血栓通注射液联合阿司匹林治疗老年急性脑梗死患者的疗效分析
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摘要
目的:观察血栓通注射液联合阿司匹林治疗老年急性脑梗死(ACI)患者的临床效果。方法:选取本院2017年1月-2018年1月住院治疗的老年急性脑梗死患者70例作为研究对象,按照随机数字表法将其分为对照组和观察组,各35例。对照组采用常规治疗措施基础上加用阿司匹林肠溶片,观察组在对照组治疗的基础上加用血栓通注射液,观察比较两组的临床疗效、治疗前后的血清炎性细胞因子表达水平及血液流变学指标情况。结果:观察组的治疗总有效率为94.29%明显高于对照组的77.14%,差异有统计学意义(X~2=4.172,P=0.022)。治疗前两组血清超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)、肿瘤坏死因子α(TNF-α)炎性细胞因子表达及血液流变学指标水平比较,差异均无统计学意义(P>0.05);治疗后,两组上述指标与治疗前比较均明显降低,且观察组均明显低于对照组,差异均有统计学意义(P<0.05)。结论:血栓通注射液联合阿司匹林不但可明显提高老年ACI患者的临床疗效,还可减轻脑组织炎症反应和改善血液流变学状态。
Objective:To observe the clinical efficacy of Xueshuantong Injection combined with Aspirin in the treatment of elderly patients with acute cerebral infarction(ACI).Method:A total of 70 elderly patients with acute cerebral infarction hospitalized in our hospital from January 2017 to January 2018 were selected as the research objects.According to the random number table method,they were divided into control group and observation group,35 cases in each group.The control group was treated with Aspirin Enteric-coated tablet on the basis of routine treatment,the observation group was treated with Xueshuantong Injection on the basis of the control group.The clinical efficacy,serum inflammatory cytokines expression level and hemorheological parameters before and after treatment between the two groups were observed and compared.Result:The total effective rate of the observation group was 94.29%,which was significantly higher than 77.14% of the control group,the difference was statistically significant( 字2=4.172,P=0.022).There were no significant differences in the levels of serum high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor α(TNF-α)inflammatory cytokines expression and hemorheological parameters between the two groups before treatment(P>0.05).After treatment,the above indexes in the two groups were significantly lower than those before treatment,and the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Xueshuantong Injection combined with Aspirin can not only significantly improve the clinical efficacy of elderly patients with ACI,but also reduce the inflammation of brain tissue and improve the state of hemorheology.
Objective:To observe the clinical efficacy of Xueshuantong Injection combined with Aspirin in the treatment of elderly patients with acute cerebral infarction(ACI).Method:A total of 70 elderly patients with acute cerebral infarction hospitalized in our hospital from January 2017 to January 2018 were selected as the research objects.According to the random number table method,they were divided into control group and observation group,35 cases in each group.The control group was treated with Aspirin Enteric-coated tablet on the basis of routine treatment,the observation group was treated with Xueshuantong Injection on the basis of the control group.The clinical efficacy,serum inflammatory cytokines expression level and hemorheological parameters before and after treatment between the two groups were observed and compared.Result:The total effective rate of the observation group was 94.29%,which was significantly higher than 77.14% of the control group,the difference was statistically significant( 字2=4.172,P=0.022).There were no significant differences in the levels of serum high-sensitivity C-reactive protein(hs-CRP),interleukin-6(IL-6),tumor necrosis factor α(TNF-α)inflammatory cytokines expression and hemorheological parameters between the two groups before treatment(P>0.05).After treatment,the above indexes in the two groups were significantly lower than those before treatment,and the observation group were significantly lower than those in the control group,the differences were statistically significant(P<0.05).Conclusion:Xueshuantong Injection combined with Aspirin can not only significantly improve the clinical efficacy of elderly patients with ACI,but also reduce the inflammation of brain tissue and improve the state of hemorheology.
引文
[1]笪正,翟正平,闫福岭.急性脑梗死进展发生的相关危险因素分析[J].中国脑血管病杂志,2014,11(11):569-575.
[2]项飞,张秀霞,蒋良福.血栓通辅助常规西药治疗对急性脑梗死患者hs-CRP、IL-6及D-二聚体的影响[J].中国中医急症,2014,23(12):2287-2289.
[3]张荣,张高峰,陈洁.注射用血栓通对急性脑梗死患者炎症因子、同型半胱氨酸的影响[J].湖北中医药大学学报,2016,18(3):24-27.
[4]中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010[J].中华神经科杂志,2010,43(2):146-163.
[5]邵伟,李克,赵玉红,等.血栓通联合纤溶酶对急性脑梗死患者血清超敏C反应蛋白及白细胞介素-6水平的影响[J].中国老年学杂志,2014,34(5):1161-1162.
[6]王焱,赵娟,严晓燕,等.血栓通注射液对急性脑梗死患者脑血流动力学及血清指标的影响[J].中华保健医学杂志,2018,20(1):40-43.
[7]于永才,吴世政,候倩.血栓通联合阿司匹林治疗老年急性脑梗死的临床研究[J].现代药物与临床,2014,29(7):782-785.
[8]于海娜.血栓通与阿司匹林联合用药对急性脑梗死患者D-二聚体、血浆组织型纤溶酶原激活物、血栓调节蛋白、纤溶酶原激活物抑制物及神经功能的影响[J].中国药物经济学,2018,13(2):90-92.
[9]倪桂莲,林翔东,徐素琴,等.不同剂量阿司匹林治疗老年急性脑梗死的疗效及安全性评价[J].中国药业,2013,22(6):15-16.
[10]麻伟兴,王保平,张翼,等.血栓通注射液与阿司匹林对急性复发性脑梗死的临床研究[J].中国临床药理学杂志,2017,33(6):554-557.
