声触诊组织定量技术评价低温条件下兔肝脏改变的初步研究
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摘要
目的探讨声触诊组织定量(VTQ)技术在低温条件下兔肝脏改变中的价值。方法建立-25℃环境下的兔低温模型,分别于低温前(T_0)、低温时(T_1~T_4)5个时间点对肝脏右叶进行二维超声及声触诊组织定量技术检查,观察各个时间点肝脏的回声、剪切波速度(SWV)。结果实验兔肝右叶回声没有发生明显改变。实验兔肝脏右叶的剪切波速度在T_1~T_4各时间点与T_0相比差异具有统计学意义(P<0.05),并且随着时间的变化肝脏的剪切波速度值逐渐升高。从T_2时间点开始,肝脏病理显示明显改变。结论声触诊组织定量技术可以通过肝脏的剪切波速度值反映低温条件下实验兔肝脏的改变,为临床判断肝脏损伤情况提供指导。
Objective To explore the value of Virtual T_ouch T_issue Quantification(VT_Q)T_echnique in the evaluation of the change of liver in rabbits in low temperature conditions.Methods Rabbits models of-25 ℃ conditions were induced.Ultrasonic examinations were performed at the times before(T_0)and after(T_1-T_4)the rabbits which were treated under-25 ℃ conditions,T_he echo of right liver lobe was evaluated by two-dimensional ultrasound and VT_Q technique.T_he echo changes of right live lobe and SWV were observed at different time.Results No significant changes were found in the echo of right liver lobe.Significant difference of SWV of right lobe of liver were found from T_1 to T_4compared with that at T_0(P<0.05).As time went by,SWV was becoming higher and higher.T_he pathology of liver changed obviously from T_2.Conclusions VTQ Technique can estimate the change of liver through SWV in rabbits in low temperature condition.It can provide guidance of damaged situation of liver for clinical diagnosis.
Objective To explore the value of Virtual T_ouch T_issue Quantification(VT_Q)T_echnique in the evaluation of the change of liver in rabbits in low temperature conditions.Methods Rabbits models of-25 ℃ conditions were induced.Ultrasonic examinations were performed at the times before(T_0)and after(T_1-T_4)the rabbits which were treated under-25 ℃ conditions,T_he echo of right liver lobe was evaluated by two-dimensional ultrasound and VT_Q technique.T_he echo changes of right live lobe and SWV were observed at different time.Results No significant changes were found in the echo of right liver lobe.Significant difference of SWV of right lobe of liver were found from T_1 to T_4compared with that at T_0(P<0.05).As time went by,SWV was becoming higher and higher.T_he pathology of liver changed obviously from T_2.Conclusions VTQ Technique can estimate the change of liver through SWV in rabbits in low temperature condition.It can provide guidance of damaged situation of liver for clinical diagnosis.
引文
[1]Ates B,Dogru MI,Gul M,et al.Protective role of caffeic acid phene-thylester in the liver of rats exposed to cold stress[J].Fundam Clin Pharmacol,2006,20(3):283-289.
[2]Iyo AY.Acoustic radiation force impulse imaging:a literature review[J].J Diag Med sonogr,2009,25:204-211.
[3]舒瑞,赵玉珍,薛薇,等.声触诊组织量化技术在肝良恶性病灶诊断中的应用[J].中华超声影像学杂志,2014,23(6):502-505.
[4]王一,杨晓云,冯钰瑾,等.声触诊组织定量技术测量妊娠期高血压患者肾脏弹性的临床价值[J].中国超声医学杂志,2015,31(6):524-526.
[5]吴丽珍,杜兴华,雷艳,等.急性低温暴露对家兔心肝肾功能的影响[J].昆明医科大学学报,2013,34(5):43-49.
[6]Marcelo Ferreira,Vitor E Valenti,Jose R Cisternas,et al.Memantine effects on liver and adrenal gland of rats exposed to cold stress[J].Int Arch Med,2011,4(1):5.
[7]Esra Betül Kalaz,Betül Evran,Seval Develi,et al.Effect of Carnosine on Prooxidant–Antioxidant Balance in Several Tissues of Rats Exposed to Chronic Cold Plus Immobilization Stress[J].J Pharmacol Sci,2012,120(2):98-104.
[8]Mariana M Gersak,Erich Sorantin,Jana Windhaber,et al.The influence of acute physical effort on liver stiffness estimation using Virtual Touch Quantification(VTQ)[J].Preliminary results.Med Ultrason,2016,18(2):151-156.
[9]黄品同,孔凡雷,王力,等.声辐射力脉冲成像技术对兔下腔静脉夹闭及再开放后肝弹性的研究[J].中华超声影像学杂志,2010,19(2):164-166.
[2]Iyo AY.Acoustic radiation force impulse imaging:a literature review[J].J Diag Med sonogr,2009,25:204-211.
[3]舒瑞,赵玉珍,薛薇,等.声触诊组织量化技术在肝良恶性病灶诊断中的应用[J].中华超声影像学杂志,2014,23(6):502-505.
[4]王一,杨晓云,冯钰瑾,等.声触诊组织定量技术测量妊娠期高血压患者肾脏弹性的临床价值[J].中国超声医学杂志,2015,31(6):524-526.
[5]吴丽珍,杜兴华,雷艳,等.急性低温暴露对家兔心肝肾功能的影响[J].昆明医科大学学报,2013,34(5):43-49.
[6]Marcelo Ferreira,Vitor E Valenti,Jose R Cisternas,et al.Memantine effects on liver and adrenal gland of rats exposed to cold stress[J].Int Arch Med,2011,4(1):5.
[7]Esra Betül Kalaz,Betül Evran,Seval Develi,et al.Effect of Carnosine on Prooxidant–Antioxidant Balance in Several Tissues of Rats Exposed to Chronic Cold Plus Immobilization Stress[J].J Pharmacol Sci,2012,120(2):98-104.
[8]Mariana M Gersak,Erich Sorantin,Jana Windhaber,et al.The influence of acute physical effort on liver stiffness estimation using Virtual Touch Quantification(VTQ)[J].Preliminary results.Med Ultrason,2016,18(2):151-156.
[9]黄品同,孔凡雷,王力,等.声辐射力脉冲成像技术对兔下腔静脉夹闭及再开放后肝弹性的研究[J].中华超声影像学杂志,2010,19(2):164-166.