温和条件下铜基催化剂催化的胺与CO_2的甲酰化反应
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- 英文论文题名：Copper-Catalyzed N-Formylation of Amines with CO_2 under Ambient Condition
- 论文作者：张素启 ; 梅清清 ; 刘航宇 ; 刘会贞 ; 韩布兴
- 英文论文作者：Suqi Zhang ; Qingqing Mei ; Hangyu Liu ; Huizhen Liu ; Buxing Han ; Beijing National Laboratory for Molecular Sciences ; Institute of Chemistry ; Chinese Academy of Sciences
- 年：2016
- 作者机构：北京分子科学国家实验室中国科学院化学研究所分子科学中心;
- 论文关键词：二氧化碳 ; 铜催化剂 ; 绿色化学 ; 甲酰胺
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十三分会：绿色化学
- 语种：中文
- 分类号：O621.251
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十三分会 ; 绿色化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：177k
- 原文格式：D
- 会议级别：全国
摘要
甲酰胺是一类具有广泛应用的化学品,可以作为工业溶剂与合成其它重要化学品的原料。在还原剂存在下,采用二氧化碳作为碳源是甲酰胺的一条重要合成路线。在本工作中我们发现乙酸铜的2,2-双(二苯基膦基)乙烷(DPPE)配合物可以有效催化胺与CO_2的甲酰化反应,并且反应条件温和。在室温、1大气压的二氧化碳条件下,0.1 mol%用量的催化剂即可催化各种脂肪胺和芳香胺与CO_2的甲酰化反应,甲酰胺的收率可以达到95%以上。在实验基础上,讨论了反应的机理。这一工作发展了一条胺与CO_2的甲酰化反应的高效路线。
Formamides are a class of chemicals with wide applications in industry as solvents and raw materials for synthesis of other chemicals.In this work,we studied N-formylation of amines with CO_2 and PhSiH_3 to produce formamides catalyzed by a copper complex.It was demonstrated that Cu(OAc)2-bis(diphenylphosphino)ethane(dppe) catalytic system was very efficient for this kind of reactions at ambient condition,and the yields of the corresponding desired products were very high only 0.1 mol%catalyst loading.
Formamides are a class of chemicals with wide applications in industry as solvents and raw materials for synthesis of other chemicals.In this work,we studied N-formylation of amines with CO_2 and PhSiH_3 to produce formamides catalyzed by a copper complex.It was demonstrated that Cu(OAc)2-bis(diphenylphosphino)ethane(dppe) catalytic system was very efficient for this kind of reactions at ambient condition,and the yields of the corresponding desired products were very high only 0.1 mol%catalyst loading.
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