高压氧联合益气补肾法治疗气虚髓减型阿尔茨海默病的临床观察
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- 论文作者：唐晶 ; 庞谊 ; 蒋一鸣 ; 顾新刚 ; 沈灯 ; 欧阳明 ; 朱林筠 ; 李青松
- 年：2016
- 作者机构：同济大学;上海中医药大学附属普陀医院;
- 论文关键词：高压氧 ; 益气补肾法 ; 阿尔茨海默病
- 英文论文关键词：hyperbaric oxygen therapy ; Qi-invigorating and kidney nourishing therapy ; Alzheimer disease
- 会议召开时间：2016-11-25
- 会议录名称：湖南中医药大学学报2016/专集：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会论文集
- 语种：中文
- 分类号：R749.16
- 学会代码：HNZY
- 会议名称：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会
- 会议地点：中国广东珠海
- 主办单位：国际数字医学会、Digital Chinese Medicine
- 学会名称：湖南中医药大学期刊杂志社
- 页数：2
- 文件大小：1899k
- 原文格式：D
- 会议级别：全国
摘要
目的:探讨高压氧联合益气补肾法治疗气虚髓减型阿尔茨海默病的临床效果。方法:将90例AD患者随机分为三组:综合治疗组和对照组1、2各30例。综合治疗组予高压氧联合益气聪明汤合左归丸加减治疗,对照组1予以高压氧治疗,对照组2予以益气聪明汤合左归丸加减进行治疗。共进行疗程8周,对三组患者治疗前后简易智能状态量表(MMSE)、日常生活能力量表(ADL)、中医证候积分及总体疗效进行比较。结果:综合治疗组治疗后MMSE评分及ADL评分均显著高于对照组,差异具有统计学意义(P<0.05);综合治疗组治疗后总体疗效及中医证候积分与对照组相比,均差异具有统计学意义(P<0.05);综合治疗组治疗后MMSE评分及ADL评分较治疗前相比,差异具有统计学意义(P<0.05);综合治疗组治疗后总体疗效及中医证候积分较治疗前相比,差异具有统计学意义(P<0.05)。结论:高压氧联合益气补肾法治疗阿尔茨海默病有较好的临床疗效。
Objective to investigate the clinical effect of hyperbaric oxygen combined with Qi- invigorating and kidney nourishing therapy on the treatment of Alzheimer diseasepatients with deficiency of Qi and marrow. Methods 90 cases of AD were randomly divided into three groups: Comprehensive treatment group and control group 1、 2, with 30 in each group. Comprehensive treatment group were treated with hyperbaric oxygen combined with Qi- invigorating smart decoction combined with Zuogui Pill treatment, the control group 1 were treated withhyperbaric oxygen therapy, the control group 2 to be treated with Qi- invigorating smart decoction combined with Zuogui Pill treatment. A total of 8 weeks of treatment, The three groups of patientsbefore and after treatment with Mini-mental state examination(MMSE), Activity of Daily Living Scale(ADL), Traditional Chinese medicine syndrome and the overall efficacy were compared. Results after treatment, the MMSE score and ADL score in the treatment group were significantly higher than those in the control groups, the difference is statistically significant(P < 0.05); compared after treatment in treatment group and in the control groups, the overall efficacy and TCM syndrome integral are different,the differences were with statistical significance(P < 0.05); compared with the scores of MMSE and ADL score in the treatment group after treatment than before treatment, the difference is statistically significant(P < 0.05); compared to the overall efficacyand TCM syndrome integral in the combined treatment group after treatment than before treatment, the difference is statistically significant(P < 0.05). Conclusion hyperbaric oxygen combinedwith Qi- invigorating and kidney nourishing therapy has better clinical efficacy in treatment of Alzheimer's disease.
Objective to investigate the clinical effect of hyperbaric oxygen combined with Qi- invigorating and kidney nourishing therapy on the treatment of Alzheimer diseasepatients with deficiency of Qi and marrow. Methods 90 cases of AD were randomly divided into three groups: Comprehensive treatment group and control group 1、 2, with 30 in each group. Comprehensive treatment group were treated with hyperbaric oxygen combined with Qi- invigorating smart decoction combined with Zuogui Pill treatment, the control group 1 were treated withhyperbaric oxygen therapy, the control group 2 to be treated with Qi- invigorating smart decoction combined with Zuogui Pill treatment. A total of 8 weeks of treatment, The three groups of patientsbefore and after treatment with Mini-mental state examination(MMSE), Activity of Daily Living Scale(ADL), Traditional Chinese medicine syndrome and the overall efficacy were compared. Results after treatment, the MMSE score and ADL score in the treatment group were significantly higher than those in the control groups, the difference is statistically significant(P < 0.05); compared after treatment in treatment group and in the control groups, the overall efficacy and TCM syndrome integral are different,the differences were with statistical significance(P < 0.05); compared with the scores of MMSE and ADL score in the treatment group after treatment than before treatment, the difference is statistically significant(P < 0.05); compared to the overall efficacyand TCM syndrome integral in the combined treatment group after treatment than before treatment, the difference is statistically significant(P < 0.05). Conclusion hyperbaric oxygen combinedwith Qi- invigorating and kidney nourishing therapy has better clinical efficacy in treatment of Alzheimer's disease.
