猪免疫应激及其营养调控
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摘要
"免疫应激"在养猪生产中普遍存在,是导致猪生长抑制的重要因素之一,给养猪生产造成很大的经济损失。免疫应激是由于饲养环境中的病原体、非病原体(如细菌、病毒和内毒素等)或疫苗接种等刺激免疫系统,导致白细胞介素(IL)-1β、IL-6和肿瘤坏死因子-α等炎性细胞因子过量释放所致。本文综述了猪的免疫应激研究进展情况,包括研究猪免疫应激问题所采用的模型,免疫应激对猪生长、代谢和生理功能的影响,免疫应激与过氧化物酶体增殖物活化受体γ、Toll样受体4和核苷酸结合寡聚化结构域信号通路的关系。最后,阐述了不同链长脂肪酸对猪免疫应激的调控作用。
引文
[1]Gabler N K,Spurlock M E.Integrating the immune system with the regulation of growth and efficiency[J].Journal of Animal Science,2008,86(14 Suppl):E64-74.
[2]Chen F,Liu Y,Zhu H,et al..Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways[J].Innate Immunity,2013,19(5):504-515.
[3]Liu Y L.Chen F,OdleJ,et al..Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge[J].Journal of Nutrition,2012,142(11):2017-2024.
[4]Liu Y L.Chen F,Li Q,et al..Fish oil alleviates activation of hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaning pigs after an LPS challenge[J].Journal of Nutrition,2013,143(11):1799-1807.
[5]Liu Y L.Chen F.Odle J,et al..Fish oil increases muscle protein mass and modulates Akt/FOXO,TLR4 and NOD signaling in weaning piglets after LPS challenge[J].Journal of Nutrition,2013,143(8):1331-1339.
[6]Liu Y L,Gong L M,Li D F,et al..Effects of fish oil on lymphocyte proliferation,cytokine production and intracellular signaling in weanling pigs[J].Archives of Animal Nutrition,2003,57(3):151-165.
[7]Liu Y L,Li D F,Gong L M,et al..Effects of fish oil supplementation on the performance and the immunological,adrenal,and somatotropic responses of weaned pigs after an Escherichia coli lipopolysaccharide challenged].Journal of Animal Science,2003,81(11):2758-2765.
[8]Liu Y.Fatty acids,inflammation and intestinal health in pigs[J].Journal of Animal Science and Biotechnology,2015,6(1):41.
[9]Zhu H,Liu Y,Chen S,et al..Fish oil enhances intestinal barrier function and inhibits corticotropin-releasing hormone/corticotropin-releasing hormone receptor 1 signalling pathway in weaned pigs after lipopolysaccharide challenge[J].British Journal of Nutrition,2016,115(11):1947-1957.
[10]Wu H,Liu Y,Pi D,et al..Asparagine attenuates hepatic injury caused by lipopolysaccharide in weaned piglets associated with modulation of Toll-like receptor 4 and nucleotide-binding oligomerisation domain protein signalling and their negative regulators[J].British Journal of Nutrition,2015,114(2):189-201.
[11]Liu Y,Wang X,Wu H,et al..Glycine Enhances Muscle Protein Mass Associated with Maintaining Akt-mTORFOXOl Signaling and Suppressing TLR4 and NOD2 Signaling in Piglets Challenged with LPS[J].American Journal of Physiology-Regulatory Integrative and Comparative Physiology,2016,25:ajpregu.00043.
[12]Schakman 0,Dehoux M.Bouchuari S,et al..Role of IGF-I and the TNFa/NF-icB pathway in the induction of muscle atrogenes by acute inflammation[J].American Journal of Physiology-Endocrinology and Metabolism,2012,303(6):E729-739.
[13]Verhees K J.Pansters N A,Baarsma H A,et al..Pharmacological inhibition of GSK-3 in a guinea pig model of LPSinduced pulmonary inflammation:II.Effects on skeletal muscle atrophy[J].Respiratory Research,2013,14:117.
[14]De Nardo D.Toll-like receptors:Activation,signalling and transcriptional modulation[J].Cytokine.2015,74(2):181-189.
[15]Houshmand G,Mansouri M T.Naghizadeh B,et al..Potentiation of indomethacin-induced anti-inflammatory response by pioglitazone in carrageenan-induced acute inflammation in rats:Role of PPARy receptors[J].International Immunopharmacology,2016,38:434-442.
[16]Liu Y,Shi J,Lu J,et al..Activation of peroxisome proliferator-activated receptor-gamma potentiates pro-inflammatory cytokine production,and adrenal and somatotropic changes of weaned pigs after Escherichia coli Upopolysaccharide challenge[J].Innate Immunity,2009,15(3):169-178.
