Chinese Herbal Medicine for Osteosarcoma in the Mouse: A Systematic Review and Meta-Analysis
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摘要
Objective: To summarize and critically assess the inhibitory effects of Chinese herbal medicine(CHM) on tumor volume and tumor weight for the treatment of osteosarcoma(OS) in mouse models. Methods:PubMed, Embase, Web of Science, China Knowledge Resource Integrated Database(CNKI), Wanfang Database, VIP Database, and Chinese BioMedical(CBM) were searched since their inception dates to March10, 2016. Two reviewers independently selected the controlled studies estimating effects of CHM on mouse OS by administration in vivo. A pair-wise meta-analysis was performed. Twenty-five studies with adequate randomization were included in the systematic review. Results: CHM may signi?cantly inhibit OS growth in mice, as assessed using the tumor weight [20 studies, n=443; 290 for CHM and 153 for the control; pooled mean difference(MD)=–2.90; 95% confidence interval(CI): –3.50 to –2.31; P<0.01], tumor volume(16 studies, n=382; 257 for CHM and 125 for the control; pooled MD =–2.57; 95% CI: –3.33 to –1.80; P<0.01) and tumor growth inhibition rate. Conclusion: CHM could significantly inhibit the growth of OS in mouse models,which might be supportive for the design of preclinical and clinical trials in future.
Objective: To summarize and critically assess the inhibitory effects of Chinese herbal medicine(CHM) on tumor volume and tumor weight for the treatment of osteosarcoma(OS) in mouse models. Methods:PubMed, Embase, Web of Science, China Knowledge Resource Integrated Database(CNKI), Wanfang Database, VIP Database, and Chinese BioMedical(CBM) were searched since their inception dates to March10, 2016. Two reviewers independently selected the controlled studies estimating effects of CHM on mouse OS by administration in vivo. A pair-wise meta-analysis was performed. Twenty-five studies with adequate randomization were included in the systematic review. Results: CHM may signi?cantly inhibit OS growth in mice, as assessed using the tumor weight [20 studies, n=443; 290 for CHM and 153 for the control; pooled mean difference(MD)=–2.90; 95% confidence interval(CI): –3.50 to –2.31; P<0.01], tumor volume(16 studies, n=382; 257 for CHM and 125 for the control; pooled MD =–2.57; 95% CI: –3.33 to –1.80; P<0.01) and tumor growth inhibition rate. Conclusion: CHM could significantly inhibit the growth of OS in mouse models,which might be supportive for the design of preclinical and clinical trials in future.
Objective: To summarize and critically assess the inhibitory effects of Chinese herbal medicine(CHM) on tumor volume and tumor weight for the treatment of osteosarcoma(OS) in mouse models. Methods:PubMed, Embase, Web of Science, China Knowledge Resource Integrated Database(CNKI), Wanfang Database, VIP Database, and Chinese BioMedical(CBM) were searched since their inception dates to March10, 2016. Two reviewers independently selected the controlled studies estimating effects of CHM on mouse OS by administration in vivo. A pair-wise meta-analysis was performed. Twenty-five studies with adequate randomization were included in the systematic review. Results: CHM may signi?cantly inhibit OS growth in mice, as assessed using the tumor weight [20 studies, n=443; 290 for CHM and 153 for the control; pooled mean difference(MD)=–2.90; 95% confidence interval(CI): –3.50 to –2.31; P<0.01], tumor volume(16 studies, n=382; 257 for CHM and 125 for the control; pooled MD =–2.57; 95% CI: –3.33 to –1.80; P<0.01) and tumor growth inhibition rate. Conclusion: CHM could significantly inhibit the growth of OS in mouse models,which might be supportive for the design of preclinical and clinical trials in future.
引文
1.Marano A,Priora F,Lenti LM,et al.Spinoglio G.Application of fluorescence in robotic general surgery:review of the literature and state of the art.World J Sur 2013;37:2800-2811.
2.Touati F,Tabish R.u-Healthcare system:state-of-the-art review and challenges.J Med Syst 2013;37:9949.
