单糖印迹的荧光纳米粒子用于癌细胞靶向识别与成像
详细信息 查看官网全文
摘要
<正>癌细胞的特异性识别是癌症靶向诊断的关键。现有癌细胞特异性识别方法的识别专一性高度依赖于抗体~([1,2])、适配体~([3,4])、凝集素~([5,6)]等具有靶向识别能力的生物分子,而这些生物分子存在许多难以避免的问题,如制备困难、价格昂贵及稳定性差等~([7,8])。因此,发展新的能克服这些缺点的癌细胞
引文
1.P.Chakravarty,R.Marches,N.S.Zimmerman,et al.,Thermal ablation of tumor cells with antibody-functionalized single-walled carbon nanotubes,Proc.Natl.Acad.Sci.USA,2008,105:8697-8702
2.E.O.Serebrovskaya,E.F.Edelweiss,O.A.Stremovskiy,et al.,Targeting cancer cells by using an antireceptor antibodyphotosensitizer fusion protein,Proc.Natl.Acad.Sci.USA,2009,106:9221-9225
3.Z.W.Tang,D.H.Shangguan,K.M.Wang,et al.,Selection of aptamers for molecular recognition and characterization of cancer cells,Anal.Chem.,2007,79:4900-4907
4.H.Shi,X.X.He,K.M.Wang,et al.,Activatable aptamer probe for contrast-enhanced in vivo cancer imaging based on cell membrane protein-triggered conformation alteration,Proc.Natl.Acad.Sci.USA,2011,108:3900-3905
5.E.Nakata,Y.Koshi,E.Koga,et al.,Double-modification of lectin using two distinct chemistries for fluorescent ratiometric sensing and imaging saccharides in test tube or in cell,J.Am.Chem.Soc.,2005,127:13253-13261
6.X.N.Zhang,Y.Q.Teng,Y.Fu,et al.,Lectin-based electrochemical biosensor constructed by functionalized carbon nanotubes for the competitive assay of glycan expression on living cancer cells,Chem.Sci.,2011,2:2353-2360
7.M.J.Edgeworth,J.J.Phillips,D.C.Lowe,et al.,Global and Local Conformation of Human Ig G Antibody Variants Rationalizes Loss of Thermodynamic Stability,Angew.Chem.Int.Ed.,2015,54:15156-15159
8.D.Ejima,K.Tsumoto,H.Fukada,et al.,Effects of Acid Exposure on the Conformation,Stability,and Aggregation of Monoclonal Antibodies,PROTEINS-Structure,Function,and Bioinformatics,2007,66:954-962
9.G.Wulff,A.Sarhan,The use of polymers with enzyme-analogous structures for the resolution of racemates,Angew.Chem.Int.Ed.,1972,11:341-345
10.G.Vlatakis,L.Andersson,R.Muller,et al.,Drug assay using antibody mimics made by molecular imprinting,Nature,1993,361:645-647
11.J.Q.Liu,G.Wulff,Functional mimicry of the active site of carboxypeptidase A by a molecular imprinting strategy:cooperativity of an amidinium and a copper ion in a transition-state imprinted cavity giving rise to high catalytic activity,J.Am.Chem.Soc.,2004,126:7452-7453
12.W.Bai,D.A.Spivak,A double-imprinted diffraction-grating sensor based on a virus responsive super-aptamer hydrogel derived from an impure extract,Angew.Chem.Int.Ed.,2014,53:2095-2098
2.E.O.Serebrovskaya,E.F.Edelweiss,O.A.Stremovskiy,et al.,Targeting cancer cells by using an antireceptor antibodyphotosensitizer fusion protein,Proc.Natl.Acad.Sci.USA,2009,106:9221-9225
3.Z.W.Tang,D.H.Shangguan,K.M.Wang,et al.,Selection of aptamers for molecular recognition and characterization of cancer cells,Anal.Chem.,2007,79:4900-4907
4.H.Shi,X.X.He,K.M.Wang,et al.,Activatable aptamer probe for contrast-enhanced in vivo cancer imaging based on cell membrane protein-triggered conformation alteration,Proc.Natl.Acad.Sci.USA,2011,108:3900-3905
5.E.Nakata,Y.Koshi,E.Koga,et al.,Double-modification of lectin using two distinct chemistries for fluorescent ratiometric sensing and imaging saccharides in test tube or in cell,J.Am.Chem.Soc.,2005,127:13253-13261
6.X.N.Zhang,Y.Q.Teng,Y.Fu,et al.,Lectin-based electrochemical biosensor constructed by functionalized carbon nanotubes for the competitive assay of glycan expression on living cancer cells,Chem.Sci.,2011,2:2353-2360
7.M.J.Edgeworth,J.J.Phillips,D.C.Lowe,et al.,Global and Local Conformation of Human Ig G Antibody Variants Rationalizes Loss of Thermodynamic Stability,Angew.Chem.Int.Ed.,2015,54:15156-15159
8.D.Ejima,K.Tsumoto,H.Fukada,et al.,Effects of Acid Exposure on the Conformation,Stability,and Aggregation of Monoclonal Antibodies,PROTEINS-Structure,Function,and Bioinformatics,2007,66:954-962
9.G.Wulff,A.Sarhan,The use of polymers with enzyme-analogous structures for the resolution of racemates,Angew.Chem.Int.Ed.,1972,11:341-345
10.G.Vlatakis,L.Andersson,R.Muller,et al.,Drug assay using antibody mimics made by molecular imprinting,Nature,1993,361:645-647
11.J.Q.Liu,G.Wulff,Functional mimicry of the active site of carboxypeptidase A by a molecular imprinting strategy:cooperativity of an amidinium and a copper ion in a transition-state imprinted cavity giving rise to high catalytic activity,J.Am.Chem.Soc.,2004,126:7452-7453
12.W.Bai,D.A.Spivak,A double-imprinted diffraction-grating sensor based on a virus responsive super-aptamer hydrogel derived from an impure extract,Angew.Chem.Int.Ed.,2014,53:2095-2098