[17]Fan W.Liu Y L,Wu Z F,et al..Effects of rosiglitazone,an agonist of the peroxisome proliferator-activated receptor gamma,on intestinal damage induced by Escherichia coli Upopolysaccharide in weaned pigs[J].American Journal of Veterinary Research,2010,71:1331-1338.
[18]陈少魁,刘玉兰,李权,等.脂多糖刺激对仔猪下丘脑-垂体-肾上腺轴Toll样受体4信号通路关键基因表达的影响[J].动物营养学报,2014(11):3356-3361.
[19]王海波,刘玉兰,李权,等.脂多糖对仔猪下丘脑-垂体-肾上腺轴内应激基因和NOD信号通路关键基因表达的影响[J].中国畜牧杂志,2015,51(1):20-24.
[20]涂治骁,刘玉兰,吴欢听,等.脂多糖刺激对仔猪肠道、肝脏和肌肉组织NODs信号通路关键基因及其负调控因子mRNA表达的影响[J].中国畜牧杂志,2016,52(11):35-38.
[21]Jacobi S K,Lin X,Corl B A,et al..Dietary arachidonate differentially alters desaturase-elongase pathway flux and gene expression in liver and intestine of suckling pigs[J].Journal of Nutrition,2011,141(4):548-553.
[22]Gaines A M,Carroll J A,Yi G F,et al..Effect of menhaden fish oil supplementation and Upopolysaccharide exposure on nursery pigs.II.Effects on the immune axis when fed simple or complex diets containing no spray-dried plasma[J].Domestic Animal Endocrinology,2003,24(4):353-365.
[23]Carroll J A,Gaines A M,Spencer J D,et al..Effect of menhaden fish oil supplementation and Upopolysaccharide exposure on nursery pigs.I.Effects on the immune axis when fed diets containing spray-dried plasma[J].Domestic Animal Endocrinology,2003,24(4):341-351.
[24]王海波.亚麻油对脂多糖诱导仔猪肠道和肝脏损伤的调控作用[D].硕士学位论文.武汉:武汉轻工大学,2016:39.
[25]Larsen T M.Toubro S,Astrup A.Efficacy and safety of dietary-supplements containing CLA for the treatment of obesity:evidence from animal and human studies[J].Journal of Lipid Research,2003,44(12):2234-2241.
[26]Bassaganya-Riera J,Hontecillas-Magarzo R,Bregendahl K,et al..Effects of dietary conjugated linoleic acid in nursery pigs of dirty and clean environments on growth,empty body composition,and immune competence[J].Journal of Animal Science,2001,79(3):714-721.
[27]Lai C,Yin J,Li D F,et al..Conjugated linoleic acid attenuates the production and gene expression of proinflammatory cytokines in weaned pigs challenged with lipopolysaccharide[J].Journal of Nutrition,2005,135(2):239-244.
[28]Bassaganya-Riera J,King J,Hontecillas R.Health benefits of conjugated linoleic acid:Lessons from pig models in biomedical research[J].European Journal of Lipid Science&Technology,2004,106(12):856-861.
[29]Hontecillas R,Wannemeulher M J,Zimmerman D R,et al..Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid[J].Journal of Nutrition,2002,132(7):2019-2027.
[30]Casellas J,Casas X,Piedrafita J,et al..Effect of medium-and long-chain triglyceride supplementation on small newborn-pig survival[J].Preventive Veterinary Medicine,2005,67(2/3):213-221.
[31]Zhang H,Li Y,Hou X,et al..Medium-chain TAG improve energy metabolism and mitochondrial biogenesis in the liver of intra-uterine growth-retarded and normal-birth-weight weanling piglets[J].British Journal of Nutrition,2016,115(9):1521-1530.
[32]Zhang H,Chen Y,Li Y,et al..Medium-chain TAG attenuate hepatic oxidative damage in intra-uterine growth-retarded weanling piglets by improving the metabolic efficiency of the glutathione redox cycle[J].British Journal of Nutrition,2014,112(6):876-885.
[33]Messens W.Goris J,Dierick N,et al..Inhibition of Salmonella typhimurium by medium-chain fatty acids in an in vitro simulation of the porcine cecum[J].Veterinary Microbiology,2010,141(1-2):73-80.
[34]Zentek J,Buchheit-Renko S,Manner K,et al..Intestinal concentrations of free and encapsulated dietary mediumchain fatty acids and effects on gastric microbial ecology and bacterial metabolic products in the digestive tract of piglets[J].Archives of Animal Nutrition,2012,66(1):14-26.
