Nutritional status as a predictor of hospitalization in inflammatory bowel disease:A review
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摘要
BACKGROUND Inflammatory bowel disease(IBD) presents an inflammatory picture that in the long run can lead to complications and consequently more hospitalizations compared to other diseases.AIM To evaluate the influence of nutritional status on the occurrence of IBD-related hospitalization.METHODS This integrative review was conducted in the online databases PubMed and MEDLINE, using the terms "obesity" and "malnutrition" accompanied by"hospitalization", each combined with "Crohn's disease" or "ulcerative colitis".Only studies conducted with humans, adults, and published in English or Spanish were selected, and those that were not directly associated with nutritional status and hospitalization were excluded from this review. The Preferred Reporting Items for Systematic Reviews and Meta-Analyzes guide was used as the basis for selection of studies.RESULTS Of the 80 studies identified, only five met the proposal of this review. None evaluated the association of good nutritional status with the risk of hospitalization. Malnutrition had a strong correlation with the risk of hospitalization related to IBD, and there was disagreement among three studies regarding the association of obesity and hospitalization rates.CONCLUSION Few studies have evaluated nutritional status as a predictor of IBD-related hospitalization. The presence of malnutrition appears to be associated with hospitalization in these patients, but further studies are needed to elucidate the issue.
BACKGROUND Inflammatory bowel disease(IBD) presents an inflammatory picture that in the long run can lead to complications and consequently more hospitalizations compared to other diseases.AIM To evaluate the influence of nutritional status on the occurrence of IBD-related hospitalization.METHODS This integrative review was conducted in the online databases PubMed and MEDLINE, using the terms "obesity" and "malnutrition" accompanied by"hospitalization", each combined with "Crohn's disease" or "ulcerative colitis".Only studies conducted with humans, adults, and published in English or Spanish were selected, and those that were not directly associated with nutritional status and hospitalization were excluded from this review. The Preferred Reporting Items for Systematic Reviews and Meta-Analyzes guide was used as the basis for selection of studies.RESULTS Of the 80 studies identified, only five met the proposal of this review. None evaluated the association of good nutritional status with the risk of hospitalization. Malnutrition had a strong correlation with the risk of hospitalization related to IBD, and there was disagreement among three studies regarding the association of obesity and hospitalization rates.CONCLUSION Few studies have evaluated nutritional status as a predictor of IBD-related hospitalization. The presence of malnutrition appears to be associated with hospitalization in these patients, but further studies are needed to elucidate the issue.
BACKGROUND Inflammatory bowel disease(IBD) presents an inflammatory picture that in the long run can lead to complications and consequently more hospitalizations compared to other diseases.AIM To evaluate the influence of nutritional status on the occurrence of IBD-related hospitalization.METHODS This integrative review was conducted in the online databases PubMed and MEDLINE, using the terms "obesity" and "malnutrition" accompanied by"hospitalization", each combined with "Crohn's disease" or "ulcerative colitis".Only studies conducted with humans, adults, and published in English or Spanish were selected, and those that were not directly associated with nutritional status and hospitalization were excluded from this review. The Preferred Reporting Items for Systematic Reviews and Meta-Analyzes guide was used as the basis for selection of studies.RESULTS Of the 80 studies identified, only five met the proposal of this review. None evaluated the association of good nutritional status with the risk of hospitalization. Malnutrition had a strong correlation with the risk of hospitalization related to IBD, and there was disagreement among three studies regarding the association of obesity and hospitalization rates.CONCLUSION Few studies have evaluated nutritional status as a predictor of IBD-related hospitalization. The presence of malnutrition appears to be associated with hospitalization in these patients, but further studies are needed to elucidate the issue.