[11]李淞.血栓通联合阿司匹林治疗老年急性脑梗死的临床研究分析[J].中国实用医药,2016,11(27):182-183.
[12]刘蓉蓉.阿司匹林联合血栓通治疗脑梗死的临床探讨[J].医学理论与实践,2015,14(17):2315-2316.
[13]李芳芳,李冬冬,单远,等.注射用血栓通临床辅助应用研究进展[J].中成药,2015,37(3):618-622.
[14]Kang J,Park T H,Lee K B,et al.Symptomatic stenoocclusion in patients with acute cerebral infarction:prevalence,distribution,and functional outcome[J].J Stroke,2014,16(1):36-43.
[15]Lambertsen K L,Biber K,Finsen B.Inflammatory cytokines in experimental and human stroke[J].Journal of Cerebral Blood Flow&Metabolism,2012,32(9):1677-1698.
[16]Ormstad H,Aass H C,Lund S N,et al.Serum levels of cytokines and C-reactive protein in acute ischemic stroke patients,and their relationship to stroke lateralization,type,and infarct volume[J].Journal of Neurology,2011,258(4):677-685.
[17]张小军,宋水江.血栓通治疗老年急性脑梗死患者的疗效及对内皮功能的影响[J].中国老年学杂志,2014,34(23):6760-6761.
[18]张勇,侯静,王凌云,等.血栓通注射液对急性脑梗死患者炎性因子与同型半胱氨酸水平的影响[J].中国生化药物杂志,2015,35(9):70-72.
[19]李爱霞,骆晓敏,刘素娟.不同剂量阿司匹林联合疏血通对老年急性脑梗死的疗效观察及其作用机制的探讨[J].慢性病学杂志,2016,17(1):52-55.
[20]束永新,丁晨云,壮新军,等.注射用血栓通对急性脑梗死患者临床疗效及凝血指标的影响[J].河南中医,2014,34(11):2121-2122.
[2]项飞,张秀霞,蒋良福.血栓通辅助常规西药治疗对急性脑梗死患者hs-CRP、IL-6及D-二聚体的影响[J].中国中医急症,2014,23(12):2287-2289.
[3]张荣,张高峰,陈洁.注射用血栓通对急性脑梗死患者炎症因子、同型半胱氨酸的影响[J].湖北中医药大学学报,2016,18(3):24-27.
[4]中华医学会神经病学分会脑血管病学组急性缺血性脑卒中诊治指南撰写组.中国急性缺血性脑卒中诊治指南2010[J].中华神经科杂志,2010,43(2):146-163.
[5]邵伟,李克,赵玉红,等.血栓通联合纤溶酶对急性脑梗死患者血清超敏C反应蛋白及白细胞介素-6水平的影响[J].中国老年学杂志,2014,34(5):1161-1162.
[6]王焱,赵娟,严晓燕,等.血栓通注射液对急性脑梗死患者脑血流动力学及血清指标的影响[J].中华保健医学杂志,2018,20(1):40-43.
[7]于永才,吴世政,候倩.血栓通联合阿司匹林治疗老年急性脑梗死的临床研究[J].现代药物与临床,2014,29(7):782-785.
[8]于海娜.血栓通与阿司匹林联合用药对急性脑梗死患者D-二聚体、血浆组织型纤溶酶原激活物、血栓调节蛋白、纤溶酶原激活物抑制物及神经功能的影响[J].中国药物经济学,2018,13(2):90-92.
[9]倪桂莲,林翔东,徐素琴,等.不同剂量阿司匹林治疗老年急性脑梗死的疗效及安全性评价[J].中国药业,2013,22(6):15-16.
[10]麻伟兴,王保平,张翼,等.血栓通注射液与阿司匹林对急性复发性脑梗死的临床研究[J].中国临床药理学杂志,2017,33(6):554-557.
[11]李淞.血栓通联合阿司匹林治疗老年急性脑梗死的临床研究分析[J].中国实用医药,2016,11(27):182-183.
[12]刘蓉蓉.阿司匹林联合血栓通治疗脑梗死的临床探讨[J].医学理论与实践,2015,14(17):2315-2316.
[13]李芳芳,李冬冬,单远,等.注射用血栓通临床辅助应用研究进展[J].中成药,2015,37(3):618-622.
[14]Kang J,Park T H,Lee K B,et al.Symptomatic stenoocclusion in patients with acute cerebral infarction:prevalence,distribution,and functional outcome[J].J Stroke,2014,16(1):36-43.
[15]Lambertsen K L,Biber K,Finsen B.Inflammatory cytokines in experimental and human stroke[J].Journal of Cerebral Blood Flow&Metabolism,2012,32(9):1677-1698.
[16]Ormstad H,Aass H C,Lund S N,et al.Serum levels of cytokines and C-reactive protein in acute ischemic stroke patients,and their relationship to stroke lateralization,type,and infarct volume[J].Journal of Neurology,2011,258(4):677-685.
[17]张小军,宋水江.血栓通治疗老年急性脑梗死患者的疗效及对内皮功能的影响[J].中国老年学杂志,2014,34(23):6760-6761.
[18]张勇,侯静,王凌云,等.血栓通注射液对急性脑梗死患者炎性因子与同型半胱氨酸水平的影响[J].中国生化药物杂志,2015,35(9):70-72.
[19]李爱霞,骆晓敏,刘素娟.不同剂量阿司匹林联合疏血通对老年急性脑梗死的疗效观察及其作用机制的探讨[J].慢性病学杂志,2016,17(1):52-55.
[20]束永新,丁晨云,壮新军,等.注射用血栓通对急性脑梗死患者临床疗效及凝血指标的影响[J].河南中医,2014,34(11):2121-2122.