中空介孔二氧化硅微球的制备及研究进展
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摘要
中空介孔二氧化硅微球具有较大的中空空腔、可控外层介孔结构、大比表面积、良好的生物相容性等特性,因而被广泛应用于药物储存与释放、纳米反应器、催化、吸附等领域。对中空介孔二氧化硅微球的制备方法进行介绍,综述和评价了模板法、选择性刻蚀法、喷雾干燥法等三类制备方法的研究进展及其优缺点,并对其应用前景进行了展望。
Hollow mesoporous silica microspheres(HMSMs),possessing remarkable structural characteristics such as large pore volume,controlled outer mesoporous structure,high specific surface area,good biocompatibility and so on,are widely used in many fields,such as drug storage and release,nano-reactor,catalysis,adsorption,etc.A variety of methods have been reported to prepare successfully HMSMs.Various preparation methods of HMSMs were reviewed,including template method,selective etching method and spray drying method.Meanwhile,the advantages and limitations of these methods were discussed,and the application prospect of HMSMs was also prospected.
Hollow mesoporous silica microspheres(HMSMs),possessing remarkable structural characteristics such as large pore volume,controlled outer mesoporous structure,high specific surface area,good biocompatibility and so on,are widely used in many fields,such as drug storage and release,nano-reactor,catalysis,adsorption,etc.A variety of methods have been reported to prepare successfully HMSMs.Various preparation methods of HMSMs were reviewed,including template method,selective etching method and spray drying method.Meanwhile,the advantages and limitations of these methods were discussed,and the application prospect of HMSMs was also prospected.
引文
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[23]Tsou C J,Hung Y,Mou C Y.Hollow mesoporous silica nanoparticles with tunable shell thickness and pore size distribution for application as broad-ranging pH nanosensor[J].Microporous&Mesoporous Materials,2014,190(190):181-188.
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[25]Botterhuis N E,Sun Q,Magusin P C,et al.Hollow silica spheres with an ordered pore structure and their application in controlled release studies[J].Chemistry,2006,12(5):1448-14456.
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[27]Liu J,Qiao S Z,Budi H S,et al.Monodisperse yolk-shell nanoparticles with a hierarchical porous structure for delivery vehicles and nanoreactors[J].Angewandte Chemie International Edtion,2010,49(29):4981-4985.
[28]Jin G W,Feng L,Hui J Z,et al.Silica hollow spheres with ordered and radially oriented amino-functionalized mesochannels[J].Chemistry of Materials,20009,21(4):612-620.
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[30]Zhu Y F,Shi J L,Chen H R,et al.A facile method to synthesize novel hollow mesoporous silica spheres and advanced storage property[J].Microporous and Mesoporous Materials,2005,84(2005):218-222.
[31]Wang S N,Zhang M C,Wang D,et al.Synthesis of hollow mesoporous silica microspheres through surface sol-gel process on polystyrene-co-poly(4-vinylpyridine)core-shell microspheres[J].Microporous and Mesoporous Materials,2011,139(1-3):1-7.
[32]张发谦,金效齐,张燕娜,等.N,N-二甲基甲酰胺对介孔二氧化硅空心球结构参数和形貌的影响[J].应用化工,2015,44(7):1180-1184.
[33]Jiao Y S,Chang A W,Zhi J L,et al.Heterogeneous organocatalysis at work:functionalization of hollow periodic mesoporous organosilica spheres with MacMillan catalyst[J].Chemistry-A European Journal,2011,17(22):6206-6213.
[34]Williamson P A,Blower P J,Green M A.Synthesis of porous hollow silica nanostructures using hydroxyapatite nanoparticle templates[J].Chemical Communications,2011,47(5):1568-1570.
[35]Liu W,Huang X B,Wei H,et al.Facile preparation of hollow crosslinked polyphosphazene submicrospheres with mesoporous shells[J].Journal of Materials Chemistry,2011,21(34):12964-12968.
[36]Fang X,Chen C,Liu Z,et al.A cationic surfactant assisted selective etching strategy to hollow mesoporous silica spheres[J].Nanoscale,2011,3(4):1632-1639.
[37]Loy D A,Shea K J.Bridged polysilsesquioxanes.highly porous hybrid organic-inorganic materials[J].Chemical Reviews,1995,95(5):1431-1442.
