二氧化硅金纳米棒复合纳米粒子的制备及其光学性质的研究
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摘要
光热治疗通过光热转换材料产生局部高温杀伤肿瘤细胞或组织,能够提高肿瘤区域的治疗效果,降低对周围正常组织的伤害。具有高的光热转换效率和靶向性、低的生物毒性的光热转换材料成为研究重点。采用银离子介导的晶种生长法制备出金纳米棒(GNR),再通过碱催化正硅酸四乙酯(TEOS)的水解缩合,在GNR表面形成二氧化硅壳层,制备出二氧化硅金纳米棒复合纳米粒子。其光学性质研究表明调节硝酸银的用量以及生长液pH可以实现GNR局域表面等离子体共振(LSPR)吸收峰在700~950nm内的调控。透射电镜结果表明,二氧化硅壳层为30nm的GNR-SiO_2呈规则的椭球形,具有明显的介孔特征。Zeta(电位)结果表明,二氧化硅包埋使GNR的表面电位发生了剧烈反转,由35.6mV变为-14.5mV。二氧化硅包埋对复合粒子的LSPR吸收峰及光热转化效率没有明显影响,而且能够在改善GNR在生物毒性、稳定性及载药率等方面的不足的同时不影响其光学特性,极大的增加了GNR在生物检测和纳米药物领域的应用潜力。
引文
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