Mn掺杂ZnS量子点的制备及其在生物传感中的应用研究进展
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摘要
近年来,Mn掺杂ZnS量子点(Mn∶ZnSQDs)由于其优异的光学性能,引起了科学家们的广泛关注。为了解Mn∶ZnSQDs的制备及其应用研究现状,进一步推广Mn∶ZnSQDs在传感分析领域的应用,从Mn∶ZnSQDs的光学特性、制备方法及其在传感分析领域中的应用等方面进行了概述,并对其今后的发展进行了展望。
In recent years,Mn-doped ZnS quantum dots(Mn∶ZnS QDs)have been extensively used as luminescent probes for biosensing and bioimaging due to their excellent optical and photophysical properties.The prevalently application of Mn∶ZnS QDs and their preparation approaches were first briefly introduced.Then Mn∶ZnS QDs used as luminescent probe for biosensing application was summarized.Moreover,perspectives on future exploration of Mn∶ZnS QDs for biosensing and bioimaging were also given.
In recent years,Mn-doped ZnS quantum dots(Mn∶ZnS QDs)have been extensively used as luminescent probes for biosensing and bioimaging due to their excellent optical and photophysical properties.The prevalently application of Mn∶ZnS QDs and their preparation approaches were first briefly introduced.Then Mn∶ZnS QDs used as luminescent probe for biosensing application was summarized.Moreover,perspectives on future exploration of Mn∶ZnS QDs for biosensing and bioimaging were also given.
引文
[1]Lesnyak V,Gaponik N,Eychmuller A.Colloidal semiconductor nanocrystals:the aqueous approach[J].Chem Soc Rev,2013,42(7):2905-2929.
[2]Freeman R,Willner I.Optical molecular sensing with semiconductor quantum dots(QDs)[J].Chem Soc Rev,2012,41(10):4067-4085.
[3]Frigerio C,Ribeiro D S M,Rodrigues S S M,et al.Application of quantum dots as analytical tools in automated chemical analysis:a review[J].Anal Chim Acta,2012,735:9-22.
[4]Howes P D,Chandrawati R,Stevens M M.Colloidal nanoparticles as advanced biological sensors[J].Science,2014,346(6205):53-63.
[5]Kagan C R,Lifshitz E,Sargent E H,et al.Building devices from colloidal quantum dots[J].Science,2016,353(6302):885-894.
[6]Han M,Gao X,Su J Z,et al.Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules[J].Nat Biotech,2001,19(7):631-635.
[7]Wu P,Yan X P.Doped quantum dots for chemo/biosensing and bioimaging[J].Chem Soc Rev,2013,42(12):5489-5521.
[8]Sapra S,Prakash A,Ghangrekar A,et al.Emission properties of manganese-doped ZnS nanocrystals[J].J Phys Chem B,2005,109(5):1663-1668.
[9]Mocatta D,Cohen G,Schattner J,et al.Heavily doped semiconductor nanocrystal quantum dots[J].Science,2011,332(6025):77-81.
[10]Norris D J,Efros A L,Erwin S C.Doped nanocrystals[J].Science,2008,319(5871):1776-1779.
[11]Pradhan N,Sarma D D.Advances in light-emitting doped semiconductor nanocrystals[J].J Phys Chem Lett,2011,2(21):2818-2826.
[12]Bhargava R N,Gallagher D,Hong X,et al.Optical properties of manganese-doped nanocrystals of ZnS[J].Phys Rev Lett,1994,72(3):416-419.
[13]Zheng J,Yuan X,Ikezawa M,et al.Efficient photoluminescence of Mn2+ions in MnS/ZnS core/shell quantum dots[J].J Phys Chem C,2009,113(39):16969-16974.
[14]Srivastava B B,Jana S,Karan N S,et al.Highly luminescent Mn-doped ZnS nanocrystals:gram-scale synthesis[J].J Phys Chem Lett,2010,1(9):1454-1458.
[15]Zhuang J,Zhang X,Wang G,et al.Synthesis of water-soluble ZnS∶Mn2+nanocrystals by using mercaptopropionic acid as stabilizer[J].J Mater Chem,2003,13(7):1853-1857.
[16]Geszke Moritz M,Piotrowska H,Murias M,et al.Thioglycerol-capped Mn-doped ZnS quantum dot bioconjugates as efficient two-photon fluorescent nano-probes for bioimaging[J].Journal of Materials Chemistry B,2013,1(5):698-706.
