仙方活命饮合五味消毒饮加减在骨折内固定术后应用
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摘要
目的观察仙方活命饮合五味消毒饮加减在骨折内固定术后应用。方法选择我院行骨折内固定术患者82例,依据随机数字表法随机分为观察组41例与对照组41例。对照组于患者术后采用常规处理,观察组在对照组基础上结合仙方活命饮合五味消毒饮加减治疗。比较两组患者术后切口感染情况、术后1d和术后4周血清超敏C-反应蛋白(hs-CRP)和中性粒细胞计数变化、疼痛视觉模拟(VAS)评分变化,及术后1周和4周骨折线和内外骨痂评分变化。结果观察组术后切口感染率明显低于对照组(P<0.05);两组术后4周血清hs-CRP和中性粒细胞计数均明显降低(P<0.05);观察组术后4周血清hs-CRP和中性粒细胞计数均低于对照组(P<0.05);两组VAS评分术后4周明显降低(P<0.05);观察组VAS评分术后4周明显低于对照组(P<0.05);观察组骨折线和内外骨痂评分术后1周、术后4周均明显高于对照组(P<0.05);观察组临床治疗总有效率明显高于对照组(P<0.05)。结论仙方活命饮合五味消毒饮加减应用于骨折内固定术后效果显著,具有重要研究意义。
Objective To observe the effect of Xianfang Huoming decoction combined with modified Wuwei Xiaodu decoction in treatment of fracture fixation. Methods 82 cases of patients with internal fixation of fracture were randomly divided into observation group and control group, 41 cases in each group. Control group received conventional treatment,observation group received Xianfang Huoming decoction combined with modified Wuwei Xiaodu decoction on the basis of control group. Infection of incision after operation were compared between the two groups. The changes of serum high sensitivity C-reactive protein(hs-CRP) and neutrophil count, pain visual analogue scale(VAS) score and the changes of fracture line and internal and external callus score at 1 and 4 weeks after operation were compared after operation. Results The infection rate of observation group was significantly lower than that of control group(P<0.05); after 4 weeks of operation, serum hs-CRP and neutrophil counts were significantly decreased in both groups(P<0.05); serum hs-CRP and neutrophil count in observation group was lower than that in control group(P<0.05); VAS scores of both groups significantly decreased(P<0.05), that of observation group was significantly lower than control group(P<0.05); the fracture line and internal and external callus score in observation group were significantly higher than those in control group at the 1 st week and the 4 th week after the operation(P<0.05). The total effective rate of clinical treatment in observation group was significantly higher than that in control group(P<0.05). Conclusion Xianfang Huoming decoction combined with modified Wuwei Xiaodu decoction is effective in treatment of fracture internal fixation with important research significance.
Objective To observe the effect of Xianfang Huoming decoction combined with modified Wuwei Xiaodu decoction in treatment of fracture fixation. Methods 82 cases of patients with internal fixation of fracture were randomly divided into observation group and control group, 41 cases in each group. Control group received conventional treatment,observation group received Xianfang Huoming decoction combined with modified Wuwei Xiaodu decoction on the basis of control group. Infection of incision after operation were compared between the two groups. The changes of serum high sensitivity C-reactive protein(hs-CRP) and neutrophil count, pain visual analogue scale(VAS) score and the changes of fracture line and internal and external callus score at 1 and 4 weeks after operation were compared after operation. Results The infection rate of observation group was significantly lower than that of control group(P<0.05); after 4 weeks of operation, serum hs-CRP and neutrophil counts were significantly decreased in both groups(P<0.05); serum hs-CRP and neutrophil count in observation group was lower than that in control group(P<0.05); VAS scores of both groups significantly decreased(P<0.05), that of observation group was significantly lower than control group(P<0.05); the fracture line and internal and external callus score in observation group were significantly higher than those in control group at the 1 st week and the 4 th week after the operation(P<0.05). The total effective rate of clinical treatment in observation group was significantly higher than that in control group(P<0.05). Conclusion Xianfang Huoming decoction combined with modified Wuwei Xiaodu decoction is effective in treatment of fracture internal fixation with important research significance.
引文
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[15]方勤,卢勤龙,庾盛平,等.活血止痛汤在骨折术后患者中的应用及效果分析[J].海峡药学,2015,21(7):169-170.
[2]孙振辉,刘月驹,李衡.髋关节置换与内固定术治疗老年移位型股骨颈骨折术后再手术率和并发症的系统评价[J].中华创伤骨科杂志,2014,16(2):115-121.
[3]聂锋锋,张英华,黄寿国,等.经皮微创椎弓根螺钉内固定与开放手术治疗胸腰椎骨折:Cobb's角与椎体前缘高度恢复的比较[J].中国组织工程研究,2014,44(10):7094-7099.
[4]王胜涛,朱红,蒲超,等.经皮钢板内固定术治疗肱骨骨折的临床应用研究[J].现代生物医学进展,2015,15(16):3106-3108.
[5]杨军,汤优民.中西医结合治疗骨折内固定术后感染疗效分析[J].中国微生态学杂志,2015,27(6):710-712.
[6]刘智鹏,张长青.骨科疾病诊断与治疗[M].北京:军事医学科学出版社,2006:126.
[7]国家中医药管理局.中医病证诊断疗效标准[S].南京:南京大学出版社,1994.
[8]李永龙,陈国胜,洪笃瑞,等.舒筋活血洗剂加减在桡骨远端C型骨折术后康复中的应用效果观察[J].四川中医,2015,11(5):135-136.
[9]李晓军,朱付平.益气活血方治疗胫腓骨骨折术后早期肿胀45例[J].湖南中医杂志,2015,31(7):89-89.
[10]席银辉.Pilon骨折术后中医分期辨证治疗对骨折愈合及相关并发症的影响[J].现代中西医结合杂志,2016,23(1):66-68.
[11]秦顺利.中医综合疗法联合西药治疗开放性胫腓骨骨折术后感染临床观察[J].四川中医,2015,14(6):139-141.
[12]陈昭心,梁伟,潘李德.中西医结合辅助用药治疗老年股骨粗隆间骨折术后疗效观察[J].中国现代医生,2014,52(15):79-81.
[13]于沛林,王元善,吉爱萍.中医骨折三期治疗对肱骨近端骨折术后的临床疗效观察[J].中医临床研究,2015,8(17):59-60.
[14]孙可.中西医结合疗法在胫骨平台骨折术后康复治疗中的临床效果观察[J].中华中医药学刊,2015,28(10):2529-2532.
[15]方勤,卢勤龙,庾盛平,等.活血止痛汤在骨折术后患者中的应用及效果分析[J].海峡药学,2015,21(7):169-170.