黄芩总黄酮在健康和2型糖尿病大鼠体内的药动学和组织分布研究
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- 英文论文题名：Flavonoid pharmacokinetics and tissue distribution in normal and type 2 diabetic rats after oral administration of Radix Scutellaria extract
- 论文作者：张学举 ; 刘志强 ; 宋凤瑞
- 英文论文作者：Xueju Zhang ; Zhiqiang Liu ; Fengrui Song ; National Center of Mass Spectrometry in Changchun ; Jilin Province Key Laboratory of Chinese Medicine Chemistry and Mass Spectrometry ; Changchun Institute of Applied Chemistry ; Chinese Academy of Sciences ; University of Chinese Academy of Sciences
- 年：2016
- 作者机构：中国科学院长春应用化学研究所;
- 论文关键词：黄芩 ; 药动学 ; 组织分布 ; UPLC-MS/MS ; 2型糖尿病
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第四十三分会：质谱分析
- 语种：中文
- 分类号：R285.5
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第四十三分会 ; 质谱分析
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：169k
- 原文格式：D
- 会议级别：全国
摘要
黄芩提取物中6种黄酮成分在健康大鼠和2型糖尿病大鼠体内的药动学和组织分布行为并不清楚。在本研究中,利用UPLC-MS/MS方法研究了健康大鼠和糖尿病大鼠口服黄芩提取物后6种黄酮的药动学和组织分布行为。结果显示,2型糖尿病大鼠体内6种黄酮成分的药动参数(如C_(max)和AUC)与健康大鼠有显著差异(p<0.05)。同时6种黄酮在2型糖尿病大鼠体内的组织分布行为随疾病状态而改变(p<0.05)。这项研究为更好地理解黄芩提取物的体内过程、作用途径和治疗机制提供了重要的依据。
Pharmacokinetic and tissue-distribution behaviors of flavonoid compounds from Radix Scutellaria in normal and type 2 diabetic rats are still unclear so far.The flavonoid compounds in rat plasma and tissues,were simultaneously measured by ultra performance liquid chromatography-tandem mass spectrometry method after oral administration of Radix Scutellaria extract to normal and type 2 diabetic rats.The results showed that baicalin,wogonoside and oroxyloside were found to have a higher Cmax and AUC(p<0.05) in type 2 diabetic rats than those in normal rats and the tissue-distribution behaviors of the six flavonoid compounds in tissues of type 2diabetic rats had obviously differences from normal rats due to such pathological state(p<0.05).The results of this study provide a crucial basis for better understanding of in vivo action pathway and anti-diabetic mechanism of the six flavonoid compounds from Radix Scutellaria.
Pharmacokinetic and tissue-distribution behaviors of flavonoid compounds from Radix Scutellaria in normal and type 2 diabetic rats are still unclear so far.The flavonoid compounds in rat plasma and tissues,were simultaneously measured by ultra performance liquid chromatography-tandem mass spectrometry method after oral administration of Radix Scutellaria extract to normal and type 2 diabetic rats.The results showed that baicalin,wogonoside and oroxyloside were found to have a higher Cmax and AUC(p<0.05) in type 2 diabetic rats than those in normal rats and the tissue-distribution behaviors of the six flavonoid compounds in tissues of type 2diabetic rats had obviously differences from normal rats due to such pathological state(p<0.05).The results of this study provide a crucial basis for better understanding of in vivo action pathway and anti-diabetic mechanism of the six flavonoid compounds from Radix Scutellaria.
引文
[1]Fong,S.Y.K.;Wong,Y.C.;Zuo,Z.J.Pharm.Biomed.Anal.2014,97:9.