生物膜界面化层层组装微胶囊
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- 英文论文题名：Biointerfacing Layer-by-Layer Self-Assembly Polymeric Microcapsules
- 论文作者：邵婧鑫 ; 戴陆如 ; 贺强
- 英文论文作者：Jingxin Shao ; Luru Dai ; Qiang He ; Key Laboratory of Micro-systems and Micro-structures Manufacturing ; Harbin Institute of Technology ; Key Lab for Biomedical Effects of Nanomaterials and Nanosafety ; National Center for Nanoscience and Technology
- 年：2016
- 作者机构：哈尔滨工业大学微结构与微系统制造教育部重点实验室;国家纳米科学中心中科院纳米生物效应与安全性重点实验室;
- 论文关键词：层层自组装 ; 聚电解质多层膜 ; 光热气泡治疗 ; 可控释放 ; 活体抗肿瘤
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十一分会：胶体与界面化学
- 语种：中文
- 分类号：TQ460.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十一分会 ; 胶体与界面化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：181k
- 原文格式：D
- 会议级别：全国
摘要
我们运用层层自组装的方法构筑生物膜界面化的金纳米棒掺杂的天然聚合物微胶囊,通过组装层数及金纳米棒密度实现了微胶囊机械性质的有效调控。活体抗肿瘤实验表明,血液环境中的微胶囊能够有效参与循环并穿越机体生物屏障富集在肿瘤部位。在高强度近红外激光照射下,可快速激发胶囊壁内金纳米棒产生光热效应形成气泡,以气泡的破裂来实现肿瘤组织的损伤及瓦解(Fig.1A)。此外,微胶囊的中空结构可载入抗肿瘤药物,结合低能量近红外激光的照射,破坏胶囊表面生物膜和囊壁结构,实现内载药物的快速释放,达到药物在活体中治疗肿瘤的目的(Fig.1B)。
We prepared biointerfacing natural polyelectrolyte microcapsules through layer-by-layer self-assembly technique.Gold nanorods(GNRs) in lipid bilayer-modified microcapsules are presented to cross the biological barriers of the body and localize at the tumor sites,and generate vapor bubbles under near-infrared(NIR)illumination with high intensity,meanwhile controlled drug release can be achieved on-demand from lipid bilayer-modified GNRs-microcapsules by using low NIR intensity.This intelligent antitumor platform proves to be a multifunctional system with the advantages of controlled release,high therapeutic efficacy,and credible biosafety.
We prepared biointerfacing natural polyelectrolyte microcapsules through layer-by-layer self-assembly technique.Gold nanorods(GNRs) in lipid bilayer-modified microcapsules are presented to cross the biological barriers of the body and localize at the tumor sites,and generate vapor bubbles under near-infrared(NIR)illumination with high intensity,meanwhile controlled drug release can be achieved on-demand from lipid bilayer-modified GNRs-microcapsules by using low NIR intensity.This intelligent antitumor platform proves to be a multifunctional system with the advantages of controlled release,high therapeutic efficacy,and credible biosafety.
引文
[1]Shao,J.X.;Xuan,M.J.;Dai,L.R.;Si,T.Y;Li,J.B.;He,Q.Angew.Chem.Int.Ed.2015,54:12782.
[2]Shao,J.X.;Xuan,M.J.;Si,T.Y.;Dai,L.R.;He,Q.Nanoscale 2015,7:19092.
[2]Shao,J.X.;Xuan,M.J.;Si,T.Y.;Dai,L.R.;He,Q.Nanoscale 2015,7:19092.