物理生物学:大科学观下针灸学的突破
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摘要
物理生物学是将生物学建立在定量的物理学基础之上的新兴学科,针灸学作为传统中医学下的二级学科,其本质是生命科学。文章论证物理生物学和针灸学的理论共性及研究对象和趋势的一致性,阐释这两种学科之间的启示,分析学科融合的切入点并探讨其可行性,在大科学观下,试图在分子生物学层次之外为针灸学研究找到新视角。
Physical biology is a new subject based on quantitative physics. Acupuncture and moxibustion, as a secondary subject under traditional Chinese medicine, is essentially life science. This paper demonstrates the theoretical commonness of physical biology and acupuncture and the consistency of research objects and trends, explains the enlightenment between the two disciplines, analyses the breakthrough point of integration of disciplines and explores its feasibility, and tries to find a new perspective for acupuncture and moxibustion research beyond the level of molecular biology under the view of macroscience.
Physical biology is a new subject based on quantitative physics. Acupuncture and moxibustion, as a secondary subject under traditional Chinese medicine, is essentially life science. This paper demonstrates the theoretical commonness of physical biology and acupuncture and the consistency of research objects and trends, explains the enlightenment between the two disciplines, analyses the breakthrough point of integration of disciplines and explores its feasibility, and tries to find a new perspective for acupuncture and moxibustion research beyond the level of molecular biology under the view of macroscience.
引文
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[43]陈波,李明月,丁沙沙,等.针刺调节神经-内分泌-免疫网络研究进展(英文).World J Acupunct Moxibustion,2014,24(4):49-53,58
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[46]Yin N,Yang H,Yao W,et al.A mathematical model of histamine-mediated neural activation during acupuncture.Biomech ModelMechanobiol,2017,16(5):1659-1668
[2]赵欣纪,高希言,陈新旺.试论针灸学内涵与外延的界定.中医药管理杂志,2016,24(2):36-38
[3]李致重.中医复兴要有大医学观.中华中医药杂志,2016,31(7):2447-2454
[4]李致重.文化繁荣要有大科学观.中华中医药杂志,2016,31(6):2031-2037
[5]Cook E B,Ellinger F,Morgan J E.The use of small laboratoryanimals in medical radiation biology.Ⅳ.correlation of physicalfactors with the biological effect produced by total-body irradiationof guinea pigs.Cancer,1956,9(4):768-772
[6]White C S.The scope of blast and shock biology and problem areasin relating physical and biological parameters.Ann N Y Acad Sci,1968,152(1):89-102
[7]Fletcher N H,Thwaites S.Physical models for the analysis ofacoustical systems in biology.Q Rev Biophys,1979,12(1):25-65
[8]Benzinger T H.Thermodynamics of living matter:Physicalfoundations of biology.Am J Physiol,1983,244(6):R743-R750
[9]Dana M.Toward a physical concept of cellular biology.Agressologie,1962,3:293-307
[10]Pauling L.One aspect of the physical sciences in relation to biology.Cell Biophys,1986,9(1-2):3-5
[11]Sumpio B E.Hemodynamic forces and the biology of theendothelium:Signal transduction pathways in endothelial cellssubjected to physical forces in vitro.J Vasc Surg,1991,13(5):744-746
[12]Wood Hole.Physical and chemical mechanisms in molecularradiation biology.Basic Life Sci,1991,58:1-517
[13]O’Reilly J J.Engineering,the physical sciences and systemsbiology:A case in point for 360 degrees interdisciplinarity.Syst Biol(Stevenage),2004,1(1):4-6
[14]Cook D L,Bookstein F L,Gennari J H.Physical properties ofbiological entities:An introduction to the ontology of physics forbiology.PLo S One,2011,6(12):e28708
