基于柱[5]芳烃的超分子嵌段两亲聚合物的癌症靶向药物运输体系
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- 英文论文题名：Targeted Drug Delivery System Constructed from Pillar[5]arene-Based Supramolecular Brush Copolymeric Amphiphile for Cancer Treatment
- 论文作者：赵润 ; 喻国灿 ; 黄飞鹤
- 英文论文作者：Run Zhao ; Guocan Yu ; Feihe Huang ; State Key Laboratory of Chemical Engineering ; Center for Chemistry of High-Performance & Novel Materials ; Department of Chemistry ; Zhejiang University
- 年：2016
- 作者机构：化学工程联合国家重点实验室高新材料化学研究中心浙江大学化学系;
- 论文关键词：柱[5]芳烃 ; 靶向药物运输 ; 超分子两亲
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十四分会：超分子组装与软物质材料
- 语种：中文
- 分类号：TQ460.1;O631.3
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十四分会 ; 超分子组装与软物质材料
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：244k
- 原文格式：D
- 会议级别：全国
摘要
基于水溶性柱[5]芳烃和紫精之间的主客体分子识别构筑两亲超分子刷共聚物。超分子共聚物自组装成纳米颗粒,利用其聚集诱导发光效应的优点作为自成像的药物递送载体。抗癌药物阿霉素的封装引起四苯乙烯和DOX生色团两者的荧光失活,这是由于能量转移中继效应,通过荧光共振能量转移和聚集诱导淬灭介导。装载DOX分子的释放可以通过低pH值和还原酶触发,由于ETR效应消失,淬灭的荧光恢复,通过观察能量转移的位置和荧光的强度变化以实现药物释放过程中的原位可视化。装载DOX的超分子纳米颗粒表面上具有生物素配体作为靶向试剂,从而可优先进攻DOX生物素受体过度表达的癌细胞。体外研究表明,通过超分子纳米材料装载的阿霉素,对癌细胞具有比正常细胞更高的选择性毒性。
The first pillararene-based amphiphilic supramolecular brush copolymer(P5-PEG-BiotinéPTPE) was constructed on the basis of the host–guest molecular recognition between a water-soluble pillar[5]arene(P5) and a viologen salt(C_5V). P5-PEG-BiotinéPTPE self-assembled into nanoparticles, which were utilized as a self-imaging drug delivery vehicle. Encapsulation of anticancer drug doxorubicin(DOX) caused deactivation of the fluorescences of both the tetraphenylethene(TPE)and DOX chromophores. The release of loaded DOX molecules can be triggered by low pH and reductase, recovering the "silenced" fluorescence, achieving in situ visualization of the drug release process by observing the location and magnitude of the energy transfer-dependent fluorescence variation.
The first pillararene-based amphiphilic supramolecular brush copolymer(P5-PEG-BiotinéPTPE) was constructed on the basis of the host–guest molecular recognition between a water-soluble pillar[5]arene(P5) and a viologen salt(C_5V). P5-PEG-BiotinéPTPE self-assembled into nanoparticles, which were utilized as a self-imaging drug delivery vehicle. Encapsulation of anticancer drug doxorubicin(DOX) caused deactivation of the fluorescences of both the tetraphenylethene(TPE)and DOX chromophores. The release of loaded DOX molecules can be triggered by low pH and reductase, recovering the "silenced" fluorescence, achieving in situ visualization of the drug release process by observing the location and magnitude of the energy transfer-dependent fluorescence variation.
引文
[1]Peer,D.;Karp,J.M.;Hong,S.;Farokhzad,O.C.;Margalit,R.;Langer,R.Nat.Nanotech.2007,2,751.