聚丙烯酸环糊精水凝胶对分子扩散行为的调控
详细信息 查看官网全文
- 英文论文题名：Molecular diffusion behavior regulated by poly(acrylic acid) grafting β-cyclodextrin hydrogel
- 论文作者：栾兴龙 ; 安琪 ; 黄滔 ; 张以河
- 英文论文作者：Xinglong Luan ; Qi An ; Tao Huang ; Yihe Zhang ; School of materials science and technology ; China University of Geosciences Beijing
- 年：2016
- 作者机构：中国地质大学(北京)材料科学与工程学院;
- 论文关键词：环糊精 ; 超分子 ; 主客体 ; 扩散 ; 梯度
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十四分会：超分子组装与软物质材料
- 语种：中文
- 分类号：O648.17
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十四分会 ; 超分子组装与软物质材料
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：291k
- 原文格式：D
- 会议级别：全国
摘要
生命过程的实现离不开物质的传输,其中扩散是一种重要的实现方式,我们采用一种合成的超分子水凝胶作为基体研究超分子结合作用对扩散行为的影响。该水凝胶由接枝beta-环糊精的聚丙烯酸(PAA-CD)组成,该水凝胶中的环糊精既可以通过自身的氢键充当交联剂,其又与扩散的分子的发生主客体识别作用。环糊精的接枝率和高分子浓度共同决定水凝胶的流变特性。客体分子偶氮苯在其中扩散的同时与receptor环糊精发生快速可逆的超分子结合,而紫外光辐照减小超分子结合常数的同时加快扩散的速率。通过实验观察与数值模拟结合的研究方法,证实快速可逆的超分子结合减慢扩散的速率;超分子结合常数与环糊精的浓度共同决定表观扩散系数的大小;由该表观扩散系数描述的分子宏观分布仍复合菲克扩散定律。对于超分子结合-扩散耦合过程物理化学规律的探索会为揭示生物复杂性加深认识,该规律有望启发可控给药、组织工程材料的设计开发。
Diffusion is an indispensable way of substance transmission in life progresses. Here we used a artificial hydrogel as substrate to study the regulated diffusion behavior of the specific molecules. The β-cyclodextrin in the hydrogel not only serve as crosslinker own to its hydrogen bonds, but also can form host-guest complex with specific molecules. Aminoazobenzene can form host-guest complex with cyclodextrin and the binding intensity can be tuned by UV light. Experimental and simulation result indicate that host-guest interaction slow down the diffusion progress and the diffusion can be described by Fick's law mathematically. This study may inspire new ways of controlled drug delivery and the design of tissue engineering materials.
Diffusion is an indispensable way of substance transmission in life progresses. Here we used a artificial hydrogel as substrate to study the regulated diffusion behavior of the specific molecules. The β-cyclodextrin in the hydrogel not only serve as crosslinker own to its hydrogen bonds, but also can form host-guest complex with specific molecules. Aminoazobenzene can form host-guest complex with cyclodextrin and the binding intensity can be tuned by UV light. Experimental and simulation result indicate that host-guest interaction slow down the diffusion progress and the diffusion can be described by Fick's law mathematically. This study may inspire new ways of controlled drug delivery and the design of tissue engineering materials.
引文
[1]Yu,S.R.,Burkhardt,M.,Nowak,M.,Ries,J.,Petrá?ek,Z.,Scholpp,S.Brand,M.Nature 2009,461:533.
[1]Perl,A.,Gomez-Casado,A.,Thompson,D.,Dam,H.H.,Jonkheijm,P.,Reinhoudt,D.N.,&Huskens,J.Nature chemistry 2011,3:317.
[1]Perl,A.,Gomez-Casado,A.,Thompson,D.,Dam,H.H.,Jonkheijm,P.,Reinhoudt,D.N.,&Huskens,J.Nature chemistry 2011,3:317.