乳腺炎性肌纤维母细胞瘤的研究进展
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摘要
炎性肌纤维母细胞瘤(inflammatory myofibroblastic tumor,IMT)作为一种低度恶性潜能的间叶组织来源的肿瘤,病因及发病机制不明。主要见于儿童和青少年,最常见的部位是肺、肠系膜、网膜,发生于乳腺的比较罕见,且往往单发。乳腺炎性肌纤维母细胞瘤的临床症状及影像学特点均不典型,术前易造成误诊,本文复习国内外文献报道的乳腺炎性肌纤维母细胞瘤,从发病机制、临床表现、影像学特征、病理学特征、鉴别诊断、治疗及预后等方面作一系统综述。
Inflammatory myofibroblastic tumor(IMT) is a kind of mesenchymal tissue-derived tumor with low malignant potential.The etiology and pathogenesis are unknown.It is mainly occured in children and adolescents.The most common sites are the lung,mesentery and omentum,which are rare in the mammary gland and often single.The clinical symptoms and imaging features of inflammatory myofibroblastic tumor of the breast are atypical,and easily misdiagnosed before operation.This article reviews the inflammatory myofibroblastic tumor of the breast reported in domestic and foreign literatures,from the aspects of pathogenesis,clinical manifestations,imaging features,pathological features,differential diagnosis,treatment and prognosis for a systematic review.
Inflammatory myofibroblastic tumor(IMT) is a kind of mesenchymal tissue-derived tumor with low malignant potential.The etiology and pathogenesis are unknown.It is mainly occured in children and adolescents.The most common sites are the lung,mesentery and omentum,which are rare in the mammary gland and often single.The clinical symptoms and imaging features of inflammatory myofibroblastic tumor of the breast are atypical,and easily misdiagnosed before operation.This article reviews the inflammatory myofibroblastic tumor of the breast reported in domestic and foreign literatures,from the aspects of pathogenesis,clinical manifestations,imaging features,pathological features,differential diagnosis,treatment and prognosis for a systematic review.
引文
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[14] Siraj F,Kaur M,Dalal V,et al.Inflammatory myofibroblastic tumor of the breast mimicking malignancy in an elderly male[J].Ochsner J,2017,17(3):277-279.
[15] Kovacs A,Mathe G,Mattsson J,et al.ALK-positive inflammatory myofibroblastic tumor of the nipple during pregnancy-An unusual presentation of a rare disease[J].Breast J,2015,21(3):297-302.
[16] Zhao HD,Wu T,Wang JQ,et al.Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis:A case report[J].Oncol Lett,2013,5(1):97-100.
[17] Choi EJ,Jin GY,Chung MJ,et al.Primary inflammatory myofibroblastic tumors of the breast with metastasis:Radiographic and histopathologic predictive factors[J].J Breast Cancer,2015,18(2):200-205.
[18] Xing P,Li J,Jin F,et al.Metaplastic breast carcinoma development following surgical resection of an inflammatory myofibroblastic tumor in the right breast:A case report[J].Oncol Lett,2014,8(3):1345-1347.
[19] Markopoulos C,Charalampoudis P,Karagiannis E,et al.Inflammatory myofibroblastic tumor of the breast[J].Case Rep Surg,2015,2015:705127.
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[21] Kim SJ,Moon WK,Kim JH,et al.Inflammatory pseudotumor of the breast:A case report with imaging findings[J].Korean J Radiol,2009,10(5):515-518.
[22] Gobbi H,Atkinson JB,Kardos TF,et al.Inflammatory myofibroblastic tumour of the breast:Report of a case with giant vacuolated cells[J].Breast,1999,8(3):135-138.
[23] Obeid E,Nanda R,Fu YX,et al.The role of tumor-associated macrophages in breast cancer progression (review)[J].Int J Oncol,2013,43(1):5-12.
[24] Wang Jian,Zhu Xiongzeng.Pathology of soft tissue tumors[M].Beijing:People' Health Publishing House,2017:332-333.[王坚,朱雄增.软组织肿瘤病理学[M].北京:人民卫生出版社,2017:332-333.]