3.Felix R,Lackner K,Thurn P.CT and the heart:present state of the art and its future.A review.Der Radiologe 1980;20:50-55.
4.Gregory JM,Knapp DE.State-of-the-art of drug usage review.Am J Hosp Pharm 1976;33:925-928.
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6.Alford CA Jr,Whitley RJ.Treatment of infections due to herpesvirus in humans:a critical review of the state of the art.J Infect Dis 1976;133 Suppl:A101-108.
7.Brodman E,Johnson MF Jr.Medical serials control systems by computer-a state of the art review.Bull Med Libr Assoc1976;64:12-19.
8.Bowman MC.Editorial:Analysis of pesticides A state-ofthe-art review.PartⅡ.J Chromatogr Sci 1975;13:255.
9.Staub NC."State of the art"review.Pathogenesis of pulmonary edema.Am Rev Respir Dis 1974;109:358-372.
10.Yakimenko SA,Logai IM.State of art of the open keratoprosthesis(literature review).Oftalmologicheskii Zhurnal 1974;29:409-416.
11.Low SA,Yang J,Kopecek J.Bone-targeted acid-sensitive doxorubicin conjugate micelles as potential osteosarcoma therapeutics.Bioconjugate Chem 2014;25:2012-2020.
12.Mishra BB,Tiwari VK.Natural products:an evolving role in future drug discovery.Eur J Med Chem 2011;46:4769-4807.
13.Koehn FE,Carter GT.The evolving role of natural products in drug discovery.Nature Rev Drug Discovery 2005;4:206-220.
14.Hughes DP.Strategies for the targeted delivery of therapeutics for osteosarcoma.Expert Opinion Drug Deliv2009;6:1311-21.
15.Anninga JK,Gelderblom H,Fiocco M,et al.Chemotherapeutic adjuvant treatment for osteosarcoma:where do we stand?Eur J Cancer 2011;47:2431-2445.
16.Yu D,Fu S,Cao Z,et al.Unraveling the novel antiosteosarcoma function of coptisine and its mechanisms.Toxicol Letters 2014;226:328-336.
17.Yoshiyuki KMS.Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis.Phytomedicine 2013;20:328-336.
18.Xie XB,Yin JQ,Wen LL,et al.Critical role of heat shock protein27 in bufalin-induced apoptosis in human osteosarcomas:a proteomic-based research.Plo S One 2012;7:e47375.
19.Wang Y,Fu Q,Zhao W.Tetramethylpyrazine inhibits osteosarcoma cel proliferation via downregulation of NF-kappa B in vitro and in vivo.Mol Med Rep 2013;8:984-988.
20.Wang Y,Chen J,Zhang D,et al.Tumoricidal effects of a selenium(Se)-polysaccharide from Ziyang green tea on human osteosarcoma U-2 OS cells.Carbohydrate Polymers2013;98:1186-1190.
21.Ren SS,Yuan F,Liu YH,et al.Effect of p27 gene combined with Pientzehuang(片仔癀)on tumor growth in osteosarcomabearing nude mice.Chin J Integr Med 2015;21:830-836.
22.Roomi MW,Ivanov V,Kalinovsky T,et al.Effect of ascorbic acid,lysine,proline,and green tea extract on human osteosarcoma cell line MNNG-HOS xenografts in nude mice evaluation of tumor growth and immunohistochemistry.Med Oncol 2006;23:411-417.
23.Roomi MW,Roomi N,Ivanov V,et al.Inhibitory effect of a mixture containing ascorbic acid,lysine,proline and green tea extract on critical parameters in angiogenesis.Oncol Rep 2005;14:807-815.
24.Liu Y,Wang W,Xu J,et al.Dihydroartemisinin inhibits tumor growth of human osteosarcoma cells by suppressing Wnt/beta-catenin signaling.Oncol Rep 2013;30:1723-1730.
25.Lin CC,Chuang YJ,Yu CC,et al.Apigenin induces apoptosis through mitochondrial dysfunction in U-2 OShuman osteosarcoma cells and inhibits osteosarcoma xenograft tumor growth in vivo.J Agricultural Food Chem2012;60:11395-11402.
