慢性鼻-鼻窦炎的免疫机制研究进展
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摘要
慢性鼻-鼻窦炎(CRS)是耳鼻咽喉科的常见病,也是长期诊疗研究所关注的焦点和难点问题。近年来的研究倾向于多因素作用的病因学说,由遗传、变应性和解剖等因素共同作用。因其病因及发病机制至今不清,给CRS的临床诊治带来一定困难,弄清楚CRS发病机制,寻找更加有效的治疗方法及治疗靶点十分必要。
Chronic rhinosinusitis(CRS) is a common disease in the Department of Otolaryngology that is a focus and difficult problem in the long-term clinical and research.The researches in recent years have in tendency to the effect of many factors,from genetic,allergic and anatomical factors.Its etiology and pathogenesis is still not clear,which brings some difficulty to clinical diagnosis and treatment of CRS.In this study,we try to explore the pathogenesis of CRS and find out more effective method of treatment and therapeutic targets.
Chronic rhinosinusitis(CRS) is a common disease in the Department of Otolaryngology that is a focus and difficult problem in the long-term clinical and research.The researches in recent years have in tendency to the effect of many factors,from genetic,allergic and anatomical factors.Its etiology and pathogenesis is still not clear,which brings some difficulty to clinical diagnosis and treatment of CRS.In this study,we try to explore the pathogenesis of CRS and find out more effective method of treatment and therapeutic targets.
引文
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[11]Sokol C L,Chu N Q,Yu S,et al.Basophils function as antigen-presenting cells for an allergeninduced T helper typer type 2 response[J].Nature Immunol,2009,10(7):713-720.
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[14]亢丽芳,平建双,王静萍,等.辅助性T细胞因子在慢性鼻-鼻窦炎和鼻息肉中的表达及意义[J].临床医药研究,2011,20(3):167-168.
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[17]Van Zele T,Claeys S,Gevaert P,et al.Differentiation of chronic sinus diseases by measurement of inflammatory mediators[J].Allergy,2006,61(11):1280-1289.
[18]Payne S C,Borish L,Steinke J W.Genetics and phenotyping in chronic sinusitis[J].J Allerdy Clin Immunol,2011,128(4):710-720.
[19]Otto Bradley A,Wenzel Sally E.The role of cytokines in chronic rhinosinusitis with nasal polyps[J].Curr Opin Otolaryngol Head Neck Surg,2008,16(3):270-274.
[20]Van Bruaene N,Perez-Novo C A,Basinski T M,et al.T-cell regulation in chronic paranasal sinus disease[J].J Aller Clin Immunol,2008,121(6):1435-1441.
[21]Zhang N,Van Zele T,Perez-Novo C,et al.Different types of T-dffdctor cells orchestrate mucosal inflammation in chronic sinus disease[J].J Aller Clin Immunol,2008,122(5):961-918.
[22]Miller L S,Cho J S.Immunity against Staphylococcus aureus cutaneous infections[J].Nature Review Immunol,2011,11(8):505-518.
[2]Fokkens W,Lund V,Mullol J,et al.European position paper on rhinosinusitis and nasal polyps 2007[J].Rhinol Suppl,2007,20(1):1-136.
[3]Tomassen P,Thibaut Van Zele,Zhang N,et al.Pathophysiology of chronic rhinosinusitis[J].Proceed Am Thoracic Society,2011,8(1):115-120.
[4]程雷,董震,周兵,等.2008年全国慢性鼻-鼻窦炎诊断和治疗专题学术会议纪要[J].中华耳鼻咽喉头颈外科杂志,2009,44(1):8-9.
[5]Fokkens W J,Lund V J,Mullol J,et al.EPOS 2012:European position paper on rhinosinusitis and nasal polyps2012.A summary for otorhinolaryngologists[J].Rhinology,2012,50(1):1-12.
[6]中华医学会耳鼻咽喉科学分会,中华耳鼻咽喉科杂志编辑委员会.慢性鼻窦炎及鼻息肉分型、分期及手术疗效评定标准(1997年,海口)[J].中华耳鼻咽喉科杂志,1998,32(3):134.
[7]Sachse F,Becker K,Basel T J,et al.IKK-2 inhibitor TPCA-1 represses nasal epithelial inflammation in vitro[J].Rhinology,2011,49(2):168-173.
[8]Soyka M B,Wawrzyniak P,Eiwegger T,et al.Defective epithelial barrier in chronic rhinosinusitis:the regulation of tight junctions by IFN-γand IL-4[J].J Aller Clin Immunol,2012,130(5):1087-1096.
[9]Kern R C,Conley D B,Walsh W,et al.Perspectives on the etiology of chronic rhinosinusitis:an immune barrier hypothesis[J].Am J Rhinol,2008,22(6):549-559.
[10]王鑫,赵春源,刘鸣,等.Toll样受体及其传导通路在慢性鼻窦炎鼻息肉中的表达[J].临床耳鼻咽喉头颈外科杂志,2009,23(23):1059-1062.
[11]Sokol C L,Chu N Q,Yu S,et al.Basophils function as antigen-presenting cells for an allergeninduced T helper typer type 2 response[J].Nature Immunol,2009,10(7):713-720.
[12]Miller S A,Weinmann A S.Common themes emerge in the transcriptional control of T helper and developmental cell fate decisions regulated by the T-box,GATA and ROR families[J].Immunology,2009,126(3):306-315.
[13]Paul W E,Zhu J,Yamane H.Differentiation of effector CD4 T cell populations[J].Ann Review Immunol,2010,28(3):445-489.
[14]亢丽芳,平建双,王静萍,等.辅助性T细胞因子在慢性鼻-鼻窦炎和鼻息肉中的表达及意义[J].临床医药研究,2011,20(3):167-168.
[15]Harlin S L,Ansel D G,Lane S R,et al.A clinical and pathologic study of chronic sinusitis:the role of the eosinophil[J].J Aller Clin Immunol,1988,81(5):867-875.
[16]Ebbens F A,Toppila-Salmi S,de Groot E J,et al.Predictors of post-operative response to treatment:a double blind placebo controlled study in chronic rhinosinusitis patients[J].Rhinology,2011,49(4):413-419.
[17]Van Zele T,Claeys S,Gevaert P,et al.Differentiation of chronic sinus diseases by measurement of inflammatory mediators[J].Allergy,2006,61(11):1280-1289.
[18]Payne S C,Borish L,Steinke J W.Genetics and phenotyping in chronic sinusitis[J].J Allerdy Clin Immunol,2011,128(4):710-720.
[19]Otto Bradley A,Wenzel Sally E.The role of cytokines in chronic rhinosinusitis with nasal polyps[J].Curr Opin Otolaryngol Head Neck Surg,2008,16(3):270-274.
[20]Van Bruaene N,Perez-Novo C A,Basinski T M,et al.T-cell regulation in chronic paranasal sinus disease[J].J Aller Clin Immunol,2008,121(6):1435-1441.
[21]Zhang N,Van Zele T,Perez-Novo C,et al.Different types of T-dffdctor cells orchestrate mucosal inflammation in chronic sinus disease[J].J Aller Clin Immunol,2008,122(5):961-918.
[22]Miller L S,Cho J S.Immunity against Staphylococcus aureus cutaneous infections[J].Nature Review Immunol,2011,11(8):505-518.