Zirconium metal-organic framework nanocrystal as microwave sensitizer for enhancement of tumor therapy

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英文篇名：Zirconium metal-organic framework nanocrystal as microwave sensitizer for enhancement of tumor therapy 作者：Yuanwen ; Zou ; Wei ; Zhang ; Hongqiao ; Zhou ; Changhui ; Fu ; Longfei ; Tan ; Zhongbing ; Huang ; Xiangling ; Ren ; Jun ; Ren ; Xudong ; Chen ; Xianwei ; Meng 英文作者：Yuanwen Zou;Wei Zhang;Hongqiao Zhou;Changhui Fu;Longfei Tan;Zhongbing Huang;Xiangling Ren;Jun Ren;Xudong Chen;Xianwei Meng;College of Materials Science and Engineering, Sichuan University;Second Clinical Medical College of Jinan University, Shenzhen People's Hospital;Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of Cryogenics Technical Institute of Physics and Chemistry Chinese Academy of Sciences (CAS); 英文关键词：Microwave thermal therapy;;Zirconium metal-organic framework;;nanocubes;;Microwave sensitizer;;Tumor therapy;;Biosafety 中文刊名：FXKB 英文刊名：中国化学快报(英文版) 机构：College of Materials Science and Engineering, Sichuan University;Second Clinical Medical College of Jinan University, Shenzhen People's Hospital;Laboratory of Controllable Preparation and Application of Nanomaterials CAS Key Laboratory of Cryogenics Technical Institute of Physics and Chemistry Chinese Academy of Sciences (CAS); 出版日期：2019-02-15 出版单位：Chinese Chemical Letters 年：2019 期：v.30 基金：financial support from the National Science Foundation of China(Nos. 61671435 and 81630053);; Beijing Natural Science Foundation(No. 4161003) 语种：英文; 页：FXKB201902050 页数：4 CN：02 ISSN：11-2710/O6 分类号：231-234

摘要

Although surgical resection and chemotherapy were widely applied in tumor therapy, the dysfunction of normal cells resulted in the side effects (such as anorexia, nausea). MW thermal therapy is a non-invasive anticancer strategy under the help of MW sensitizer, with the safety and higher efficacy. Zirconium metal-organic framework nanocubes (ZrMOF NCs) modified with polyethylene glycol, were prepared via one pot method and carbodiimide technique, resulting in their large specific surface area and porosity.Our results showed that non-ion-loaded ZrMOF NCs in 0.9% NaCl solution exhibited better heating effect,higher than that in pure water, due to the robust collision among the ions under MW irradiation. The in vivo experiments confirmed that ZrMOF-PEG NCs + MW group exhibited the higher temperature in the tumor region than that of only MW treatment, suggesting a better MW thermal therapeutic anticancer efficacy. This work provides a new preparation strategy of biosafety nanomaterial as MW sensitizer for enhancing MW thermal anticancer therapy.
        Although surgical resection and chemotherapy were widely applied in tumor therapy, the dysfunction of normal cells resulted in the side effects (such as anorexia, nausea). MW thermal therapy is a non-invasive anticancer strategy under the help of MW sensitizer, with the safety and higher efficacy. Zirconium metal-organic framework nanocubes (ZrMOF NCs) modified with polyethylene glycol, were prepared via one pot method and carbodiimide technique, resulting in their large specific surface area and porosity.Our results showed that non-ion-loaded ZrMOF NCs in 0.9% NaCl solution exhibited better heating effect,higher than that in pure water, due to the robust collision among the ions under MW irradiation. The in vivo experiments confirmed that ZrMOF-PEG NCs + MW group exhibited the higher temperature in the tumor region than that of only MW treatment, suggesting a better MW thermal therapeutic anticancer efficacy. This work provides a new preparation strategy of biosafety nanomaterial as MW sensitizer for enhancing MW thermal anticancer therapy.

引文

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