超小多功能纳米粒子的化学合成及其在癌症诊疗一体的应用
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- 英文论文题名：Ultra-small nanoparticles as multifunctional theranostics for cancer therapy
- 论文作者：谷战军 ; 雍媛
- 英文论文作者：Zhanjun Gu ; Yuan Yong ; CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety ; Institute of High Energy Physics ; Chinese Academy of Sciences
- 年：2016
- 作者机构：中国科学院高能物理研究所;
- 论文关键词：超小纳米粒子 ; 癌症 ; 诊疗一体
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第三十八分会：纳米生物效应与纳米药物化学
- 语种：中文
- 分类号：R73-3;TB383.1
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第三十八分会 ; 纳米生物效应与纳米药物化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：2
- 文件大小：225k
- 原文格式：D
- 会议级别：全国
摘要
放射治疗是通过高能X射线与癌细胞DNA相互作用,破坏DNA结构,从而达到杀伤肿瘤细胞的作用。但是放疗的缺点是对于乏氧细胞不敏感,而光热治疗恰好能够改善肿瘤细胞的乏氧环境。因此,将光热治疗和放疗协同能够有效增敏放疗,提高抗肿瘤效果。我们通过设计合成既有高效光热转换效率又可以有效吸收X-ray的超小纳米粒子WS_2和多酸团簇等,实现单一纳米粒子介导的光热与放疗协同治疗。(ACS nano,2015,9(12),12451-12463;NPG Asia materials,2016,accepted)与常规热疗和放疗相比,由于纳米材料的EPR效应,可以靶向肿瘤组织,提高细胞摄取效率,大大提高肿瘤细胞的对热疗与放疗的敏感性,从而实现协同效应。实验结果表明,纳米粒子介导的热疗/放疗协同治疗,可以显著改善肿瘤内部乏氧环境,提高血氧浓度,抑制肿瘤转移,提高肿瘤杀伤效果。此外,由于制备的纳米粒子尺寸非常小(<5nm),可以被有效的清除出体外,减少了对其安全性的担忧,为其临床应用提供了可能。
Designing a multifunctional nanomedicine for integration of precise diagnosis and effective treatment of tumor is desirable but remains a great challenge. Here, we reported the novel multifunctional nanomedicines based on WS_2 quantum dots(QDs) and gadolinium polytungstates nanoclusters. The as-obtained WS_2 QDs and gadolinium polytungstates nanoclusters with ultra-small size(<3 nm) possess not only significant X-ray computed tomography(CT) signal enhancement but also remarkable photothermal therapy(PTT)/radiotherapy therapy(RT) synergistic effect for tumor therapy. With CT imaging and the synergistic effect between PTT and RT, the tumor could be accurately positioned and thorough eradicated in vivo after i.v. injection of the NPs. Moreover, hematoxylin & eosin(HE) staining, blood hematology and biochemistry analysis revealed no noticeable toxicity of these nanoparticles in vitro and in vivo, which confirmed that WS_2 QDs and gadolinium polytungstates nanoclusters possess well biocompatibility. These multifunctional nanoparticles could play an important role in facilitating simultaneously multimodal imaging and synergistic PTT/RT therapy to achieve better therapeutic efficacy.
Designing a multifunctional nanomedicine for integration of precise diagnosis and effective treatment of tumor is desirable but remains a great challenge. Here, we reported the novel multifunctional nanomedicines based on WS_2 quantum dots(QDs) and gadolinium polytungstates nanoclusters. The as-obtained WS_2 QDs and gadolinium polytungstates nanoclusters with ultra-small size(<3 nm) possess not only significant X-ray computed tomography(CT) signal enhancement but also remarkable photothermal therapy(PTT)/radiotherapy therapy(RT) synergistic effect for tumor therapy. With CT imaging and the synergistic effect between PTT and RT, the tumor could be accurately positioned and thorough eradicated in vivo after i.v. injection of the NPs. Moreover, hematoxylin & eosin(HE) staining, blood hematology and biochemistry analysis revealed no noticeable toxicity of these nanoparticles in vitro and in vivo, which confirmed that WS_2 QDs and gadolinium polytungstates nanoclusters possess well biocompatibility. These multifunctional nanoparticles could play an important role in facilitating simultaneously multimodal imaging and synergistic PTT/RT therapy to achieve better therapeutic efficacy.
引文
[1]Yong,Y.;Cheng,X.;Bao,T.;Zu,M.;Yan,L.;Yin,W.;Ge,C.;Wang,D.;Gu,Z.;Zhao,Y.,ACS Nano,2015,9:12451.
[2]Yong,Y.;Zhou,L.;Zhang,S.;Yan,L.;Gu,Z.;Zhang,G.;Zhao,Y.;NPG Asia Materials,2016,accepted.
[2]Yong,Y.;Zhou,L.;Zhang,S.;Yan,L.;Gu,Z.;Zhang,G.;Zhao,Y.;NPG Asia Materials,2016,accepted.