正常SD大鼠心电图Ⅱ导联参考值范围
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摘要
目的建立正常大鼠心电图Ⅱ导联参考值范围。方法应用SP2006心电图分析系统测得正常SD大鼠心脏电活动各个指标,并以IBM SPSS Statistics V22.0软件进行统计描述,获得参考值范围。结果雄性与雌性大鼠心率比较差异无统计学意义,但心电图P波、R波、QRS波持续时间、QT间期等差异有统计学意义(P<0.05),这较好地反映人类心血管疾病发病率的男女差异在心电图上的表现。结论已建立正常SD大鼠雄性、雌性与总体的心率与心电图Ⅱ导联各个参考值范围。
Objective Establishing ECG leadⅡreference values of normal rats. Methods Detection of cardiac electrical activity in normal SD rats by SP2006 ECG analysis system, And use IBM SPSS Statistics V22.0 software for statistical description, get the reference range. Results There was no significant difference in heart rate between male and female rats, but the difference of P wave, R wave, QRS duration and QT interval of ECG was statistically significant(P<0.05), which better reflected the difference between men and women in the incidence of cardiovascular disease in humans. Performance on the ECG. Conclusion The reference range of male, female and total heart rate and ECG II leads in normal SD rats has been established.
Objective Establishing ECG leadⅡreference values of normal rats. Methods Detection of cardiac electrical activity in normal SD rats by SP2006 ECG analysis system, And use IBM SPSS Statistics V22.0 software for statistical description, get the reference range. Results There was no significant difference in heart rate between male and female rats, but the difference of P wave, R wave, QRS duration and QT interval of ECG was statistically significant(P<0.05), which better reflected the difference between men and women in the incidence of cardiovascular disease in humans. Performance on the ECG. Conclusion The reference range of male, female and total heart rate and ECG II leads in normal SD rats has been established.
引文
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[12] Markandeya YS, Feng L, Best JM, et al. Loss of Caveolin-3 Results in QtC Prolongation and Causes Delayed Cardiac Repolarization in a Cardiac-Specific Conditional CAV-3 Knockout Mouse Model[J]. Biophysical Journal, 2013,104(2):209a-209a.
[13]心脏病预后与存活率的性别差异[J].基础医学与临床,2014,34(3):338.
[14] Soltysinska E, Thomsen M B. Torsades de Pointes in the Guinea-Pig Heart[J]. Cardiovascular Drugs&Therapy, 2012,26(6):437-439.
[15] Ducroq J. Sensitivity and Specificity of the In Vitro Guinea Pig Papillary Muscle Action Potential Duration for the Assessment of Drug-Induced Torsades De Pointes Liability in Humans[J]. Handb Exp Pharmacol, 2015,229:205-219.
[16] Franconi F, Campesi I, Occhioni S, et al. Sex-gender differences in diabetes vascular complications and treatment[J]. Endocrine Metabolic&Immune Disorders Drug Targets, 2012,12(2):179-196.
[17] Bai CX, Kurokawa J, Tamagawa M, et al. Nontranscriptional Regulation of Cardiac Repolarization Currents by Testosterone[J]. Circulation, 2005,112(12):1701-1710.
[2]姚震,陈林.我国心血管疾病现状与展望[J].海南医学,2013,24(13):1873-1876.
[3]陈金堂,张静,周昆,等.六种全身麻醉药对豚鼠心电图的影响[J].实验动物科学,2010,27(6):23-25,54.
[4]刘明波,刘韫宁,王文,等.2004-2011年中国人群心血管病死亡的性别差异分析[J].中国慢性病预防与控制,2014,22(3):267-269.
[5]沈洁.城市人群期望寿命趋势及影响因素研究[D].复旦大学,2013.
[6]吴杰,Jan A.Kors,Peter R, et al..中国人群心电图时间参数的年龄和性别差异[J].中华心血管病杂志,2001(10):45-48.
[7] Maas AHEM, Appelman YEA. Gender differences in coronary heart disease[J]. Netherlands Heart Journal,2010,18(12):598-603.
[8]那开完,余平,张桂云.冠心病危险因素的性别差异[J].中国临床医生,2009,37(11):3-7.
[9] Lehmann MH, Hardy S, Archibald D, et al. Sex difference in risk of torsade de pointes with d,l-sotalol[J]. Circulation, 1996,94(10):2535.
[10] Marco Stramba-Badiale M, Diego Spagnolo M, Giuliano Bosi M, et al. Are gender differences in QTc present at birth?[J]. American Journal of Cardiology,2016,75(17):1278-1281.
[11]张良根,潘海英.阵发性室上性心动过速不同折返类型的基础心脏病、年龄和性别差异[J].社区医学杂志,2014,12(12):79-81.
[12] Markandeya YS, Feng L, Best JM, et al. Loss of Caveolin-3 Results in QtC Prolongation and Causes Delayed Cardiac Repolarization in a Cardiac-Specific Conditional CAV-3 Knockout Mouse Model[J]. Biophysical Journal, 2013,104(2):209a-209a.
[13]心脏病预后与存活率的性别差异[J].基础医学与临床,2014,34(3):338.
[14] Soltysinska E, Thomsen M B. Torsades de Pointes in the Guinea-Pig Heart[J]. Cardiovascular Drugs&Therapy, 2012,26(6):437-439.
[15] Ducroq J. Sensitivity and Specificity of the In Vitro Guinea Pig Papillary Muscle Action Potential Duration for the Assessment of Drug-Induced Torsades De Pointes Liability in Humans[J]. Handb Exp Pharmacol, 2015,229:205-219.
[16] Franconi F, Campesi I, Occhioni S, et al. Sex-gender differences in diabetes vascular complications and treatment[J]. Endocrine Metabolic&Immune Disorders Drug Targets, 2012,12(2):179-196.
[17] Bai CX, Kurokawa J, Tamagawa M, et al. Nontranscriptional Regulation of Cardiac Repolarization Currents by Testosterone[J]. Circulation, 2005,112(12):1701-1710.