肝功能储备评估研究进展
摘要
<正>肝功能储备指肝脏耐受手术、创伤及打击时的额外潜能,即除了机体所需的代谢、蛋白质合成或降解、解毒功能以外的创伤修复能力和肝脏再生能力。随着肝移植技术、门静脉栓塞术(PVE)、联合肝脏分割和门静脉结扎的分阶段肝切除术(ALPPS)等治疗方案的出现及成熟,大范围肝切除患者数量正逐步增加,其相较于姑息治疗及小范围肝切除而言,在显著提高患者生存率的同时,往往存在着出血、肝衰竭等
引文
[1]NANASHIMA A,YAMAGUCHI H,SHIBASAKI S,et al.Measurement of serum hyaluronic acid level during the perioperative period of liver resection for evaluation of functional liver reserve[J].J Gastroenterol Hepatol,2001,16(10):1158-1163.
[2]HOEKSTRA LT,DE GRAAF W,NIBOURG GA,et al.Physiological and biochemical basis of clinical liver function tests:a review[J].Ann Surg,2013,257(1):27-36.
[3]CHENG J,ZHAO PU,LIU J,et al.Preoperative aspartate aminotransferase-to-platelet ratio index(APRI)is a predictor on postoperative outcomes of hepatocellular carcinoma[J].Medicine(Baltimore),2016,95(48):e5486.
[4]JI F,FU S,GUO Z,et al.Prognostic significance of preoperative aspartate aminotransferase to neutrophil ratio index in patients with hepatocellular carcinoma after hepatic resection[J].Oncotarget,2016,7(44):72276-72289.
[5]FURUYAMA T,KUDO A,MATSUMURA S,et al.Preoperative direct bilirubin to prothrombin time ratio index to prevent liver failure after minor hepatectomy[J].J Hepatobiliary Pancreat Sci,2016,23(12):763-770.
[6]OMAGARI K,OHBA K,KADOKAWA Y,et al.Comparison of the grade evaluated by"Liver damage"of liver cancer study group of Japan and child-pugh classification in patients with hepatocellular carcinoma[J].Hepatol Res,2006,34(4):266-272.
[7]GARCEA G,ONG SL,MADDERN GJ.Predicting liver failure following major hepatectomy[J].Dig Liver Dis,2009,41(11):798-806.
[8]MANIZATE F,HIOTIS SP,LABOW D,et al.Liver functional reserve estimation:state of the art and relevance to local treatments[J].Oncology,2010,78(Suppl1):131-134.
[9]IMAMURA H,SANO K,SUGAWARA Y,et al.Assessment of hepatic reserve for indication of hepatic resection:decision tree incorporating indocyanine green test[J].J Hepatobiliary Pancreat Surg,2005,12(1):16-22.
[10]GUENGERICH FP,KRAUSER JA,JOHNSON WW.Rate-limiting steps in oxidations catalyzed by rabbit cytochrome P4501A2[J].Biochemistry,2004,43(33):10775-10788.
[11]STOCKMANN M,LOCK JF,RIECKE B,et al.Prediction of postoperative outcome after hepatectomy with a new bedside test for maximal liver function capacity[J].Ann Surg,2009,250(1):119-125.
[12]OELLERICH M,ARMSTRONG VW.The MEGX test:a tool for the real-time assessment of hepatic function[J].Ther Drug Monit,2001,23(2):81-92.
[13]HOEKSTRA LT,DE GRAAF W,NIBOURG GA,et al.Physiological and biochemical basis of clinical liver function tests:a review[J].Ann Surg,2013,257(1):27-36.
[14]FRULIO N,LAUMONIER H,CARTERET T,et al.Evaluation of liver tumors using acoustic radiation force impulse elastography and correlation with histologic data[J].J Ultrasound Med,2013,32(1):121-130.
[15]GALLOTTI A,D′ONOFRIO M,ROMANINI L,et al.Acoustic radiation force impulse(ARFI)ultrasound imaging of solid focal liver lesions[J].Eur J Radiol,2012,81(3):451-455.
[16]TONG C,XU X,LIU C,et al.Assessment of liver volume variation to evaluate liver function[J].Front Med,2012,6(4):421-427.
[17]MARTEL G,CIESLAK KP,HUANG R,et al.Comparison of techniques for volumetric analysis of the future liver remnant:implications for major hepatic resections[J].HPB(Oxford),2015,17(12):1051-1057.
[18]DE GRAAF W,VAN LIENDEN KP,VAN GULIK TM,et al.99mTcmebrofenin hepatobiliary scintigraphy with SPECT for the assessment of hepatic function and liver functional volume before partial hepatectomy[J].J Nucl Med,2010,51(2):229-236.
[19]DE GRAAF W,VAN LIENDEN KP,VAN DEN ESSCHERT JW,et al.Increase in future remnant liver function after preoperative portal vein embolization[J].Br J Surg,2011,98(6):825-834.
