Marine sponges of the genus Stelletta as promising drug sources: chemical and biological aspects
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摘要
Marine sponges of the genus Stelletta are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabolites, with novel structures and promising biological activities, have attracted a lot of attention from chemists seeking to perform their total synthesis in parallel to intensive biological studies towards new drug leads. In this review, we summarized the distribution of the chemically investigated Stelletta sponges, the isolation, synthesis and biological activities of their secondary metabolites, covering the literature from 1982 to early 2018.
Marine sponges of the genus Stelletta are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabolites, with novel structures and promising biological activities, have attracted a lot of attention from chemists seeking to perform their total synthesis in parallel to intensive biological studies towards new drug leads. In this review, we summarized the distribution of the chemically investigated Stelletta sponges, the isolation, synthesis and biological activities of their secondary metabolites, covering the literature from 1982 to early 2018.
Marine sponges of the genus Stelletta are well known as rich sources of diverse and complex biologically relevant natural products, including alkaloids, terpenoids, peptides, lipids, and steroids. Some of these metabolites, with novel structures and promising biological activities, have attracted a lot of attention from chemists seeking to perform their total synthesis in parallel to intensive biological studies towards new drug leads. In this review, we summarized the distribution of the chemically investigated Stelletta sponges, the isolation, synthesis and biological activities of their secondary metabolites, covering the literature from 1982 to early 2018.
引文
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3.Li S,Ye F,Zhu Z,Huang H,Mao S,Guo Y.Cembrane-type diterpenoids from the South China Sea soft coral Sarcophyton mililatensis.Acta Pharm Sin B 2018.http://dx.doi.org/10.1016/j.apsb.2018.06.004.
4.Kang HK,Seo CH,Park Y.Marine peptides and their anti-infective activities.Mar Drugs 2015;13:618-54.
5.Wang YQ,Miao ZH.Marine-derived angiogenesis inhibitors for cancer therapy.Mar Drugs 2013;11:903-33.
6.Wu Q,Sun J,Chen J,Zhang H,Guo YW,Wang H.Terpenoids from marine soft coral of the genus Lemnalia:chemistry and biological activities.Mar Drugs 2018;16:320.
7.Wang SX,Zhang XS,Guan HS,Wang W.Potential anti-HPV and related cancer agents from marine resources:an overview.Mar Drugs 2014;12:2019-35.
8.Newman DJ,Cragg GM.Drugs and drug candidates from marine sources:an assessment of the current“state of play”.Planta Med2016;82:775-89.
9.Russo P,Kisialiou A,Lamonaca P,Moroni R,Prinzi G,Fini M.New drugs from marine organisms in Alzheimer's disease.Mar Drugs2016;14:5.
10.Mayer AM,Glaser KB,Cuevas C,Jacobs RS,Kem W,Little RD,et al.The odyssey of marine pharmaceuticals:a current pipeline perspective.Trends Pharmacol Sci 2010;31:255-65.
11.Ebada SS,Proksch P.Chemical and pharmacological significance of natural guanidines from marine invertebrates.Mini Rev Med Chem2011;11:225-46.
12.Grienke U,Silke J,Tasdemir D.Bioactive compounds from marine mussels and their effects on human health.Food Chem 2014;142:48-60.
13.Menna M.Important classes of bioactive alkaloids from marine ascidians:structures,isolation and bioactivity.Curr Top Med Chem2014;14:207-23.
14.Bordbar S,Anwar F,Saari N.High-value components and bioactives from sea cucumbers for functional foods-a review.Mar Drugs2011;9:1761-805.
15.Mehbub MF,Lei J,Franco C,Zhang W.Marine sponge derived natural products between 2001 and 2010:trends and opportunities for discovery of bioactives.Mar Drugs 2014;12:4539-77.
16.García-Ruiz C,Sarabia F.Chemistry and biology of bengamides and bengazoles,bioactive natural products from Jaspis sponges.Mar Drugs 2014;12:1580-622.
17.Wang W,Mun B,Lee Y,Venkat Reddy M,Park Y,Lee J,et al.Bioactive sesterterpenoids from a Korean sponge Monanchora sp.JNat Prod 2013;76:170-7.
18.Youssef DT,Shaala LA,Alshali KZ.Bioactive hydantoin alkaloids from the Red Sea marine sponge Hemimycale arabica.Mar Drugs2015;13:6609-19.
19.Mioso R,Marante FJ,Bezerra RS,Borges FV,Santos BV,Laguna IH.Cytotoxic compounds derived from marine sponges.A review(2010-2012).Molecules 2017;22:E208.
20.Lindequist U.Marine-derived pharmaceuticals-challenges and opportunities.Biomol Ther 2016;24:561-71.
21.Wang ZL,Zhang HJ,Lin HW,Sun JB,Liu GL,Zhang C.Secondary metabolites from marine sponges Stelletta and their bioactivities.Chin J Mar Drug 2004;23:42-7.
22.Hirota H,Matsunaga S,Fusetani N.Stellettahide A,an antifungal alkaloid from a marine sponge of the genus Stelletta.Tetrahedron Lett 1990;31:4163-4.
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24.Whitlock GA,Carreira EM.Enantioselective synthesis of entStellettamide A via a novel dipolar cycloaddition reaction of(trimethylsilyl)diazomethane.J Org Chem 1997;62:7916-7.
25.Yamazaki N,Suzuki T,Yoshimura Y,Kibayashi C,Aoyagi S.Asymmetric synthesis of Stellettamides A and C.Heterocycles2008;75:285-90.
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