超分子超支化聚合物自组装体形貌调控及程序化控释研究
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- 英文论文题名：Morphology transitions and programmed drug release of supramolecular hyperbranched polymer self-assemblies
- 论文作者：姚灏 ; 宋昕 ; 张海涛 ; 刘月舟 ; 田威
- 英文论文作者：Hao Yao ; Xin Song ; Hai-tao Zhang ; Yue-zhou Liu ; Wei Tian ; Shanxi Key Laboratory of Macromolecular Science and Technology ; School of Science ; Northwestern Polytechnical University
- 年：2016
- 作者机构：陕西省高分子科学与技术重点实验室西北工业大学理学院;
- 论文关键词：超分子超支化聚合物自组装 ; 超声响应 ; 光响应 ; 程序化控制释放
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十四分会：超分子组装与软物质材料
- 语种：中文
- 分类号：O631.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十四分会 ; 超分子组装与软物质材料
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：316k
- 原文格式：D
- 会议级别：全国
摘要
超分子超支化聚合物自组装体凭借其独特的物理化学特性,在生物医学和纳米科技等领域具有广泛的应用前景。本文首先合成了一种同时含有偶氮苯基团和双环糊精单元的AB_2型单体(Azo-CD_2)。在水溶液中,Azo-CD_2自发地形成球状自组装形貌,而当施加超声振动后逐渐转变为超支化状组装体;该自组装体被进一步施加紫外光照后可解离成尺寸较小的支化自组装体,其在可见光作用下又可以可逆地变回超支化自组装形貌。利用该超分子超支化聚合物自组装体在水溶液中的可逆形貌转化特性,通过连续地施加超声振动和紫外光,可实现对阿霉素的三阶段程序化控制释放。
In this paper, we reported the controllable morphology transitions and programmed drug release of supramolecular hyperbranched polymer self-assemblies based amphiphilic β-cyclodextrin dimers(Azo-CD_2). The Azo-CD_2 first self-assembled into spherical self-assemblies in aqueous solution. The primary self-assemblies dissociated and then secondarily formed bigger self-assemblies with hyperbranched morphology under ultrasonication. Upon UV light irradiation, the self-assemblies were dissociated into small branched aggregates, which could revert to hyperbranched self-assemblies under the irradiation by visible light. The reversible self-assembly morphology transitions were utilized to conduct programmed drug release with three stages.
In this paper, we reported the controllable morphology transitions and programmed drug release of supramolecular hyperbranched polymer self-assemblies based amphiphilic β-cyclodextrin dimers(Azo-CD_2). The Azo-CD_2 first self-assembled into spherical self-assemblies in aqueous solution. The primary self-assemblies dissociated and then secondarily formed bigger self-assemblies with hyperbranched morphology under ultrasonication. Upon UV light irradiation, the self-assemblies were dissociated into small branched aggregates, which could revert to hyperbranched self-assemblies under the irradiation by visible light. The reversible self-assembly morphology transitions were utilized to conduct programmed drug release with three stages.
引文
[1]Yao,H.;Qi,M.;Liu,Y.;Tian,W.Chem.Eur.J.2016,in press.
[2]Zhang,H.;Fan,X.;Suo,R.;Li,H.;Yang,Z.;Zhang,W.;Bai,Y.;Yao,H.;Tian,W.Chem.Commun.2015,51:15366.
[3]Li,H.;Fan,X.;Tian,W.;Zhang,H.;Zhang,W.;Yang,Z.Chem.Commun.2014,50:14666.
[2]Zhang,H.;Fan,X.;Suo,R.;Li,H.;Yang,Z.;Zhang,W.;Bai,Y.;Yao,H.;Tian,W.Chem.Commun.2015,51:15366.
[3]Li,H.;Fan,X.;Tian,W.;Zhang,H.;Zhang,W.;Yang,Z.Chem.Commun.2014,50:14666.