Comparative study on pattern recognition receptors in non-teleost ray-finned fishes and their evolutionary significance in primitive vertebrates
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摘要
Pattern recognition receptors(PRRs) play important roles in innate immunity system and trigger the specific pathogen recognition by detecting the pathogen-associated molecular patterns. The main four PRRs components including Toll-like receptors(TLRs), RIG-I-like receptors(RLRs), NOD-like receptors(NLRs) and C-type lectin receptors(CLRs) were surveyed in the five genomes of non-teleost ray-finned fishes(NTR) including bichir(Polypterus senegalus), American paddlefish(Polyodon spathula), alligator gar(Atractosteus spatula), spotted gar(Lepisosteus oculatus) and bowfin(Amia calva), representing all the four major basal groups of ray-finned fishes. The result indicates that all the four PRRs components have been well established in these NTR fishes. In the RLR-MAVS signal pathway, which detects intracellular RNA ligands to induce production of type I interferons(IFNs), the MAVS was lost in bichir particularly. Also, the essential genes of recognition of Lipopolysaccharide(LPS) commonly in mammals like MD2, LY96 and LBP could not be identified in NTR fishes. It is speculated that TLR4 in NTR fishes may act as a cooperator with other PRRs and has a different pathway of recognizing LPS compared with that in mammals. In addition, we provide a survey of NLR and CLR in NTR fishes. The CLRs results suggest that Group V receptors are absent in fishes and Group II and VI receptors are well established in the early vertebrate evolution. Our comprehensive research of PRRs involving NTR fishes provides a new insight into PRR evolution in primitive vertebrate.
Pattern recognition receptors(PRRs) play important roles in innate immunity system and trigger the specific pathogen recognition by detecting the pathogen-associated molecular patterns. The main four PRRs components including Toll-like receptors(TLRs), RIG-I-like receptors(RLRs), NOD-like receptors(NLRs) and C-type lectin receptors(CLRs) were surveyed in the five genomes of non-teleost ray-finned fishes(NTR) including bichir(Polypterus senegalus), American paddlefish(Polyodon spathula), alligator gar(Atractosteus spatula), spotted gar(Lepisosteus oculatus) and bowfin(Amia calva), representing all the four major basal groups of ray-finned fishes. The result indicates that all the four PRRs components have been well established in these NTR fishes. In the RLR-MAVS signal pathway, which detects intracellular RNA ligands to induce production of type I interferons(IFNs), the MAVS was lost in bichir particularly. Also, the essential genes of recognition of Lipopolysaccharide(LPS) commonly in mammals like MD2, LY96 and LBP could not be identified in NTR fishes. It is speculated that TLR4 in NTR fishes may act as a cooperator with other PRRs and has a different pathway of recognizing LPS compared with that in mammals. In addition, we provide a survey of NLR and CLR in NTR fishes. The CLRs results suggest that Group V receptors are absent in fishes and Group II and VI receptors are well established in the early vertebrate evolution. Our comprehensive research of PRRs involving NTR fishes provides a new insight into PRR evolution in primitive vertebrate.
Pattern recognition receptors(PRRs) play important roles in innate immunity system and trigger the specific pathogen recognition by detecting the pathogen-associated molecular patterns. The main four PRRs components including Toll-like receptors(TLRs), RIG-I-like receptors(RLRs), NOD-like receptors(NLRs) and C-type lectin receptors(CLRs) were surveyed in the five genomes of non-teleost ray-finned fishes(NTR) including bichir(Polypterus senegalus), American paddlefish(Polyodon spathula), alligator gar(Atractosteus spatula), spotted gar(Lepisosteus oculatus) and bowfin(Amia calva), representing all the four major basal groups of ray-finned fishes. The result indicates that all the four PRRs components have been well established in these NTR fishes. In the RLR-MAVS signal pathway, which detects intracellular RNA ligands to induce production of type I interferons(IFNs), the MAVS was lost in bichir particularly. Also, the essential genes of recognition of Lipopolysaccharide(LPS) commonly in mammals like MD2, LY96 and LBP could not be identified in NTR fishes. It is speculated that TLR4 in NTR fishes may act as a cooperator with other PRRs and has a different pathway of recognizing LPS compared with that in mammals. In addition, we provide a survey of NLR and CLR in NTR fishes. The CLRs results suggest that Group V receptors are absent in fishes and Group II and VI receptors are well established in the early vertebrate evolution. Our comprehensive research of PRRs involving NTR fishes provides a new insight into PRR evolution in primitive vertebrate.
引文
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Brownlie,R.,and Allan,B.(2011).Avian toll-like receptors.Cell Tissue Res 343,121-130.
Bruns,A.M.,and Horvath,C.M.(2012).Activation of RIG-I-like receptor signal transduction.Crit Rev Biochem Mol Biol 47,194-206.