[35]Zentek J,Ferrara F.Pieper R,et al..Effects of dietary combinations of organic acids and medium chain fatty acids on the gastrointestinal microbial ecology and bacterial metabolites in the digestive tract of weaning piglets[J].Journal of Animal Science,2013,91(7):3200-3210.
[36]Papada E,Kaliora A C,Gioxari A,et al..Anti-inflammatory effect of elemental diets with different fat composition in experimental colitis[J].British Journal of Nutrition,2014,111(7)il213-1220.
[37]Kono H.Fujii H,Asakawa M,et al..Medium-chain triglycerides enhance secretory IgA expression in rat intestine after administration of endotoxin[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2004,286(6):G1081-1089.
[38]陈少魁.中链脂肪酸对脂多糖诱导仔猪肠道和肝脏损伤的调控作用[D].硕士学位论文.武汉:武汉轻工大学,2016:48.
[39]Kasubuchi M.Hasegawa S.Hiramatsu T,et al..Dietary gut microbial metabolites,short-chain fatty acids,and host metabolic regulation[J].Nutrients,2015,7(4):2839-2849.
[40]Fang C L,Sun H,Wu J,et al..Effects of sodium butyrate on growth performance,haematological and immunological characteristics of weanling piglets[J].Journal of Animal Physiology and Animal Nutrition,2014;98(4):680-685.
[41]Hou Y Q.Liu Yl,Hu J,et al..Effects of lactitol and tributyrin on growth performance,small intestinal morphology and enzyme activity in weaned pigs[J].Asian Australasian Journal of Animal Sciences,2006,19(10):1470-1477.
[42]Hou Y.Wang L,Yi D,et al..Dietary supplementation with tributyrin alleviates intestinal injury in piglets challenged with intrarectal administration of acetic acid[J].British Journal of Nutrition,2014,111(10):1748-1758.
[43]Ferrara F,Tedin L,Pieper R,et al..Influence of medium-chain fatty acids and short-chain organic acids on jejunal morphology and intra-epithelial immune cells in weaned piglets[J].Journal of Animal Physiology and Animal Nutrition,2016.doi:10.1111/jpn.12490.
[44]Vinolo M A,Rodrigues H G.Nachbar R T,et al..Regulation of inflammation by short chain fatty acids[J].Nutrients,2011,3(10):858-876.
[45]Remely M,Aumueller E.Merold C.et al..Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity[J].Gene,2014,537(1):85-92.
[2]Chen F,Liu Y,Zhu H,et al..Fish oil attenuates liver injury caused by LPS in weaned pigs associated with inhibition of TLR4 and nucleotide-binding oligomerization domain protein signaling pathways[J].Innate Immunity,2013,19(5):504-515.
[3]Liu Y L.Chen F,OdleJ,et al..Fish oil enhances intestinal integrity and inhibits TLR4 and NOD2 signaling pathways in weaned pigs after LPS challenge[J].Journal of Nutrition,2012,142(11):2017-2024.
[4]Liu Y L.Chen F,Li Q,et al..Fish oil alleviates activation of hypothalamic-pituitary-adrenal axis associated with inhibition of TLR4 and NOD signaling pathways in weaning pigs after an LPS challenge[J].Journal of Nutrition,2013,143(11):1799-1807.
[5]Liu Y L.Chen F.Odle J,et al..Fish oil increases muscle protein mass and modulates Akt/FOXO,TLR4 and NOD signaling in weaning piglets after LPS challenge[J].Journal of Nutrition,2013,143(8):1331-1339.
[6]Liu Y L,Gong L M,Li D F,et al..Effects of fish oil on lymphocyte proliferation,cytokine production and intracellular signaling in weanling pigs[J].Archives of Animal Nutrition,2003,57(3):151-165.
[7]Liu Y L,Li D F,Gong L M,et al..Effects of fish oil supplementation on the performance and the immunological,adrenal,and somatotropic responses of weaned pigs after an Escherichia coli lipopolysaccharide challenged].Journal of Animal Science,2003,81(11):2758-2765.
[8]Liu Y.Fatty acids,inflammation and intestinal health in pigs[J].Journal of Animal Science and Biotechnology,2015,6(1):41.
[9]Zhu H,Liu Y,Chen S,et al..Fish oil enhances intestinal barrier function and inhibits corticotropin-releasing hormone/corticotropin-releasing hormone receptor 1 signalling pathway in weaned pigs after lipopolysaccharide challenge[J].British Journal of Nutrition,2016,115(11):1947-1957.
