盐酸右美托咪定对老年2型糖尿病患者气管插管期QTc间期的影响
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- 论文作者：谢淑芬 ; 谢海辉 ; 张曙 ; 王杰荣
- 年：2016
- 作者机构：广东省东莞市人民医院;
- 论文关键词：盐酸右美托咪定 ; 2型糖尿病 ; QTc间期 ; 气管插管
- 会议召开时间：2016-11-25
- 会议录名称：湖南中医药大学学报2016/专集：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会论文集
- 语种：中文
- 分类号：R614
- 学会代码：HNZY
- 会议名称：国际数字医学会数字中医药分会成立大会暨首届数字中医药学术交流会
- 会议地点：中国广东珠海
- 主办单位：国际数字医学会、Digital Chinese Medicine
- 学会名称：湖南中医药大学期刊杂志社
- 页数：1
- 文件大小：2016k
- 原文格式：D
- 会议级别：全国
摘要
目的:研究静脉注射盐酸右美托咪定在全麻诱导气管插管期间对老年2型糖尿病患者QTc间期的影响。方法:82例择期腹部手术老年2型糖尿病患者,随机分成盐酸右美托咪定(D组n=41,诱导前给予负荷剂量右美托咪定0.7ug/kg,注射泵缓慢静脉注射,输注时间超过10 min,维持剂量以0.4 ug/(kg·h)持续静脉注射)和安慰剂组(P组n=41,诱导前静脉注射等容量氯化钠溶液),分别于麻醉前(T0)、麻醉诱导后1 min(T1)、麻醉诱导后5 min(插管前,T2)及插管后1min(T3)、6min(T4)记录QTc间期、血压及HR变化。结果:与T0比较,T3-T4时C组QTc间期延长(P<0.05)。组间比较,T3-T4时C组QTc间期明显长于D组(P<0.05)。结论:全麻诱导围气管插管期老年2型糖尿病患者QTc间期延长,静注盐酸右美托咪定能明显抑制插管操作引起的QTc间期延长。
引文
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[3]Liu G1,Song H1,Qiu L,et al.,Dexmedetomidine preconditioning inhibits the long term inflammation induced by renal ischemia/reperfusion injury in rats.Acta Cir Bras.2016,31(1):8-14.
[4]许忠玲,徐兴国,崔松勤.盐酸右美托咪定对食管癌根治术患者围术期血糖、в-内啡肽、TNF-a及IL-6表达的影响.第二军医大学报,2010,31(12):1130-1132.
[5]程华春,杭燕南.心率、心率变异性与麻醉.国外医学麻醉学与复苏分册,2000,20(2):94-96.庞明,李维,关浩增.冠心病患者心电图复极离散度的研究[J].广西医学,2010,32(4):401-402.
[6]范晶,周波,李启富.2型糖尿病患者周围攻动脉疾病相关因素的调查[J].重庆医学,2009,38(2):139-141.
[7]Madsen LB,Rasmussen JK,Moller DS,et a1.Heart rate variability in White-coat hypertention[J].Blood Pressure Monitoring,2008,13(2):65-71.
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[9]Li Y,He R,Chen S,et a1.Effect of dexmedetomidine on early postoperative cognitive dysfunction and peri-operative inflammation in elderly patients undergoing laparoscopic cholecystectomy.Exp Ther Med.2015,10(5):1635-1642.