26.Jiang W,Huang Y,Wang JP,et al.The synergistic anticancer effect of artesunate combined with allicin in osteosarcoma cell line in vitro and in vivo.Asian Pacific JCancer Prev 2013;14:4615-4619.
27.Fu Z,Deng B,Liao Y,et al.The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis.BMC Cancer 2013;13:580-590.
28.Chen Z,Huang C,Yang YL,et al.Inhibition of the STAT3signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells.Acta Pharmacol Sin2012;33:101-108.
29.Wan D,Jiang C,Hua X,et al.Cell cycle arrest and apoptosis induced by aspidin PB through the p53/p21 and mitochondria-dependent pathways in human osteosarcoma cells.Anti-cancer Drugs 2015;26:931-941.
30.Liu Y,Bi T,Dai W,et al.Lupeol induces apoptosis and cell cycle arrest of human osteosarcoma cells through PI3K/AKT/m TOR pathway.Technol Cancer Res Treat 2016;15(6)NP16-NP24.
31.Li HY,Zhang J,Sun LL,et al.Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells:an in vitro and in vivo study.Cell Death Dis 2015;6:e1604.
32.Park KR,Yun HM,Quang TH,et al.4-Methoxydalbergione suppresses growth and induces apoptosis in human osteosarcoma cells in vitro and in vivo xenograft model through down-regulation of the JAK2_STAT3 pathway.Oncotarget 2016;7:6960-6971.
33.Zhang RN.An Experimental Study on the effects and mechanisms of Duhuojisheng decoction in Inhibiting Carcinoma[dissertation].Xi'an:The Fourth Military Medical University;2004.
34.Shi QW,Li SG,Li J,et al.Anti-tumor effects of triptolide on osteosarcoma cells in vitro and in vivo:an experimental research.Chin J IntegrTradit West Med(Chin)2013;33:659-663.
35.Liu YL.The anti-tumor effect of dihydroarteminin on humanosteasarcoma[dissertation].Chongging:Chongqing Medical University;2013.
36.Li XW,Du MC.Intervention of strengthening genuine qi on growth and metastasis of osteosarcoma.Chin J Cancer Prev Treat 2008;15:1721-1723.
37.Huang YM,He RR,Liu JW,et al.Effects of modified Siwu Decoction on expressions of VEGF and its receptors in osteosarcoma-bearing mice.Chin J Tradit Med Traum Orthop(Chin)2009;17:1-3.
38.Han F,Jiang N,Yang F.Experimental research of Pingtiaoyin on presented and expressed of PCNA,Ki-67,EGF and EGFR in S180 osteosarcoma mouse.Aerospace Med 2006;17:131-132.
39.Yu D.The selective inhibitory effects and mechanisms of coptisine on osteosarcoma cell growth and vasculogenic mimicry[dissertation].Suzhou:Sochow University;2014.
40.Zhang Y,Sun S,Chen J,et al.Oxymatrine induces mitochondria dependent apoptosis in human osteosarcoma MNNG/HOS cells through inhibition of PI3K/Akt pathway.Tumour Biol J Int Soc Oncodev Biol Med 2014;35:1619-1625.
41.Pittler MH,Abbot NC,Harkness EF,et al.Location bias in controlled clinical trials of complementary/alternative therapies.J Clin Epidemiol 2000;53:485-489.
42.Higgins JP.Commentary:Heterogeneity in meta-analysis should be expected and appropriately quantified.Int JEpidemiol 2008;37:1158-1160.
43.Vesterinen HM,Sena ES,Egan KJ,et al.Meta-analysis of data from animal studies:a practical guide.J Neurosci Methods 2014;221:92-102.
2.Touati F,Tabish R.u-Healthcare system:state-of-the-art review and challenges.J Med Syst 2013;37:9949.
3.Felix R,Lackner K,Thurn P.CT and the heart:present state of the art and its future.A review.Der Radiologe 1980;20:50-55.
4.Gregory JM,Knapp DE.State-of-the-art of drug usage review.Am J Hosp Pharm 1976;33:925-928.
