抗-E合并抗-Wra抗体鉴定
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摘要
目的:探讨抗-Wra抗体的鉴定过程及该抗体潜在的临床意义。方法:对1例不规则抗体检测阳性男性骨髓增生异常综合征患者进行抗体特异性鉴定。盐水法、凝聚胺法以及抗人球法进行交叉配血试验。结果:患者血清中检出抗-E及抗-Wra抗体,E抗原阴性的血液与患者进行交叉配血,3种交叉配血法均相合。结论:输血后患者无任何不良输血反应。对anti-Wra抗体及其他低频抗体进行检测有利于了解其临床意义。
Objective:To describe the process of detection of anti-Wra antibody and the potential clinical risk of missing it.Method:One male patient diagnosed MDS with positive antibody screening was identified with Panel cells.Crossmatching that include saline test,polybrene test and antiglobulin test(AGT)were used to get compatible blood.Result:Anti-E and anti-Wra antibodies were identified in the person's serum.Compatibility blood without E antigen was chosen to transfuse.No adverse transfusion reactions occurred.Conclusion:It's essential to study the clinical significance of anti-Wra and other low incidence antibodies on our Chinese people.
Objective:To describe the process of detection of anti-Wra antibody and the potential clinical risk of missing it.Method:One male patient diagnosed MDS with positive antibody screening was identified with Panel cells.Crossmatching that include saline test,polybrene test and antiglobulin test(AGT)were used to get compatible blood.Result:Anti-E and anti-Wra antibodies were identified in the person's serum.Compatibility blood without E antigen was chosen to transfuse.No adverse transfusion reactions occurred.Conclusion:It's essential to study the clinical significance of anti-Wra and other low incidence antibodies on our Chinese people.
引文
[1]吴迪.9013例输血者不规则抗体筛查结果及意义[J].首都医科大学学报,2017,38(5):754-757.
[2] Reid ME,Lomas-Francis C.The blood group antigen factsbook[M].2nd ed.San Diego,CA:Academic Press,2003:298-331.
[3] Arriaga F,Llopis F,de la Rubia J,et al.Incidence of Wra antigen and anti-Wra in a Spanish population[J].Transfusion,2005,45:1324-1326.
[4]朱自严,沈伟,陈和平,等.上海地区部分人群Jk(ab-)、Dib-、Wrb-、K0、Ena-、Tja-、Ge-稀有血型筛选[J].中国输血杂志,2002,15(4):232-233.
[5]温机智,付涌水,罗广平,等.广州地区汉族人群Diego血型系统多态性调查[J].中国输血杂志,2015,28(6)663-665.
[6]朱自严.人类血型[M].北京:科学出版社,2007:426-429.
[7] Squires A,Nasef N,Lin Y,et al.Hemolytic disease of the newborn caused by anti-Wright(anti-Wra):case report and review of literature[J].Neonatal Netw,2012,2:69-80.
[8] Chen C,Tan J,Wang L,et al.Unexpected red blood cell antibody distributions in Chinese people by a systematic literature review[J].Transfusion,2016,56:975-979.
[9] Muniz JG,Arnoni CP,Gazito D,et al.Frequency of Wr(a)antigen and anti-Wr(a)in Brazilian blood donors[J].Rev Bras Hematol Hemoter,2015,37:316-319.
[10]李勇,马学严.实用血液免疫学:血型理论和实验技术[M].北京:科学出版社,2006:244-245,457.
[11]Hoffmann.Anti-Wra:to screen or not to screen?[J].Transfusion,2007,47:948-949.
[12]George Garratty.How concerned should we be about missing antibodies to low incidence antigens?[J].Transfusion,2003,43:844-847.
[13]Schonewille H,van Zijl AM,Wijermans PW.The importance of antibodies against low-incidence RBC antigens in complete and abbreviated cross-matching[J].Transfusion,2003,43:939-944.
[14]Fung MK,Lewis MR,Bushor S,et al.Antibodies to low-incidence antigens:do we need a different set of rules in prenatal laboratory evaluation?[J].Transfusion,2007,47:2170-2171.
[2] Reid ME,Lomas-Francis C.The blood group antigen factsbook[M].2nd ed.San Diego,CA:Academic Press,2003:298-331.
[3] Arriaga F,Llopis F,de la Rubia J,et al.Incidence of Wra antigen and anti-Wra in a Spanish population[J].Transfusion,2005,45:1324-1326.
[4]朱自严,沈伟,陈和平,等.上海地区部分人群Jk(ab-)、Dib-、Wrb-、K0、Ena-、Tja-、Ge-稀有血型筛选[J].中国输血杂志,2002,15(4):232-233.
[5]温机智,付涌水,罗广平,等.广州地区汉族人群Diego血型系统多态性调查[J].中国输血杂志,2015,28(6)663-665.
[6]朱自严.人类血型[M].北京:科学出版社,2007:426-429.
[7] Squires A,Nasef N,Lin Y,et al.Hemolytic disease of the newborn caused by anti-Wright(anti-Wra):case report and review of literature[J].Neonatal Netw,2012,2:69-80.
[8] Chen C,Tan J,Wang L,et al.Unexpected red blood cell antibody distributions in Chinese people by a systematic literature review[J].Transfusion,2016,56:975-979.
[9] Muniz JG,Arnoni CP,Gazito D,et al.Frequency of Wr(a)antigen and anti-Wr(a)in Brazilian blood donors[J].Rev Bras Hematol Hemoter,2015,37:316-319.
[10]李勇,马学严.实用血液免疫学:血型理论和实验技术[M].北京:科学出版社,2006:244-245,457.
[11]Hoffmann.Anti-Wra:to screen or not to screen?[J].Transfusion,2007,47:948-949.
[12]George Garratty.How concerned should we be about missing antibodies to low incidence antigens?[J].Transfusion,2003,43:844-847.
[13]Schonewille H,van Zijl AM,Wijermans PW.The importance of antibodies against low-incidence RBC antigens in complete and abbreviated cross-matching[J].Transfusion,2003,43:939-944.
[14]Fung MK,Lewis MR,Bushor S,et al.Antibodies to low-incidence antigens:do we need a different set of rules in prenatal laboratory evaluation?[J].Transfusion,2007,47:2170-2171.