引文
1 Allegretti JR,Borges L,Lucci M,Chang M,Cao B,Collins E,Vogel B,Arthur E,Emmons D,Korzenik JR.Risk Factors for Rehospitalization Within 90 Days in Patients with Inflammatory Bowel Disease.Inflamm Bowel Dis 2015;21:2583-2589[PMID:26244647 DOI:10.1097/MIB.0000000000000537]
2 S?külmez P,Demirba?AE,Arslan P,Di?ibeyaz S.Effects of enteral nutritional support on malnourished patients with inflammatory bowel disease by subjective global assessment.Turk J Gastroenterol 2014;25:493-507[PMID:25417609 DOI:10.5152/tjg.2014.4955]
3 Matsumoto S,Yoshida Y.What are the factors that affect hospitalization and surgery for aggravation of ulcerative colitis?Eur J Gastroenterol Hepatol 2014;26:282-287[PMID:24374839 DOI:10.1097/MEG.0000000000000028]
4 Blain A,Cattan S,Beaugerie L,Carbonnel F,Gendre JP,Cosnes J.Crohn's disease clinical course and severity in obese patients.Clin Nutr 2002;21:51-57[PMID:11884013 DOI:10.1054/clnu.2001.0503]
5 Flores A,Burstein E,Cipher DJ,Feagins LA.Obesity in Inflammatory Bowel Disease:A Marker of Less Severe Disease.Dig Dis Sci 2015;60:2436-2445[PMID:25799938 DOI:10.1007/s10620-015-3629-5]
6 Seminerio JL,Koutroubakis IE,Ramos-Rivers C,Hashash JG,Dudekula A,Regueiro M,Baidoo L,Barrie A,Swoger J,Schwartz M,Weyant K,Dunn MA,Binion DG.Impact of Obesity on the Management and Clinical Course of Patients with Inflammatory Bowel Disease.Inflamm Bowel Dis 2015;21:2857-2863[PMID:26241001 DOI:10.1097/MIB.0000000000000560]
7 Ananthakrishnan AN,McGinley EL,Binion DG,Saeian K.A novel risk score to stratify severity of Crohn's disease hospitalizations.Am J Gastroenterol 2010;105:1799-1807[PMID:20216534 DOI:10.1038/ajg.2010.105]
8 Gajendran M,Umapathy C,Loganathan P,Hashash JG,Koutroubakis IE,Binion DG.Analysis of Hospital-Based Emergency Department Visits for Inflammatory Bowel Disease in the USA.Dig Dis Sci2016;61:389-399[PMID:26423080 DOI:10.1007/s10620-015-3895-2]
9 Moher D,Liberati A,Tetzlaff J,Altman DG;PRISMA Group.Preferred reporting items for systematic reviews and meta-analyses:the PRISMA statement.Int J Surg 2010;8:336-341[PMID:20171303 DOI:10.1016/j.ijsu.2010.02.007]
10 Lacey KM,Pritchett ER.Nutrition Diagnosis:A Critical Step in the Nutrition Care Process.J Am Diet Assoc 2006[DOI:10.1053/JADA.2003.50564]
11 Carneiro Roriz AK,Santana Passos LC,Cunha De Oliveira C,Eickemberg M,De Almeida Moreira P,Barbosa Ramos L.Anthropometric clinical indicators in the assessment of visceral obesity:an update.Nutr Clínica Y Dietética Hosp 2016;36:168-179[DOI:10.12873/362carneirororiz]
12 Skowrońska-Piekarska U,Matysiak K,Sowińska A.The impact of the nutritional state of patients on the results of the surgical treatment of ulcerative colitis.Pol Przegl Chir 2013;85:424-432[PMID:24009052DOI:10.2478/pjs-2013-0065]
13 Norman K,Kirchner H,Lochs H,Pirlich M.Malnutrition affects quality of life in gastroenterology patients.World J Gastroenterol 2006;12:3380-3385[PMID:16733855 DOI:10.3748/wjg.v12.i21.3380]
14 Nguyen GC,Munsell M,Harris ML.Nationwide prevalence and prognostic significance of clinically diagnosable protein-calorie malnutrition in hospitalized inflammatory bowel disease patients.Inflamm Bowel Dis 2008;14:1105-1111[PMID:18302272 DOI:10.1002/ibd.20429]
