以PGC-1α为靶点的天然药物研究进展
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摘要
依据药物结构,将PGC-1α为靶点的天然药物分为生物碱类、酚类、黄酮类、多糖类、萜类、糖苷类等,并总结促进PGC-1α转录活性的40种天然药物的研究进展,为研究天然药物对PGC-1α的药理作用机制及开发提供新的思路。
According to the classification of structure, this article reviewed the research progress of 40 PGC-1α activators from natural products, including alkaloid, phenylpropanoid, flavonoid, phenol, saponin. It provides new ideas for the pharmacological effects and mechanisms of natural products on PGC-1α and the development of new drugs.
According to the classification of structure, this article reviewed the research progress of 40 PGC-1α activators from natural products, including alkaloid, phenylpropanoid, flavonoid, phenol, saponin. It provides new ideas for the pharmacological effects and mechanisms of natural products on PGC-1α and the development of new drugs.
引文
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[2] Aatsinki S M,Buler M,Salom ki H,et al. Metformin induces PGC-1 expression and selectively affects hepatic PGC-1 functions[J].Br J Pharmacol,2014,171(9):2351-2363.
[3] Festuccia W T, Blanchard P G, Oliveira T B, et al.PPAR activation attenuates cold-induced upregulation of thyroid status and brown adipose tissue PGC-1 and D2[J].Am J Physiol Regul Integr Comp Physiol,2012,303(12):R1277-R1285.
[4] Li S,Yu Q,Wang G X,Lin J D. The biological clock is regulated by adrenergic signaling in brown fat but is dispensable for cold-induced thermogenesis[J].2013,PLOS One,8(8):e70109.
[5] Koka S,Aluri H S,Xi L,et al. Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts:potential role of NO/SIRT1/PGC-1αsignaling[J].Am J Physiol Heart Circ Physiol,2014,306(11):H1558-H1568.
[6] Lai L,Wang M,Martin O J,et al. A role for peroxisome proliferator-activated receptor coactivator 1(PGC-1)in the regulation of cardiac mitochondrial phospholipid biosynthesis[J].J Biol Chem,2014,289(4):2250-2259.
[7] Li Q,Qiu Y,Mao M,et al. Antioxidant mechanism of Rutin on hypoxia-induced pulmonary arterial cell proliferation[J].Molecules,2014,19(11):19036-19049.
[8] Handschin C,Spiegelman B M. Peroxisome proliferatoractivated receptor gamma coactivator 1 coactivators,energy hemeostasis, and metabolism[J].Endocr Rev,2006,27(7):728-735.
[9] Ham P B, 3rd, Raju R. Mitochondrial function in hypoxic ischemic injury and influence of aging[J].Prog Neurobiol,2016(157):92-116.
[10] Hu J,Lang Y,Cao Y,et al. The Neuroprotective Effect of Tetramethylpyrazine Against Contusive Spinal Cord Injury by Activating PGC-1alpha in Rats[J].Neurochem Res,2015,40(7):1393-1401.
[11] Xu Q,Xia P,Li X,et al. Tetramethylpyrazine ameliorates high glucose-induced endothelial dysfunction by increasing mitochondrial biogenesis[J].PLOS One,2014,9(2):e88243.
[12] Zhang Z, Zhang H, Li B, et al. Berberine activates thermogenesis in white and brown adipose tissue[J].Nat Commun,2015,5(5):5493.
[13] Luo Z D,Ma L Q,Zhao Z G,et al. TRPV1 activation improves exercise endurance and energy metabolism through PGC-1 alpha upregulation in mice[J].Cell Research,2012,22(3):551-564.
[14] Kang J H,Goto T,Han I S,et al. Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet[J].Obesity(Silver Spring),2010,18(4):780-787.
[15] Yang W, Huang L, Gao J, et al. Betaine attenuates chronic alcoholinduced fatty liver by broadly regulating hepatic lipid metabolism[J].Mol Med Rep,2017,16(4):5225-5234.
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[17] Takanche J S, Lee Y H, Kim J S, et al. Anti-inflammatory and antioxidant properties of Schisandrin C promote mitochondrial biogenesis in human dental pulp cells[J].Int Endod J,2017,51(4):438-447.
[18] Wu R M,Sun Y Y,Zhou T T,et al. Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways[J].Acta Pharmacol Sin,2014,35(10):1274-1284.
