重大病毒病导向的绿色农药化学研究
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- 英文论文题名：Chemical Research on Green Pesticide Targeted on Key Plant Virus
- 论文作者：宋宝安 ; 杨新玲 ; 汪清民
- 英文论文作者：Baoan Song ; Xinling Yang ; Qingmin Wang ; Key Laboratory of Green Pesticide and Agricultural Bioengineering ; Ministry of Education ; Guizhou University ; College of Science ; China Agriculture University ; College of Chemistry ; Nankai University
- 年：2016
- 作者机构：贵州大学绿色农药与农业生物工程教育部重点实验室;中国农业大学理学院;南开大学化学学院;
- 论文关键词：绿色农药 ; 重大病毒病 ; 先导发现 ; 分子靶标 ; 创制
- 英文论文关键词：green pesticide ; key plant virus ; lead compound ; molecular targets ; creation
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十八分会：化学生物学
- 语种：中文
- 分类号：TQ450.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十八分会 ; 化学生物学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：2
- 文件大小：232k
- 原文格式：D
- 会议级别：全国
摘要
植物病毒病素有植物"癌症"之称,是一种世界性病害,研究和防治病毒病一直是农业生产中的世界重大难题。本文以我国粮经作物中重大病毒害黄瓜花叶病、烟草花叶病、水稻病毒病害为研究对象,围绕化学信息干扰重大病毒病侵染、复制、传播生态节点靶标的分子机制这一关键科学问题,采用以"病毒生物学"结合"病毒生态学"的研究策略,基于植物免疫激活的抗病毒先导发现与化学生物学、媒介昆虫化学信息干扰的先导发现及化学生物学、抑制植物病毒复制的先导化合物发现与化学生物学研究三个紧密相关、相辅相成的方面,开展了调控重大作物病毒侵染复制传播的农药化学生物学基础研究,发现了5个原创性的农药先导化合物,3个具有潜在应用前景的高活性化合物,2个杀虫抗病毒药剂的新靶标。寻找出新的作用机制与新先导,为创制具有自主知识产权的绿色农药新品种提供理论依据和指导。
Plant virus disease is considered as plant cancer and is a worldwide important threat to agriculture.Since the mechanism of parasitism and invasion into plant cell of virus is not clear yet,it poses a difficult problem for us to study the prevention and control of plant viral diseases.Based on these important and difficult technical problems we are facing against Cucumber mosaic virus,tobacco mosaic virus,rice virus diseases,our group carried out intensive research work on solving the key scientific questions of the molecular mechanism of the infection,duplication,and spreading of important plant viral.The strategies of "Virus Biology" as well as "Virus Ecology" were combined to tackle this challenge,which include the discovery and chemical biology investigation of antivirus lead compound activating plant immune system,insecticidal lead compound interfering transmission insect pheromone communication,antivirus lead compound inhibiting virus duplication.In general,our research works are carrying out chemical biology research on antiviral agents regulating the infection,duplication,and spreading of import antiviral to look for new action mode,lead compound,which will provide theoretical guidance for future green pesticide innovation.Through the proposed research work,5 original lead structures,3 potential high active compounds,2 novel molecular targets were achieved.
Plant virus disease is considered as plant cancer and is a worldwide important threat to agriculture.Since the mechanism of parasitism and invasion into plant cell of virus is not clear yet,it poses a difficult problem for us to study the prevention and control of plant viral diseases.Based on these important and difficult technical problems we are facing against Cucumber mosaic virus,tobacco mosaic virus,rice virus diseases,our group carried out intensive research work on solving the key scientific questions of the molecular mechanism of the infection,duplication,and spreading of important plant viral.The strategies of "Virus Biology" as well as "Virus Ecology" were combined to tackle this challenge,which include the discovery and chemical biology investigation of antivirus lead compound activating plant immune system,insecticidal lead compound interfering transmission insect pheromone communication,antivirus lead compound inhibiting virus duplication.In general,our research works are carrying out chemical biology research on antiviral agents regulating the infection,duplication,and spreading of import antiviral to look for new action mode,lead compound,which will provide theoretical guidance for future green pesticide innovation.Through the proposed research work,5 original lead structures,3 potential high active compounds,2 novel molecular targets were achieved.
引文
[1]Song,B.A.;Yang,S.;Jin,L.H.;Bhadury,P.S.Environment-Friendly Anti-Plant Viral Agent.Springer press2009.
[2]Yang,Y.;Liu,Y.X.;Wang,Q.M.Org.Lett.2015,17:5714
[3]Namitharan,K.;Zhu,T.S.;Cheng,J.J.;Zheng,P.C.;Li,X.Y.;Yang,S.;Song,B.A.;Chi,Y.G.Nature Comm.2014,5:4982
[2]Yang,Y.;Liu,Y.X.;Wang,Q.M.Org.Lett.2015,17:5714
[3]Namitharan,K.;Zhu,T.S.;Cheng,J.J.;Zheng,P.C.;Li,X.Y.;Yang,S.;Song,B.A.;Chi,Y.G.Nature Comm.2014,5:4982