摘要
目的探讨PIAS3在胃癌(GC)组织中的表达及其与临床病理及预后的关系。方法选取2006年1月~2008年5月于我院确诊的112例GC患者的癌组织和配对癌旁正常胃黏膜组织分别作为研究组和对照组。采用免疫组化染色法检测PIAS3在GC组织和癌旁正常胃黏膜组织的表达水平,并分析PIAS3蛋白在GC组织表达水平与患者各临床病理学特征及预后的关系。结果 PIAS3蛋白在GC组织中的水平低于癌旁正常胃黏膜组织,差异具有统计学意义(P<0.05);不同性别、年龄、肿瘤大小、肿瘤部位、Lauren分型的GC患者组织中PIAS3蛋白水平比较差异无统计学意义(P>0.05);肿瘤浸润程度、淋巴结转移不同的GC患者组织中PIAS3蛋白水平比较差异无统计学意义(P<0.05);PIAS3水平不同的GC患者生存曲线比较差异无统计学意义(P<0.05);PIAS3低表达的GC患者死亡风险高于高表达患者(P<0.05)。结论 PIAS3蛋白在GC组织中呈低表达,其水平与肿瘤浸润、淋巴结转移及GC预后相关。
Objective To investigate the correlation of PIAS3 expression level with clinicopathological features and prognosisin gastric cancer(GC) patients. Methods The cancer tissues(study group) and adjacent normal tissues(control group) of 112 patients with GC diagnosed in our hospital from January 2006 to May 2008 were selected. Then the expression levels of PIAS3 in both groups were detected by immunohistochemical staining, and its correlation with clinicopathological features and prognosis was also analyzed. Results The high expression rate of PIAS3 in the study group was lower than that of the control group(P<0.05). The expression level of PIAS3 was not correlated with gender, age, tumor size, tumor location and Lauren classification(P>0.05), while was correlated with tumor invasion degrees and lymph node metastasis(P<0.05). The survival curves of GC patients with different PIAS3 expression was significantly different(P<0.05). The mortality risk was significantly higher in patients with low PIAS3 expression than in patients with high PIAS3 expression(P<0.05).Conclusion The expression level of PIAS3 protein in GC tissues is relatively low, which is correlated with tumor invasion, lymph node metastasis and prognosis.
引文
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