15 Zhu W,Guo Z,Zuo L,Gong J,Li Y,Gu L,Cao L,Li N,Li J.CONSORT:Different End-Points of Preoperative Nutrition and Outcome of Bowel Resection of Crohn Disease:A Randomized Clinical Trial.Medicine(Baltimore)2015;94:e1175[PMID:26200619 DOI:10.1097/MD.0000000000001175]
16 Yao GX,Wang XR,Jiang ZM,Zhang SY,Ni AP.Role of perioperative parenteral nutrition in severely malnourished patients with Crohn's disease.World J Gastroenterol 2005;11:5732-5734[PMID:16237776 DOI:10.3748/wjg.v11.i36.5732]
17 Henriksen M,Jahnsen J,Lygren I,Stray N,Sauar J,Vatn MH,Moum B;IBSEN Study Group.C-reactive protein:a predictive factor and marker of inflammation in inflammatory bowel disease.Results from a prospective population-based study.Gut 2008;57:1518-1523[PMID:18566104 DOI:10.1136/gut.2007.146357]
18 Vagianos K,Bector S,McConnell J,Bernstein CN.Nutrition assessment of patients with inflammatory bowel disease.JPEN J Parenter Enteral Nutr 2007;31:311-319[PMID:17595441 DOI:10.1177/0148607107031004311]
19 Tinsley A,Naymagon S,Mathers B,Kingsley M,Sands BE,Ullman TA.Early readmission in patients hospitalized for ulcerative colitis:incidence and risk factors.Scand J Gastroenterol 2015;50:1103-1109[PMID:25866237 DOI:10.3109/00365521.2015.1020862]
20 Ha C,Maser EA,Kornbluth A.Clinical presentation and outcomes of inflammatory bowel disease patients admitted to the intensive care unit.J Clin Gastroenterol 2013;47:485-490[PMID:23388843 DOI:10.1097/MCG.0b013e318275d981]
21 Ananthakrishnan AN,Cagan A,Gainer VS,Cai T,Cheng SC,Savova G,Chen P,Szolovits P,Xia Z,De Jager PL,Shaw SY,Churchill S,Karlson EW,Kohane I,Plenge RM,Murphy SN,Liao KP.Normalization of plasma 25-hydroxy vitamin D is associated with reduced risk of surgery in Crohn's disease.Inflamm Bowel Dis 2013;19:1921-1927[PMID:23751398 DOI:10.1097/MIB.0b013e3182902ad9]
22 Kabbani TA,Koutroubakis IE,Schoen RE,Ramos-Rivers C,Shah N,Swoger J,Regueiro M,Barrie A,Schwartz M,Hashash JG,Baidoo L,Dunn MA,Binion DG.Association of Vitamin D Level With Clinical Status in Inflammatory Bowel Disease:A 5-Year Longitudinal Study.Am J Gastroenterol 2016;111:712-719[PMID:26952579 DOI:10.1038/ajg.2016.53]
23 Gozdzik A,Barta JL,Wu H,Wagner D,Cole DE,Vieth R,Whiting S,Parra EJ.Low wintertime vitamin D levels in a sample of healthy young adults of diverse ancestry living in the Toronto area:associations with vitamin D intake and skin pigmentation.BMC Public Health 2008;8:336[PMID:18817578 DOI:10.1186/1471-2458-8-336]
24 Venkata KVR,Arora SS,Xie FL,Malik TA.Impact of vitamin D on the hospitalization rate of Crohn's disease patients seen at a tertiary care center.World J Gastroenterol 2017;23:2539-2544[PMID:28465638 DOI:10.3748/wjg.v23.i14.2539]
25 Nic Suibhne T,Raftery TC,McMahon O,Walsh C,O'Morain C,O'Sullivan M.High prevalence of overweight and obesity in adults with Crohn's disease:associations with disease and lifestyle factors.JCrohns Colitis 2013;7:e241-e248[PMID:23040290 DOI:10.1016/j.crohns.2012.09.009]
26 Steed H,Walsh S,Reynolds N.A brief report of the epidemiology of obesity in the inflammatory bowel disease population of Tayside,Scotland.Obes Facts 2009;2:370-372[PMID:20090388 DOI:10.1159/000262276]