5.Murray JF.Review of the state of the art in intermittent positive pressure breathing therapy.Am Rev Respir Dis1974;110:193-1999.
6.Alford CA Jr,Whitley RJ.Treatment of infections due to herpesvirus in humans:a critical review of the state of the art.J Infect Dis 1976;133 Suppl:A101-108.
7.Brodman E,Johnson MF Jr.Medical serials control systems by computer-a state of the art review.Bull Med Libr Assoc1976;64:12-19.
8.Bowman MC.Editorial:Analysis of pesticides A state-ofthe-art review.PartⅡ.J Chromatogr Sci 1975;13:255.
9.Staub NC."State of the art"review.Pathogenesis of pulmonary edema.Am Rev Respir Dis 1974;109:358-372.
10.Yakimenko SA,Logai IM.State of art of the open keratoprosthesis(literature review).Oftalmologicheskii Zhurnal 1974;29:409-416.
11.Low SA,Yang J,Kopecek J.Bone-targeted acid-sensitive doxorubicin conjugate micelles as potential osteosarcoma therapeutics.Bioconjugate Chem 2014;25:2012-2020.
12.Mishra BB,Tiwari VK.Natural products:an evolving role in future drug discovery.Eur J Med Chem 2011;46:4769-4807.
13.Koehn FE,Carter GT.The evolving role of natural products in drug discovery.Nature Rev Drug Discovery 2005;4:206-220.
14.Hughes DP.Strategies for the targeted delivery of therapeutics for osteosarcoma.Expert Opinion Drug Deliv2009;6:1311-21.
15.Anninga JK,Gelderblom H,Fiocco M,et al.Chemotherapeutic adjuvant treatment for osteosarcoma:where do we stand?Eur J Cancer 2011;47:2431-2445.
16.Yu D,Fu S,Cao Z,et al.Unraveling the novel antiosteosarcoma function of coptisine and its mechanisms.Toxicol Letters 2014;226:328-336.
17.Yoshiyuki KMS.Anti-tumor and anti-metastatic actions of wogonin isolated from Scutellaria baicalensis roots through anti-lymphangiogenesis.Phytomedicine 2013;20:328-336.
18.Xie XB,Yin JQ,Wen LL,et al.Critical role of heat shock protein27 in bufalin-induced apoptosis in human osteosarcomas:a proteomic-based research.Plo S One 2012;7:e47375.
19.Wang Y,Fu Q,Zhao W.Tetramethylpyrazine inhibits osteosarcoma cel proliferation via downregulation of NF-kappa B in vitro and in vivo.Mol Med Rep 2013;8:984-988.
20.Wang Y,Chen J,Zhang D,et al.Tumoricidal effects of a selenium(Se)-polysaccharide from Ziyang green tea on human osteosarcoma U-2 OS cells.Carbohydrate Polymers2013;98:1186-1190.
21.Ren SS,Yuan F,Liu YH,et al.Effect of p27 gene combined with Pientzehuang(片仔癀)on tumor growth in osteosarcomabearing nude mice.Chin J Integr Med 2015;21:830-836.
22.Roomi MW,Ivanov V,Kalinovsky T,et al.Effect of ascorbic acid,lysine,proline,and green tea extract on human osteosarcoma cell line MNNG-HOS xenografts in nude mice evaluation of tumor growth and immunohistochemistry.Med Oncol 2006;23:411-417.
23.Roomi MW,Roomi N,Ivanov V,et al.Inhibitory effect of a mixture containing ascorbic acid,lysine,proline and green tea extract on critical parameters in angiogenesis.Oncol Rep 2005;14:807-815.
24.Liu Y,Wang W,Xu J,et al.Dihydroartemisinin inhibits tumor growth of human osteosarcoma cells by suppressing Wnt/beta-catenin signaling.Oncol Rep 2013;30:1723-1730.
25.Lin CC,Chuang YJ,Yu CC,et al.Apigenin induces apoptosis through mitochondrial dysfunction in U-2 OShuman osteosarcoma cells and inhibits osteosarcoma xenograft tumor growth in vivo.J Agricultural Food Chem2012;60:11395-11402.