[20]OLTHOF PB,TOMASSINI F,HUESPE PE,et al.Hepatobiliary scintigraphy to evaluate liver function in associating liver partition and portal vein ligation for staged hepatectomy:liver volume overestimates liver function[J].Surgery,2017,162(4):775-783.
[21]SOURBRON S,SOMMER WH,REISER MF,et al.Combined quantification of liver perfusion and function with dynamic gadoxetic acidenhanced Mr imaging[J].Radiology,2012,263(3):874-883.
[22]SAITO K,LEDSAM J,SOURBRON S,et al.Measuring hepatic functional reserve using low temporal resolution Gd-EOB-DTPAdynamic contrast-enhanced MRI:apreliminary study comparing galactosyl human serum albumin scintigraphy with indocyanine green retention[J].Eur Radiol,2014,24(1):112-119.
[23]NANASHIMA A,YAMAGUCHI H,SHIBASAKI S,et al.Relationship between indocyanine green test and technetium-99mgalactosyl serum albumin scintigraphy in patients scheduled for hepatectomy:clinical evaluation and patient outcome[J].Hepatol Res,2004,28(4):184-190.
[24]MIKI K,MATSUI Y,TERUYA M,et al.Index of convexity:a novel liver function index using Tc-GSA scintigraphy[J].World JGastroenterol,2013,19(1):92-96.
[25]SATOH K,YAMAMOTO Y,NISHIYAMA Y,et al.99mTc-GSAliver dynamic SPECT for the preoperative assessment of hepatectomy[J].Ann Nucl Med,2003,17(1):61-67.
[26]IIMURO Y,KASHIWAGI T,YAMANAKA J,et al.Preoperative estimation of asialoglycoprotein receptor expression in the remnant liver from CT/99mTc-GSA SPECT fusion images correlates well with postoperative liver function parameters[J].J Hepatobiliary Pancreat Sci,2010,17(5):673-681.
[27]HIRAI I,KIMURA W,FUSE A,et al.Evaluation of preoperative portal embolization for safe hepatectomy,with special reference to assessment of nonembolized lobe function with 99mTc-GSA SPECTscintigraphy[J].Surgery,2003,133(5):495-506.
[28]NISHIYAMA Y,YAMAMOTO Y,HINO I,et al.99mTc galactosyl human serum albumin liver dynamic SPET for pre-operative assessment of hepatectomy in relation to percutaneous transhepatic portal embolization[J].Nucl Med Commun,2003,24(7):809-817.
[29]HENDRIKSE NH,KUIPERS F,MEIJER C,et al.In vivo imaging of hepatobiliary transport function mediated by multidrug resistance associated protein and P-glycoprotein[J].Cancer Chemother Pharmacol,2004,54(2):131-138.
[30]DE GRAAF W,VAN LIENDEN KP,DINANT S,et al.Assessment of future remnant liver function using hepatobiliary scintigraphy in patients undergoing major liver resection[J].J Gastrointest Surg,2010,14(2):369-378.
[2]HOEKSTRA LT,DE GRAAF W,NIBOURG GA,et al.Physiological and biochemical basis of clinical liver function tests:a review[J].Ann Surg,2013,257(1):27-36.
[3]CHENG J,ZHAO PU,LIU J,et al.Preoperative aspartate aminotransferase-to-platelet ratio index(APRI)is a predictor on postoperative outcomes of hepatocellular carcinoma[J].Medicine(Baltimore),2016,95(48):e5486.
[4]JI F,FU S,GUO Z,et al.Prognostic significance of preoperative aspartate aminotransferase to neutrophil ratio index in patients with hepatocellular carcinoma after hepatic resection[J].Oncotarget,2016,7(44):72276-72289.
[5]FURUYAMA T,KUDO A,MATSUMURA S,et al.Preoperative direct bilirubin to prothrombin time ratio index to prevent liver failure after minor hepatectomy[J].J Hepatobiliary Pancreat Sci,2016,23(12):763-770.
[6]OMAGARI K,OHBA K,KADOKAWA Y,et al.Comparison of the grade evaluated by"Liver damage"of liver cancer study group of Japan and child-pugh classification in patients with hepatocellular carcinoma[J].Hepatol Res,2006,34(4):266-272.
[7]GARCEA G,ONG SL,MADDERN GJ.Predicting liver failure following major hepatectomy[J].Dig Liver Dis,2009,41(11):798-806.
[8]MANIZATE F,HIOTIS SP,LABOW D,et al.Liver functional reserve estimation:state of the art and relevance to local treatments[J].Oncology,2010,78(Suppl1):131-134.
[9]IMAMURA H,SANO K,SUGAWARA Y,et al.Assessment of hepatic reserve for indication of hepatic resection:decision tree incorporating indocyanine green test[J].J Hepatobiliary Pancreat Surg,2005,12(1):16-22.
[10]GUENGERICH FP,KRAUSER JA,JOHNSON WW.Rate-limiting steps in oxidations catalyzed by rabbit cytochrome P4501A2[J].Biochemistry,2004,43(33):10775-10788.