[19] Zhang J, Song J, Wu D, et al. Hesperetin induces the apoptosis of hepatocellular carcinoma cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species,ATP and calcium[J].Med Oncol,2015,32(4):101.
[20] Ma H, Feng X, Ding S et al. Hesperetin attenuates ventilator-induced acute lung injury through inhibition of NF-kappaB-mediated inflammation[J].Eur J Pharmacol,2015(769):333-341.
[21] Hwang S L,Lin J A,Shih P H, et al. Pro-cellular survival and neurop rotection of citrus flavonoid:the actions of hesperetin in PC12 cells[J].Food&Function,2012,3(10):1082-1090.
[22] Xu X, Zheng N, Chen Z, et al. Puerarin, isolated from Pueraria lobata(Willd.),protects against diabetic nephropathy by attenuating oxidative stress[J].Gene,2016,591(2):411-416.
[23] Sharma D R, Sunkaria A, Wani W Y, et al.Quercetin protects against aluminium induced oxidative stress and promotes mitochondrial biogenesis via activation of the PGC-1alpha signaling pathway[J].Neurotoxicology,2015(51):116-137.
[24] Liu P,Zou D,Yi L,et al. Quercetin ameliorates hypobaric hypoxia-induced memory impairment through mitochondrial and neuron function adaptation via the PGC-1 alpha pathway[J].Restorative Neurology and Neuroscience,2015,33(2):143-157.
[25] Su K Y, Yu C Y, Chen Y W, et al. Rutin, a flavonoid and principal component of saussurea involucrata,attenuates physical fatigue in a forced swimming mouse model[J].Int J Med Sci,2014,11(5):528-537.
[26] Seo S, Lee M S, Chang E, et al. Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats[J].Nutrients,2015,7(9):8152-8169.
[27] Fang P,Yu M,Zhang L,et al. Baicalin against obesity and insulin resistance through activation of AKT/AS160/GLUT4 pathway[J].Mol Cell Endocrinol,2017(448):77-86.
[28] Zhang K, Lu J, Mori T, et al. Baicalin increases VEGF expression and angiogenesis by activating the ERR{alpha}/PGC-1{alpha}pathway[J].Cardiovasc Res,2011,89(2):426-435.
[29] Ding L,Liang X G,Zhu D Y,et al. Icariin promotes expression of PGC-1 alpha,PPAR alpha,and NRF-1during cardiomyocyte differentiation of murine embryonic stem cells in vitro[J].Acta Pharmacologica Sinica,2007,28(10):1541-1549.
[30] Zhu H R,Wang Z Y,Zhu X L, et al. Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke[J].Neuropharmacology,2010,59(1/2):70-76.
[31] Suh K S,Chon S,Choi E M,et al. Luteolin alleviates methylglyoxal-induced cytotoxicity in osteoblastic MC3T3-E1 cells[J].Cytotechnology,2016,68(6):2539-2552.
[32] Jang Y J,Son H J,Choi Y M,et al. Apigenin enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7[J].Oncotarget,2017,8(45):78300-78311.
[33] Palacios-Gonzalez B,Zarain-Herzberg A,Flores-Galicia I,et al. Genistein stimulates fatty acid oxidation in a leptin receptor-independent manner through the JAK2-mediated phosphorylation and activation of AMPK in skeletal muscle[J].Biochimica Et Biophysica ActaMolecular and Cell Biology of Lipids,2014,1841(1):132-140.
[34] Lagouge M, Argmann C, Gerhart-Hines Z, et al.Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha[J].Cell,2006,127(6):1109-1122.
[35] Ljubicic V,Burt M,Lunde J A,et al. Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1alpha axis[J].Am J Physiol Cell Physiol,2014,307(1):66-82.
[36] Zhang M, Tang J, Li Y, et al. Curcumin attenuates skeletal muscle mitochondrial impairment in COPD rats:PGC-1alpha/SIRT3 pathway involved[J].Chem Biol Interact,2017(277):168-175.
[37] Zhai X,Qiao H,Guan W,et al. Curcumin regulates peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression by AMPK pathway in hepatic stellate cells in vitro[J].Eur J Pharmacol,2015(746):56-62.
