脊髓出血性损伤动物模型建立的研究进展
摘要
脊髓损伤是一种严重的神经系统损伤,其致残率和致死率较高,临床治疗起来难度较高,给家庭和社会带来沉重负担。目前国内外对脊髓出血性损伤建模的研究极少,为进一步认识脊髓损伤的发病机制,提高临床救治水平,有必要对脊髓损伤动物模型研究进行不断完善与发展。本文就脊髓损伤动物实验模型的研究进展予以回顾与展望。
引文
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[8]陈星月,陈栋,陈春慧,等.中国创伤性脊髓损伤流行病学和疾病经济负担的系统评价[J].中国循证医学杂志,2018,18(02):143-150.
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[11]Simon FH,Erhart P,Vcelar B,et al.Erythropoietin preconditioning improves clinical and histologic outcome in an acute spinal cord ischemia and reperfusion rabbit model[J].Journal of Vascular Surgery,2015,64(6):1797-1804.1804.
[12]金华,郭光琼,李江.脊柱缺血再灌注损伤模型的改进及对大鼠神经行为学的影响[J].中风与神经疾病杂志,2012,29(10):879-882.
[2]Emamhadi M,Soltani B,Babaei P,et al.Influence of sexuality in functional recovery after spinal cord injury in rats[J].ArchBone J Surg,2016,4(1):56-59.
[3]Vanden Berg ME,Castellote JM,Mahillo-Fernandez I,et al.Incidence of spinal cord injury worldwide:a systematic review[J].Neuroepidemiology,2010,34(3):184-192.
[4]汪红林,汪军玉,徐祝军.环扎法致大鼠脊髓损伤早期减压后caspase-3的表达及其与神经细胞凋亡相关性研究[J].中国矫形外科杂志,2012(4):358-362.
[5]Kwon BK,Streijger F,Hill CE,et al.Large animal and primate modelsof spinal cord injury for the testing of novel therapies[J].Experimental Neurology,2015(269):154-168.
[6]李敏,杨孝,向武,等.大鼠脊髓损伤动物模型建立的研究进展[J].世界最新医学信息文摘,2018,18(72):111-112.
[7]张军,陈晓,张荣佳,等.脊髓损伤动物模型的研究进展[J].中华全科医学,2017,15(03):501-504.
[8]陈星月,陈栋,陈春慧,等.中国创伤性脊髓损伤流行病学和疾病经济负担的系统评价[J].中国循证医学杂志,2018,18(02):143-150.
[9]Cheriyan T,Ryan DJ,Weinreb JH,et al.Spinal cord injury models:areview[J].Spinal Cord,2014,52(8):588-595.
[10]秦慧慧,王文春,葛杜鹃,等.改良钳夹型脊髓损伤大鼠模型的建立及神经功能评价[J].西南军医,2014,16(1):1-4.
[11]Simon FH,Erhart P,Vcelar B,et al.Erythropoietin preconditioning improves clinical and histologic outcome in an acute spinal cord ischemia and reperfusion rabbit model[J].Journal of Vascular Surgery,2015,64(6):1797-1804.1804.
[12]金华,郭光琼,李江.脊柱缺血再灌注损伤模型的改进及对大鼠神经行为学的影响[J].中风与神经疾病杂志,2012,29(10):879-882.