小儿荨麻疹应用中西医结合治疗的效果分析
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- 英文论文题名：The Effect of Integrated Traditional Chinese and Western Medicine Treatment of Urticariain Children
- 论文作者：王家娜
- 英文论文作者：Wang Jiana
- 年：2017
- 作者机构：四川眉山彭山区妇幼保健计划生育服务中心;
- 论文关键词：小儿 ; 荨麻疹 ; 中西医结合治疗 ; 疗效
- 英文论文关键词：Children ; urticaria ; integrated traditional Chinese and western medicine ; clinical effect
- 会议召开时间：2017-05-26
- 会议录名称：2017年《中国组织化学与细胞化学杂志》临床研讨会论文集
- 语种：中文
- 分类号：R758.24
- 学会代码：ZHXB
- 会议名称：2017年《中国组织化学与细胞化学杂志》临床研讨会
- 会议地点：中国湖北武汉
- 主办单位：《中国组织化学与细胞化学杂志》社有限公司
- 学会名称：《中国组织化学与细胞化学杂志》社有限公司
- 页数：2
- 文件大小：248k
- 原文格式：O
- 会议级别：全国
摘要
目的:观察并探讨应用中西医结合治疗小儿荨麻疹的临床疗效以及安全性分析。方法:将本院收治的72例小儿荨麻疹患者随机分为两组,对照组36例患儿接受西药(阿司咪唑或氯雷他定)治疗,联合用药组36例患儿接受中西医联合治疗,即在口服阿司咪唑或氯雷他定的基础上,另外加服本院自制中药制剂防风通圣散。观察患儿治疗效果、不良反应以及复发情况。结果:联合用药组患儿经中西医联合治疗后的总有效率为91.7%,复发率为8%;对照组患儿仅口服抗组胺类药物治疗后的总有效率为69.4%,复发率为18.8%。两组患儿比较,总有效率和复发率都具有统计学差异(p<0.05)。另外,两组患儿安全性均良好,可偶见嗜睡、口感、便秘、腹泻等不良事件,没有统计学差异(p>0.05)。经实验室检查,所有患者治疗后,血清中IgE和IL-4水平均显著降低,有明显的统计学差异。Ⅰ结论:采用中西医结合治疗小儿荨麻疹疗效显著,复发率较低,具有良好的临床应用前景。
Objective:To observe and discuss the therapeutic effect of integrated traditional Chinese and western medicine treatment on urticaria in children.Methods:Seventy-two Children with urticaria were randomly divided into the combined treatment group and the control group.Thirty-six cases in the combined treatment group were treated with integrated traditional Chinese and western medicine,and the other thirty-six cases in the control group were only treated with the western medicine(Astemizole or Loratadine).Results The total effective rates in the combinedtreatment group and control group were 91.7%and 69.4%respectively(p <0.05).Meanwhile,there were 2 cases and 3 cases with recurrence,and the recurrence rateswere 8%and 18.8%respectively.The difference was statistically significant,p <0.05.In addition,no serious adverse effects to the both treatments were observed,except for occasional somnolence,dry mouth,nausea,constipation,or diarrhea.We suggested that the combined treatments were safe and well tolerated.By laboratory examination,the level of the serum IgE and IL-4 in both groups were decreased significantly after treatment,p <0.01.However,there was no statistical significance in total IgE and IL-4 between the combined treatment group and the control group after treatment.Conclusion:The integrated traditional Chinese and western medicine treatment of urticaria in children is found to be effective in treating the urticaria of children,and the recurrence rate is rather low.Hence,it is worthy to be popularized.
Objective:To observe and discuss the therapeutic effect of integrated traditional Chinese and western medicine treatment on urticaria in children.Methods:Seventy-two Children with urticaria were randomly divided into the combined treatment group and the control group.Thirty-six cases in the combined treatment group were treated with integrated traditional Chinese and western medicine,and the other thirty-six cases in the control group were only treated with the western medicine(Astemizole or Loratadine).Results The total effective rates in the combinedtreatment group and control group were 91.7%and 69.4%respectively(p <0.05).Meanwhile,there were 2 cases and 3 cases with recurrence,and the recurrence rateswere 8%and 18.8%respectively.The difference was statistically significant,p <0.05.In addition,no serious adverse effects to the both treatments were observed,except for occasional somnolence,dry mouth,nausea,constipation,or diarrhea.We suggested that the combined treatments were safe and well tolerated.By laboratory examination,the level of the serum IgE and IL-4 in both groups were decreased significantly after treatment,p <0.01.However,there was no statistical significance in total IgE and IL-4 between the combined treatment group and the control group after treatment.Conclusion:The integrated traditional Chinese and western medicine treatment of urticaria in children is found to be effective in treating the urticaria of children,and the recurrence rate is rather low.Hence,it is worthy to be popularized.
引文
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[2]刘酉合。抗敏汤治疗慢性荨麻疹随机平行对照研究[J].实用中医内科杂志,2016,30(11):25-27.
[3]竹佳,黄巧玲,胡玉平。白芍总苷联合抗组胺药治疗慢性荨麻疹疗效和安全性的Meta分析[J].中国现代应用药学.2016;33(11):1463-1468.
[4]石春蕊,石春波,匡钱华,等。当归引子治疗慢性荨麻疹疗效与安全性的系统评价[J].中国循证医学杂志。2012;12(10):1261-1269
[5]Weller K,Zuberbier T,Maurer M.,et al.Clinically relevant outcome measures for assessing disease activity,disease control and quality of life impairment in patients with chronic spontaneous urticaria and recurrent angioedema[J].Curr Opin Allergy C lin Inununol.2015;15(3):220-226.
[6]Ferrer M,et al.Immunological events in chronic spontaneous urticaria[J].Clin Transl Allergy.2015;5(30):1-8.
[7]马家驹,张广中。经方治疗荨麻疹探讨[J].中华中医药杂志.2013;4(28):997-1000.
[8]Arik Yilmaz E,Karaatmaca B,Sackesen C,et al.Parasitic Infections in Children with Chronic Spontaneous Urticaria[J].Int Arch Allergy Inmunol.2016;2;171(2):130-135.
[2]刘酉合。抗敏汤治疗慢性荨麻疹随机平行对照研究[J].实用中医内科杂志,2016,30(11):25-27.
[3]竹佳,黄巧玲,胡玉平。白芍总苷联合抗组胺药治疗慢性荨麻疹疗效和安全性的Meta分析[J].中国现代应用药学.2016;33(11):1463-1468.
[4]石春蕊,石春波,匡钱华,等。当归引子治疗慢性荨麻疹疗效与安全性的系统评价[J].中国循证医学杂志。2012;12(10):1261-1269
[5]Weller K,Zuberbier T,Maurer M.,et al.Clinically relevant outcome measures for assessing disease activity,disease control and quality of life impairment in patients with chronic spontaneous urticaria and recurrent angioedema[J].Curr Opin Allergy C lin Inununol.2015;15(3):220-226.
[6]Ferrer M,et al.Immunological events in chronic spontaneous urticaria[J].Clin Transl Allergy.2015;5(30):1-8.
[7]马家驹,张广中。经方治疗荨麻疹探讨[J].中华中医药杂志.2013;4(28):997-1000.
[8]Arik Yilmaz E,Karaatmaca B,Sackesen C,et al.Parasitic Infections in Children with Chronic Spontaneous Urticaria[J].Int Arch Allergy Inmunol.2016;2;171(2):130-135.