主客体相互作用增强的聚集诱导发射效应用于细胞成像研究
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- 英文论文题名：Host–Guest Interaction Enhanced Aggregation-Induced Emission and Its Application in Cell Imaging
- 论文作者：周炯 ; 喻国灿 ; 黄飞鹤
- 英文论文作者：Jiong Zhou ; Guocan Yu ; Feihe Huang ; State Key Laboratory of Chemical Engineering ; Center for Chemistry of High-Performance & Novel Materials ; Department of Chemistry Department of Chemistry ; Zhejiang University
- 年：2016
- 作者机构：化学工程联合国家重点实验室高新材料化学研究中心浙江大学化学系;
- 论文关键词：主客体相互作用 ; 聚集诱导发射 ; 柱芳烃 ; 细胞成像
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十四分会：超分子组装与软物质材料
- 语种：中文
- 分类号：O657.3
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十四分会 ; 超分子组装与软物质材料
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：302k
- 原文格式：D
- 会议级别：全国
摘要
荧光成像由于其高灵敏度和非侵入性,已逐渐成为可视化不同种类生物目标的重要技术。由于高的发射效率和在生物体内良好的生物相容性,通过超分子方法来修饰聚集诱导发射荧光团已变得越发重要。主客体相互作用由于良好的选择性和环境响应性,在发展超分子材料方面扮演重要角色。柱芳烃,作为新一代大环主体,已经被广泛地研究。本文基于单官能团化柱[5]芳烃和四苯基乙烯衍生物构筑了一个主客体包合物,利用主客体相互作用限制四苯基乙烯的旋转,导致其荧光增强,进一步应用于细胞成像研究。
Fluorescence imaging has appeared as a significant technology for visualizing diverse biological targets. Supramolecular methods to modify AIE fluorogens are highly desirable for high emission efficiency and good biocompatibility. As a new generation of macrocyclic host, pillar[n]arenes, have been extensively studied. Herein, we prepared a host–guest inclusion complex based on a monofunctionalized pillar[5]arene and a tetraphenylethene derivative by the utilization of host–guest interactions to restrict the rotations process of AIE molecules, resulting in the enhanced emission of the tetraphenylethene-based guest, which was applied in cell imaging.
Fluorescence imaging has appeared as a significant technology for visualizing diverse biological targets. Supramolecular methods to modify AIE fluorogens are highly desirable for high emission efficiency and good biocompatibility. As a new generation of macrocyclic host, pillar[n]arenes, have been extensively studied. Herein, we prepared a host–guest inclusion complex based on a monofunctionalized pillar[5]arene and a tetraphenylethene derivative by the utilization of host–guest interactions to restrict the rotations process of AIE molecules, resulting in the enhanced emission of the tetraphenylethene-based guest, which was applied in cell imaging.
引文
[1]Zhou,J.;Hua,B.;Shao,L.;Feng,H.;Yu,G.Chem.Commun.2016,DOI:10.1039/c6cc01860b.