流感病毒HA受体结合位点抑制剂研究进展
详细信息 查看官网全文
- 英文论文题名：Progress on the virus entry inhibitor agents of the receptor binding site on Influenza Virus' HA
- 论文作者：王文超 ; 汪雨 ; 王心竹 ; 赵玉军 ; 王欣 ; 李化生 ; 原婧 ; 尹荣焕
- 英文论文作者：WANG Wen-chao ; WANG Yu ; WANG Xin-zhu ; ZHAO Yu-jun ; YUAN Jing ; WANG Xin ; Li Hua-sheng ; YIN Rong-huan ; Shenyang Agricultural University ; Liaoning Agricultural college
- 年：2016
- 作者机构：沈阳农业大学;辽宁农业职业技术学校;
- 论文关键词：流感病毒 ; HA ; 受体结合位点 ; 病毒进入抑制剂
- 英文论文关键词：influenza virus ; HA ; receptor binding site ; virus entry inhibitor agents
- 会议召开时间：2016-07-20
- 会议录名称：中国畜牧兽医学会兽医公共卫生学分会第五次学术研讨会论文集
- 语种：中文
- 分类号：S852.65
- 学会代码：SYGW
- 会议名称：中国畜牧兽医学会兽医公共卫生学分会第五次学术研讨会
- 会议地点：中国内蒙古通辽
- 主办单位：中国畜牧兽医学会兽医公共卫生学分会
- 学会名称：中国畜牧兽医学会兽医公共卫生学分会
- 页数：4
- 文件大小：471k
- 原文格式：D
- 会议级别：全国
摘要
目前抗流感病毒的药物和疫苗受到病毒耐药性、疫苗滞后性等诸多因素的限制,使能阻止病毒进入细胞的流感病毒进入抑制剂成为当前研究的热点。唾液酸是HA的受体,但研究表明唾液酸并不适合作为研制流感病毒进入抑制剂的结构模型。研究发现流感病毒的HA受体结合位点抗体能与HA受体结合位点的保守氨基酸残基结合,能有效的抑制流感病毒感染宿主。针对HA受体结合位点的突变逃逸株失去感染能力。因此,可用HA受体结合位点抗体作为流感病毒进入抑制剂的模型,研制流感病毒抑制剂。
At present,the anti flu drugs and vaccines were restricted by drug resistance,hysteresis and other factors,so the influenza virus entry inhibitors which can prevent virus entry host cell become a research hotspot.Sialic acid is the receptor of HA,but it not suitable as a structure model of influenza virus entry inhibitors.The study found that the HA receptor binding sites' s antibody can binding the conserved amino acid residues,can effectively inhibit influenza virus infection.The HA receptor binding site mutation escape mutant loses the ability of infection.So the HA receptor binding sites' s antibody is a suitable model for inhibitors of influenza virus entry
At present,the anti flu drugs and vaccines were restricted by drug resistance,hysteresis and other factors,so the influenza virus entry inhibitors which can prevent virus entry host cell become a research hotspot.Sialic acid is the receptor of HA,but it not suitable as a structure model of influenza virus entry inhibitors.The study found that the HA receptor binding sites' s antibody can binding the conserved amino acid residues,can effectively inhibit influenza virus infection.The HA receptor binding site mutation escape mutant loses the ability of infection.So the HA receptor binding sites' s antibody is a suitable model for inhibitors of influenza virus entry
引文
[1]W.WEIS,J.H.BROWN,S.CUSACK,et al.Structure of the influenza virus haemagglutinin complexed with its receptor,sialic acid[J].Nature,1988,333(6172):426-431.
[2]XU RUI,A.Wilson.Structural characterization of an early fusion intermediate of influenza virus hemagglutinin[J].J Virol,2011,85(10):5172-5182.
[3]MIKHAIL Matrosovich,KLENK Hans-Dieter.Natural and synthetic sialic acid-containing inhibitors of influenza virus receptor binding[J].Rev Med Virol,2003,13(2):85-97.
[4]NOBUKO Ohshima,YOSHITAKE Iba,RITSUKO Kubota Koketsu,et al.Naturally occurring antibodies in humans can neutralize a variety of influenza virus strains,including H3,H1,H2,and H5[J].J Virol,2011,85(21):11047-11057.
[5]KRAUSEA Jens C,TSHIDI Tsibanec,TERRENCE M,et al.Human monoclonal antibodies to pandemic 1957H2N2 and pandemic 1968 H3N2 influenza viruses[J].J Virol,2012,86(11):6334-6340.
[6]WHITTLE James R,ZHANG Ruijun,SURENDER Khuranac,et al.Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin[J].PNAS,2011,108(34):14216-14221.
[7]EKIERT Damian C,KASHYAP Arun K.,JOHN Steel,et al.Cross-neutralization of influenza A viruses mediated by a single antibody loop[J].Nature,2012,489(7417):526-532.
[8]LEEA Peter S.,REIKO Yoshidab,EKIERTA Damian C.,et al.Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity[J].Proc Natl Acad Sci USA,2012,109(42):17040-17045.
[9]XU Rui,KRAUSE Jens C,RYAN Mc Bride,et al.A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin[J].Nat Struct Mol Biol,2013,20(3):363-370.
[2]XU RUI,A.Wilson.Structural characterization of an early fusion intermediate of influenza virus hemagglutinin[J].J Virol,2011,85(10):5172-5182.
[3]MIKHAIL Matrosovich,KLENK Hans-Dieter.Natural and synthetic sialic acid-containing inhibitors of influenza virus receptor binding[J].Rev Med Virol,2003,13(2):85-97.
[4]NOBUKO Ohshima,YOSHITAKE Iba,RITSUKO Kubota Koketsu,et al.Naturally occurring antibodies in humans can neutralize a variety of influenza virus strains,including H3,H1,H2,and H5[J].J Virol,2011,85(21):11047-11057.
[5]KRAUSEA Jens C,TSHIDI Tsibanec,TERRENCE M,et al.Human monoclonal antibodies to pandemic 1957H2N2 and pandemic 1968 H3N2 influenza viruses[J].J Virol,2012,86(11):6334-6340.
[6]WHITTLE James R,ZHANG Ruijun,SURENDER Khuranac,et al.Broadly neutralizing human antibody that recognizes the receptor-binding pocket of influenza virus hemagglutinin[J].PNAS,2011,108(34):14216-14221.
[7]EKIERT Damian C,KASHYAP Arun K.,JOHN Steel,et al.Cross-neutralization of influenza A viruses mediated by a single antibody loop[J].Nature,2012,489(7417):526-532.
[8]LEEA Peter S.,REIKO Yoshidab,EKIERTA Damian C.,et al.Heterosubtypic antibody recognition of the influenza virus hemagglutinin receptor binding site enhanced by avidity[J].Proc Natl Acad Sci USA,2012,109(42):17040-17045.
[9]XU Rui,KRAUSE Jens C,RYAN Mc Bride,et al.A recurring motif for antibody recognition of the receptor-binding site of influenza hemagglutinin[J].Nat Struct Mol Biol,2013,20(3):363-370.