引文
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[16]李经伦;邹俊涛;刘长征.高压氧对帕金森小鼠模型脑递质及认知障碍的影响[J].脑与神经疾病杂志2005 13(3):196-199.
[17]Regan C,Katona C,Walker Z,et al.Relationship of vascular risk to the Progression of Alzheimers disease[J]Neuorology,2006,67:1357-1362.
[18]Riekse RG,Leverenz JB,Mc Cormick W,et al.Effect of vascular lesions on cognition in Alzheimer disease:a community-based study[J].J Am Geriatr Soc,2004,52:1442-19.
[19]彭志坚;李继锋;章少;等.高压氧对高血压性心脏病左室重构的影响[J].河北医学2011,17(5):620-623.
[20]李海东;庄晓明;王泳.高压氧对2型糖尿病Kk-ay小鼠大血管病变内皮功能的影响[A]中华医学会第二十二次全国高压氧医学学术论文汇编[C].2013:38.
[2]Korczyn AD,Vakhapova V,6rinberg LT.Vascular dementia[J].JNeurol Sci.2012,322(1/2):2-10.
[3]郑筱萸.中药新药治疗老年期痴呆的临床研究指导原则.中国医药科技出版社.2002,5:91-99.
[4]张作记.行为医学量表手册[M].北京:中华医学电子音像出版社.2005:177—179,392.
[5]杨晓娟,郝慧宁等.健脑益智汤对阿尔茨海默病大鼠海马凋亡蛋白表达的影响.中国药物与临床.2016,16(6):781-783.
[6]董秀清,李想.老年性痴呆的中医诊断及治疗研究.中国卫生标准管理.2016,7(4):125-126.
[7]梁红英,李凤荣等.高压氧联合申捷治疗老年性痴呆43例疗效观察.中华航海医学与高气压医学杂志.2010,17(3):181-183.
[8]高春锦,杨捷云,翟晓辉.高压氧医学基础与临床[M].人民卫生出版社,2008:70-71.[8]Garcia AJ 3rd,Putnam RW,Dean JB.Hyperbaric hyperoxia and normobari C reoxygenati Oil increase excitability and actirate oxygen induced potentiation in CAl hippocampal neurons[J].J Appl Physiol,2010,109(3):804—819.
[9]周宏图;周红;严丽荣,等.高压氧对老年痴呆模型小鼠抗痴呆作用的实验研究[J]中华航海医学与高气压医学杂志.2011,18(5):288-391.
[10]周海燕;刘皖生;卢素雅,等.高压氧下大鼠脑缺血区域脑组织MMP-9表达及作用[J]现代实用医学.2011,25(5):493-495.
[11]张祥根;王国华;李永财,等.高压氧疗法对创伤性脑损伤大鼠氧化应激指标及促/抗炎细胞因子水平的影响[J]中国应用生理学杂志.2010,26(3):373-376.
[12]夏佐中;包长顺;李映良,等.高压氧对大鼠脑创伤后炎症反应影响的实验研究[A]中华医学会第八次全国小儿外科学术会论文集[C].2010:270-271.
[13]彭争荣;肖平田;郭华;等.早期高压氧对脑缺血再灌注损伤大鼠神经细胞凋亡及学习记忆的影响(英文)[J].中南大学学报(医学版)2009,34(6):468-475.
[14]房金勇;李红玲;纪庆红;等.高压氧对两种实验性脑出血大鼠模型出血灶周围水肿及水通道蛋白-4表达的影响[J].中国康复医学杂志2012,27(11):987-992.
[15]徐恩斌,张忠兵,谢渭芬.乙酰胆碱酯酶的研究进展[J].国外医学(生理、病理科学与临床分册).2003(01):73-75.
[16]李经伦;邹俊涛;刘长征.高压氧对帕金森小鼠模型脑递质及认知障碍的影响[J].脑与神经疾病杂志2005 13(3):196-199.
[17]Regan C,Katona C,Walker Z,et al.Relationship of vascular risk to the Progression of Alzheimers disease[J]Neuorology,2006,67:1357-1362.
[18]Riekse RG,Leverenz JB,Mc Cormick W,et al.Effect of vascular lesions on cognition in Alzheimer disease:a community-based study[J].J Am Geriatr Soc,2004,52:1442-19.
[19]彭志坚;李继锋;章少;等.高压氧对高血压性心脏病左室重构的影响[J].河北医学2011,17(5):620-623.
[20]李海东;庄晓明;王泳.高压氧对2型糖尿病Kk-ay小鼠大血管病变内皮功能的影响[A]中华医学会第二十二次全国高压氧医学学术论文汇编[C].2013:38.