[17]Ban R,Li J,Cao J,et al.Highly luminescent glutathionecapped ZnS∶Mn/ZnS core/shell doped quantum dots for targeted mannosyl groups expression on the cell surface[J].Analytical Methods,2013,5(21):5929-5937.
[18]Murase N,Jagannathan R,Kanematsu Y,et al.Fluorescence and EPR characteristics of Mn2+-doped ZnS nanocrystals prepared by aqueous colloidal method[J].J Phys Chem B,1999,103(5):754-760.
[19]He Y,Wang H F,Yan X P.Exploring Mn-doped ZnS quantum dots for the room-temperature phosphorescence detection of enoxacin in biological fluids[J].Anal Chem,2008,80(10):3832-3837.
[20]Tu R,Liu B,Wang Z,et al.Amine-capped ZnS-Mn2+nanocrystals for fluorescence detection of trace TNT explosive[J].Anal Chem,2008,80(9):3458-3465.
[21]Zou W S,Sheng D,Ge X,et al.Room-temperature phosphorescence chemosensor and rayleigh scattering chemodosimeter dual-recognition probe for 2,4,6-trinitrotoluene based on manganese-doped ZnS quantum dots[J].Anal Chem,2010,83(1):30-37.
[22]Wu P,He Y,Wang H F,et al.Conjugation of glucose oxidase onto Mn-doped ZnS quantum dots for phosphorescent sensing of glucose in biological fluids[J].Anal Chem,2010,82(4):1427-1433.
[23]Sotelo Gonzalez E,Fernandez Argüelles M T,Costa Fernandez J M,et al.Mn-doped ZnS quantum dots for the determination of acetone by phosphorescence attenuation[J].Anal Chim Acta,2012,712:120-126.
[24]Ban R,Zhu J J,Zhang J R.Manganese-doped ZnS quantum dots as a phosphorescent probe for use in the bi-enzymatic determination of organophosphorus pesticides[J].Microchim Acta,2014,181(13/14):1591-1599.
[25]Wang Y,Zou W.3-Aminopropyltriethoxysilane-functionalized manganese doped ZnS quantum dots for room-temperature phosphorescence sensing ultratrace 2,4,6-trinitrotoluene in aqueous solution[J].Talanta,2011,85(1):469-475.
[26]Miao Y,Zhang Z,Gong Y,et al.Self-assembly of manganese doped zinc sulfide quantum dots/CTAB nanohybrids for detection of rutin[J].Biosens Bioelectron,2014,52:271-276.
[27]Wang H F,He Y,Ji T R,et al.Surface molecular imprinting on Mn-doped ZnS quantum dots for room-temperature phosphorescence optosensing of pentachlorophenol in water[J].Anal Chem,2009,81(4):1615-1621.
[28]Liu J,Chen H,Lin Z,et al.Preparation of surface imprinting polymer capped Mn-Doped ZnS quantum dots and their application for chemiluminescence detection of 4-nitrophenol in tap water[J].Anal Chem,2010,82(17):7380-7386.
[29]班睿,李玉美,杜海军,等.基于Mn∶ZnS量子点荧光共振能量转移法测定水体中孔雀石绿[J].环境化学,2014,33(4):684-688.
[30]李艳,苗艳明,杨茂青,等.基于Mn掺杂ZnS量子点室温磷光法测定水样中百草枯[J].分析科学学报,2016,32(5):624-628.
[31]Zhao Y,Ma Y,Li H,et al.Composite QDs@MIP nanospheres for specific recognition and direct fluorescent quantification of pesticides in aqueous media[J].Anal Chem,2011,84(1):386-395.
[32]Wang H F,Li Y,Wu Y Y,et al.Ascorbic acid induced enhancement of room temperature phosphorescence of sodium tripolyphosphate-capped Mn-doped ZnS quantum dots:mechanism and bioprobe applications[J].Chem-Eur J,2010,16(43):12988-12994.
[33]Xie W Y,Huang W T,Luo H Q,et al.CTAB-capped Mndoped ZnS quantum dots and label-free aptamer for roomtemperature phosphorescence detection of mercury ions[J].Analyst,2012,137(20):4651-4653.
[34]Ren H B,Wu B Y,Chen J T,et al.Silica-coated S2--enriched manganese-doped ZnS quantum dots as a photoluminescence probe for imaging intracellular Zn2+ions[J].Anal Chem,2011,83(21):8239-8244.
