抗菌肽的免疫调节功能及其作用机制
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- 英文论文题名：Immunomodulatory Function and Mechanism of Action of Antimicrobial Peptides
- 论文作者：卫旭彪 ; 武如娟 ; 郑召君 ; 廖秀冬 ; 张日俊
- 英文论文作者：WEI Xu-biao ; WU Ru-juan ; ZHENG Zhao-jun ; LIAO Xiu-dong ; ZHANG Ri-jun ; Laboratory of Feed Biotechnology ; State Key Laboratory of Animal Nutrition ; China Agricultural University
- 年：2016
- 作者机构：中国农业大学饲料生物技术实验室动物营养学国家重点实验室;
- 论文关键词：抗菌肽 ; 生物学功能 ; 抗炎机制 ; 免疫调节机制
- 英文论文关键词：antimicrobial peptides ; biological function ; anti-inflammatory mechanism ; immunomodulatory mechanism
- 会议召开时间：2016-11-04
- 会议录名称：中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会论文集
- 语种：中文
- 分类号：S816.7
- 学会代码：ZGXJ
- 会议名称：中国畜牧兽医学会动物微生态学分会第五届第十二次全国学术研讨会
- 会议地点：中国山东青岛
- 主办单位：中国畜牧兽医学会动物微生态学分会
- 学会名称：中国畜牧兽医学会
- 页数：4
- 文件大小：371k
- 原文格式：O
- 会议级别：全国
摘要
抗菌肽存在于自然界的各种生物体中,包括昆虫、植物、哺乳动物以及非哺乳类的脊椎动物。本文重点阐述了抗菌肽的概念、特性及多种生物学功能,介绍了其在抗炎和免疫调节中的作用机制,也阐述了作者对抗菌肽在科学研究和疾病治疗方面发展趋势的看法。
Antimicrobial peptides are found in every complex species,existing in organisms from insects to plants to mammals and non-mammalian vertebrates.This paper expatiates the concept,characteristics and varied biological function of antimicrobial peptides,and introduces its anti-inflammatory and immunomodulatory mechanisms.The author also elaborates on scientific research and therapeutics trends of antimicrobial peptides.
Antimicrobial peptides are found in every complex species,existing in organisms from insects to plants to mammals and non-mammalian vertebrates.This paper expatiates the concept,characteristics and varied biological function of antimicrobial peptides,and introduces its anti-inflammatory and immunomodulatory mechanisms.The author also elaborates on scientific research and therapeutics trends of antimicrobial peptides.
引文
[1]黎观红,洪智敏,贾永杰,等.抗菌肽的抗菌作用及其机制[J].动物营养学报.2011(04):546-555.
[2]Hancock R E,Rozek A.Role of membranes in the activities of antimicrobial cationic peptides[J].FEMS Microbiol Lett.2002,206(2):143-149.
[3]Zasloff M.Antimicrobial peptides of multicellular organisms[J].Nature.2002,415(6870):389-395.
[4]Yang D,Biragyn A,Kwak L W,et al.Mammalian defensins in immunity:more than just microbicidal[J].Trends Immunol.2002,23(6):291-296.
[5]Heilborn J D,Nilsson M F,Jimenez C I,et al.Antimicrobial protein hCAP18/LL-37 is highly expressed in breast cancer and is a putative growth factor for epithelial cells[J].Int J Cancer.2005,114(5):713-719.
[6]Islam D,Bandholtz L,Nilsson J,et al.Downregulation of bactericidal peptides in enteric infections:a novel immune escape mechanism with bacterial DNA as a potential regulator[J].Nat Med.2001,7(2):180-185.
[7]Fang X M,Shu Q,Chen Q X,et al.Differential expression of alpha-and beta-defensins in human peripheral blood[J].Eur J Clin Invest.2003,33(1):82-87.
[8]Duits L A,Ravensbergen B,Rademaker M,et al.Expression of beta-defensin 1 and 2 mRNA by human monocytes,macrophages and dendritic cells[J].Immunology.2002,106(4):517-525.
[9]Harder J,Meyer-Hoffert U,Wehkamp K,et al.Differential gene induction of human beta-defensins(hBD-1,-2,-3,and-4)in keratinocytes is inhibited by retinoic acid[J].J Invest Dermatol.2004,123(3):522-529.
[2]Hancock R E,Rozek A.Role of membranes in the activities of antimicrobial cationic peptides[J].FEMS Microbiol Lett.2002,206(2):143-149.
[3]Zasloff M.Antimicrobial peptides of multicellular organisms[J].Nature.2002,415(6870):389-395.
[4]Yang D,Biragyn A,Kwak L W,et al.Mammalian defensins in immunity:more than just microbicidal[J].Trends Immunol.2002,23(6):291-296.
[5]Heilborn J D,Nilsson M F,Jimenez C I,et al.Antimicrobial protein hCAP18/LL-37 is highly expressed in breast cancer and is a putative growth factor for epithelial cells[J].Int J Cancer.2005,114(5):713-719.
[6]Islam D,Bandholtz L,Nilsson J,et al.Downregulation of bactericidal peptides in enteric infections:a novel immune escape mechanism with bacterial DNA as a potential regulator[J].Nat Med.2001,7(2):180-185.
[7]Fang X M,Shu Q,Chen Q X,et al.Differential expression of alpha-and beta-defensins in human peripheral blood[J].Eur J Clin Invest.2003,33(1):82-87.
[8]Duits L A,Ravensbergen B,Rademaker M,et al.Expression of beta-defensin 1 and 2 mRNA by human monocytes,macrophages and dendritic cells[J].Immunology.2002,106(4):517-525.
[9]Harder J,Meyer-Hoffert U,Wehkamp K,et al.Differential gene induction of human beta-defensins(hBD-1,-2,-3,and-4)in keratinocytes is inhibited by retinoic acid[J].J Invest Dermatol.2004,123(3):522-529.