[25] Mohammad N,Haimes JD,Mishkin S,et al.ALK is a specific diagnostic marker for inflammatory myofibroblastic tumor of the uterus[J].Am J Surg Pathol,2018,42(10):1353-1359.
[26] Maruyama Y,Fukushima T,Gomi D,et al.Relapsed and unresectable inflammatory myofibroblastic tumor responded to chemotherapy:A case report and review of the literature[J].Mol Clin Oncol,2017,7(4):521-524.
[27] Nagumo Y,Maejima A,Toyoshima Y,et al.Neoadjuvant crizotinib in ALK-rearranged inflammatory myofibroblastic tumor of the urinary bladder:A case report[J].Int J Surg Case Rep,2018,48:1-4.
[28] Mossé YP,Voss SD,Lim MS,et al.Targeting ALK with crizotinib in pediatric anaplastic large cell lymphoma and inflammatory myofibroblastic tumor:A children's oncology group study[J].J Clin Oncol,2017,35(28):3215-3221.
[29] Su W,Ko A,O' Connell T,et al.Treatment of pseudotumors with nonsteroidal antiinflammatory drugs[J].J Pediatr Surg,2000,35(11):1635-1637.
[30] Strianese D,Tranfa F,Finelli M,et al.Inflammatory myofibroblastic tumor of the orbit:A clinico-pathological study of 25 cases[J].Saudi J Ophthalmol,2018,32(1):33-39.
[2] Yagnik V,Chadha A,Chaudhari S,et al.Inflammatory myofibroblastic tumor of the urinary bladder[J].Urol Ann,2010,2(2):78-79.
[3] Vecchio GM,Amico P,Grasso G,et al.Post-traumatic inflammatory pseudotumor of the breast with atypical morphological features:A potential diagnostic pitfall.Report of a case and a critical review of the literature[J].Pathol Res Pract,2011,207(5):322-326.
[4] Zen Y,Kasahara Y,Horita K,et al.Inflammatory pseudotumor of the breast in a patient with a high serum IgG4 level:Histologic similarity to sclerosing pancreatitis[J].Am J Surg Pathol,2005,29(2):275-278.
[5] Park SB,Kim HH,Shin HJ,et al.Inflammatory pseudotumor (myoblastic tumor) of the breast:A case report and review of the literature[J].J Clin Ultrasound,2010,38(1):52-55.
[6] Coffin CM,Hornick JL,Fletcher CD.Inflammatory myofibroblastic tumor:Comparison of clinicopathologic,histologic,and immunohistochemical features including ALK expression in atypical and aggressive cases[J].Am J Surg Pathol,2007,31(4):509-520.
[7] Takeuchi K,Soda M,Togashi Y,et al.Pulmonary inflammatory myofibroblastic tumor expressing a novel fusion,PPFIBP1-ALK:Reappraisal of anti-ALK immunohistochemistry as a tool for novel ALK fusion identification[J].Clin Cancer Res,2011,17(10):3341-3348.
[8] Butrynski JE,D'Adamo DR,Hornick JL,et al.Crizotinib in ALK-rearranged inflammatory myofibroblastic tumor[J].N Engl J Med,2010,363(18):1727-1733.
[9] Griffin CA,Hawkins AL,Dvorak C,et al.Recurrent involvement of 2p23 in inflammatory myofibroblastic tumors[J].Cancer Res,1999,59(12):2776-2780.
[10] Yamamoto H,Oda Y,Saito T,et al.p53 Mutation and MDM2 amplification in inflammatory myofibroblastic tumours[J].Histopathology,2003,42(5):431-439.
[11] Schaefer IM,Cote GM,Hornick JL.Contemporary sarcoma diagnosis,genetics,and genomics[J].J Clin Oncol,2018,36(2):101-110.
[12] Lovly CM,Gupta A,Lipson D,et al.Inflammatory myofibroblastic tumors harbor multiple potentially actionable kinase fusions[J].Cancer Discov,2014,4(8):889-895.