27 Karmiris K,Koutroubakis IE,Xidakis C,Polychronaki M,Voudouri T,Kouroumalis EA.Circulating levels of leptin,adiponectin,resistin,and ghrelin in inflammatory bowel disease.Inflamm Bowel Dis 2006;12:100-105[PMID:16432373 DOI:10.1097/01.MIB.0000200345.38837.46]
28 Mendall MA,Gunasekera AV,John BJ,Kumar D.Is obesity a risk factor for Crohn's disease?Dig Dis Sci2011;56:837-844[PMID:21221790 DOI:10.1007/s10620-010-1541-6]
29 Hu Q,Ren J,Li G,Wu X,Li J.The Impact of Obesity on the Clinical Course of Inflammatory Bowel Disease:A Meta-Analysis.Med Sci Monit 2017;23:2599-2606[PMID:28552901 DOI:10.12659/MSM.901969]
30 Obesity:preventing and managing the global epidemic.Report of a WHO consultation.World Health Organ Tech Rep Ser 2000;894:i-xii,1-253[PMID:11234459 DOI:10.1002/jps.3080150106]
31 Singh S,Dulai PS,Zarrinpar A,Ramamoorthy S,Sandborn WJ.Obesity in IBD:epidemiology,pathogenesis,disease course and treatment outcomes.Nat Rev Gastroenterol Hepatol 2017;14:110-121[PMID:27899815 DOI:10.1038/nrgastro.2016.181]
32 Fain JN,Madan AK,Hiler ML,Cheema P,Bahouth SW.Comparison of the release of adipokines by adipose tissue,adipose tissue matrix,and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans.Endocrinology 2004;145:2273-2282[PMID:14726444 DOI:10.1210/en.2003-1336]
33 Aminian A,Andalib A,Ver MR,Corcelles R,Schauer PR,Brethauer SA.Outcomes of Bariatric Surgery in Patients with Inflammatory Bowel Disease.Obes Surg 2016;26:1186-1190[PMID:26420765 DOI:10.1007/s11695-015-1909-y]
34 Keidar A,Hazan D,Sadot E,Kashtan H,Wasserberg N.The role of bariatric surgery in morbidly obese patients with inflammatory bowel disease.Surg Obes Relat Dis 2015;11:132-136[PMID:25547057 DOI:10.1016/j.soard.2014.06.022]
2 S?külmez P,Demirba?AE,Arslan P,Di?ibeyaz S.Effects of enteral nutritional support on malnourished patients with inflammatory bowel disease by subjective global assessment.Turk J Gastroenterol 2014;25:493-507[PMID:25417609 DOI:10.5152/tjg.2014.4955]
3 Matsumoto S,Yoshida Y.What are the factors that affect hospitalization and surgery for aggravation of ulcerative colitis?Eur J Gastroenterol Hepatol 2014;26:282-287[PMID:24374839 DOI:10.1097/MEG.0000000000000028]
4 Blain A,Cattan S,Beaugerie L,Carbonnel F,Gendre JP,Cosnes J.Crohn's disease clinical course and severity in obese patients.Clin Nutr 2002;21:51-57[PMID:11884013 DOI:10.1054/clnu.2001.0503]
5 Flores A,Burstein E,Cipher DJ,Feagins LA.Obesity in Inflammatory Bowel Disease:A Marker of Less Severe Disease.Dig Dis Sci 2015;60:2436-2445[PMID:25799938 DOI:10.1007/s10620-015-3629-5]
6 Seminerio JL,Koutroubakis IE,Ramos-Rivers C,Hashash JG,Dudekula A,Regueiro M,Baidoo L,Barrie A,Swoger J,Schwartz M,Weyant K,Dunn MA,Binion DG.Impact of Obesity on the Management and Clinical Course of Patients with Inflammatory Bowel Disease.Inflamm Bowel Dis 2015;21:2857-2863[PMID:26241001 DOI:10.1097/MIB.0000000000000560]
7 Ananthakrishnan AN,McGinley EL,Binion DG,Saeian K.A novel risk score to stratify severity of Crohn's disease hospitalizations.Am J Gastroenterol 2010;105:1799-1807[PMID:20216534 DOI:10.1038/ajg.2010.105]