26.Jiang W,Huang Y,Wang JP,et al.The synergistic anticancer effect of artesunate combined with allicin in osteosarcoma cell line in vitro and in vivo.Asian Pacific JCancer Prev 2013;14:4615-4619.
27.Fu Z,Deng B,Liao Y,et al.The anti-tumor effect of shikonin on osteosarcoma by inducing RIP1 and RIP3 dependent necroptosis.BMC Cancer 2013;13:580-590.
28.Chen Z,Huang C,Yang YL,et al.Inhibition of the STAT3signaling pathway is involved in the antitumor activity of cepharanthine in SaOS2 cells.Acta Pharmacol Sin2012;33:101-108.
29.Wan D,Jiang C,Hua X,et al.Cell cycle arrest and apoptosis induced by aspidin PB through the p53/p21 and mitochondria-dependent pathways in human osteosarcoma cells.Anti-cancer Drugs 2015;26:931-941.
30.Liu Y,Bi T,Dai W,et al.Lupeol induces apoptosis and cell cycle arrest of human osteosarcoma cells through PI3K/AKT/m TOR pathway.Technol Cancer Res Treat 2016;15(6)NP16-NP24.
31.Li HY,Zhang J,Sun LL,et al.Celastrol induces apoptosis and autophagy via the ROS/JNK signaling pathway in human osteosarcoma cells:an in vitro and in vivo study.Cell Death Dis 2015;6:e1604.
32.Park KR,Yun HM,Quang TH,et al.4-Methoxydalbergione suppresses growth and induces apoptosis in human osteosarcoma cells in vitro and in vivo xenograft model through down-regulation of the JAK2_STAT3 pathway.Oncotarget 2016;7:6960-6971.
33.Zhang RN.An Experimental Study on the effects and mechanisms of Duhuojisheng decoction in Inhibiting Carcinoma[dissertation].Xi'an:The Fourth Military Medical University;2004.
34.Shi QW,Li SG,Li J,et al.Anti-tumor effects of triptolide on osteosarcoma cells in vitro and in vivo:an experimental research.Chin J IntegrTradit West Med(Chin)2013;33:659-663.
35.Liu YL.The anti-tumor effect of dihydroarteminin on humanosteasarcoma[dissertation].Chongging:Chongqing Medical University;2013.
36.Li XW,Du MC.Intervention of strengthening genuine qi on growth and metastasis of osteosarcoma.Chin J Cancer Prev Treat 2008;15:1721-1723.
37.Huang YM,He RR,Liu JW,et al.Effects of modified Siwu Decoction on expressions of VEGF and its receptors in osteosarcoma-bearing mice.Chin J Tradit Med Traum Orthop(Chin)2009;17:1-3.
38.Han F,Jiang N,Yang F.Experimental research of Pingtiaoyin on presented and expressed of PCNA,Ki-67,EGF and EGFR in S180 osteosarcoma mouse.Aerospace Med 2006;17:131-132.
39.Yu D.The selective inhibitory effects and mechanisms of coptisine on osteosarcoma cell growth and vasculogenic mimicry[dissertation].Suzhou:Sochow University;2014.
40.Zhang Y,Sun S,Chen J,et al.Oxymatrine induces mitochondria dependent apoptosis in human osteosarcoma MNNG/HOS cells through inhibition of PI3K/Akt pathway.Tumour Biol J Int Soc Oncodev Biol Med 2014;35:1619-1625.
41.Pittler MH,Abbot NC,Harkness EF,et al.Location bias in controlled clinical trials of complementary/alternative therapies.J Clin Epidemiol 2000;53:485-489.
42.Higgins JP.Commentary:Heterogeneity in meta-analysis should be expected and appropriately quantified.Int JEpidemiol 2008;37:1158-1160.
43.Vesterinen HM,Sena ES,Egan KJ,et al.Meta-analysis of data from animal studies:a practical guide.J Neurosci Methods 2014;221:92-102.