[38]Liu X,Jiao Z,Song T,et al.Surfactant-assisted selective etching strategy for generation of rattle-like mesoporous silica nanoparticles[J].Journal of Colloid&Interface Science,2017,490(2017):497-504.
[39]Tan L F,Liu T L,Li L L,et al.Uniform double-shelled silica hollow spheres:acid/base selective-etching synthesis and their drug delivery application[J].RSC Advances,2013,3(16):5649-5655.
[40]Cho Y S.Fabrication of hollow or macroporous silica particles by spray drying of colloidal dispersion[J].Journal of Dispersion Science&Technology,2015,37(1):23-33.
[2]Li Y,Shi J.Hollow-structured mesoporous materials:chemical synthesis,functionalization and applications[J].Advanced Materials,2014,26(20):3176-3205.
[3]Popat A,Hartono S B,Stahr F,et al.Mesoporous silica nanoparticles for bioadsorption,enzyme immobilisation,and delivery carriers[J].Nanoscale,2011,3(7):2801-2818.
[4]许俊强,张川,郭芳,等.MCM-41介孔壳层包覆的核壳结构复合分子筛研究进展[J].硅酸盐学报,2017,45(4):592-600.
[5]刘慧,李洪亮,朱伶俐,等.硅源对介孔SiO2空心球结构的影响[J].化工新型材料,2016,44(8):135-137.
[6]郑昆,杨红,温刚,等.中空介孔二氧化硅纳米材料HMSNs的合成及其生物相容性[J].吉林大学学报,2016,56(1):148-151.
[7]Chen F,Hong H,Shi S,et al.Engineering of hollow mesoporous silica nanoparticles for remarkably enhanced tumor active targeting efficacy[J].Scientific Reports,2014,4(3):5080.
[8]Luo Z,Hu Y,Cai K,et al.Intracellular redox-activated anticancer drug delivery by functionalized hollow mesoporous silica nanoreservoirs with tumor specificity[J].Biomaterials,2014,35(27):7951-7962.
[9]Knezevic N Z,Durand J O.Large pore mesoporous silica nanomaterials for application in delivery of biomolecules[J].Nanoscale,2015,7(6):2199-2209.
[10]王海媛,周芳,于蒙蒙,等.冰片-中空介孔二氧化硅球载药体系的制备及对冰片挥发性影响的研究[J].中国中药杂志,2016,41(15):2809-2813.
[11]梁樱,马莹,陈霞.高负载中空介孔二氧化硅微粒的可控药物释放[J].东华大学学报,2017,43(1):64-70.
[12]葛金龙,秦英月,王传虎,等.SiO2微球的制备及药物溶出性能研究[J].化工新型材料,2014,42(2):53-55.
[13]桂万元,王文谦,焦翔宇,等.基于中空介孔二氧化硅小球的pH响应性控制释放系统[J].中国科学,2015,45(7):703-709.
[14]Li D,Shijun L,Hussam A K,et al.Controlled-access hollow mechanized silica nanocontainers[J].Journal of the American Chemical Society,2009,131(42):15136-15142.
[15]Luo X W,Archer L A,Yang Z C.Hollow micro-/nanostructures:synthesis and applications[J].Advanced Materials,2008,20(21):3987-4019.
[16]Yasutaka K,Yuki S,Kensei F,et al.Facile synthesis of yolkshell nanostructured photocatalyst with improved adsorption properties and molecular-sieving properties[J].Chem Cat Chem,2016,8(17):2781-2788.
[17]Jiao J,Wang H,Guo W,et al.In situ confined growth based on a self-templating reduction strategy of highly dispersed Ni nanoparticles in hierarchical yolk-shell Fe@SiO2structures as efficient catalysts[J].Chemistry-An Asian Journal,2016,11(24):3534-3540.
[18]Kuwahara Y,Sumida Y,Fujiwara K,et al.Facile synthesis of yolk-shell nanostructured photocatalyst with improved adsorption properties and molecular-sieving properties[J].Chem Cat Chem,2016,8(17):2781-2788.
[19]Chew T L,Ahmad A L,Bhatia S.Ordered mesoporous silica(OMS)as an adsorbent and membrane for separation of carbon dioxide(CO2)[J].Advances in Colloid&Interface Science,2010,153(1-2):43-57.
[20]邵艳秋,赵婷婷,付文婷,等.氨基改性SBA-15介孔材料的制备及对Pb(Ⅱ)的吸附性能研究[J].硅酸盐通报,2016,35(2):587-592.