Camacho,C.,Coulouris,G.,Avagyan,V.,Ma,N.,Papadopoulos,J.,Bealer,K.,and Madden,T.L.(2009).Blast+:Architecture and applications.BMC BioInf 10,421.
Chen,S.N.,Zou,P.F.,and Nie,P.(2017).Retinoic acid-inducible gene I(RIG-I)-like receptors(RLRs)in fish:Current knowledge and future perspectives.Immunology 151,16-25.
Chen,W.Q.,Hu,Y.W.,Zou,P.F.,Ren,S.S.,Nie,P.,and Chang,M.X.(2015).MAVS splicing variants contribute to the induction of interferon and interferon-stimulated genes mediated by RIG-I-like receptors.Dev Comp Immunol 49,19-30.
Dambuza,I.M.,and Brown,G.D.(2015).C-type lectins in immunity:Recent developments.Curr Opin Immunol 32,21-27.
Drickamer,K.,and Taylor,M.E.(2015).Recent insights into structures and functions of C-type lectins in the immune system.Curr Opin Struct Biol34,26-34.
Edgar,R.C.(2004).Muscle:Multiple sequence alignment with high accuracy and high throughput.Nucleic Acids Res 32,1792-1797.
Feng,X.,Zhang,Y.,Yang,C.,Liao,L.,Wang,Y.,and Su,J.(2015).Functional characterizations of IPS-1 in cik cells:Potential roles in regulating IFN-I response dependent on IFN-7 but not irf3.Dev Comp Immunol 53,23-32.
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Geijtenbeek,T.B.H.,and Gringhuis,S.I.(2016).C-type lectin receptors in the control of T helper cell differentiation.Nat Rev Immunol 16,433-448.
Guindon,S.,Dufayard,J.F.,Lefort,V.,Anisimova,M.,Hordijk,W.,and Gascuel,O.(2010).New algorithms and methods to estimate maximum-likelihood phylogenies:Assessing the performance of phyml 3.0.Systatic Biol 59,307-321.
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Huang,R.,Dong,F.,Jang,S.,Liao,L.,Zhu,Z.,and Wang,Y.(2012).Isolation and analysis of a novel grass carp toll-like receptor 4(TLR4)gene cluster involved in the response to grass carp reovirus.Dev Comp Immunol 38,383-388.
Huang,S.,Yuan,S.,Guo,L.,Yu,Y.,Li,J.,Wu,T.,Liu,T.,Yang,M.,Wu,K.,Liu,H.,et al.(2008).Genomic analysis of the immune gene repertoire of amphioxus reveals extraordinary innate complexity and diversity.Genome Res 18,1112-1126.
Hwang,S.D.,Asahi,T.,Kondo,H.,Hirono,I.,and Aoki,T.(2010).Molecular cloning and expression study on toll-like receptor 5 paralogs in Japanese flounder,Paralichthys olivaceus.Fish Shellfish Immunol 29,630-638.
Iliev,D.B.,Roach,J.C.,Mackenzie,S.,Planas,J.V.,and Goetz,F.W.(2005).Endotoxin recognition:In fish or not in fish?FEBS Lett 579,6519-6528.
Ishii,A.,Kawasaki,M.,Matsumoto,M.,Tochinai,S.,and Seya,T.(2007a).Phylogenetic and expression analysis of amphibian xenopus toll-like receptors.Immunogenetics 59,281-293.
Ishii,A.,Matsuo,A.,Sawa,H.,Tsujita,T.,Shida,K.,Matsumoto,M.,and Seya,T.(2007b).Lamprey TLRs with properties distinct from those of the variable lymphocyte receptors.J Immunol 178,397-406.
Jault,C.,Pichon,L.,and Chluba,J.(2004).Toll-like receptor gene family and TIR-domain adapters in Danio rerio.Mol Immunol 40,759-771.
Jia,P.,Jin,Y.,Chen,L.,Zhang,J.,Jia,K.,and Yi,M.(2016).Molecular characterization and expression analysis of mitochondrial antiviral signaling protein gene in sea perch,lateolabrax japonicus.Dev Comp Immunol 55,188-193.
Kasamatsu,J.,Oshiumi,H.,Matsumoto,M.,Kasahara,M.,and Seya,T.(2010).Phylogenetic and expression analysis of lamprey toll-like receptors.Dev Comp Immunol 34,855-865.
Kawai,T.,and Akira,S.(2011).Toll-like receptors and their crosstalk with other innate receptors in infection and immunity.Immunity 34,637-650.
Kufer,T.A.,and Sansonetti,P.J.(2011).NLR functions beyond pathogen recognition.Nat Immunol 12,121-128.
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