[38] Li Y,Tran V H,Kota B P,et al. Preventative effect of Zingiber officinale on insulin resistance in a high-fat high-carbohydrate diet-fed rat model and its mechanism of action[J].Basic Clin Pharmacol Toxicol,2014,115(2):209-215.
[39] Feng Z, Bai L, Yan J, et al. Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction:regulatory effects of hydroxytyrosol[J].Free Radic Biol Med,2011,50(10):1437-1446.
[40] Signorile A,Micelli L,De Rasmo D,et al. Regulation of the biogenesis of OXPHOS complexes in cell transition from replicating to quiescent state:involvement of PKA and effect of hydroxytyrosol[J].Biochim Biophys Acta,2014,1843(4):675-684.
[41] Yan Y, Yang X, Zhao T, et al. Salicylates promote mitochondrial biogenesis by regulating the expression of PGC-1alpha in murine 3T3-L1 pre-adipocytes[J].Biochem Biophys Res Commun,2017,491(2):436-441.
[42] Matsukawa T, Motojima H, Sato Y, et al. Upregulation of skeletal muscle PGC-1alpha through the elevation of cyclic AMP levels by Cyanidin-3-glucoside enhances exercise performance[J].Sci Rep,2017(7):44799.
[43]杨金玲,高丽丽,朱平.人参皂苷生物合成研究进展[J].药学学报,2013,48(2):170-178.
[44]王巍,苏光悦,胡婉琦,等.近10年人参皂苷对心血管疾病的药理作用研究进展[J].中草药,2016,47(20):3736-3741.
[45] Wang X,Liu R,Zhang W,et al. Oleanolic acid improves hepatic insulin resistance via antioxidant, hypolipidemic and anti-inflammatory effects[J].Mol Cell Endocrinol,2013,376(1/2):70-80.
[46] Mu Q Q, Fang X, Li X K, et al. Ginsenoside Rb1promotes browning through regulation of PPAR gamma in 3T3-L1 adipocytes[J].Biochemical and Biophysical Research Communications,2015,466(3):530-535.
[47] Wei S N,Li W,Yu Y,et al. Ginsenoside Compound K suppresses the hepatic gluconeogenesis via activating adenosine-5’ monophosphate kinase:A study in vitro and in vivo[J].Life Sciences,2015(139):8-15.
[48] Sun M, Huang C, Wang C, et al. Ginsenoside Rg3improves cardiac mitochondrial population quality:mimetic exercise training[J].Biochem Biophys Res Commun,2013,441(1):169-174.
[49]邬丹丹,张素萍,杨育红,等.人参皂苷Rg1对异丙肾上腺素致乳鼠心肌细胞肥大及过氧化物酶体增殖活化受体γ辅助活化因子1α的影响[J].中药药理与临床,2014,30(6):29-32.
[50]王辉,高航.人参皂苷Rg1通过调控PGC-1α抑制异丙肾上腺素诱导大鼠心肌细胞肥大[J].中药药理与临床,2015,31(3):55-59.
[51] Zhang S, Tang F, Yang Y, et al. Astragaloside IV protects against isoproterenol-induced cardiac hypertrophy by regulating NF-kappaB/PGC-1alpha signaling mediated energy biosynthesis[J].PLOS One,2015,10(3):e0118759.
[52] Lu Y,Li S,Wu H,et al. Beneficial effects of astragaloside IV against angiotensin II-induced mitochondrial dysfunction in rat vascular smooth muscle cells[J].Int J Mol Med,2015,36(5):1223-1232.
[53] Chen J H,Wong H S,Leong P K, et al. Ursolic acid induces mitochondrial biogenesis through the activation of AMPK and PGC-1 in C2C12 myotubes:a possible mechanism underlying its beneficial effect on exercise endurance[J].Food&Function,2017,8(7):2425-2436.
[54] Hou S,Zhang T,Li Y,et al. Glycyrrhizic Acid Prevents Diabetic Nephropathy by Activating AMPK/SIRT1/PGC-1alpha Signaling in db/db Mice[J].J Diabetes Res,2017(2017):2865912.
[55] Zhang Y,Chen L,Li F,et al. Cryptotanshinone protects against adriamycin-induced mitochondrial dysfunction in cardiomyocytes[J].Pharm Biol,2016,54(2):237-242.