[35]Zhao T,Hou X,Xie Y N,et al.Phosphorescent sensing of Cr3+with protein-functionalized Mn-doped ZnS quantum dots[J].Analyst,2013,138(21):6589-6594.
[36]Shang Y,Qi L,Wu F Y.Functionalized manganese-doped zinc sulfide quantum dot-based fluorescent probe for zinc ion[J].Microchim Acta,2012,177(3):333-339.
[37]Dong B,Cao L,Su G,et al.Synthesis and characterization of the water-soluble silica-coated ZnS∶Mn nanoparticles as fluorescent sensor for Cu2+ions[J].J Colloid Interface Sci,2009,339(1):78-82.
[38]Zhang B,Qi L,Wu F.Functionalized manganese-doped zinc sulfide core/shell quantum dots as selective fluorescent chemodosimeters for silver ion[J].Microchim Acta,2010,170(1):147-153.
[39]He Y,Yan X P.Mn-doped ZnS quantum dots/methyl violet nanohybrids for room temperature phosphorescence sensing of DNA[J].Science China Chemistry,2011,54(8):1254-1259.
[40]Wu P,Zhao T,Tian Y,et al.Protein-directed synthesis of Mndoped ZnS quantum dots:a dual-channel biosensor for two proteins[J].Chem-Eur J,2013,19(23):7473-7479.
[41]任呼博,杨成雄,严秀平.微波-超声波辅助合成聚乙烯亚胺包覆Mn掺杂ZnS量子点用于室温磷光检测三磷酸鸟苷[J].分析测试学报,2012,31(9):1042-1050.
[42]Wu P,Zhao T,Zhang J,et al.Analyte-activable probe for protease based on cytochrome C-capped Mn∶ZnS quantum dots[J].Anal Chem,2014,86(20):10078-10083.
[43]Sang L J,Wang H F.Aminophenylboronic-acid-conjugated polyacrylic acid-Mn-doped ZnS quantum dot for highly sensitive discrimination of glycoproteins[J].Anal Chem,2014,86(12):5706-5712.
[44]杨茂青,苗艳明,闫桂琴.基于Mn掺杂ZnS量子点-BSA纳米复合材料检测头孢曲松钠[J].发光学报,2015,36(4):472-479.
[45]Chang S Q,Kang B,Dai Y D,et al.One-step fabrication of biocompatible chitosan-coated ZnS and ZnS∶Mn2+quantum dots via a gamma-radiation route[J].Nanoscale Res Lett,2011,6(1):591-598.
[46]Koyakutty M,Seby J,Deepa T,et al.Bio-conjugated luminescent quantum dots of doped ZnS:a cyto-friendly system for targeted cancer imaging[J].Nanotechnology,2009,20(6):65102-65115.
[47]Geszke M,Murias M,Balan L,et al.Folic acid-conjugated core/shell ZnS∶Mn/ZnS quantum dots as targeted probes for two photon fluorescence imaging of cancer cells[J].Acta Biomaterialia,2011,7(3):1327-1338.
[2]Freeman R,Willner I.Optical molecular sensing with semiconductor quantum dots(QDs)[J].Chem Soc Rev,2012,41(10):4067-4085.
[3]Frigerio C,Ribeiro D S M,Rodrigues S S M,et al.Application of quantum dots as analytical tools in automated chemical analysis:a review[J].Anal Chim Acta,2012,735:9-22.
[4]Howes P D,Chandrawati R,Stevens M M.Colloidal nanoparticles as advanced biological sensors[J].Science,2014,346(6205):53-63.
[5]Kagan C R,Lifshitz E,Sargent E H,et al.Building devices from colloidal quantum dots[J].Science,2016,353(6302):885-894.
[6]Han M,Gao X,Su J Z,et al.Quantum-dot-tagged microbeads for multiplexed optical coding of biomolecules[J].Nat Biotech,2001,19(7):631-635.
[7]Wu P,Yan X P.Doped quantum dots for chemo/biosensing and bioimaging[J].Chem Soc Rev,2013,42(12):5489-5521.
[8]Sapra S,Prakash A,Ghangrekar A,et al.Emission properties of manganese-doped ZnS nanocrystals[J].J Phys Chem B,2005,109(5):1663-1668.
[9]Mocatta D,Cohen G,Schattner J,et al.Heavily doped semiconductor nanocrystal quantum dots[J].Science,2011,332(6025):77-81.