[10]Wu H,Liu Y,Pi D,et al..Asparagine attenuates hepatic injury caused by lipopolysaccharide in weaned piglets associated with modulation of Toll-like receptor 4 and nucleotide-binding oligomerisation domain protein signalling and their negative regulators[J].British Journal of Nutrition,2015,114(2):189-201.
[11]Liu Y,Wang X,Wu H,et al..Glycine Enhances Muscle Protein Mass Associated with Maintaining Akt-mTORFOXOl Signaling and Suppressing TLR4 and NOD2 Signaling in Piglets Challenged with LPS[J].American Journal of Physiology-Regulatory Integrative and Comparative Physiology,2016,25:ajpregu.00043.
[12]Schakman 0,Dehoux M.Bouchuari S,et al..Role of IGF-I and the TNFa/NF-icB pathway in the induction of muscle atrogenes by acute inflammation[J].American Journal of Physiology-Endocrinology and Metabolism,2012,303(6):E729-739.
[13]Verhees K J.Pansters N A,Baarsma H A,et al..Pharmacological inhibition of GSK-3 in a guinea pig model of LPSinduced pulmonary inflammation:II.Effects on skeletal muscle atrophy[J].Respiratory Research,2013,14:117.
[14]De Nardo D.Toll-like receptors:Activation,signalling and transcriptional modulation[J].Cytokine.2015,74(2):181-189.
[15]Houshmand G,Mansouri M T.Naghizadeh B,et al..Potentiation of indomethacin-induced anti-inflammatory response by pioglitazone in carrageenan-induced acute inflammation in rats:Role of PPARy receptors[J].International Immunopharmacology,2016,38:434-442.
[16]Liu Y,Shi J,Lu J,et al..Activation of peroxisome proliferator-activated receptor-gamma potentiates pro-inflammatory cytokine production,and adrenal and somatotropic changes of weaned pigs after Escherichia coli Upopolysaccharide challenge[J].Innate Immunity,2009,15(3):169-178.
[17]Fan W.Liu Y L,Wu Z F,et al..Effects of rosiglitazone,an agonist of the peroxisome proliferator-activated receptor gamma,on intestinal damage induced by Escherichia coli Upopolysaccharide in weaned pigs[J].American Journal of Veterinary Research,2010,71:1331-1338.
[18]陈少魁,刘玉兰,李权,等.脂多糖刺激对仔猪下丘脑-垂体-肾上腺轴Toll样受体4信号通路关键基因表达的影响[J].动物营养学报,2014(11):3356-3361.
[19]王海波,刘玉兰,李权,等.脂多糖对仔猪下丘脑-垂体-肾上腺轴内应激基因和NOD信号通路关键基因表达的影响[J].中国畜牧杂志,2015,51(1):20-24.
[20]涂治骁,刘玉兰,吴欢听,等.脂多糖刺激对仔猪肠道、肝脏和肌肉组织NODs信号通路关键基因及其负调控因子mRNA表达的影响[J].中国畜牧杂志,2016,52(11):35-38.
[21]Jacobi S K,Lin X,Corl B A,et al..Dietary arachidonate differentially alters desaturase-elongase pathway flux and gene expression in liver and intestine of suckling pigs[J].Journal of Nutrition,2011,141(4):548-553.
[22]Gaines A M,Carroll J A,Yi G F,et al..Effect of menhaden fish oil supplementation and Upopolysaccharide exposure on nursery pigs.II.Effects on the immune axis when fed simple or complex diets containing no spray-dried plasma[J].Domestic Animal Endocrinology,2003,24(4):353-365.
[23]Carroll J A,Gaines A M,Spencer J D,et al..Effect of menhaden fish oil supplementation and Upopolysaccharide exposure on nursery pigs.I.Effects on the immune axis when fed diets containing spray-dried plasma[J].Domestic Animal Endocrinology,2003,24(4):341-351.
[24]王海波.亚麻油对脂多糖诱导仔猪肠道和肝脏损伤的调控作用[D].硕士学位论文.武汉:武汉轻工大学,2016:39.
[25]Larsen T M.Toubro S,Astrup A.Efficacy and safety of dietary-supplements containing CLA for the treatment of obesity:evidence from animal and human studies[J].Journal of Lipid Research,2003,44(12):2234-2241.
[26]Bassaganya-Riera J,Hontecillas-Magarzo R,Bregendahl K,et al..Effects of dietary conjugated linoleic acid in nursery pigs of dirty and clean environments on growth,empty body composition,and immune competence[J].Journal of Animal Science,2001,79(3):714-721.