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[65] Gu C,Zeng Y,Tang Z,et al. Astragalus polysaccharides affect insulin resistance by regulating the hepatic SIRT1-PGC-1alpha/PPARalpha-FGF21 signaling pathway in male Sprague Dawley rats undergoing catch-up growth[J].Mol Med Rep,2015,12(5):6451-6460.
[2] Aatsinki S M,Buler M,Salom ki H,et al. Metformin induces PGC-1 expression and selectively affects hepatic PGC-1 functions[J].Br J Pharmacol,2014,171(9):2351-2363.
[3] Festuccia W T, Blanchard P G, Oliveira T B, et al.PPAR activation attenuates cold-induced upregulation of thyroid status and brown adipose tissue PGC-1 and D2[J].Am J Physiol Regul Integr Comp Physiol,2012,303(12):R1277-R1285.
[4] Li S,Yu Q,Wang G X,Lin J D. The biological clock is regulated by adrenergic signaling in brown fat but is dispensable for cold-induced thermogenesis[J].2013,PLOS One,8(8):e70109.
[5] Koka S,Aluri H S,Xi L,et al. Chronic inhibition of phosphodiesterase 5 with tadalafil attenuates mitochondrial dysfunction in type 2 diabetic hearts:potential role of NO/SIRT1/PGC-1αsignaling[J].Am J Physiol Heart Circ Physiol,2014,306(11):H1558-H1568.
[6] Lai L,Wang M,Martin O J,et al. A role for peroxisome proliferator-activated receptor coactivator 1(PGC-1)in the regulation of cardiac mitochondrial phospholipid biosynthesis[J].J Biol Chem,2014,289(4):2250-2259.
[7] Li Q,Qiu Y,Mao M,et al. Antioxidant mechanism of Rutin on hypoxia-induced pulmonary arterial cell proliferation[J].Molecules,2014,19(11):19036-19049.
[8] Handschin C,Spiegelman B M. Peroxisome proliferatoractivated receptor gamma coactivator 1 coactivators,energy hemeostasis, and metabolism[J].Endocr Rev,2006,27(7):728-735.
[9] Ham P B, 3rd, Raju R. Mitochondrial function in hypoxic ischemic injury and influence of aging[J].Prog Neurobiol,2016(157):92-116.
[10] Hu J,Lang Y,Cao Y,et al. The Neuroprotective Effect of Tetramethylpyrazine Against Contusive Spinal Cord Injury by Activating PGC-1alpha in Rats[J].Neurochem Res,2015,40(7):1393-1401.
[11] Xu Q,Xia P,Li X,et al. Tetramethylpyrazine ameliorates high glucose-induced endothelial dysfunction by increasing mitochondrial biogenesis[J].PLOS One,2014,9(2):e88243.
[12] Zhang Z, Zhang H, Li B, et al. Berberine activates thermogenesis in white and brown adipose tissue[J].Nat Commun,2015,5(5):5493.
[13] Luo Z D,Ma L Q,Zhao Z G,et al. TRPV1 activation improves exercise endurance and energy metabolism through PGC-1 alpha upregulation in mice[J].Cell Research,2012,22(3):551-564.
[14] Kang J H,Goto T,Han I S,et al. Dietary capsaicin reduces obesity-induced insulin resistance and hepatic steatosis in obese mice fed a high-fat diet[J].Obesity(Silver Spring),2010,18(4):780-787.
[15] Yang W, Huang L, Gao J, et al. Betaine attenuates chronic alcoholinduced fatty liver by broadly regulating hepatic lipid metabolism[J].Mol Med Rep,2017,16(4):5225-5234.
[16] Yu X, Zhang L, Yang X, et al. Salvianolic acid A protects the peripheral nerve function in diabetic rats through regulation of the AMPK-PGC1alpha-Sirt3 axis[J].Molecules,2012,17(9):11216-11228.
[17] Takanche J S, Lee Y H, Kim J S, et al. Anti-inflammatory and antioxidant properties of Schisandrin C promote mitochondrial biogenesis in human dental pulp cells[J].Int Endod J,2017,51(4):438-447.
[18] Wu R M,Sun Y Y,Zhou T T,et al. Arctigenin enhances swimming endurance of sedentary rats partially by regulation of antioxidant pathways[J].Acta Pharmacol Sin,2014,35(10):1274-1284.
