Effects of Xuebijing Combined with Ulinastatin on Coagulation Function of Sepsis Patients
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摘要
[Objectives] To study the effects of Xuebijing combined with ulinastatin on coagulation function of sepsis patients. [Methods]Fifty six patients conforming to the diagnosis criteria for sepsis and receiving the treatment from May 2015 to January 2019 were selected. They were randomly divided into treatment group and control group according to the order of treatment. The two groups were treated according to the International Guidelines for Management of Severe Sepsis and Septic Shock( 2012),in which ulinastatin and Xuebijing were added to the treatment group. Before the treatment and on the seventh day after the treatment,both groups of patients were measured for the activated partial thromboplastin time( APTT),fibrinogen( Fi B),platelet( PLT),and prothrombin time( PT) were measured; the treatment status of the both groups was continuously observed for 7 d,and the mechanical ventilation time,ICU hospitalization time,and 30-day survival rate were recorded. [Results] Both FIB and PLT of the treatment group were significantly increased,and both APTT and PT were significantly shortened.Compared with the control group,the difference was statistically significant( P < 0. 05). The mechanical ventilation time and ICU hospitalization time of the treatment group were significantly shorter than that of the control group,and the 30-day survival rate of the treatment group was significantly higher than that of the control group,and the difference was statistically significant( P < 0. 05). [Conclusions]Xuebijing combined with ulinastatin can improve coagulation disorders of sepsis patients.
[Objectives] To study the effects of Xuebijing combined with ulinastatin on coagulation function of sepsis patients. [Methods]Fifty six patients conforming to the diagnosis criteria for sepsis and receiving the treatment from May 2015 to January 2019 were selected. They were randomly divided into treatment group and control group according to the order of treatment. The two groups were treated according to the International Guidelines for Management of Severe Sepsis and Septic Shock( 2012),in which ulinastatin and Xuebijing were added to the treatment group. Before the treatment and on the seventh day after the treatment,both groups of patients were measured for the activated partial thromboplastin time( APTT),fibrinogen( Fi B),platelet( PLT),and prothrombin time( PT) were measured; the treatment status of the both groups was continuously observed for 7 d,and the mechanical ventilation time,ICU hospitalization time,and 30-day survival rate were recorded. [Results] Both FIB and PLT of the treatment group were significantly increased,and both APTT and PT were significantly shortened.Compared with the control group,the difference was statistically significant( P < 0. 05). The mechanical ventilation time and ICU hospitalization time of the treatment group were significantly shorter than that of the control group,and the 30-day survival rate of the treatment group was significantly higher than that of the control group,and the difference was statistically significant( P < 0. 05). [Conclusions]Xuebijing combined with ulinastatin can improve coagulation disorders of sepsis patients.
[Objectives] To study the effects of Xuebijing combined with ulinastatin on coagulation function of sepsis patients. [Methods]Fifty six patients conforming to the diagnosis criteria for sepsis and receiving the treatment from May 2015 to January 2019 were selected. They were randomly divided into treatment group and control group according to the order of treatment. The two groups were treated according to the International Guidelines for Management of Severe Sepsis and Septic Shock( 2012),in which ulinastatin and Xuebijing were added to the treatment group. Before the treatment and on the seventh day after the treatment,both groups of patients were measured for the activated partial thromboplastin time( APTT),fibrinogen( Fi B),platelet( PLT),and prothrombin time( PT) were measured; the treatment status of the both groups was continuously observed for 7 d,and the mechanical ventilation time,ICU hospitalization time,and 30-day survival rate were recorded. [Results] Both FIB and PLT of the treatment group were significantly increased,and both APTT and PT were significantly shortened.Compared with the control group,the difference was statistically significant( P < 0. 05). The mechanical ventilation time and ICU hospitalization time of the treatment group were significantly shorter than that of the control group,and the 30-day survival rate of the treatment group was significantly higher than that of the control group,and the difference was statistically significant( P < 0. 05). [Conclusions]Xuebijing combined with ulinastatin can improve coagulation disorders of sepsis patients.
引文
[1]PURUSHOTHAMAN S,NAIR RENUMAKA R,HARIKRISHNAN VS,et al. Temporal relation of cardiac hypertrophty,oxidative stress,and fatty acid metabolism in spontaneously hypertensive rat[J]. Molecular and Cellular Biochemistry,2011,351(1-2):59-64.
[2]KATO Y,KUDU M,SHINKAWA T,et al. Role of O-linked carbohydrate of human urinary trypsin inhibitor on its lysosomal membrane-stabilizing property[J]. Biochemical and Biophysical Research Communications,1998,243(2):377-383.
[3]XU KQ,CHEN BX,HUANG WQ,et al. Effects of ulinastatin on lung inflammatory response to cardiopulmonary bypass[J]. Chinese Journal of Anesthesilolgy,2002,22(6):325.(in Chinese).
[4]WANG JD. The idea and method of treating acute critical illness with integrated traditional Chinese and western medicine[J]. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care,2000,7(6):323.(in Chinese).
[5]WANG YM. Pharmacology of traditional Chinese medicine[M]. Shanghai:Shanghai Science and Technique Publishing House,1995:73-75.(in Chinese).
[6]LIANG XQ,LI ZJ,LIU HS,et al. 42 cases of Xuebijing injection for sepsis[J]. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care,2005,10(4):251.(in Chinese).
[2]KATO Y,KUDU M,SHINKAWA T,et al. Role of O-linked carbohydrate of human urinary trypsin inhibitor on its lysosomal membrane-stabilizing property[J]. Biochemical and Biophysical Research Communications,1998,243(2):377-383.
[3]XU KQ,CHEN BX,HUANG WQ,et al. Effects of ulinastatin on lung inflammatory response to cardiopulmonary bypass[J]. Chinese Journal of Anesthesilolgy,2002,22(6):325.(in Chinese).
[4]WANG JD. The idea and method of treating acute critical illness with integrated traditional Chinese and western medicine[J]. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care,2000,7(6):323.(in Chinese).
[5]WANG YM. Pharmacology of traditional Chinese medicine[M]. Shanghai:Shanghai Science and Technique Publishing House,1995:73-75.(in Chinese).
[6]LIANG XQ,LI ZJ,LIU HS,et al. 42 cases of Xuebijing injection for sepsis[J]. Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care,2005,10(4):251.(in Chinese).