[10]Norris D J,Efros A L,Erwin S C.Doped nanocrystals[J].Science,2008,319(5871):1776-1779.
[11]Pradhan N,Sarma D D.Advances in light-emitting doped semiconductor nanocrystals[J].J Phys Chem Lett,2011,2(21):2818-2826.
[12]Bhargava R N,Gallagher D,Hong X,et al.Optical properties of manganese-doped nanocrystals of ZnS[J].Phys Rev Lett,1994,72(3):416-419.
[13]Zheng J,Yuan X,Ikezawa M,et al.Efficient photoluminescence of Mn2+ions in MnS/ZnS core/shell quantum dots[J].J Phys Chem C,2009,113(39):16969-16974.
[14]Srivastava B B,Jana S,Karan N S,et al.Highly luminescent Mn-doped ZnS nanocrystals:gram-scale synthesis[J].J Phys Chem Lett,2010,1(9):1454-1458.
[15]Zhuang J,Zhang X,Wang G,et al.Synthesis of water-soluble ZnS∶Mn2+nanocrystals by using mercaptopropionic acid as stabilizer[J].J Mater Chem,2003,13(7):1853-1857.
[16]Geszke Moritz M,Piotrowska H,Murias M,et al.Thioglycerol-capped Mn-doped ZnS quantum dot bioconjugates as efficient two-photon fluorescent nano-probes for bioimaging[J].Journal of Materials Chemistry B,2013,1(5):698-706.
[17]Ban R,Li J,Cao J,et al.Highly luminescent glutathionecapped ZnS∶Mn/ZnS core/shell doped quantum dots for targeted mannosyl groups expression on the cell surface[J].Analytical Methods,2013,5(21):5929-5937.
[18]Murase N,Jagannathan R,Kanematsu Y,et al.Fluorescence and EPR characteristics of Mn2+-doped ZnS nanocrystals prepared by aqueous colloidal method[J].J Phys Chem B,1999,103(5):754-760.
[19]He Y,Wang H F,Yan X P.Exploring Mn-doped ZnS quantum dots for the room-temperature phosphorescence detection of enoxacin in biological fluids[J].Anal Chem,2008,80(10):3832-3837.
[20]Tu R,Liu B,Wang Z,et al.Amine-capped ZnS-Mn2+nanocrystals for fluorescence detection of trace TNT explosive[J].Anal Chem,2008,80(9):3458-3465.
[21]Zou W S,Sheng D,Ge X,et al.Room-temperature phosphorescence chemosensor and rayleigh scattering chemodosimeter dual-recognition probe for 2,4,6-trinitrotoluene based on manganese-doped ZnS quantum dots[J].Anal Chem,2010,83(1):30-37.
[22]Wu P,He Y,Wang H F,et al.Conjugation of glucose oxidase onto Mn-doped ZnS quantum dots for phosphorescent sensing of glucose in biological fluids[J].Anal Chem,2010,82(4):1427-1433.
[23]Sotelo Gonzalez E,Fernandez Argüelles M T,Costa Fernandez J M,et al.Mn-doped ZnS quantum dots for the determination of acetone by phosphorescence attenuation[J].Anal Chim Acta,2012,712:120-126.
[24]Ban R,Zhu J J,Zhang J R.Manganese-doped ZnS quantum dots as a phosphorescent probe for use in the bi-enzymatic determination of organophosphorus pesticides[J].Microchim Acta,2014,181(13/14):1591-1599.
[25]Wang Y,Zou W.3-Aminopropyltriethoxysilane-functionalized manganese doped ZnS quantum dots for room-temperature phosphorescence sensing ultratrace 2,4,6-trinitrotoluene in aqueous solution[J].Talanta,2011,85(1):469-475.
[26]Miao Y,Zhang Z,Gong Y,et al.Self-assembly of manganese doped zinc sulfide quantum dots/CTAB nanohybrids for detection of rutin[J].Biosens Bioelectron,2014,52:271-276.
[27]Wang H F,He Y,Ji T R,et al.Surface molecular imprinting on Mn-doped ZnS quantum dots for room-temperature phosphorescence optosensing of pentachlorophenol in water[J].Anal Chem,2009,81(4):1615-1621.
[28]Liu J,Chen H,Lin Z,et al.Preparation of surface imprinting polymer capped Mn-Doped ZnS quantum dots and their application for chemiluminescence detection of 4-nitrophenol in tap water[J].Anal Chem,2010,82(17):7380-7386.