[27]Lai C,Yin J,Li D F,et al..Conjugated linoleic acid attenuates the production and gene expression of proinflammatory cytokines in weaned pigs challenged with lipopolysaccharide[J].Journal of Nutrition,2005,135(2):239-244.
[28]Bassaganya-Riera J,King J,Hontecillas R.Health benefits of conjugated linoleic acid:Lessons from pig models in biomedical research[J].European Journal of Lipid Science&Technology,2004,106(12):856-861.
[29]Hontecillas R,Wannemeulher M J,Zimmerman D R,et al..Nutritional regulation of porcine bacterial-induced colitis by conjugated linoleic acid[J].Journal of Nutrition,2002,132(7):2019-2027.
[30]Casellas J,Casas X,Piedrafita J,et al..Effect of medium-and long-chain triglyceride supplementation on small newborn-pig survival[J].Preventive Veterinary Medicine,2005,67(2/3):213-221.
[31]Zhang H,Li Y,Hou X,et al..Medium-chain TAG improve energy metabolism and mitochondrial biogenesis in the liver of intra-uterine growth-retarded and normal-birth-weight weanling piglets[J].British Journal of Nutrition,2016,115(9):1521-1530.
[32]Zhang H,Chen Y,Li Y,et al..Medium-chain TAG attenuate hepatic oxidative damage in intra-uterine growth-retarded weanling piglets by improving the metabolic efficiency of the glutathione redox cycle[J].British Journal of Nutrition,2014,112(6):876-885.
[33]Messens W.Goris J,Dierick N,et al..Inhibition of Salmonella typhimurium by medium-chain fatty acids in an in vitro simulation of the porcine cecum[J].Veterinary Microbiology,2010,141(1-2):73-80.
[34]Zentek J,Buchheit-Renko S,Manner K,et al..Intestinal concentrations of free and encapsulated dietary mediumchain fatty acids and effects on gastric microbial ecology and bacterial metabolic products in the digestive tract of piglets[J].Archives of Animal Nutrition,2012,66(1):14-26.
[35]Zentek J,Ferrara F.Pieper R,et al..Effects of dietary combinations of organic acids and medium chain fatty acids on the gastrointestinal microbial ecology and bacterial metabolites in the digestive tract of weaning piglets[J].Journal of Animal Science,2013,91(7):3200-3210.
[36]Papada E,Kaliora A C,Gioxari A,et al..Anti-inflammatory effect of elemental diets with different fat composition in experimental colitis[J].British Journal of Nutrition,2014,111(7)il213-1220.
[37]Kono H.Fujii H,Asakawa M,et al..Medium-chain triglycerides enhance secretory IgA expression in rat intestine after administration of endotoxin[J].American Journal of Physiology:Gastrointestinal and Liver Physiology,2004,286(6):G1081-1089.
[38]陈少魁.中链脂肪酸对脂多糖诱导仔猪肠道和肝脏损伤的调控作用[D].硕士学位论文.武汉:武汉轻工大学,2016:48.
[39]Kasubuchi M.Hasegawa S.Hiramatsu T,et al..Dietary gut microbial metabolites,short-chain fatty acids,and host metabolic regulation[J].Nutrients,2015,7(4):2839-2849.
[40]Fang C L,Sun H,Wu J,et al..Effects of sodium butyrate on growth performance,haematological and immunological characteristics of weanling piglets[J].Journal of Animal Physiology and Animal Nutrition,2014;98(4):680-685.
[41]Hou Y Q.Liu Yl,Hu J,et al..Effects of lactitol and tributyrin on growth performance,small intestinal morphology and enzyme activity in weaned pigs[J].Asian Australasian Journal of Animal Sciences,2006,19(10):1470-1477.
[42]Hou Y.Wang L,Yi D,et al..Dietary supplementation with tributyrin alleviates intestinal injury in piglets challenged with intrarectal administration of acetic acid[J].British Journal of Nutrition,2014,111(10):1748-1758.
[43]Ferrara F,Tedin L,Pieper R,et al..Influence of medium-chain fatty acids and short-chain organic acids on jejunal morphology and intra-epithelial immune cells in weaned piglets[J].Journal of Animal Physiology and Animal Nutrition,2016.doi:10.1111/jpn.12490.
[44]Vinolo M A,Rodrigues H G.Nachbar R T,et al..Regulation of inflammation by short chain fatty acids[J].Nutrients,2011,3(10):858-876.
[45]Remely M,Aumueller E.Merold C.et al..Effects of short chain fatty acid producing bacteria on epigenetic regulation of FFAR3 in type 2 diabetes and obesity[J].Gene,2014,537(1):85-92.