[21]唐振平,唐海琼,刘迎九,等.疏水性MCM-41分子模板剂对水中U(Ⅵ)的吸附性能试验研究[J].硅酸盐通报,2017,36(6):1868-1874.
[22]李苗苗,宫玉梅,郭静,等.中空介孔二氧化硅锚固聚偕胺肟吸附Cr(Ⅵ)[J].高等学校化学学报,2017,38(1):159-164.
[23]Tsou C J,Hung Y,Mou C Y.Hollow mesoporous silica nanoparticles with tunable shell thickness and pore size distribution for application as broad-ranging pH nanosensor[J].Microporous&Mesoporous Materials,2014,190(190):181-188.
[24]Imhof A,Pine D J.Orderedmacroporous materialsbyemulsion templating[J].Nature,1997,389(6654):948-951.
[25]Botterhuis N E,Sun Q,Magusin P C,et al.Hollow silica spheres with an ordered pore structure and their application in controlled release studies[J].Chemistry,2006,12(5):1448-14456.
[26]Wu S H,Tseng C T,Lin Y S,et al.Catalytic nano-rattle of Au@hollow silica:towards a poison-resistant nanocatalyst[J].Journal of Materials Chemistry,2011,21(3):789-794.
[27]Liu J,Qiao S Z,Budi H S,et al.Monodisperse yolk-shell nanoparticles with a hierarchical porous structure for delivery vehicles and nanoreactors[J].Angewandte Chemie International Edtion,2010,49(29):4981-4985.
[28]Jin G W,Feng L,Hui J Z,et al.Silica hollow spheres with ordered and radially oriented amino-functionalized mesochannels[J].Chemistry of Materials,20009,21(4):612-620.
[29]Kruk M.Access to ultralarge-pore ordered mesoporous materials through selection of surfactant/swelling-agent micellar templates[J].Accounts of Chemical Research,2012,45(10):1678-1687.
[30]Zhu Y F,Shi J L,Chen H R,et al.A facile method to synthesize novel hollow mesoporous silica spheres and advanced storage property[J].Microporous and Mesoporous Materials,2005,84(2005):218-222.
[31]Wang S N,Zhang M C,Wang D,et al.Synthesis of hollow mesoporous silica microspheres through surface sol-gel process on polystyrene-co-poly(4-vinylpyridine)core-shell microspheres[J].Microporous and Mesoporous Materials,2011,139(1-3):1-7.
[32]张发谦,金效齐,张燕娜,等.N,N-二甲基甲酰胺对介孔二氧化硅空心球结构参数和形貌的影响[J].应用化工,2015,44(7):1180-1184.
[33]Jiao Y S,Chang A W,Zhi J L,et al.Heterogeneous organocatalysis at work:functionalization of hollow periodic mesoporous organosilica spheres with MacMillan catalyst[J].Chemistry-A European Journal,2011,17(22):6206-6213.
[34]Williamson P A,Blower P J,Green M A.Synthesis of porous hollow silica nanostructures using hydroxyapatite nanoparticle templates[J].Chemical Communications,2011,47(5):1568-1570.
[35]Liu W,Huang X B,Wei H,et al.Facile preparation of hollow crosslinked polyphosphazene submicrospheres with mesoporous shells[J].Journal of Materials Chemistry,2011,21(34):12964-12968.
[36]Fang X,Chen C,Liu Z,et al.A cationic surfactant assisted selective etching strategy to hollow mesoporous silica spheres[J].Nanoscale,2011,3(4):1632-1639.
[37]Loy D A,Shea K J.Bridged polysilsesquioxanes.highly porous hybrid organic-inorganic materials[J].Chemical Reviews,1995,95(5):1431-1442.
[38]Liu X,Jiao Z,Song T,et al.Surfactant-assisted selective etching strategy for generation of rattle-like mesoporous silica nanoparticles[J].Journal of Colloid&Interface Science,2017,490(2017):497-504.
[39]Tan L F,Liu T L,Li L L,et al.Uniform double-shelled silica hollow spheres:acid/base selective-etching synthesis and their drug delivery application[J].RSC Advances,2013,3(16):5649-5655.
[40]Cho Y S.Fabrication of hollow or macroporous silica particles by spray drying of colloidal dispersion[J].Journal of Dispersion Science&Technology,2015,37(1):23-33.