[13] Inoue M,Ohta T,Shioya H,et al.Inflammatory myofibroblastic tumors of the breast with simultaneous intracranial,lung,and pancreas involvement:Ultrasonographic findings and a review of the literature[J].J Med Ultrason (2001),2018,45(2):331-335.
[14] Siraj F,Kaur M,Dalal V,et al.Inflammatory myofibroblastic tumor of the breast mimicking malignancy in an elderly male[J].Ochsner J,2017,17(3):277-279.
[15] Kovacs A,Mathe G,Mattsson J,et al.ALK-positive inflammatory myofibroblastic tumor of the nipple during pregnancy-An unusual presentation of a rare disease[J].Breast J,2015,21(3):297-302.
[16] Zhao HD,Wu T,Wang JQ,et al.Primary inflammatory myofibroblastic tumor of the breast with rapid recurrence and metastasis:A case report[J].Oncol Lett,2013,5(1):97-100.
[17] Choi EJ,Jin GY,Chung MJ,et al.Primary inflammatory myofibroblastic tumors of the breast with metastasis:Radiographic and histopathologic predictive factors[J].J Breast Cancer,2015,18(2):200-205.
[18] Xing P,Li J,Jin F,et al.Metaplastic breast carcinoma development following surgical resection of an inflammatory myofibroblastic tumor in the right breast:A case report[J].Oncol Lett,2014,8(3):1345-1347.
[19] Markopoulos C,Charalampoudis P,Karagiannis E,et al.Inflammatory myofibroblastic tumor of the breast[J].Case Rep Surg,2015,2015:705127.
[20] Bosse K,Ott C,Biegner T,et al.23-year-old female with an inflammatory myofibroblastic tumour of the breast:A case report and a review of the literature[J].Geburtshilfe Frauenheilkd,2014,74(2):167-170.
[21] Kim SJ,Moon WK,Kim JH,et al.Inflammatory pseudotumor of the breast:A case report with imaging findings[J].Korean J Radiol,2009,10(5):515-518.
[22] Gobbi H,Atkinson JB,Kardos TF,et al.Inflammatory myofibroblastic tumour of the breast:Report of a case with giant vacuolated cells[J].Breast,1999,8(3):135-138.
[23] Obeid E,Nanda R,Fu YX,et al.The role of tumor-associated macrophages in breast cancer progression (review)[J].Int J Oncol,2013,43(1):5-12.
[24] Wang Jian,Zhu Xiongzeng.Pathology of soft tissue tumors[M].Beijing:People' Health Publishing House,2017:332-333.[王坚,朱雄增.软组织肿瘤病理学[M].北京:人民卫生出版社,2017:332-333.]
[25] Mohammad N,Haimes JD,Mishkin S,et al.ALK is a specific diagnostic marker for inflammatory myofibroblastic tumor of the uterus[J].Am J Surg Pathol,2018,42(10):1353-1359.
[26] Maruyama Y,Fukushima T,Gomi D,et al.Relapsed and unresectable inflammatory myofibroblastic tumor responded to chemotherapy:A case report and review of the literature[J].Mol Clin Oncol,2017,7(4):521-524.
[27] Nagumo Y,Maejima A,Toyoshima Y,et al.Neoadjuvant crizotinib in ALK-rearranged inflammatory myofibroblastic tumor of the urinary bladder:A case report[J].Int J Surg Case Rep,2018,48:1-4.
[28] Mossé YP,Voss SD,Lim MS,et al.Targeting ALK with crizotinib in pediatric anaplastic large cell lymphoma and inflammatory myofibroblastic tumor:A children's oncology group study[J].J Clin Oncol,2017,35(28):3215-3221.
[29] Su W,Ko A,O' Connell T,et al.Treatment of pseudotumors with nonsteroidal antiinflammatory drugs[J].J Pediatr Surg,2000,35(11):1635-1637.
[30] Strianese D,Tranfa F,Finelli M,et al.Inflammatory myofibroblastic tumor of the orbit:A clinico-pathological study of 25 cases[J].Saudi J Ophthalmol,2018,32(1):33-39.