Diterpenoids from the aerial parts of Leonurus macranthus
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摘要
Four new diterpenoids including one cis clerodane-type(1) and three highly oxygenated labdane-type diterpenes(2–4) were isolated from the aerial parts of Leonurus macranthus. Their structures were elucidated on the basis of spectroscopic data(NMR, UV, IR, and MS). Compound 1 represents the first example of cis clerodane-type diterpene in the plants of Leonurus genus. Compounds 1 and 4 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC_(50) values of 35.8 ± 3.6 mmol/L and 48.6 ± 4.8 mmol/L, respectively
Four new diterpenoids including one cis clerodane-type(1) and three highly oxygenated labdane-type diterpenes(2–4) were isolated from the aerial parts of Leonurus macranthus. Their structures were elucidated on the basis of spectroscopic data(NMR, UV, IR, and MS). Compound 1 represents the first example of cis clerodane-type diterpene in the plants of Leonurus genus. Compounds 1 and 4 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC_(50) values of 35.8 ± 3.6 mmol/L and 48.6 ± 4.8 mmol/L, respectively
Four new diterpenoids including one cis clerodane-type(1) and three highly oxygenated labdane-type diterpenes(2–4) were isolated from the aerial parts of Leonurus macranthus. Their structures were elucidated on the basis of spectroscopic data(NMR, UV, IR, and MS). Compound 1 represents the first example of cis clerodane-type diterpene in the plants of Leonurus genus. Compounds 1 and 4 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC_(50) values of 35.8 ± 3.6 mmol/L and 48.6 ± 4.8 mmol/L, respectively
引文
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[5]H.Li,M.M.Li,X.Q.Su,et al.,J.Nat.Prod.77(2014)1047-1053.
[6]J.Li,K.W.Zeng,S.P.Shi,et al.,Fitoterapia 83(2012)896-900.
[7]K.W.Zeng,J.Li,X.Dong,et al.,Toxicol.Appl.Pharmacol.273(2013)159-171.
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[9]H.D.Sun,Natural Product Chemistry-Diterpene Chemistry,Chemical Industry Press,Beijing,2012.
[10]Z.K.Liu,D.R.Wu,Y.M.Shi,et al.,Chin.Chem.Lett.25(2014)677-679.
[11]H.Wu,J.Li,F.R.Fronczek,et al.,Phytochemistry 91(2013)229-235.