8 Gajendran M,Umapathy C,Loganathan P,Hashash JG,Koutroubakis IE,Binion DG.Analysis of Hospital-Based Emergency Department Visits for Inflammatory Bowel Disease in the USA.Dig Dis Sci2016;61:389-399[PMID:26423080 DOI:10.1007/s10620-015-3895-2]
9 Moher D,Liberati A,Tetzlaff J,Altman DG;PRISMA Group.Preferred reporting items for systematic reviews and meta-analyses:the PRISMA statement.Int J Surg 2010;8:336-341[PMID:20171303 DOI:10.1016/j.ijsu.2010.02.007]
10 Lacey KM,Pritchett ER.Nutrition Diagnosis:A Critical Step in the Nutrition Care Process.J Am Diet Assoc 2006[DOI:10.1053/JADA.2003.50564]
11 Carneiro Roriz AK,Santana Passos LC,Cunha De Oliveira C,Eickemberg M,De Almeida Moreira P,Barbosa Ramos L.Anthropometric clinical indicators in the assessment of visceral obesity:an update.Nutr Clínica Y Dietética Hosp 2016;36:168-179[DOI:10.12873/362carneirororiz]
12 Skowrońska-Piekarska U,Matysiak K,Sowińska A.The impact of the nutritional state of patients on the results of the surgical treatment of ulcerative colitis.Pol Przegl Chir 2013;85:424-432[PMID:24009052DOI:10.2478/pjs-2013-0065]
13 Norman K,Kirchner H,Lochs H,Pirlich M.Malnutrition affects quality of life in gastroenterology patients.World J Gastroenterol 2006;12:3380-3385[PMID:16733855 DOI:10.3748/wjg.v12.i21.3380]
14 Nguyen GC,Munsell M,Harris ML.Nationwide prevalence and prognostic significance of clinically diagnosable protein-calorie malnutrition in hospitalized inflammatory bowel disease patients.Inflamm Bowel Dis 2008;14:1105-1111[PMID:18302272 DOI:10.1002/ibd.20429]
15 Zhu W,Guo Z,Zuo L,Gong J,Li Y,Gu L,Cao L,Li N,Li J.CONSORT:Different End-Points of Preoperative Nutrition and Outcome of Bowel Resection of Crohn Disease:A Randomized Clinical Trial.Medicine(Baltimore)2015;94:e1175[PMID:26200619 DOI:10.1097/MD.0000000000001175]
16 Yao GX,Wang XR,Jiang ZM,Zhang SY,Ni AP.Role of perioperative parenteral nutrition in severely malnourished patients with Crohn's disease.World J Gastroenterol 2005;11:5732-5734[PMID:16237776 DOI:10.3748/wjg.v11.i36.5732]
17 Henriksen M,Jahnsen J,Lygren I,Stray N,Sauar J,Vatn MH,Moum B;IBSEN Study Group.C-reactive protein:a predictive factor and marker of inflammation in inflammatory bowel disease.Results from a prospective population-based study.Gut 2008;57:1518-1523[PMID:18566104 DOI:10.1136/gut.2007.146357]
18 Vagianos K,Bector S,McConnell J,Bernstein CN.Nutrition assessment of patients with inflammatory bowel disease.JPEN J Parenter Enteral Nutr 2007;31:311-319[PMID:17595441 DOI:10.1177/0148607107031004311]
19 Tinsley A,Naymagon S,Mathers B,Kingsley M,Sands BE,Ullman TA.Early readmission in patients hospitalized for ulcerative colitis:incidence and risk factors.Scand J Gastroenterol 2015;50:1103-1109[PMID:25866237 DOI:10.3109/00365521.2015.1020862]
20 Ha C,Maser EA,Kornbluth A.Clinical presentation and outcomes of inflammatory bowel disease patients admitted to the intensive care unit.J Clin Gastroenterol 2013;47:485-490[PMID:23388843 DOI:10.1097/MCG.0b013e318275d981]
21 Ananthakrishnan AN,Cagan A,Gainer VS,Cai T,Cheng SC,Savova G,Chen P,Szolovits P,Xia Z,De Jager PL,Shaw SY,Churchill S,Karlson EW,Kohane I,Plenge RM,Murphy SN,Liao KP.Normalization of plasma 25-hydroxy vitamin D is associated with reduced risk of surgery in Crohn's disease.Inflamm Bowel Dis 2013;19:1921-1927[PMID:23751398 DOI:10.1097/MIB.0b013e3182902ad9]
