摘要
目的了解血站冷沉淀凝血因子的质量状况,为临床输注提供准确的数据支持。方法统计2015年1月—2017年12月某血站抽检及跟踪检测的172份冷沉淀凝血因子质量监测结果,分析Ⅷ因子含量不合格的原因。结果172份冷沉淀凝血因子外观、容量、无菌试验合格率100.0%,Ⅷ因子含量合格率83.1%(143/172),纤维蛋白原含量合格率98.3%(169/172)。29份Ⅷ因子含量不合格的冷沉淀多数分布在夏季和春节前后。结论优化流程,增加速冻设备;严格按操作规程作业,降低人为因素对质量的影响;融化后尽快输注,减少Ⅷ因子活性的衰减,确保其安全有效。
Objective To understand the quality status of cryoprecipitated antihemophilicfactor in a blood station,so as to provide the accurate datum support for clinical infusion.MethodsFrom January 2015 to December 2017, 172 sam-ples of cryoprecipitated antihemophilic factor and coagulation factors were collected and tracked, and the causes of unquali-fied content of factor Ⅷ were analyzed.ResultsAmong the 172 samples of cryoprecipitation coagulation factor, the quali-fied rates of appearance, volume, and aseptic test were all 100%. The qualified rate of Ⅷ factor content was 83.1% (143/172). The qualified rate of fibrinogen content was 98.3% (169/172). Among the 29 samples of unqualified content of factorⅧ, the majority of cold precipitation was distributed around summer and Spring Festival.ConclusionIt is necessary to op-timize the process, increase the quick-freezing equipment, and strictly follow the operating procedures, and so on, so as toimprove the efficiency and safety of the infusion.
引文
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