[19] Zhang J, Song J, Wu D, et al. Hesperetin induces the apoptosis of hepatocellular carcinoma cells via mitochondrial pathway mediated by the increased intracellular reactive oxygen species,ATP and calcium[J].Med Oncol,2015,32(4):101.
[20] Ma H, Feng X, Ding S et al. Hesperetin attenuates ventilator-induced acute lung injury through inhibition of NF-kappaB-mediated inflammation[J].Eur J Pharmacol,2015(769):333-341.
[21] Hwang S L,Lin J A,Shih P H, et al. Pro-cellular survival and neurop rotection of citrus flavonoid:the actions of hesperetin in PC12 cells[J].Food&Function,2012,3(10):1082-1090.
[22] Xu X, Zheng N, Chen Z, et al. Puerarin, isolated from Pueraria lobata(Willd.),protects against diabetic nephropathy by attenuating oxidative stress[J].Gene,2016,591(2):411-416.
[23] Sharma D R, Sunkaria A, Wani W Y, et al.Quercetin protects against aluminium induced oxidative stress and promotes mitochondrial biogenesis via activation of the PGC-1alpha signaling pathway[J].Neurotoxicology,2015(51):116-137.
[24] Liu P,Zou D,Yi L,et al. Quercetin ameliorates hypobaric hypoxia-induced memory impairment through mitochondrial and neuron function adaptation via the PGC-1 alpha pathway[J].Restorative Neurology and Neuroscience,2015,33(2):143-157.
[25] Su K Y, Yu C Y, Chen Y W, et al. Rutin, a flavonoid and principal component of saussurea involucrata,attenuates physical fatigue in a forced swimming mouse model[J].Int J Med Sci,2014,11(5):528-537.
[26] Seo S, Lee M S, Chang E, et al. Rutin Increases Muscle Mitochondrial Biogenesis with AMPK Activation in High-Fat Diet-Induced Obese Rats[J].Nutrients,2015,7(9):8152-8169.
[27] Fang P,Yu M,Zhang L,et al. Baicalin against obesity and insulin resistance through activation of AKT/AS160/GLUT4 pathway[J].Mol Cell Endocrinol,2017(448):77-86.
[28] Zhang K, Lu J, Mori T, et al. Baicalin increases VEGF expression and angiogenesis by activating the ERR{alpha}/PGC-1{alpha}pathway[J].Cardiovasc Res,2011,89(2):426-435.
[29] Ding L,Liang X G,Zhu D Y,et al. Icariin promotes expression of PGC-1 alpha,PPAR alpha,and NRF-1during cardiomyocyte differentiation of murine embryonic stem cells in vitro[J].Acta Pharmacologica Sinica,2007,28(10):1541-1549.
[30] Zhu H R,Wang Z Y,Zhu X L, et al. Icariin protects against brain injury by enhancing SIRT1-dependent PGC-1alpha expression in experimental stroke[J].Neuropharmacology,2010,59(1/2):70-76.
[31] Suh K S,Chon S,Choi E M,et al. Luteolin alleviates methylglyoxal-induced cytotoxicity in osteoblastic MC3T3-E1 cells[J].Cytotechnology,2016,68(6):2539-2552.
[32] Jang Y J,Son H J,Choi Y M,et al. Apigenin enhances skeletal muscle hypertrophy and myoblast differentiation by regulating Prmt7[J].Oncotarget,2017,8(45):78300-78311.
[33] Palacios-Gonzalez B,Zarain-Herzberg A,Flores-Galicia I,et al. Genistein stimulates fatty acid oxidation in a leptin receptor-independent manner through the JAK2-mediated phosphorylation and activation of AMPK in skeletal muscle[J].Biochimica Et Biophysica ActaMolecular and Cell Biology of Lipids,2014,1841(1):132-140.
[34] Lagouge M, Argmann C, Gerhart-Hines Z, et al.Resveratrol improves mitochondrial function and protects against metabolic disease by activating SIRT1 and PGC-1alpha[J].Cell,2006,127(6):1109-1122.
[35] Ljubicic V,Burt M,Lunde J A,et al. Resveratrol induces expression of the slow, oxidative phenotype in mdx mouse muscle together with enhanced activity of the SIRT1-PGC-1alpha axis[J].Am J Physiol Cell Physiol,2014,307(1):66-82.
