozolomide or gemcitabine in glioblastoma[J].PLo S One,2012,7(4):e35857.
[19]Mardor Y,Roth Y,Ochershvilli A,et al.Pretreatment prediction of brain tumors'response to radiation therapy using high b-value diffusion-weighted MRI[J].Neoplasia,2004,6(2):136-142.
[20]Liu L,Wu N,Ouyang H,et al.Diffusion-weighted MRI in early assessment of tumor response to radiotherapy in high-risk prostate cancer[J].Br J Radiol,2014,87(1043):20140359.
[21]Baur A,Huber A,Arbogast S,et al.Diffusion-weighted imaging of tumor recurrencies and posttherapeutical soft tissue changes in humans[J].Eur Radiol,2001,11(5):828-833.
[22]张森,康钰,杜湘珂.扩散加权成像评估结直肠癌区域淋巴结转移预后相关因素分析[J].中国医学影像学杂志,2015,23(7):513-516,522.
[23]Xu Jifei,Wu Xingwang,Wang Wanqin,et al.Value of diffusion-weighted magnetic resonance imaging on the follow-up of nasopharyngeal carcinoma after radiotherapy[J].Journal of X-Ray Science and Technology,2014,22(5):605-612.
[24]Li Hong,Li Na,Xiang Qin,et al.Value of hepatic diffusionweighted magnetic resonance imaging in evaluating liver fibrosis following transarterial chemoembolization with low doses of chemotherapy[J].Experimental And Theraputic Medicine,2014,8(2):642-646.
[25]Kuehl H,Antoch G,Stergar H,et al.Comparison of FDG-PET,PET/CT and MRI for follow-up of colorectal liver metastases treated with radiofrequency ablation:initial results[J].Eur J Radiol,2008,67(2):362-371.
[26]Zhao XJ,Wei JP,Wen TL,et al.Effect of b value on monitoring therapeutic response by diffusion-weighted imaging[J].World J Gastroenterol,2008,14(38):5893-5899.
[27]李跃明,邢振,林娜,等.3.0T MRI在小肝细胞癌与肝脏局灶性结节增生中的鉴别诊断价值[J].中国医学影像学杂志,2014,22(7):501-504.
[28]Buijs M,Vossen JA,Geschwind JF,et al.Quantitative proton MR spectroscopy as a biomarker of tumor necrosis in the rabbit VX2 liver tumor[J].J Vasc Interv Radiol,2011,22(8):1175-1180.
[29]Tang ZY,Zhao JN,Zhong WJ,et al.The value of proton magnetic resonance spectroscopy in high-intensity focused ultrasound treatment of experimental liver cancer[J].Transl Oncol,2015,8(3):163-168.
[30]李勇刚,王仁法,张景峰,等.兔VX2软组织肿瘤的1H-MRS研究[J].中国临床医学影像杂志,2005,16(12):707-709.
[31]Zhang Z,Zeng Q,Liu Y,et al.Assessment of the intrinsic radiosensitivity of glioma cells and monitoring of metabolite ratio changes after irradiation by 14.7-T high-resolution1H MRS[J].NMR Biomed,2014,27(5):547-552.
[32]Lee SC,Poptani H,Pickup S,et al.Early detection of radiation therapy response in non-Hodgkin’s lymphoma xenografts by in vivo1H magnetic resonance spectroscopy and imaging[J].NMR Biomed,2010,23(6):624-632.