集诊断-靶向-控制释药一体的纳米脂质体
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- 英文论文题名：Liposomes of controlled drug release, targeted therapies and fluorescent tracer technique
- 论文作者：安学勤 ; 李烈列 ; Xiaojuan Yan
- 英文论文作者：Xueqin An ; Lielie Li ; Xiaojuan Yan ; Department of Chemistry ; East China University of Science and Technology
- 年：2016
- 作者机构：华东理工大学;
- 论文关键词：荧光示踪 ; 靶向 ; 刺激响应 ; 控制释放 ; 脂质体
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：TQ460.6
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：170k
- 原文格式：D
- 会议级别：全国
摘要
脂质体具有由磷脂双分子层围绕水池构成的球形囊泡结构,被认为是一种药物输送系统的有效工具,已被广泛用于药物输送,但往往因其靶向性差、不能在线监测和控制释药临床应用受到限制。目前,最具有挑战性的问题是制备具有靶向-示踪-控制释药为一体的纳米脂质体。本课题将具有靶向特性的生物活性物质(siRNA、叶酸等)和生物相容性好的荧光纳米材料有效地负载于脂质体,并利用脂质体的低临界溶液温度(LCST)相转变的基本原理,实现刺激响应控制释放药物(温控、磁控、光控、pH控制)。
Liposomes are self-assembling structures in a lipid dipersion in water and a useful tool for drug delivery as a container for the storage, transfer, and controllable release of agents. Liposomes have been recognized as drug nanocarriers for decades, but their clinical applications are often limited by uncontrolled release and poor targeting ability in vivo in humans. A major challenge for drug delivery is controlled release both spatially and temporally. Bioactive substance with targeting action and fluorescent nanoparticles with good biocompatibility were effectively load in liposomes to synthesize multifunctional liposomes with stimulate response control release drug. Based on principle of bilayer phase transfer of the liposomes, stimulate response control release drug was realized by controlling lower critical solution temperature of the liposomes.
Liposomes are self-assembling structures in a lipid dipersion in water and a useful tool for drug delivery as a container for the storage, transfer, and controllable release of agents. Liposomes have been recognized as drug nanocarriers for decades, but their clinical applications are often limited by uncontrolled release and poor targeting ability in vivo in humans. A major challenge for drug delivery is controlled release both spatially and temporally. Bioactive substance with targeting action and fluorescent nanoparticles with good biocompatibility were effectively load in liposomes to synthesize multifunctional liposomes with stimulate response control release drug. Based on principle of bilayer phase transfer of the liposomes, stimulate response control release drug was realized by controlling lower critical solution temperature of the liposomes.
引文
[1]An,X.Q.Zhang,F.and Zhu Y.Y.,Chemical Communication,2010,46:7202
[2]Li,L.L.An,X.Q.and Yan X.J.,Colloids and Surfaces B:Biointerfaces,2015,134:235
[2]Li,L.L.An,X.Q.and Yan X.J.,Colloids and Surfaces B:Biointerfaces,2015,134:235