[29]班睿,李玉美,杜海军,等.基于Mn∶ZnS量子点荧光共振能量转移法测定水体中孔雀石绿[J].环境化学,2014,33(4):684-688.
[30]李艳,苗艳明,杨茂青,等.基于Mn掺杂ZnS量子点室温磷光法测定水样中百草枯[J].分析科学学报,2016,32(5):624-628.
[31]Zhao Y,Ma Y,Li H,et al.Composite QDs@MIP nanospheres for specific recognition and direct fluorescent quantification of pesticides in aqueous media[J].Anal Chem,2011,84(1):386-395.
[32]Wang H F,Li Y,Wu Y Y,et al.Ascorbic acid induced enhancement of room temperature phosphorescence of sodium tripolyphosphate-capped Mn-doped ZnS quantum dots:mechanism and bioprobe applications[J].Chem-Eur J,2010,16(43):12988-12994.
[33]Xie W Y,Huang W T,Luo H Q,et al.CTAB-capped Mndoped ZnS quantum dots and label-free aptamer for roomtemperature phosphorescence detection of mercury ions[J].Analyst,2012,137(20):4651-4653.
[34]Ren H B,Wu B Y,Chen J T,et al.Silica-coated S2--enriched manganese-doped ZnS quantum dots as a photoluminescence probe for imaging intracellular Zn2+ions[J].Anal Chem,2011,83(21):8239-8244.
[35]Zhao T,Hou X,Xie Y N,et al.Phosphorescent sensing of Cr3+with protein-functionalized Mn-doped ZnS quantum dots[J].Analyst,2013,138(21):6589-6594.
[36]Shang Y,Qi L,Wu F Y.Functionalized manganese-doped zinc sulfide quantum dot-based fluorescent probe for zinc ion[J].Microchim Acta,2012,177(3):333-339.
[37]Dong B,Cao L,Su G,et al.Synthesis and characterization of the water-soluble silica-coated ZnS∶Mn nanoparticles as fluorescent sensor for Cu2+ions[J].J Colloid Interface Sci,2009,339(1):78-82.
[38]Zhang B,Qi L,Wu F.Functionalized manganese-doped zinc sulfide core/shell quantum dots as selective fluorescent chemodosimeters for silver ion[J].Microchim Acta,2010,170(1):147-153.
[39]He Y,Yan X P.Mn-doped ZnS quantum dots/methyl violet nanohybrids for room temperature phosphorescence sensing of DNA[J].Science China Chemistry,2011,54(8):1254-1259.
[40]Wu P,Zhao T,Tian Y,et al.Protein-directed synthesis of Mndoped ZnS quantum dots:a dual-channel biosensor for two proteins[J].Chem-Eur J,2013,19(23):7473-7479.
[41]任呼博,杨成雄,严秀平.微波-超声波辅助合成聚乙烯亚胺包覆Mn掺杂ZnS量子点用于室温磷光检测三磷酸鸟苷[J].分析测试学报,2012,31(9):1042-1050.
[42]Wu P,Zhao T,Zhang J,et al.Analyte-activable probe for protease based on cytochrome C-capped Mn∶ZnS quantum dots[J].Anal Chem,2014,86(20):10078-10083.
[43]Sang L J,Wang H F.Aminophenylboronic-acid-conjugated polyacrylic acid-Mn-doped ZnS quantum dot for highly sensitive discrimination of glycoproteins[J].Anal Chem,2014,86(12):5706-5712.
[44]杨茂青,苗艳明,闫桂琴.基于Mn掺杂ZnS量子点-BSA纳米复合材料检测头孢曲松钠[J].发光学报,2015,36(4):472-479.
[45]Chang S Q,Kang B,Dai Y D,et al.One-step fabrication of biocompatible chitosan-coated ZnS and ZnS∶Mn2+quantum dots via a gamma-radiation route[J].Nanoscale Res Lett,2011,6(1):591-598.
[46]Koyakutty M,Seby J,Deepa T,et al.Bio-conjugated luminescent quantum dots of doped ZnS:a cyto-friendly system for targeted cancer imaging[J].Nanotechnology,2009,20(6):65102-65115.
[47]Geszke M,Murias M,Balan L,et al.Folic acid-conjugated core/shell ZnS∶Mn/ZnS quantum dots as targeted probes for two photon fluorescence imaging of cancer cells[J].Acta Biomaterialia,2011,7(3):1327-1338.