曲唑酮治疗焦虑性失眠的临床研究
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- 英文论文题名：Clinical study of Trazodone in the treatment of insomnia caused by anxiety
- 论文作者：王珏 ; 谭云飞 ; 廖峥娈 ; 仇雅菊 ; 朱骏鹏 ; 于恩彦
- 英文论文作者：Wang Jue ; TAN Yun-Fei ; LIAO Zheng-Luan ; QIU Ya-Ju ; ZHU-Jun-Peng ; YUN En-Yan
- 年：2014
- 论文关键词：曲唑酮 ; 唑吡坦 ; 失眠
- 英文论文关键词：trazodone ; zolpidem ; insomnia
- 会议召开时间：2014-11-20
- 会议录名称：2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会论文汇编
- 语种：中文
- 分类号：R740;R749.72
- 学会代码：ZJKX
- 会议名称：2014浙江省医学会精神病学分会学术年会、浙江省医师协会精神科医师分会第七届年会
- 会议地点：中国浙江湖州
- 主办单位：浙江省医学会精神病学分会（The Society of Psychiatry ; ZJMA）、浙江省医师协会精神科医师分会
- 学会名称：浙江省科学技术协会
- 页数：3
- 文件大小：241k
- 原文格式：O
- 会议级别：地方
摘要
目的:观察失眠患者使用曲唑酮后的睡眠改善情况,评价曲唑酮治疗失眠的疗效与安全性。方法:将入组的60例患者随机分为曲唑酮治疗组(30例)、唑吡坦治疗组(30例),疗程为4周。于治疗前和治疗后第4周末分别采用汉密尔顿焦虑量表(HAMA)、匹兹堡睡眠指数量表(PSQI)评定疗效与副反应量表(TESS)评定患者的副反应情况。结果:治疗第4周末,曲唑酮组的显效率为80%,唑吡坦组的显效率为56.7%,两组相比有统计学差异(p<0.05)。曲唑酮组,唑吡坦组在治疗前和治疗第4周末PSQI评分都显著降低(P<0.05);但两者对焦虑性失眠的总体疗效并无统计学差异(p>0.05),不良反应均轻。结论:曲唑酮治疗焦虑性失眠与唑吡坦总体疗效相当,两者疗效均好,不良反应轻。
Objective To investigate the clinical effect and side effects of trazodone in treating insomnia caused by anxiety.Methods sixty inpatients with insomnia caused by anxiety were randomly divied into trazodone group(30 cases) and Zolpidem group(30 cases).The course of treatment was 4 weeks.The efficacy and side effects were assessed by HAMA、 PSQI before treatment and at the and of 4th week after treatment,as well as the TESS used by the end of the 4~(th) week after treatment.Results After 4 week,the improved rates were 80%in trazodone group and 56.7%in Zolpidem group,there was significant differences between two groups(p<0.05);Before the treatmment and at the 4~(th) weeks treatment,the score of PSQI showed significant differences(p<0.05)in each group.But there were no significant differences(p<0.05)between the two groups after the 4~(th) treatment.The side effects in two groups were few.Conclusion The curative effect of trazodone used in insomnia caused by anxiety were equal compared with zolpidem,both of them are effective with high safety and low side effective.
Objective To investigate the clinical effect and side effects of trazodone in treating insomnia caused by anxiety.Methods sixty inpatients with insomnia caused by anxiety were randomly divied into trazodone group(30 cases) and Zolpidem group(30 cases).The course of treatment was 4 weeks.The efficacy and side effects were assessed by HAMA、 PSQI before treatment and at the and of 4th week after treatment,as well as the TESS used by the end of the 4~(th) week after treatment.Results After 4 week,the improved rates were 80%in trazodone group and 56.7%in Zolpidem group,there was significant differences between two groups(p<0.05);Before the treatmment and at the 4~(th) weeks treatment,the score of PSQI showed significant differences(p<0.05)in each group.But there were no significant differences(p<0.05)between the two groups after the 4~(th) treatment.The side effects in two groups were few.Conclusion The curative effect of trazodone used in insomnia caused by anxiety were equal compared with zolpidem,both of them are effective with high safety and low side effective.
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