[15]Cook D L,Neal M L,Bookstein F L,et al.Ontology of physicsfor biology:Representing physical dependencies as a basis forbiological processes.J Biomed Semantics,2013,4(1):41
[16]Morange M.Recent opportunities for an increasing role forphysical explanations in biology.Stud Hist Philos Biol BiomedSci,2011,42(2):139-144
[17]Ramanan V,Agrawal N J,Liu J,et al.Systems biology and physicalbiology of clathrin-mediated endocytosis.Integr Biol(Camb),2011,3(8):803-815
[18]Robinson D N,Iglesias P A.Bringing the physical sciences into yourcell biology research.Mol Biol Cell,2012,23(21):4167-4170
[19]Lowell S.Getting the measure of things:The physical biology of stemcells.Development,2013,140(20):4125-4128
[20]Selvarajoo K,Tomita M.Physical laws shape biology.Science,2013,339(6120):646
[21]Keller R.Developmental biology.Physical biology returns tomorphogenesis.Science,2012,338(6104):201-203
[22]Moore N M,Nagahara L A.Physical biology in cancer.1.Cellularphysics of cancer metastasis.Am J Physiol Cell Physiol,2014,306(2):C78-C79
[23]Mitchell M J,King M R.Physical biology in cancer.3.The role ofcell glycocalyx in vascular transport of circulating tumor cells.Am JPhysiol Cell Physiol,2014,306(2):C89-C97
[24]Bordeleau F,Alcoser T A,Reinhart-King C A.Physical biologyin cancer.5.The rocky road of metastasis:The role of cytoskeletalmechanics in cell migratory response to 3D matrix topography.AmJ Physiol Cell Physiol,2014,306(2):C110-C120
[25]StrokaKM,KonstantopoulosK.Physicalbiologyincancer.4.Physical cues guide tumor cell adhesion and migration.Am J Physiol Cell Physiol,2014,306(2):C98-C109
[26]Budday S,Steinmann P,Kuhl E.Physical biology of human braindevelopment.Front Cell Neurosci,2015,9:257
[27]Freguglia P.Mathematical,computational and physical tools fortheoretical biology.Theor Biol Forum,2012,105(2):11-12
[28]Thomas Y.From high dilutions to digital biology:The physicalnature of the biological signal.Homeopathy,2015,104(4):295-300
[29]Wang K,Cai L H,Lan B,et al.Hidden in the mist no more:Physicalforce in cell biology.Nat Methods,2016,13(2):124-125
[30]Offroy M,Duponchel L.Topological data analysis:A promising bigdata exploration tool in biology,analytical chemistry and physicalchemistry.Anal Chim Acta,2016,910:1-11
[31]Phillips R,Kondev J,Theriot J.Physical biology of the cell.UnitedStates of America:Garland Science,2012:1-1058
[32]湛垦华.普利高津与耗散结构理论.西安:陕西科学技术出版社,1998:1-338
[33]赵喜新.中医阴阳学说的数学模型.河南中医,1997,17(5):8-9
[34]丁占鳌.建立“中医阴阳五行学说”的数学模型.黑龙江大学自然科学学报,1993,10(2):59-62
[35]陈秋锐.中医阴阳五行学说的一个数学模型.第十届中国青年信息与管理学者大会论文集,2008:164-169
[36]王涛.五行学说动力学模型研究.上海:复旦大学,2008
[37]林宗振,杨冠群.试建中医阴阳学说的数学模型.暨南大学学报(自然科学与医学版),2003,24(5):23-29
[38]张启明.健康成人五脏精气变化规律的数学模拟.系统工程理论与实践,1998(7):131-136
[39]赵致镛.中医阴阳理论的数学模型之建立及其微积分定量的研究.四川中医,2005,23(11):11-13
[40]叶嘉礼.伤寒论六经辨证与“圆运动”相关性研究及规律探讨.广州:广州中医药大学,2014
[41]王米渠.论从“肾为先天之本”到“中医遗传学”.中国中医基础医学杂志,1996,2(4):6-9
[42]托马斯·迈耶斯.解剖列车.纽约:丘吉尔利文斯通出版社,2014
[43]陈波,李明月,丁沙沙,等.针刺调节神经-内分泌-免疫网络研究进展(英文).World J Acupunct Moxibustion,2014,24(4):49-53,58
[44]Li Y,Li X,Zhou D,et al.Microcirculation perfusion monitor on theback of the health volunteers.Evid Based Complement AlternatMed,2013,2013:590698
[45]李灿辉.精准医学研究系列-肌筋膜张力敏感性通道作为针刺效应启动器的研究.(2016-11-09)[2017-05-06].http://www.360doc.com/content/16/1109/08/34812915_605070220.shtml
[46]Yin N,Yang H,Yao W,et al.A mathematical model of histamine-mediated neural activation during acupuncture.Biomech ModelMechanobiol,2017,16(5):1659-1668