基于S-Hg~(2+)配位诱导的荧光探针的构筑及其识别性能研究
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- 英文论文题名：Construction and recognition performance of fluorescent probe based on the induction of S-Hg~(2+) coordination
- 论文作者：厍梦尧 ; 马思悦 ; 王兆晖 ; 李杰 ; 周鹏程 ; 李剑利
- 英文论文作者：She Mengyao ; Ma Siyue ; Wang Zhaohui ; Li Jie ; Zhou Pengcheng ; Li Jianli ; Ministry of Education Key Laboratory of Synthetic and Natural Functional Molecule Chemistry ; College of Chemistry & Materials Science ; Northwest University
- 年：2016
- 作者机构：西北大学化学与材料科学学院合成与天然功能分子化学教育部重点实验室;
- 论文关键词：分子识别 ; 荧光探针 ; 罗丹明 ; 配位作用
- 会议召开时间：2016-07-01
- 会议录名称：中国化学会第30届学术年会摘要集-第二十七分会：光化学
- 语种：中文
- 分类号：O641.4;O657.3
- 学会代码：ZGHY
- 会议名称：中国化学会第30届学术年会-第二十七分会 ; 光化学
- 会议地点：中国辽宁大连
- 主办单位：中国化学会
- 学会名称：中国化学会
- 页数：1
- 文件大小：271k
- 原文格式：D
- 会议级别：全国
摘要
分子识别行为广泛存在于自然界中,其所加载及表达的信息往往对于重大科学问题具有先导性。在这其中,荧光分子探针技术因其优良的特异性识别、较高的检测灵敏度、较宽的动态响应范围等优点,被广泛应用在复杂生物和环境体系的内状态信息表达、药物筛选等领域。我们课题组基于近年来生命体系荧光探针构筑的研究,设计合成一类基于S-Hg~(2+)配位效应诱导的罗丹明型硫内酰肼Hg~(2+)荧光探针,通过修饰、变构识别基团调整其结合位点空间位阻效应和电子效应实现对探针荧光性能的调节。该类荧光探针已成功应用于生物细胞微环境Hg~(2+)的检测,应用前景广阔。
Molecular recognition plays a vital role in significant scientific researches. Fluorescent probes have been applied widely in various due to their specific recognition, superior detection sensitivity, wide dynamic response, etc.Our research group achieved construction and recognition performance of fluorescent probes based on the induction of S-Hg~(2+) coordination on the foundation of recent researches. The recognition of these probes could be regulated and controlled through the regulation of the electronic characteristics and spatial structure of the functional group. In addition, the synthesized probes have been successfully applied for the detection of Hg~(2+) in living cells.
Molecular recognition plays a vital role in significant scientific researches. Fluorescent probes have been applied widely in various due to their specific recognition, superior detection sensitivity, wide dynamic response, etc.Our research group achieved construction and recognition performance of fluorescent probes based on the induction of S-Hg~(2+) coordination on the foundation of recent researches. The recognition of these probes could be regulated and controlled through the regulation of the electronic characteristics and spatial structure of the functional group. In addition, the synthesized probes have been successfully applied for the detection of Hg~(2+) in living cells.
引文
[1]Yang,Z.;She,M.;Yin,B.;Hao,L.,Obst,M.;Liu,P.;Li,J.Anal.Chim.Acta.2015,868:53.
[2]Yang,Z.;Hao,L.,Yin,B.;She,M.;Obst,M.;Kappler,A.;Li,J.Org.Lett.2013,15:4334.
[3]黄阳阳,王梦嘉,厍梦尧,杨征,刘萍,李剑利,史真.有机化学,2014,34:1.
[2]Yang,Z.;Hao,L.,Yin,B.;She,M.;Obst,M.;Kappler,A.;Li,J.Org.Lett.2013,15:4334.
[3]黄阳阳,王梦嘉,厍梦尧,杨征,刘萍,李剑利,史真.有机化学,2014,34:1.