[11]STOCKMANN M,LOCK JF,RIECKE B,et al.Prediction of postoperative outcome after hepatectomy with a new bedside test for maximal liver function capacity[J].Ann Surg,2009,250(1):119-125.
[12]OELLERICH M,ARMSTRONG VW.The MEGX test:a tool for the real-time assessment of hepatic function[J].Ther Drug Monit,2001,23(2):81-92.
[13]HOEKSTRA LT,DE GRAAF W,NIBOURG GA,et al.Physiological and biochemical basis of clinical liver function tests:a review[J].Ann Surg,2013,257(1):27-36.
[14]FRULIO N,LAUMONIER H,CARTERET T,et al.Evaluation of liver tumors using acoustic radiation force impulse elastography and correlation with histologic data[J].J Ultrasound Med,2013,32(1):121-130.
[15]GALLOTTI A,D′ONOFRIO M,ROMANINI L,et al.Acoustic radiation force impulse(ARFI)ultrasound imaging of solid focal liver lesions[J].Eur J Radiol,2012,81(3):451-455.
[16]TONG C,XU X,LIU C,et al.Assessment of liver volume variation to evaluate liver function[J].Front Med,2012,6(4):421-427.
[17]MARTEL G,CIESLAK KP,HUANG R,et al.Comparison of techniques for volumetric analysis of the future liver remnant:implications for major hepatic resections[J].HPB(Oxford),2015,17(12):1051-1057.
[18]DE GRAAF W,VAN LIENDEN KP,VAN GULIK TM,et al.99mTcmebrofenin hepatobiliary scintigraphy with SPECT for the assessment of hepatic function and liver functional volume before partial hepatectomy[J].J Nucl Med,2010,51(2):229-236.
[19]DE GRAAF W,VAN LIENDEN KP,VAN DEN ESSCHERT JW,et al.Increase in future remnant liver function after preoperative portal vein embolization[J].Br J Surg,2011,98(6):825-834.
[20]OLTHOF PB,TOMASSINI F,HUESPE PE,et al.Hepatobiliary scintigraphy to evaluate liver function in associating liver partition and portal vein ligation for staged hepatectomy:liver volume overestimates liver function[J].Surgery,2017,162(4):775-783.
[21]SOURBRON S,SOMMER WH,REISER MF,et al.Combined quantification of liver perfusion and function with dynamic gadoxetic acidenhanced Mr imaging[J].Radiology,2012,263(3):874-883.
[22]SAITO K,LEDSAM J,SOURBRON S,et al.Measuring hepatic functional reserve using low temporal resolution Gd-EOB-DTPAdynamic contrast-enhanced MRI:apreliminary study comparing galactosyl human serum albumin scintigraphy with indocyanine green retention[J].Eur Radiol,2014,24(1):112-119.
[23]NANASHIMA A,YAMAGUCHI H,SHIBASAKI S,et al.Relationship between indocyanine green test and technetium-99mgalactosyl serum albumin scintigraphy in patients scheduled for hepatectomy:clinical evaluation and patient outcome[J].Hepatol Res,2004,28(4):184-190.
[24]MIKI K,MATSUI Y,TERUYA M,et al.Index of convexity:a novel liver function index using Tc-GSA scintigraphy[J].World JGastroenterol,2013,19(1):92-96.
[25]SATOH K,YAMAMOTO Y,NISHIYAMA Y,et al.99mTc-GSAliver dynamic SPECT for the preoperative assessment of hepatectomy[J].Ann Nucl Med,2003,17(1):61-67.
[26]IIMURO Y,KASHIWAGI T,YAMANAKA J,et al.Preoperative estimation of asialoglycoprotein receptor expression in the remnant liver from CT/99mTc-GSA SPECT fusion images correlates well with postoperative liver function parameters[J].J Hepatobiliary Pancreat Sci,2010,17(5):673-681.
[27]HIRAI I,KIMURA W,FUSE A,et al.Evaluation of preoperative portal embolization for safe hepatectomy,with special reference to assessment of nonembolized lobe function with 99mTc-GSA SPECTscintigraphy[J].Surgery,2003,133(5):495-506.
[28]NISHIYAMA Y,YAMAMOTO Y,HINO I,et al.99mTc galactosyl human serum albumin liver dynamic SPET for pre-operative assessment of hepatectomy in relation to percutaneous transhepatic portal embolization[J].Nucl Med Commun,2003,24(7):809-817.
[29]HENDRIKSE NH,KUIPERS F,MEIJER C,et al.In vivo imaging of hepatobiliary transport function mediated by multidrug resistance associated protein and P-glycoprotein[J].Cancer Chemother Pharmacol,2004,54(2):131-138.
[30]DE GRAAF W,VAN LIENDEN KP,DINANT S,et al.Assessment of future remnant liver function using hepatobiliary scintigraphy in patients undergoing major liver resection[J].J Gastrointest Surg,2010,14(2):369-378.