22 Kabbani TA,Koutroubakis IE,Schoen RE,Ramos-Rivers C,Shah N,Swoger J,Regueiro M,Barrie A,Schwartz M,Hashash JG,Baidoo L,Dunn MA,Binion DG.Association of Vitamin D Level With Clinical Status in Inflammatory Bowel Disease:A 5-Year Longitudinal Study.Am J Gastroenterol 2016;111:712-719[PMID:26952579 DOI:10.1038/ajg.2016.53]
23 Gozdzik A,Barta JL,Wu H,Wagner D,Cole DE,Vieth R,Whiting S,Parra EJ.Low wintertime vitamin D levels in a sample of healthy young adults of diverse ancestry living in the Toronto area:associations with vitamin D intake and skin pigmentation.BMC Public Health 2008;8:336[PMID:18817578 DOI:10.1186/1471-2458-8-336]
24 Venkata KVR,Arora SS,Xie FL,Malik TA.Impact of vitamin D on the hospitalization rate of Crohn's disease patients seen at a tertiary care center.World J Gastroenterol 2017;23:2539-2544[PMID:28465638 DOI:10.3748/wjg.v23.i14.2539]
25 Nic Suibhne T,Raftery TC,McMahon O,Walsh C,O'Morain C,O'Sullivan M.High prevalence of overweight and obesity in adults with Crohn's disease:associations with disease and lifestyle factors.JCrohns Colitis 2013;7:e241-e248[PMID:23040290 DOI:10.1016/j.crohns.2012.09.009]
26 Steed H,Walsh S,Reynolds N.A brief report of the epidemiology of obesity in the inflammatory bowel disease population of Tayside,Scotland.Obes Facts 2009;2:370-372[PMID:20090388 DOI:10.1159/000262276]
27 Karmiris K,Koutroubakis IE,Xidakis C,Polychronaki M,Voudouri T,Kouroumalis EA.Circulating levels of leptin,adiponectin,resistin,and ghrelin in inflammatory bowel disease.Inflamm Bowel Dis 2006;12:100-105[PMID:16432373 DOI:10.1097/01.MIB.0000200345.38837.46]
28 Mendall MA,Gunasekera AV,John BJ,Kumar D.Is obesity a risk factor for Crohn's disease?Dig Dis Sci2011;56:837-844[PMID:21221790 DOI:10.1007/s10620-010-1541-6]
29 Hu Q,Ren J,Li G,Wu X,Li J.The Impact of Obesity on the Clinical Course of Inflammatory Bowel Disease:A Meta-Analysis.Med Sci Monit 2017;23:2599-2606[PMID:28552901 DOI:10.12659/MSM.901969]
30 Obesity:preventing and managing the global epidemic.Report of a WHO consultation.World Health Organ Tech Rep Ser 2000;894:i-xii,1-253[PMID:11234459 DOI:10.1002/jps.3080150106]
31 Singh S,Dulai PS,Zarrinpar A,Ramamoorthy S,Sandborn WJ.Obesity in IBD:epidemiology,pathogenesis,disease course and treatment outcomes.Nat Rev Gastroenterol Hepatol 2017;14:110-121[PMID:27899815 DOI:10.1038/nrgastro.2016.181]
32 Fain JN,Madan AK,Hiler ML,Cheema P,Bahouth SW.Comparison of the release of adipokines by adipose tissue,adipose tissue matrix,and adipocytes from visceral and subcutaneous abdominal adipose tissues of obese humans.Endocrinology 2004;145:2273-2282[PMID:14726444 DOI:10.1210/en.2003-1336]
33 Aminian A,Andalib A,Ver MR,Corcelles R,Schauer PR,Brethauer SA.Outcomes of Bariatric Surgery in Patients with Inflammatory Bowel Disease.Obes Surg 2016;26:1186-1190[PMID:26420765 DOI:10.1007/s11695-015-1909-y]
34 Keidar A,Hazan D,Sadot E,Kashtan H,Wasserberg N.The role of bariatric surgery in morbidly obese patients with inflammatory bowel disease.Surg Obes Relat Dis 2015;11:132-136[PMID:25547057 DOI:10.1016/j.soard.2014.06.022]