[36] Zhang M, Tang J, Li Y, et al. Curcumin attenuates skeletal muscle mitochondrial impairment in COPD rats:PGC-1alpha/SIRT3 pathway involved[J].Chem Biol Interact,2017(277):168-175.
[37] Zhai X,Qiao H,Guan W,et al. Curcumin regulates peroxisome proliferator-activated receptor-gamma coactivator-1alpha expression by AMPK pathway in hepatic stellate cells in vitro[J].Eur J Pharmacol,2015(746):56-62.
[38] Li Y,Tran V H,Kota B P,et al. Preventative effect of Zingiber officinale on insulin resistance in a high-fat high-carbohydrate diet-fed rat model and its mechanism of action[J].Basic Clin Pharmacol Toxicol,2014,115(2):209-215.
[39] Feng Z, Bai L, Yan J, et al. Mitochondrial dynamic remodeling in strenuous exercise-induced muscle and mitochondrial dysfunction:regulatory effects of hydroxytyrosol[J].Free Radic Biol Med,2011,50(10):1437-1446.
[40] Signorile A,Micelli L,De Rasmo D,et al. Regulation of the biogenesis of OXPHOS complexes in cell transition from replicating to quiescent state:involvement of PKA and effect of hydroxytyrosol[J].Biochim Biophys Acta,2014,1843(4):675-684.
[41] Yan Y, Yang X, Zhao T, et al. Salicylates promote mitochondrial biogenesis by regulating the expression of PGC-1alpha in murine 3T3-L1 pre-adipocytes[J].Biochem Biophys Res Commun,2017,491(2):436-441.
[42] Matsukawa T, Motojima H, Sato Y, et al. Upregulation of skeletal muscle PGC-1alpha through the elevation of cyclic AMP levels by Cyanidin-3-glucoside enhances exercise performance[J].Sci Rep,2017(7):44799.
[43]杨金玲,高丽丽,朱平.人参皂苷生物合成研究进展[J].药学学报,2013,48(2):170-178.
[44]王巍,苏光悦,胡婉琦,等.近10年人参皂苷对心血管疾病的药理作用研究进展[J].中草药,2016,47(20):3736-3741.
[45] Wang X,Liu R,Zhang W,et al. Oleanolic acid improves hepatic insulin resistance via antioxidant, hypolipidemic and anti-inflammatory effects[J].Mol Cell Endocrinol,2013,376(1/2):70-80.
[46] Mu Q Q, Fang X, Li X K, et al. Ginsenoside Rb1promotes browning through regulation of PPAR gamma in 3T3-L1 adipocytes[J].Biochemical and Biophysical Research Communications,2015,466(3):530-535.
[47] Wei S N,Li W,Yu Y,et al. Ginsenoside Compound K suppresses the hepatic gluconeogenesis via activating adenosine-5’ monophosphate kinase:A study in vitro and in vivo[J].Life Sciences,2015(139):8-15.
[48] Sun M, Huang C, Wang C, et al. Ginsenoside Rg3improves cardiac mitochondrial population quality:mimetic exercise training[J].Biochem Biophys Res Commun,2013,441(1):169-174.
[49]邬丹丹,张素萍,杨育红,等.人参皂苷Rg1对异丙肾上腺素致乳鼠心肌细胞肥大及过氧化物酶体增殖活化受体γ辅助活化因子1α的影响[J].中药药理与临床,2014,30(6):29-32.
[50]王辉,高航.人参皂苷Rg1通过调控PGC-1α抑制异丙肾上腺素诱导大鼠心肌细胞肥大[J].中药药理与临床,2015,31(3):55-59.
[51] Zhang S, Tang F, Yang Y, et al. Astragaloside IV protects against isoproterenol-induced cardiac hypertrophy by regulating NF-kappaB/PGC-1alpha signaling mediated energy biosynthesis[J].PLOS One,2015,10(3):e0118759.
[52] Lu Y,Li S,Wu H,et al. Beneficial effects of astragaloside IV against angiotensin II-induced mitochondrial dysfunction in rat vascular smooth muscle cells[J].Int J Mol Med,2015,36(5):1223-1232.
[53] Chen J H,Wong H S,Leong P K, et al. Ursolic acid induces mitochondrial biogenesis through the activation of AMPK and PGC-1 in C2C12 myotubes:a possible mechanism underlying its beneficial effect on exercise endurance[J].Food&Function,2017,8(7):2425-2436.
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